mGluR2 positive allosteric modulators: a patent review (2009 - present). (Q38085707)

28 August 2017

mGluR2 positive allosteric modulators: a patent review (2009 - present). (English)

1 reference

28 August 2017

Andrés A Trabanco

1

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author name string

José María Cid

series ordinal

2

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PubMed ID

23452205

28 August 2017

language of work or name

English

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publication date

2 March 2013

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Expert Opinion on Therapeutic Patents

28 August 2017

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28 August 2017

23

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28 August 2017

5

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28 August 2017

629-647

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Metabotropic glutamate receptors: physiology, pharmacology, and disease

28 August 2017

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Mood disorders: regulation by metabotropic glutamate receptors

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Group 1 mGluR-dependent synaptic long-term depression: mechanisms and implications for circuitry and disease

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Metabotropic glutamate receptors and the control of chronic pain

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Metabotropic glutamate receptor ligands as potential therapeutics for addiction

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Glutamate receptors as therapeutic targets for Parkinson's disease

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l-glutamate as a central neurotransmitter: looking back

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Ionotropic and metabotropic glutamate receptor structure and pharmacology

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Interdomain movements in metabotropic glutamate receptor activation

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Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors

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Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors

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Regulation of neurotransmitter release by metabotropic glutamate receptors

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Distribution of the messenger RNA for a metabotropic glutamate receptor, mGluR2, in the central nervous system of the rat.

21 January 2018

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Distribution and abundance of metabotropic glutamate receptor subtype 2 in rat brain revealed by [3H]LY354740 binding in vitro and quantitative radioautography: correlation with the sites of synthesis, expression, and agonist stimulation of [35S]GTP

21 January 2018

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Differential expression of metabotropic glutamate receptors 2 and 3 in schizophrenia: a mechanism for antipsychotic drug action?

21 January 2018

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Targeting of metabotropic glutamate receptors for the treatment of schizophrenia

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Design, synthesis, and pharmacological characterization of (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740): a potent, selective, and orally active group 2 metabotropic glutamate receptor agonist possessing anticonvulsant and anxioly

21 January 2018

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Metabotropic glutamate receptors as novel targets for anxiety and stress disorders

21 January 2018

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Efficacy and tolerability of an mGlu2/3 agonist in the treatment of generalized anxiety disorder

21 January 2018

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Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial

21 January 2018

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Group II metabotropic glutamate receptor agonists and positive allosteric modulators as novel treatments for schizophrenia

21 January 2018

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Regulation of group II metabotropic glutamate receptors by G protein-coupled receptor kinases: mGlu2 receptors are resistant to homologous desensitization

21 January 2018

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Metabotropic glutamate receptor mGlu2 is resistant to homologous agonist-induced desensitization but undergoes protein kinase C-mediated heterologous desensitization.

21 January 2018

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Receptor activation involving positive allosteric modulation, unlike full agonism, does not result in GABAB receptor desensitization

21 January 2018

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Allosteric modulation of family C G-protein-coupled receptors: from molecular insights to therapeutic perspectives

21 January 2018

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Discovery of allosteric potentiators for the metabotropic glutamate 2 receptor: synthesis and subtype selectivity of N-(4-(2-methoxyphenoxy)phenyl)-N-(2,2,2- trifluoroethylsulfonyl)pyrid-3-ylmethylamine

21 January 2018

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Biphenyl-indanones: allosteric potentiators of the metabotropic glutamate subtype 2 receptor

21 January 2018

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Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s).

21 January 2018

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A selective allosteric potentiator of metabotropic glutamate (mGlu) 2 receptors has effects similar to an orthosteric mGlu2/3 receptor agonist in mouse models predictive of antipsychotic activity

21 January 2018

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Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice

21 January 2018

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Recent progress in the synthesis and characterization of group II metabotropic glutamate receptor allosteric modulators.

21 January 2018

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Progress in the developement of positive allosteric modulators of the metabotropic glutamate receptor 2.

21 January 2018

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Phenyl-tetrazolyl acetophenones: discovery of positive allosteric potentiatiors for the metabotropic glutamate 2 receptor

21 January 2018

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Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 2: 4-thiopyridyl acetophenones as non-tetrazole containing mGlu2 receptor potentiators.

21 January 2018

1 reference

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3-(2-Ethoxy-4-{4-[3-hydroxy-2-methyl-4-(3-methylbutanoyl)phenoxy]butoxy}phenyl)propanoic acid: a brain penetrant allosteric potentiator at the metabotropic glutamate receptor 2 (mGluR2).

