RNA interference--a silent but an efficient therapeutic tool (Q38076055)

28 August 2017

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title

RNA interference--a silent but an efficient therapeutic tool (English)

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28 August 2017

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Puthucode Venkatakrishnan Ramachandran

series ordinal

1

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PubMed ID

23340870

28 August 2017

Savarimuthu Ignacimuthu

series ordinal

2

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28 August 2017

23 January 2013

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Applied Biochemistry and Biotechnology

28 August 2017

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28 August 2017

169

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28 August 2017

6

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28 August 2017

1774-1789

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https://scigraph.springernature.com/pub.10.1007/s12010-013-0098-1

28 August 2017

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21 January 2018

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21 January 2018

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RNA polymerase III transcribes human microRNAs

21 January 2018

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21 January 2018

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Chromatin structure analyses identify miRNA promoters

21 January 2018

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Recognition and cleavage of primary microRNA precursors by the nuclear processing enzyme Drosha

21 January 2018

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The nuclear RNase III Drosha initiates microRNA processing

21 January 2018

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The Microprocessor complex mediates the genesis of microRNAs

21 January 2018

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Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs

21 January 2018

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Ribonuclease activity and RNA binding of recombinant human Dicer

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21 January 2018

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New insights in the mechanism of microRNA-mediated target repression

21 January 2018

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An mRNA m7G cap binding-like motif within human Ago2 represses translation

21 January 2018

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MicroRNA silencing through RISC recruitment of eIF6

21 January 2018

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Cationic liposome-mediated delivery of siRNAs in adult mice

21 January 2018

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Supramolecular assemblies in functional siRNA delivery: where do we stand?

21 January 2018

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21 January 2018

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21 January 2018

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A review of nanocarriers for the delivery of small interfering RNA.

21 January 2018

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Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

RNA interference therapy via functionalized scaffolds

21 January 2018

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21 January 2018

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21 January 2018

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Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

A DNA vector-based RNAi technology to suppress gene expression in mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

U6 promoter-driven siRNAs with four uridine 3' overhangs efficiently suppress targeted gene expression in mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Inducible silencing of KILLER/DR5 in vivo promotes bioluminescent colon tumor xenograft growth and confers resistance to chemotherapeutic agent 5-fluorouracil

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Inducible, reversible, and stable RNA interference in mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

siRNA-mediated gene silencing in vitro and in vivo.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Polycistronic RNA polymerase II expression vectors for RNA interference based on BIC/miR-155.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Multiple shRNAs expressed by an inducible pol II promoter can knock down the expression of multiple target genes

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Multi-miRNA hairpin method that improves gene knockdown efficiency and provides linked multi-gene knockdown

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Unity and diversity in the human adenoviruses: exploiting alternative entry pathways for gene therapy.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Use of adenovirus-delivered siRNA to target oncoprotein p28GANK in hepatocellular carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

ASH1 gene is a specific therapeutic target for lung cancers with neuroendocrine features.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Knockdown of hepatic ABCA1 by RNA interference decreases plasma HDL cholesterol levels and influences postprandial lipemia in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

RNAi-mediated gene silencing in tumour tissue using replication-competent retroviral vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Recent advances in lentiviral vector development and applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Lentivirus-based genetic manipulations of cortical neurons and their optical and electrophysiological monitoring in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

In vivo gene silencing of CD81 by lentiviral expression of small interference RNAs suppresses cocaine-induced behaviour.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Viral vectors for gene transfer: current status of gene therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Small silencing RNAs: state-of-the-art

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Adeno-associated virus (AAV) vectors in the CNS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Sustained suppression of Bcr-Abl-driven lymphoid leukemia by microRNA mimics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

RNA interference as a new strategy against viral hepatitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Stable suppression of tumorigenicity by virus-mediated RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Silencing of H-ras gene expression by retrovirus-mediated siRNA decreases transformation efficiency and tumorgrowth in a model of human ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

RNA interference is a functional pathway with therapeutic potential in human myeloid leukemia cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Synthetic small inhibiting RNAs: efficient tools to inactivate oncogenic mutations and restore p53 pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

A small interfering RNA targeting vascular endothelial growth factor as cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Ewing's Sarcoma: Development of RNA Interference-Based Therapy for Advanced Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Knockdown of AKT2 expression by RNA interference inhibits proliferation, enhances apoptosis, and increases chemosensitivity to the anticancer drug VM-26 in U87 glioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

ShRNA silencing glycogen synthase kinase-3 beta inhibits tumor growth and angiogenesis in pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Combinational RNAi gene therapy of hepatocellular carcinoma by targeting human EGFR and TERT.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

RNA interference: ready to silence cancer?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

