AMPA receptor positive allosteric modulators: a patent review (Q38081162)

28 August 2017

AMPA receptor positive allosteric modulators: a patent review (English)

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28 August 2017

Bernard Pirotte

1

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28 August 2017

Pierre Francotte

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2

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28 August 2017

Eric Goffin

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3

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28 August 2017

Pascal de Tullio

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4

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28 August 2017

language of work or name

English

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publication date

13 February 2013

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Expert Opinion on Therapeutic Patents

28 August 2017

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28 August 2017

23

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28 August 2017

5

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28 August 2017

615-628

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In search of novel AMPA potentiators

28 August 2017

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https://api.crossref.org/works/10.1517%2F13543776.2013.770840

The molecular pharmacology and cell biology of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.770840

Heteromeric AMPA receptors assemble with a preferred subunit stoichiometry and spatial arrangement

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2013.770840

AMPA receptor biogenesis and trafficking

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2013.770840

Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.770840

Structure and function of AMPA receptors

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2013.770840

Receptor trafficking and synaptic plasticity

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2013.770840

Flip and Flop: A Cell-Specific Functional Switch in Glutamate-Operated Channels of the CNS

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.770840

AMPA receptor potentiators for the treatment of CNS disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.770840

The role of AMPA receptor modulation in the treatment of neuropsychiatric diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.770840

Emerging role of glutamate in the pathophysiology of major depressive disorder.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.770840

Ring-fused thiadiazines as core structures for the development of potent AMPA receptor potentiators

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.770840

Recent advances in the discovery of selective AMPA receptor positive allosteric modulators.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.770840

Positive allosteric modulators of AMPA receptors are neuroprotective against lesions induced by an NMDA agonist in neonatal mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.770840

A role for AMPA receptors in mood disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.770840

A placebo-controlled pilot study of the ampakine CX516 added to clozapine in schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.770840

AMPA receptor modulators as cognitive enhancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.770840

Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.770840

Chronic elevation of brain-derived neurotrophic factor by ampakines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.770840

Ampakines cause sustained increases in brain-derived neurotrophic factor signaling at excitatory synapses without changes in AMPA receptor subunit expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.770840

The AMPA receptor as a therapeutic target: current perspectives and emerging possibilities

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.770840

AMPA receptor potentiators: application for depression and Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.770840

Pharmacology of ampakine modulators: from AMPA receptors to synapses and behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.770840

Challenges for and current status of research into positive modulators of AMPA receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.770840

Positive allosteric modulators of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.770840

The ampakine CX546 restores the prepulse inhibition and latent inhibition deficits in mGluR5-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.770840

Benzoxazinones as potent positive allosteric AMPA receptor modulators: part I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.770840

Substituted benzoxazinones as potent positive allosteric AMPA receptor modulators: part II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.770840

Diazoxide blocks glutamate desensitization and prolongs excitatory postsynaptic currents in rat hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.770840

Allosteric potentiation by diazoxide of AMPA receptor currents and synaptic potentials

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.770840

7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide (IDRA 21), a congener of aniracetam, potently abates pharmacologically induced cognitive impairments in patas monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.770840

Design, synthesis, and pharmacology of novel 7-substituted 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides as positive allosteric modulators of AMPA receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.770840

4H-1,2,4-Pyridothiadiazine 1,1-dioxides and 2,3-dihydro-4H-1,2, 4-pyridothiadiazine 1,1-dioxides chemically related to diazoxide and cyclothiazide as powerful positive allosteric modulators of (R/S)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.770840

5'-alkyl-benzothiadiazides: a new subgroup of AMPA receptor modulators with improved affinity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.770840

Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.770840

New fluorinated 1,2,4-benzothiadiazine 1,1-dioxides: discovery of an orally active cognitive enhancer acting through potentiation of the 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.770840

5-Arylbenzothiadiazine Type Compounds as Positive Allosteric Modulators of AMPA/Kainate Receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.770840

Discovery of N-[(2S)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide, a novel clinical AMPA receptor positive modulator

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.770840

N-substituted pyrrolidines and tetrahydrofurans as novel AMPAR positive modulators.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.770840

A novel class of positive allosteric modulators of AMPA receptors: design, synthesis, and structure-activity relationships of 3-biphenyl-4-yl-4-cyano-5-ethyl-1-methyl-1H-pyrrole-2-carboxylic acid, LY2059346.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.770840

A novel series of positive modulators of the AMPA receptor: discovery and structure based hit-to-lead studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.770840

A novel series of positive modulators of the AMPA receptor: structure-based lead optimization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.770840

Structure based evolution of a novel series of positive modulators of the AMPA receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.770840

Integration of lead optimization with crystallography for a membrane-bound ion channel target: discovery of a new class of AMPA receptor positive allosteric modulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.770840

10.1517/13543776.2013.770840

21 January 2018

Identifiers

DOI

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28 August 2017

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