21 January 2018

1 reference

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Benzazoles as allosteric potentiators of metabotropic glutamate receptor 2 (mGluR2): efficacy in an animal model for schizophrenia

21 January 2018

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Discovery of 1,5-disubstituted pyridones: a new class of positive allosteric modulators of the metabotropic glutamate 2 receptor

21 January 2018

1 reference

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Discovery of 1,4-disubstituted 3-cyano-2-pyridones: a new class of positive allosteric modulators of the metabotropic glutamate 2 receptor

21 January 2018

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3-Benzyl-1,3-oxazolidin-2-ones as mGluR2 positive allosteric modulators: Hit-to lead and lead optimization.

21 January 2018

1 reference

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3-Aryl-5-phenoxymethyl-1,3-oxazolidin-2-ones as positive allosteric modulators of mGluR2 for the treatment of schizophrenia: Hit-to-lead efforts

21 January 2018

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3-(Imidazolyl methyl)-3-aza-bicyclo[3.1.0]hexan-6-yl)methyl ethers: a novel series of mGluR2 positive allosteric modulators.

21 January 2018

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The identification of structurally novel, selective, orally bioavailable positive modulators of mGluR2.

21 January 2018

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1-[(1-methyl-1H-imidazol-2-yl)methyl]-4-phenylpiperidines as mGluR2 positive allosteric modulators for the treatment of psychosis

21 January 2018

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Positive allosteric modulators of the metabotropic glutamate receptor subtype 2 (mGluR2).

21 January 2018

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Positive allosteric modulators of the metabotropic glutamate receptor 2 for the treatment of schizophrenia

21 January 2018

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Metabotropic glutamate receptors as therapeutic targets for schizophrenia

21 January 2018

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Therapeutic potential of metabotropic glutamate receptor modulators

21 January 2018

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N-(4-((2-(trifluoromethyl)-3-hydroxy-4-(isobutyryl)phenoxy)methyl)benzyl)-1-methyl-1H-imidazole-4-carboxamide (THIIC), a novel metabotropic glutamate 2 potentiator with potential anxiolytic/antidepressant properties: in vivo profiling suggests a lin

21 January 2018

1 reference

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Group II metabotropic glutamate receptor type 2 allosteric potentiators prevent sodium lactate-induced panic-like response in panic-vulnerable rats.

21 January 2018

1 reference

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Scaffold hopping from pyridones to imidazo[1,2-a]pyridines. New positive allosteric modulators of metabotropic glutamate 2 receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.777043

Imidazo[1,2-a]pyridines: orally active positive allosteric modulators of the metabotropic glutamate 2 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.777043

Modulation of group II metabotropic glutamate receptor (mGlu2) elicits common changes in rat and mice sleep-wake architecture

21 January 2018

1 reference

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Discovery of 3-cyclopropylmethyl-7-(4-phenylpiperidin-1-yl)-8-trifluoromethyl[1,2,4]triazolo[4,3-a]pyridine (JNJ-42153605): a positive allosteric modulator of the metabotropic glutamate 2 receptor.

21 January 2018

1 reference

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Synthesis, evaluation, and radiolabeling of new potent positive allosteric modulators of the metabotropic glutamate receptor 2 as potential tracers for positron emission tomography imaging.

21 January 2018

1 reference

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Discovery of Oxazolobenzimidazoles as Positive Allosteric Modulators for the mGluR2 Receptor

21 January 2018

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Design and synthesis of an orally active metabotropic glutamate receptor subtype-2 (mGluR2) positive allosteric modulator (PAM) that decreases cocaine self-administration in rats

21 January 2018

1 reference

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Orally active metabotropic glutamate subtype 2 receptor positive allosteric modulators: structure-activity relationships and assessment in a rat model of nicotine dependence

21 January 2018

1 reference

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The mGlu2 but not the mGlu3 receptor mediates the actions of the mGluR2/3 agonist, LY379268, in mouse models predictive of antipsychotic activity

21 January 2018

1 reference

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Use of MGLUR2 and MGLUR3 knockout mice to explore in vivo receptor specificity of the MGLUR2/3 selective antagonist LY341495.

21 January 2018

1 reference

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Evidence for the role of metabotropic glutamate (mGlu)2 not mGlu3 receptors in the preclinical antipsychotic pharmacology of the mGlu2/3 receptor agonist (-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]hexane-4,6-dicarboxylic acid (LY404039).

21 January 2018

1 reference

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10.1517/13543776.2013.777043

21 January 2018

Identifiers

DOI

1 reference

28 August 2017

1 reference

PubMed ID

23452205