Understanding the hypoxic niche of multiple myeloma: therapeutic implications and contributions of mouse models. (Q38056889)

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16 February 2020

1 reference

3 December 2020

Understanding the hypoxic niche of multiple myeloma: therapeutic implications and contributions of mouse models (English)

1 reference

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16 February 2020

0 references

5 references

22 March 2019

3 April 2019

17 June 2019

20 June 2019

19 September 2019

biomedical investigative technique

1 reference

19 September 2019

1 reference

3 December 2020

3

1 reference

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16 February 2020

author name string

Jinsong Hu

1

1 reference

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16 February 2020

Els Van Valckenborgh

2

1 reference

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16 February 2020

Elke De Bruyne

4

1 reference

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16 February 2020

Karin Vanderkerken

5

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publication date

1 November 2012

7 references

22 March 2019

3 April 2019

17 June 2019

20 June 2019

19 September 2019

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16 February 2020

3 December 2020

Disease Models & Mechanisms

7 references

22 March 2019

3 April 2019

17 June 2019

20 June 2019

19 September 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23115205%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

3 December 2020

5

1 reference

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16 February 2020

issue

6

1 reference

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16 February 2020

page(s)

763-771

1 reference

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Drug response in a genetically engineered mouse model of multiple myeloma is predictive of clinical efficacy

16 February 2020

cites work

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18F-fluromisonidazole PET imaging as a biomarker for the response to 5,6-dimethylxanthenone-4-acetic acid in colorectal xenograft tumors.

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Effect of a topical vasodilator on tumor hypoxia and tumor oxygen guided radiotherapy using EPR oximetry

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A therapeutic role for targeting c-Myc/Hif-1-dependent signaling pathways

6 September 2017

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HIF-1 and HIF-2 transcription factors--similar but not identical

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Hypoxia-inducible factor-2 is a novel regulator of aberrant CXCL12 expression in multiple myeloma plasma cells.

6 September 2017

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Intermittent hypoxia-mediated plasticity of acute O2 sensing requires altered red-ox regulation by HIF-1 and HIF-2.

6 September 2017

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A murine model of myeloma that allows genetic manipulation of the host microenvironment

6 September 2017

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Targeting the hypoxia-inducible factor (HIF) pathway in cancer.

6 September 2017

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Multiple myeloma bone marrow niche

6 September 2017

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CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy.

6 September 2017

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An imaging comparison of 64Cu-ATSM and 60Cu-ATSM in cancer of the uterine cervix

6 September 2017

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6 September 2017

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Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets

6 September 2017

1 reference

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Hematopoietic progenitor cell mobilization results in hypoxia with increased hypoxia-inducible transcription factor-1 alpha and vascular endothelial growth factor A in bone marrow

6 September 2017

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The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis

6 September 2017

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Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia

6 September 2017

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Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice

6 September 2017

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Mechanisms of regulation of CXCR4/SDF-1 (CXCL12)-dependent migration and homing in multiple myeloma

6 September 2017

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Targeting the PAS-A domain of HIF-1alpha for development of small molecule inhibitors of HIF-1.

6 September 2017

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Importance of the bone marrow microenvironment in inducing the angiogenic response in multiple myeloma

6 September 2017

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6 September 2017

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Synergistic activity of the proteasome inhibitor PS-341 with non-myeloablative 153-Sm-EDTMP skeletally targeted radiotherapy in an orthotopic model of multiple myeloma

6 September 2017

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Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity

6 September 2017

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Hypoxia-dependent activation of HIF into a transcriptional regulator

6 September 2017

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Targeting multiple myeloma cells and their bone marrow microenvironment

6 September 2017

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Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist

6 September 2017

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6 September 2017

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Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma

6 September 2017

1 reference

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Targeting HIF-1 for cancer therapy

6 September 2017

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Insights into the multistep transformation of MGUS to myeloma using microarray expression analysis

6 September 2017

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Proteasome inhibitors disrupt the unfolded protein response in myeloma cells

6 September 2017

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Multiple myeloma biology: lessons from the 5TMM models

6 September 2017

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Regulation of angiogenesis by hypoxia: role of the HIF system

6 September 2017

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Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1

6 September 2017

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Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation

6 September 2017

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Signal transduction to hypoxia-inducible factor 1

6 September 2017

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The 5TMM series: a useful in vivo mouse model of human multiple myeloma

6 September 2017

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HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus

6 September 2017

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Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects

6 September 2017

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6 September 2017

Measuring Tumor Hypoxia

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Diverse karyotypic abnormalities of the c-myc locus associated with c-myc dysregulation and tumor progression in multiple myeloma

6 September 2017

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Carbogen-induced changes in rat mammary tumour oxygenation reported by near infrared spectroscopy

6 September 2017

1 reference

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Frequent dysregulation of the c-maf proto-oncogene at 16q23 by translocation to an Ig locus in multiple myeloma

6 September 2017

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Bone marrow angiogenesis and progression in multiple myeloma.

