Involvement of PDGF in fibrosis and scleroderma: recent insights from animal models and potential therapeutic opportunities (Q38073213)

28 August 2017

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title

Involvement of PDGF in fibrosis and scleroderma: recent insights from animal models and potential therapeutic opportunities (English)

1 reference

28 August 2017

Tomoaki Iwayama

1

1 reference

PMCID

5570472

28 August 2017

Lorin E Olson

series ordinal

2

1 reference

28 August 2017

1 February 2013

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Current Rheumatology Reports

28 August 2017

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28 August 2017

15

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28 August 2017

2

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28 August 2017

304

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https://scigraph.springernature.com/pub.10.1007/s11926-012-0304-0

28 August 2017

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B-cell depletion therapy in patients with diffuse systemic sclerosis associates with a significant decrease in PDGFR expression and activation in spindle-like cells in the skin

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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Increased PDGFRalpha activation disrupts connective tissue development and drives systemic fibrosis

6 September 2017

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Role of platelet-derived growth factors in physiology and medicine

6 September 2017

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Systemic sclerosis: a prototypic multisystem fibrotic disorder

6 September 2017

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Interleukin-10 is not a critical regulator of infarct healing and left ventricular remodeling

6 September 2017

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Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma

6 September 2017

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A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling

6 September 2017

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Regulation of PDGF and its receptors in fibrotic diseases

6 September 2017

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Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression.

6 September 2017

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Additive effects of PDGF receptor beta signaling pathways in vascular smooth muscle cell development

6 September 2017

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Roles of PDGF in animal development

6 September 2017

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Prevalence, incidence, survival, and disease characteristics of systemic sclerosis in a large US population

6 September 2017

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Transgenic overexpression of platelet-derived growth factor-C in the mouse heart induces cardiac fibrosis, hypertrophy, and dilated cardiomyopathy

6 September 2017

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Abnormal gastrointestinal development in PDGF-A and PDGFR-(alpha) deficient mice implicates a novel mesenchymal structure with putative instructive properties in villus morphogenesis

6 September 2017

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Mechanism of action and in vivo role of platelet-derived growth factor

6 September 2017

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Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse

6 September 2017

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Roles for PDGF-A and sonic hedgehog in development of mesenchymal components of the hair follicle

6 September 2017

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The PDGF alpha receptor is required for neural crest cell development and for normal patterning of the somites

6 September 2017

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Pericyte loss and microaneurysm formation in PDGF-B-deficient mice

6 September 2017

1 reference

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Replication and phenotypic expression of control and scleroderma human fibroblasts: responses to growth factors

6 September 2017

1 reference

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Connective tissue synthesis by scleroderma skin fibroblasts in cell culture

6 September 2017

1 reference

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A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro

6 September 2017

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Lack of evidence of stimulatory autoantibodies to platelet-derived growth factor receptor in patients with systemic sclerosis

6 September 2017

1 reference

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Lack of detection of agonist activity by antibodies to platelet-derived growth factor receptor alpha in a subset of normal and systemic sclerosis patient sera.

14 September 2017

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White fat progenitor cells reside in the adipose vasculature.

14 September 2017

1 reference

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Epicardial-derived cell epithelial-to-mesenchymal transition and fate specification require PDGF receptor signaling.

28 September 2017

1 reference

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Cardiac mast cells cause atrial fibrillation through PDGF-A-mediated fibrosis in pressure-overloaded mouse hearts

23 June 2018

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Postnatal induction of transforming growth factor beta signaling in fibroblasts of mice recapitulates clinical, histologic, and biochemical features of scleroderma

23 June 2018

1 reference

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Imatinib mesylate reduces production of extracellular matrix and prevents development of experimental dermal fibrosis

23 June 2018

1 reference

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Platelets as a source of fibroblast growth-promoting activity.

23 June 2018

1 reference

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Lineage tracing and genetic ablation of ADAM12(+) perivascular cells identify a major source of profibrotic cells during acute tissue injury

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5570472

Aberrant mural cell recruitment to lymphatic vessels and impaired lymphatic drainage in a murine model of pulmonary fibrosis.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5570472

Imatinib in active diffuse cutaneous systemic sclerosis: Results of a six-month, randomized, double-blind, placebo-controlled, proof-of-concept pilot study at a single center.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5570472

Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5570472

Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5570472

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5570472

Treatment with imatinib prevents fibrosis in different preclinical models of systemic sclerosis and induces regression of established fibrosis

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5570472

An allelic series at the PDGFalphaR locus indicates unequal contributions of distinct signaling pathways during development.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5570472

Increased expression of platelet-derived growth factor type b receptors in the skin of patients with systemic sclerosis

31 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS11926-012-0304-0

PDGF-A Signaling Is a Critical Event in Lung Alveolar Myofibroblast Development and Alveogenesis

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS11926-012-0304-0

Decreased lymphatic vessel counts in patients with systemic sclerosis: association with fingertip ulcers

21 January 2018

1 reference

12 December 2020

CXCL10 (alpha) and CCL2 (beta) chemokines in systemic sclerosis--a longitudinal study

1 reference

12 December 2020

Elevated levels of platelet derived growth factor and transforming growth factor-beta 1 in bronchoalveolar lavage fluid from patients with scleroderma

1 reference

12 December 2020

Stimulatory Autoantibodies to the PDGF Receptor in Systemic Sclerosis

1 reference

12 December 2020

Phenotypical and functional characteristics of in vitro expanded bone marrow mesenchymal stem cells from patients with systemic sclerosis

1 reference

12 December 2020

Immunohistologic demonstration of platelet-derived growth factor (PDGF) and sis-oncogene expression in scleroderma

1 reference

12 December 2020

Increased Plasma Levels of Platelet-Derived Growth Factor Activity in Patients with Progressive Systemic Sclerosis

1 reference

12 December 2020

Platelet-derived growth factor D induces cardiac fibrosis and proliferation of vascular smooth muscle cells in heart-specific transgenic mice

1 reference

12 December 2020

Activation of microvascular pericytes in autoimmune Raynaud's phenomenon and systemic sclerosis

1 reference

12 December 2020

Sunitinib inhibits the phosphorylation of platelet-derived growth factor receptor β in the skin of mice with scleroderma-like features and prevents the development of the disease

1 reference

12 December 2020

10.1007/S11926-012-0304-0

Identifiers

DOI

1 reference

PMCID

5570472

Dimensions Publication ID

28 August 2017

0 references

1 reference

28 August 2017

1 reference

PMCID

5570472