RNA Interference and Cancer Therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Inhibition of Virus Replication by RNA Interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Inhibition of hepatitis B virus in mice by RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Small interfering RNA Inhibits Hepatitis B virus replication in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Inhibition of hepatitis B virus replication in vivo by nucleoside analogues and siRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

The "Trojan horse" model-delivery of anti-HBV small interfering RNAs by a recombinant HBV vector.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Targeting 2A protease by RNA interference attenuates coxsackieviral cytopathogenicity and promotes survival in highly susceptible mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

A randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Inhibition of respiratory viruses by nasally administered siRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Efficient initiation of HCV RNA replication in cell culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Selectable subgenomic and genome-length dicistronic RNAs derived from an infectious molecular clone of the HCV-N strain of hepatitis C virus replicate efficiently in cultured Huh7 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Enhancement of hepatitis C virus RNA replication by cell culture-adaptive mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Characterization of cell lines carrying self-replicating hepatitis C virus RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Subgenomic replicon derived from a cell line infected with the hepatitis C virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

RNA interference in adult mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

RNA interference blocks gene expression and RNA synthesis from hepatitis C replicons propagated in human liver cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Potent and specific inhibition of human immunodeficiency virus type 1 replication by RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

RNA interference directed against viral and cellular targets inhibits human immunodeficiency Virus Type 1 replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Prevention of HIV-1 infection in human peripheral blood mononuclear cells by specific RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Modulation of HIV-1 replication by RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Inhibition of HIV-1 infection by small interfering RNA-mediated RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Inhibition of HIV-1 by lentiviral vector-transduced siRNAs in T lymphocytes differentiated in SCID-hu mice and CD34+ progenitor cell-derived macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Inhibition of HIV-1 infection by lentiviral vectors expressing Pol III-promoted anti-HIV RNAs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Human immunodeficiency virus type 1 escape from RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

RNA interference as a tool for exploring HIV-1 robustness

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Targeting angiogenesis, the underlying disorder in neovascular age-related macular degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Inhibition of ocular angiogenesis by siRNA targeting vascular endothelial growth factor pathway genes: therapeutic strategy for herpetic stromal keratitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Sequence- and target-independent angiogenesis suppression by siRNA via TLR3

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Cathepsin B expression and down-regulation by gene silencing and antisense DNA in human chondrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Potentials for RNAi in sarcoma research and therapy: Ewing's sarcoma as a model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Identification of target genes in their native cellular context: an analysis of EWS/FLI in Ewing's sarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Suppressed severity of collagen-induced arthritis by in vivo transfection of nuclear factor kappaB decoy oligodeoxynucleotides as a gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

NF-kappaB as a potential therapeutic target in osteoarthritis and rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Effects of treatment with small interfering RNA on joint inflammation in mice with collagen-induced arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

RNA therapeutics targeting osteoclast-mediated excessive bone resorption

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

MicroRNAs: regulating a change of heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

MicroRNA-195 suppresses tumorigenicity and regulates G1/S transition of human hepatocellular carcinoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

MicroRNA-133 controls cardiac hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

MicroRNAs play an essential role in the development of cardiac hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

MicroRNA expression is required for pancreatic islet cell genesis in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

miR-375 targets 3'-phosphoinositide-dependent protein kinase-1 and regulates glucose-induced biological responses in pancreatic beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

MicroRNA-125a is over-expressed in insulin target tissues in a spontaneous rat model of Type 2 Diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Identification of glucose-regulated miRNAs from pancreatic {beta} cells reveals a role for miR-30d in insulin transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

AAV8-mediated gene transfer of interleukin-4 to endogenous beta-cells prevents the onset of diabetes in NOD mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Directing stem cell fate by controlled RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Phase 1 dose-escalation study of a siRNA targeting the RTP801 gene in age-related macular degeneration patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Ocular neuroprotection by siRNA targeting caspase-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Confirming the RNAi-mediated mechanism of action of siRNA-based cancer therapeutics in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Systemic delivery of siRNA nanoparticles targeting RRM2 suppresses head and neck tumor growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Therapeutic targeting of gene expression by siRNAs directed against BCR-ABL transcripts in a patient with imatinib-resistant chronic myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

Immunoproteasome down-modulation enhances the ability of dendritic cells to stimulate antitumor immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

RNA interference, RSV, and lung transplantation: a promising future for siRNA therapeutics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12010-013-0098-1

10.1007/S12010-013-0098-1

21 January 2018

Identifiers

DOI

1 reference

PubMed ID

23340870

Dimensions Publication ID

28 August 2017

0 references

1 reference

PubMed ID

23340870