Expansion of the aptamer library from a "natural soup" to an "unnatural soup". (Q38071194)

28 August 2017

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title

Expansion of the aptamer library from a "natural soup" to an "unnatural soup". (English)

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28 August 2017

Takanori Uzawa

1

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28 August 2017

Seiichi Tada

series ordinal

2

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28 August 2017

Wei Wang

series ordinal

3

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28 August 2017

Yoshihiro Ito

series ordinal

4

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28 August 2017

language of work or name

English

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publication date

2 January 2013

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28 August 2017

Chemical Communications

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28 August 2017

49

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28 August 2017

18

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28 August 2017

1786-1795

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In vitro selection of RNA molecules that bind specific ligands

28 August 2017

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

In vitro selection and evolution of functional proteins by using ribosome display

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

In vitro virus: bonding of mRNA bearing puromycin at the 3'-terminal end to the C-terminal end of its encoded protein on the ribosome in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

RNA-peptide fusions for the in vitro selection of peptides and proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

A general method for site-specific incorporation of unnatural amino acids into proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

SELEX--a (r)evolutionary method to generate high-affinity nucleic acid ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

An allosteric synthetic DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Selection-by-function: efficient enrichment of cathepsin E inhibitors from a DNA library

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

PCR product with strands of unequal length

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Nucleic acid evolution and minimization by nonhomologous random recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Improvement of RNA aptamer activity against myasthenic autoantibodies by extended sequence selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

SERF: in vitro election of random RNA fragments to identify protein binding sites within large RNAs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Structure, recognition and adaptive binding in RNA aptamer complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Adaptive recognition by nucleic acid aptamers

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

High-resolution molecular discrimination by RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Interlocking structural motifs mediate molecular discrimination by a theophylline-binding RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Diversity of oligonucleotide functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Conformational plasticity of RNA for target recognition as revealed by the 2.15 A crystal structure of a human IgG-aptamer complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Application of locked nucleic acids to improve aptamer in vivo stability and targeting function

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Combinatorial selection and binding of phosphorothioate aptamers targeting human NF-kappa B RelA(p65) and p50.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

In vitro selection of phosphorothiolated aptamers

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Nuclease-resistant nucleic acid ligands to vascular permeability factor/vascular endothelial growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Direct in vitro selection of a 2'-O-methyl aptamer to VEGF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

A novel, modification-dependent ATP-binding aptamer selected from an RNA library incorporating a cationic functionality

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Sialyllactose-binding modified DNA aptamer bearing additional functionality by SELEX.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Aptamer-based multiplexed proteomic technology for biomarker discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

A novel genetic system to detect protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

An in vitro polysome display system for identifying ligands from very large peptide libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

STABLE: protein-DNA fusion system for screening of combinatorial protein libraries in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Intracellular ribosome display via SecM translation arrest as a selection for antibodies with enhanced cytosolic stability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

A novel strategy by the action of ricin that connects phenotype and genotype without loss of the diversity of libraries.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Modified peptide selection in vitro by introduction of a protein-RNA interaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Ribosome display selection of a metal-binding motif from an artificial peptide library

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Polypeptide aptamer selection using a stabilized ribosome display

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Specific bonding of puromycin to full-length protein at the C-terminus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Man-made cell-like compartments for molecular evolution.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

DNA display for in vitro selection of diverse peptide libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Covalent DNA display as a novel tool for directed evolution of proteins in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Selection of optical biosensors from chemisynthetic antibody libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

A novel strategy for in vitro selection of peptide-drug conjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Random peptide libraries: a source of specific protein binding molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Screening of cyclic peptide phage libraries identifies ligands that bind streptavidin with high affinities

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

A general route for post-translational cyclization of mRNA display libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Design of cyclic peptides that bind protein surfaces with antibody-like affinity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Phage-encoded combinatorial chemical libraries based on bicyclic peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

In vitro selection of mRNA display libraries containing an unnatural amino acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Incorporation of nonnatural amino acids into proteins by using various four-base codons in an Escherichia coli in vitro translation system

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Four-base codon mediated mRNA display to construct peptide libraries that contain multiple nonnatural amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

