LIM-domain-only proteins in cancer. (Q38072838)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23303138%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

review article

1 reference

title

LIM-domain-only proteins in cancer (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23303138%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

author

Jacqueline M Matthews

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23303138%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

David J Curtis

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23303138%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

author name string

Krystal Lester

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23303138%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

Soumya Joseph

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23303138%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

language of work or name

English

0 references

publication date

10 January 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23303138%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

published in

Nature Reviews Cancer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23303138%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

volume

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23303138%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23303138%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

page(s)

111-122

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23303138%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nrc3418

21 February 2020

exact match

0 references

cites work

The LIM domain: regulation by association

1 reference

It takes two to tango: the structure and function of LIM, RING, PHD and MYND domains.

21 January 2018

1 reference

The t(11;14)(p15;q11) in a T-cell acute lymphoblastic leukemia cell line activates multiple transcripts, including Ttg-1, a gene encoding a potential zinc finger protein

21 January 2018

1 reference

The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13

21 January 2018

1 reference

Negative regulatory elements are present in the human LMO2 oncogene and may contribute to its expression in leukemia.

21 January 2018

1 reference

Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia

21 January 2018

1 reference

A previously unrecognized promoter of LMO2 forms part of a transcriptional regulatory circuit mediating LMO2 expression in a subset of T-acute lymphoblastic leukaemia patients

21 January 2018

1 reference

Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators.

21 January 2018

1 reference

The oncogenic cysteine-rich LIM domain protein rbtn2 is essential for erythroid development

21 January 2018

1 reference

The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation

21 January 2018

1 reference

The T cell leukemia LIM protein Lmo2 is necessary for adult mouse hematopoiesis.

21 January 2018

1 reference

The oncogenic LIM-only transcription factor Lmo2 regulates angiogenesis but not vasculogenesis in mice

21 January 2018

1 reference

The Lmo2 oncogene initiates leukemia in mice by inducing thymocyte self-renewal

21 January 2018

1 reference

Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes.

21 January 2018

1 reference

Thymus-autonomous T cell development in the absence of progenitor import

21 January 2018

1 reference

Thymocytes may persist and differentiate without any input from bone marrow progenitors

21 January 2018

1 reference

Activating Notch1 mutations in mouse models of T-ALL.

21 January 2018

1 reference

Functional interactions between Lmo2, the Arf tumor suppressor, and Notch1 in murine T-cell malignancies

21 January 2018

1 reference

NKL homeobox genes in leukemia.

21 January 2018

1 reference

Integrated transcript and genome analyses reveal NKX2-1 and MEF2C as potential oncogenes in T cell acute lymphoblastic leukemia.

21 January 2018

1 reference

The homeobox gene Hex induces T-cell-derived lymphomas when overexpressed in hematopoietic precursor cells

21 January 2018

1 reference

NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia

21 January 2018

1 reference

Transcriptional activation of prostate specific homeobox gene NKX3-1 in subsets of T-cell lymphoblastic leukemia (T-ALL).

21 January 2018

1 reference

The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins

21 January 2018

1 reference

The oncogenic T cell LIM-protein Lmo2 forms part of a DNA-binding complex specifically in immature T cells

21 January 2018

1 reference

Differential genomic targeting of the transcription factor TAL1 in alternate haematopoietic lineages

21 January 2018

1 reference

Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia.

21 January 2018

1 reference

SCL and associated proteins distinguish active from repressive GATA transcription factor complexes

21 January 2018

1 reference

The genome-wide dynamics of the binding of Ldb1 complexes during erythroid differentiation

21 January 2018

1 reference

Identification of the key LMO2-binding determinants on Ldb1.

21 January 2018

1 reference

LIM-domain-binding protein 1: a multifunctional cofactor that interacts with diverse proteins.

