IGF-1 and BRCA1 signalling pathways in familial cancer (Q38062611)

28 August 2017

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title

IGF-1 and BRCA1 signalling pathways in familial cancer (English)

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28 August 2017

2

Ilan Bruchim

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28 August 2017

Haim Werner

1

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PubMed ID

23182194

28 August 2017

language of work or name

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1 December 2012

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Lancet Oncology Commission

28 August 2017

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28 August 2017

13

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28 August 2017

e537-44

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28 August 2017

12

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28 August 2017

Global cancer statistics

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

Proportion of breast cancer cases in the United States explained by well-established risk factors

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

Mechanisms of endocrine resistance in breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

Evolving novel anti-HER2 strategies

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

Insulin and insulin-like growth factor signalling in neoplasia

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

The role of endocrine insulin-like growth factor-I and insulin in breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

The insulin-like growth factor-I receptor as an oncogene

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

The type 1 insulin-like growth factor receptor pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

Targeting insulin-like growth factor 1 receptor in sarcomas

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

Targeting the type 1 insulin-like growth factor receptor as a treatment for cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

Targeting the IGF1 axis in cancer proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

Emerging role of insulin-like growth factor receptor inhibitors in oncology: early clinical trial results and future directions

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

Insulin-like growth factor 1 (IGF1), IGF binding protein 3 (IGFBP3), and breast cancer risk: pooled individual data analysis of 17 prospective studies

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

Circulating concentrations of insulin-like growth factor I and risk of breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

Circulating Insulin-Like Growth Factor-I and Binding Protein-3 and the Risk of Breast Cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

IGF-I, IGFBP-3 and breast cancer risk in women: The European Prospective Investigation into Cancer and Nutrition (EPIC)

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

Insulin-like growth factor-I, its binding proteins (IGFBP-1 and IGFBP-3), and growth hormone and breast cancer risk in The Nurses Health Study II

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

Growth hormone, the insulin-like growth factor axis, insulin and cancer risk.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

The localization of the insulin-like growth factor receptor 1 (IGFR-1) in benign and malignant breast tissue

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

IGF system components as prognostic markers in breast cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

Estrogen receptor regulates insulin-like growth factor-I receptor gene expression in breast tumor cells: involvement of transcription factor Sp1.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

Down-regulation of insulin-like growth factor-I receptor and insulin receptor substrate-1 expression in advanced human breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

Insulin-like growth factor receptor (IGF-1R) in breast cancer subtypes.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

The IGF-I receptor in cancer research

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

The role of the IGF system in cancer growth and metastasis: overview and recent insights

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

The insulin-like growth factor-I receptor gene: a downstream target for oncogene and tumor suppressor action.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

BRCA mutations in the management of breast cancer: the state of the art.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

Mutational analyses ofBRCA1 andBRCA2 in Ashkenazi and non-Ashkenazi Jewish women with familial breast and ovarian cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

BRCA1 suppresses insulin-like growth factor-I receptor promoter activity: potential interaction between BRCA1 and Sp1.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

BRCA1–Sp1 interactions in transcriptional regulation of the IGF‐IR gene

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

Tumor suppressor BRCA1 is expressed in prostate cancer and controls insulin-like growth factor I receptor (IGF-IR) gene transcription in an androgen receptor-dependent manner

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

BRCA1 is expressed in uterine serous carcinoma (USC) and controls insulin-like growth factor I receptor (IGF-IR) gene expression in USC cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

Functional and physical interactions between BRCA1 and p53 in transcriptional regulation of the IGF-IR gene

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

The developmental pattern of Brca1 expression implies a role in differentiation of the breast and other tissues

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

TGF-beta1 inhibits BRCA1 expression through a pathway that requires pRb

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

Insulin-like growth factor-I controls BRCA1 gene expression through activation of transcription factor Sp1.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

AKT regulates BRCA1 stability in response to hormone signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

Elevated insulin-like growth factor-I receptor (IGF-IR) levels in primary breast tumors associated with BRCA1 mutations

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

Insulin-like growth factor (IGF)-system mRNA quantities in normal and tumor breast tissue of women with sporadic and familial breast cancer risk.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

Intratumoral IGF-I protein expression is selectively upregulated in breast cancer patients with BRCA1/2 mutations

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

Endocrinology of the wild and mutant BRCA1 gene and types of hormonal carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

The pathology of familial breast cancer: Immunohistochemistry and molecular analysis

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

Relationship of patients' age to histopathological features of breast tumours in BRCA1 and BRCA2 and mutation-negative breast cancer families

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

Role of direct interaction in BRCA1 inhibition of estrogen receptor activity

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

Regulation of the estrogen-inducible gene expression profile by the breast cancer susceptibility gene BRCA1.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

BRCA1 expression is not directly responsive to estrogen.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

Modifiers of risk of hereditary breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

Genetic variation in insulin-like growth factor signaling genes and breast cancer risk among BRCA1 and BRCA2 carriers

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

Genetic variation in IGF2 and HTRA1 and breast cancer risk among BRCA1 and BRCA2 carriers

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

Serum levels of IGF-I and BRCA penetrance: a case control study in breast cancer families

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

IGF1 htSNPs in relation to IGF-1 levels in young women from high-risk breast cancer families: implications for early-onset breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

Functional variant of KLOTHO: a breast cancer risk modifier among BRCA1 mutation carriers of Ashkenazi origin

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

Diabetes and breast cancer among women with BRCA1 and BRCA2 mutations

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

BRCA1 affects lipid synthesis through its interaction with acetyl-CoA carboxylase

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

Relevance of DNA methylation in the management of cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

Aberrant methylation of the BRCA1 CpG island promoter is associated with decreased BRCA1 mRNA in sporadic breast cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

Promoter hypermethylation of BRCA1 correlates with absence of expression in hereditary breast cancer tumors

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

BRCA1 promoter methylation in peripheral blood DNA was identified in sporadic breast cancer and controls

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

Progression to metastatic stage in a cellular model of prostate cancer is associated with methylation of the androgen receptor gene and transcriptional suppression of the insulin-like growth factor-I receptor gene

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

Global methylation analysis identifies PITX2 as an upstream regulator of the androgen receptor and IGF-I receptor genes in prostate cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

MiRNA expression in psoriatic skin: reciprocal regulation of hsa-miR-99a and IGF-1R

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

Tumor suppressor BRCA1 epigenetically controls oncogenic microRNA-155

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

The insulin and insulin-like growth factor receptor family in neoplasia: an update

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

Loss of BRCA1 function increases the antitumor activity of cisplatin against human breast cancer xenografts in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

p53 Regulates insulin-like growth factor-I receptor gene expression in uterine serous carcinoma and predicts responsiveness to an insulin-like growth factor-I receptor-directed targeted therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970362-5

7 January 2021

10.1016/S1470-2045(12)70362-5

Identifiers

DOI

1 reference

28 August 2017

1 reference

PubMed ID

23182194