A highly flexible tRNA acylation method for non-natural polypeptide synthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Natural product-like macrocyclic N-methyl-peptide inhibitors against a ubiquitin ligase uncovered from a ribosome-expressed de novo library.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Patterned staining by fluorescein-labeled oligonucleotides obtained by in vitro selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Molecular aptamer beacons for real-time protein recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Single quantum-dot-based aptameric nanosensor for cocaine

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Competitive binding assay for thyroxine using in vitro selected oligonucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

A sensitive, label-free, aptamer-based biosensor using a gold nanoparticle-initiated chemiluminescence system

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Multifunctional oval-shaped gold-nanoparticle-based selective detection of breast cancer cells using simple colorimetric and highly sensitive two-photon scattering assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

A novel colorimetric aptasensor using gold nanoparticle for a highly sensitive and specific detection of oxytetracycline.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

An electronic, aptamer-based small-molecule sensor for the rapid, label-free detection of cocaine in adulterated samples and biological fluids

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

An RNA aptamer-based electrochemical biosensor for detection of theophylline in serum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Aptamer/nanoparticle-based sensitive, multiplexed electronic coding of proteins and small biomolecules through a backfilling strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Applications of aptamers as sensors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Aptamer-based molecular recognition for biosensor development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Expanding the scope of RNA catalysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Evolutionary optimization of the catalytic properties of a DNA-cleaving ribozyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

A DNA enzyme that cleaves RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

In vitro selection of a ligase ribozyme carrying alkylamino groups in the side chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

A ribozyme for the aldol reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Photocleavable initiator nucleotide substrates for an aldolase ribozyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Directed evolution of novel polymerase activities: mutation of a DNA polymerase into an efficient RNA polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Expanding the substrate repertoire of a DNA polymerase by directed evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Selection and evolution of enzymes from a partially randomized non-catalytic scaffold

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Selection of single-stranded DNA molecules that bind and inhibit human thrombin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

2'-Fluoropyrimidine RNA-based aptamers to the 165-amino acid form of vascular endothelial growth factor (VEGF165). Inhibition of receptor binding and VEGF-induced vascular permeability through interactions requiring the exon 7-encoded domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

In vitro selection of state-specific peptide modulators of G protein signaling using mRNA display.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Characterization of novel calmodulin-binding peptides with distinct inhibitory effects on calmodulin-dependent enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

A novel class of small functional peptides that bind and inhibit human alpha-thrombin isolated by mRNA display

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Discovery of macrocyclic peptides armed with a mechanism-based warhead: isoform-selective inhibition of human deacetylase SIRT2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

In vitro selection of highly modified cyclic peptides that act as tight binding inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Precise engineering of targeted nanoparticles by using self-assembled biointegrated block copolymers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Superparamagnetic iron oxide nanoparticle-aptamer bioconjugates for combined prostate cancer imaging and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Aptamer-targeted cell-specific RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Nanoparticle-aptamer bioconjugates: a new approach for targeting prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Design and synthesis of binding growth factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Specificity and biomineralization activities of Ti-binding peptide-1 (TBP-1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Directional BMP-2 for functionalization of titanium surfaces

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Next-generation phage display: integrating and comparing available molecular tools to enable cost-effective high-throughput analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Quantitative selection of DNA aptamers through microfluidic selection and high-throughput sequencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

By-passing immunization. Human antibodies from V-gene libraries displayed on phage

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Properties, production, and applications of camelid single-domain antibody fragments

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Fluorescence imaging of cellular metabolites with RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Aptamer in bioanalytical applications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

An aptazyme-based molecular device that converts a small-molecule input into an RNA output.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Nanotechnology and aptamers: applications in drug delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

21 January 2018

DNA as a ‘Nanomaterial’

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

In vitro selection of a photo-responsive peptide aptamer using ribosome display

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

In vitro selection of peptide aptamers with affinity to single-wall carbon nanotubes using a ribosome display.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Ligand binding of a ribosome-displayed protein detected in solution at the single molecule level by fluorescence correlation spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

Phage display selection of peptides possessing aldolase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

RNA-catalysed carbon–carbon bond formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC2CC36348H

21 January 2018

Identifiers

DOI

10.1039/C2CC36348H

1 reference

28 August 2017

1 reference