21 January 2018

1 reference

A positive role for NLI/Ldb1 in long-range beta-globin locus control region function

21 January 2018

1 reference

Chip, a widely expressed chromosomal protein required for segmentation and activity of a remote wing margin enhancer in Drosophila

21 January 2018

1 reference

Functional analysis of the nuclear LIM domain interactor NLI

21 January 2018

1 reference

The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors

21 January 2018

1 reference

Structural basis of simultaneous recruitment of the transcriptional regulators LMO2 and FOG1/ZFPM1 by the transcription factor GATA1

21 January 2018

1 reference

Structure of the leukemia oncogene LMO2: implications for the assembly of a hematopoietic transcription factor complex

21 January 2018

1 reference

The GATA2 transcriptional network is requisite for RAS oncogene-driven non-small cell lung cancer

21 January 2018

1 reference

Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival

21 January 2018

1 reference

Nuclear adaptor Ldb1 regulates a transcriptional program essential for the maintenance of hematopoietic stem cells

21 January 2018

1 reference

GATA-2 mediated regulation of normal hematopoietic stem/progenitor cell function, myelodysplasia and myeloid leukemia

21 January 2018

1 reference

GATA-3 regulates hematopoietic stem cell maintenance and cell-cycle entry

21 January 2018

1 reference

E2A deficiency leads to abnormalities in alphabeta T-cell development and to rapid development of T-cell lymphomas

21 January 2018

1 reference

Role of DNA sequence in the binding specificity of synthetic basic-helix-loop-helix domains

21 January 2018

1 reference

A DNA-binding mutant of TAL1 cooperates with LMO2 to cause T cell leukemia in mice

21 January 2018

1 reference

The DNA binding activity of TAL-1 is not required to induce leukemia/lymphoma in mice

21 January 2018

1 reference

Prediction of survival in diffuse large-B-cell lymphoma based on the expression of six genes

21 January 2018

1 reference

The oncoprotein LMO2 is expressed in normal germinal-center B cells and in human B-cell lymphomas

21 January 2018

1 reference

LMO2 expression reflects the different stages of blast maturation and genetic features in B-cell acute lymphoblastic leukemia and predicts clinical outcome.

21 January 2018

1 reference

Identification of LMO2 transcriptome and interactome in diffuse large B-cell lymphoma

21 January 2018

1 reference

Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia

21 January 2018

1 reference

Hlf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia

21 January 2018

1 reference

The LIM-only protein, LMO4, and the LIM domain-binding protein, LDB1, expression in squamous cell carcinomas of the oral cavity

21 January 2018

1 reference

LMO4 expression in squamous cell carcinoma of the anterior tongue.

21 January 2018

1 reference

Expression of LMO4 and outcome in pancreatic ductal adenocarcinoma

21 January 2018

1 reference

LMO2 is a novel predictive marker for a better prognosis in pancreatic cancer.

21 January 2018

1 reference

Defective neural tube closure and anteroposterior patterning in mice lacking the LIM protein LMO4 or its interacting partner Deaf-1

21 January 2018

1 reference

Null mutation of the Lmo4 gene or a combined null mutation of the Lmo1/Lmo3 genes causes perinatal lethality, and Lmo4 controls neural tube development in mice

21 January 2018

1 reference

Molecular cloning of LMO41, a new human LIM domain gene

21 January 2018

1 reference

The LIM domain gene LMO4 inhibits differentiation of mammary epithelial cells in vitro and is overexpressed in breast cancer.

21 January 2018

1 reference

Overexpression of LMO4 induces mammary hyperplasia, promotes cell invasion, and is a predictor of poor outcome in breast cancer

21 January 2018

1 reference

Aberrant expression of LMO4 induces centrosome amplification and mitotic spindle abnormalities in breast cancer cells

21 January 2018

1 reference

The LIM-only factor LMO4 regulates expression of the BMP7 gene through an HDAC2-dependent mechanism, and controls cell proliferation and apoptosis of mammary epithelial cells

21 January 2018

1 reference

Expression of an engrailed-LMO4 fusion protein in mammary epithelial cells inhibits mammary gland development in mice

21 January 2018

1 reference

Two promoters within the human LMO4 gene contribute to its overexpression in breast cancer cells

21 January 2018

1 reference

LMO4 is an essential mediator of ErbB2/HER2/Neu-induced breast cancer cell cycle progression

21 January 2018

1 reference

The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity

21 January 2018

1 reference

¹H, ¹⁵N and ¹³C assignments of an intramolecular LMO4-LIM1/CtIP complex

21 January 2018

1 reference

Inactivation of CtIP leads to early embryonic lethality mediated by G1 restraint and to tumorigenesis by haploid insufficiency

21 January 2018

1 reference

Negative regulation of estrogen receptor alpha transactivation functions by LIM domain only 4 protein

21 January 2018

1 reference

The tumor suppressor LKB1 induces p21 expression in collaboration with LMO4, GATA-6, and Ldb1.

21 January 2018

1 reference

Contribution of DEAF1 structural domains to the interaction with the breast cancer oncogene LMO4.

21 January 2018

1 reference

Identification and characterization of LMO4, an LMO gene with a novel pattern of expression during embryogenesis

21 January 2018

1 reference

Identification of the LMO4 gene encoding an interaction partner of the LIM-binding protein LDB1/NLI1: a candidate for displacement by LMO proteins in T cell acute leukaemia.

21 January 2018

1 reference

Tandem LIM domains provide synergistic binding in the LMO4:Ldb1 complex

21 January 2018

1 reference

Structural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4

21 January 2018

1 reference

Stabilization of a binary protein complex by intein-mediated cyclization

21 January 2018

1 reference

The LIM-only protein LMO4 modulates the transcriptional activity of HEN1

21 January 2018

1 reference

LMO4 functions as a co-activator of neurogenin 2 in the developing cortex.

21 January 2018

1 reference

E2F-HDAC complexes negatively regulate the tumor suppressor gene ARHI in breast cancer

21 January 2018

1 reference

The significance of LMO2 expression in the progression of prostate cancer

21 January 2018

1 reference

Advances in mouse models of prostate cancer

21 January 2018

1 reference

21 January 2018

1 reference

Grhl3 and Lmo4 play coordinate roles in epidermal migration.

21 January 2018

1 reference

Neural development. A 'LIM code' for motor neurons?

21 January 2018

1 reference

LMO3 interacts with neuronal transcription factor, HEN2, and acts as an oncogene in neuroblastoma

21 January 2018

1 reference

Oncogenic LMO3 collaborates with HEN2 to enhance neuroblastoma cell growth through transactivation of Mash1

21 January 2018

1 reference

A novel MASH1 enhancer with N-myc and CREB-binding sites is active in neuroblastoma.

21 January 2018

1 reference

Integrative genomics identifies LMO1 as a neuroblastoma oncogene

21 January 2018

1 reference

Epithelial organization, cell polarity and tumorigenesis

21 January 2018

1 reference

EMT, the cytoskeleton, and cancer cell invasion

21 January 2018

1 reference

Regulation of EMT by TGFβ in cancer.

21 January 2018

1 reference

LIM-domain proteins in transforming growth factor β-induced epithelial-to-mesenchymal transition and myofibroblast differentiation

21 January 2018

1 reference

The LIM domain: from the cytoskeleton to the nucleus

21 January 2018

1 reference

TAL-1/SCL and its partners E47 and LMO2 up-regulate VE-cadherin expression in endothelial cells

21 January 2018

1 reference

An antibody inhibitor of the LMO2-protein complex blocks its normal and tumorigenic functions

21 January 2018

1 reference

Targeting LMO2 with a peptide aptamer establishes a necessary function in overt T-cell neoplasia

21 January 2018

1 reference

The LIM-domain protein Lmo2 is a key regulator of tumour angiogenesis: a new anti-angiogenesis drug target

21 January 2018

1 reference

Unsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular development

21 January 2018

1 reference

Angiopoietin-2 is a direct transcriptional target of TAL1, LYL1 and LMO2 in endothelial cells

21 January 2018

1 reference

Solution structure of a tethered Lmo2LIM2/Ldb1LIDcomplex

21 January 2018

1 reference

Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease

21 January 2018

1 reference

Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector

21 January 2018

1 reference

Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients

21 January 2018

1 reference

Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1

21 January 2018

1 reference

Identification of a high incidence region for retroviral vector integration near exon 1 of the LMO2 locus

21 January 2018

1 reference

Fragile sites are preferential targets for integrations of MLV vectors in gene therapy

21 January 2018

1 reference

Murine leukemias with retroviral insertions at Lmo2 are predictive of the leukemias induced in SCID-X1 patients following retroviral gene therapy

21 January 2018

1 reference

The role of LMO2 in development and in T cell leukemia after chromosomal translocation or retroviral insertion

21 January 2018

1 reference

LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1

21 January 2018

1 reference

Launching the T-cell-lineage developmental programme

21 January 2018

1 reference

The molecular basis of Lmo2-induced T-cell acute lymphoblastic leukemia.

21 January 2018

1 reference

LIM Domain Binding Proteins 1 and 2 Have Different Oligomeric States

21 January 2018

1 reference

The cryptic chromosomal deletion del(11)(p12p13) as a new activation mechanism of LMO2 in pediatric T-cell acute lymphoblastic leukemia

21 January 2018

1 reference

SCL and LMO1 alter thymocyte differentiation: inhibition of E2A-HEB function and pre-T alpha chain expression

31 March 2020

1 reference

Tal-1 induces T cell acute lymphoblastic leukemia accelerated by casein kinase IIalpha.

31 March 2020

1 reference

Assembly of the oncogenic DNA-binding complex LMO2-Ldb1-TAL1-E12

31 March 2020

1 reference

The E2A-HLF oncogenic fusion protein acts through Lmo2 and Bcl-2 to immortalize hematopoietic progenitors

31 March 2020

1 reference

Expression of LIM protein genes Lmo1, Lmo2, and Lmo3 in adult mouse hippocampus and other forebrain regions: differential regulation by seizure activity.

31 March 2020

1 reference

Design, production and characterization of FLIN2 and FLIN4: the engineering of intramolecular ldb1:LMO complexes

31 March 2020

1 reference

Cyclin D2 dysregulation by chromosomal translocations to TCR loci in T-cell acute lymphoblastic leukemias

31 March 2020

1 reference

Ectopic retroviral expression of LMO2, but not IL2Rgamma, blocks human T-cell development from CD34+ cells: implications for leukemogenesis in gene therapy.

31 March 2020

1 reference

Disruption of T-cell differentiation precedes T-cell tumor formation in LMO-2 (rhombotin-2) transgenic mice.

31 March 2020

1 reference

12 December 2020

The rhombotin gene belongs to a class of transcriptional regulators with a potential novel protein dimerisation motif.

1 reference

12 December 2020

The TTG-2/RBTN2 T cell oncogene encodes two alternative transcripts from two promoters: the distal promoter is removed by most 11p13 translocations in acute T cell leukaemia's (T-ALL).

1 reference

12 December 2020

The mechanism of chromosomal translocation t(11;14) involving the T-cell receptor C delta locus on human chromosome 14q11 and a transcribed region of chromosome 11p15

1 reference

12 December 2020

Expression of the cellular adhesion molecule E-cadherin is reduced or absent in high-grade prostate cancer

1 reference

12 December 2020

T cell tumours of disparate phenotype in mice transgenic for Rbtn-2

1 reference

12 December 2020

LMO4 can interact with Smad proteins and modulate transforming growth factor-beta signaling in epithelial cells

1 reference

12 December 2020

Differential expression of invasion promoting genes in childhood rhabdomyosarcoma

1 reference

12 December 2020

TTG-2, a new gene encoding a cysteine-rich protein with the LIM motif, is overexpressed in acute T-cell leukaemia with the t(11;14)(p13;q11)

1 reference

12 December 2020

Protein dimerization between Lmo2 (Rbtn2) and Tal1 alters thymocyte development and potentiates T cell tumorigenesis in transgenic mice

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRC3418

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23303138%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

21 February 2020

0 references

1 reference