6 September 2017

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Haematologic Adaptation in Patients with Chronic Bronchitis and Pulmonary Insufficiency

6 September 2017

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(1)H NMR metabolomics identification of markers of hypoxia-induced metabolic shifts in a breast cancer model system

6 September 2017

1 reference

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Investigation on tumor hypoxia in resectable primary prostate cancer as demonstrated by 18F-FAZA PET/CT utilizing multimodality fusion techniques

14 September 2017

1 reference

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Inhibition of hypoxia-inducible factor-1 function enhances the sensitivity of multiple myeloma cells to melphalan

14 September 2017

1 reference

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Targeting angiogenesis via a c-Myc/hypoxia-inducible factor-1alpha-dependent pathway in multiple myeloma

14 September 2017

1 reference

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A RNA antagonist of hypoxia-inducible factor-1alpha, EZN-2968, inhibits tumor cell growth

14 September 2017

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The anti-cancer drug lenalidomide inhibits angiogenesis and metastasis via multiple inhibitory effects on endothelial cell function in normoxic and hypoxic conditions

14 September 2017

1 reference

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The new tumor-suppressor gene inhibitor of growth family member 4 (ING4) regulates the production of proangiogenic molecules by myeloma cells and suppresses hypoxia-inducible factor-1 alpha (HIF-1alpha) activity: involvement in myeloma-induced angio

14 September 2017

1 reference

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CHIR-258 is efficacious in a newly developed fibroblast growth factor receptor 3-expressing orthotopic multiple myeloma model in mice

14 September 2017

1 reference

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Antimyeloma activity of heat shock protein-90 inhibition.

14 September 2017

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A clinically relevant SCID-hu in vivo model of human multiple myeloma

14 September 2017

1 reference

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Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1alpha.

14 September 2017

1 reference

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Expansion of human SCID-repopulating cells under hypoxic conditions

14 September 2017

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A murine model of human myeloma bone disease

14 September 2017

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Idiopathic paraproteinemia. II. Transplantation of the paraprotein-producing clone from old to young C57BL/KaLwRij mice

28 September 2017

1 reference

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A unique three-dimensional SCID-polymeric scaffold (SCID-synth-hu) model for in vivo expansion of human primary multiple myeloma cells.

28 September 2017

1 reference

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Cultivation of rat marrow-derived mesenchymal stem cells in reduced oxygen tension: effects on in vitro and in vivo osteochondrogenesis

23 June 2018

1 reference

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Quantification of CCI-103F labeling heterogeneity in canine solid tumors

23 June 2018

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Animal model of human disease. Multiple myeloma.

23 June 2018

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Oxygenation of carcinomas of the uterine cervix: evaluation by computerized O2 tension measurements.

23 June 2018

1 reference

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Thermally induced conformational changes of tobacco mosaic virus and their protein assemblies

23 June 2018

1 reference

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Hypoxia and activated VEGF/receptor pathway in multiple myeloma.

23 June 2018

1 reference

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Targeting the multiple myeloma hypoxic niche with TH-302, a hypoxia-activated prodrug

31 August 2018

1 reference

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18F-EF5: a new PET tracer for imaging hypoxia in head and neck cancer.

31 August 2018

1 reference

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AID-dependent activation of a MYC transgene induces multiple myeloma in a conditional mouse model of post-germinal center malignancies.

31 August 2018

1 reference

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Modeling multiple myeloma by AID-dependent conditional activation of MYC.

31 August 2018

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Bortezomib inhibits tumor adaptation to hypoxia by stimulating the FIH-mediated repression of hypoxia-inducible factor-1.

31 August 2018

1 reference

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Determination of tumour hypoxia with the PET tracer [18F]EF3: improvement of the tumour-to-background ratio in a mouse tumour model.

31 August 2018

1 reference

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Genetic abnormalities and survival in multiple myeloma: the experience of the Intergroupe Francophone du Myélome.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3484859

Role of the hypoxic bone marrow microenvironment in 5T2MM murine myeloma tumor progression.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3484859

Insertion of c-Myc into Igh induces B-cell and plasma-cell neoplasms in mice.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3484859

AID is required for c-myc/IgH chromosome translocations in vivo

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3484859

Identification of genes modulated in multiple myeloma using genetically identical twin samples

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3484859

YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3484859

Characterization and validation of noninvasive oxygen tension measurements in human glioma xenografts by 19F-MR relaxometry.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3484859

Measurement of PDT-induced hypoxia in Dunning prostate tumors by iodine-123-iodoazomycin arabinoside.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3484859

Low bone marrow oxygen tension and hypoxia-inducible factor-1α overexpression characterize patients with multiple myeloma: role on the transcriptional and proangiogenic profiles of CD138+ cells

31 August 2018

1 reference

12 December 2020

Animal models: Towards a myeloma mouse

1 reference

12 December 2020

A novel transgenic mouse model of the human multiple myeloma chromosomal translocation t(14;16)(q32;q23)

1 reference

12 December 2020

Augmentation of in vitro human marrow erythropoiesis under physiological oxygen tensions is mediated by monocytes and T lymphocytes

1 reference

12 December 2020

The development of a model for the homing of multiple myeloma cells to human bone marrow

1 reference

12 December 2020

Myeloma progenitors in the blood of patients with aggressive or minimal disease: engraftment and self-renewal of primary human myeloma in the bone marrow of NOD SCID mice

1 reference

12 December 2020

Observations on Long Bone Medullary Pressure in Relation to Mean Arterial Blood Pressure in the Anaesthetized Dog

1 reference

12 December 2020

Measurement of hypoxia in vivo using a 2-nitroimidazole (NITP)

1 reference

12 December 2020

Primary myeloma cells growing in SCID-hu mice: a model for studying the biology and treatment of myeloma and its manifestations

1 reference

12 December 2020

Technetium-99m-labeled HL91 to identify tumor hypoxia: correlation with fluorine-18-FDG

1 reference

12 December 2020

Cryospectrophotometric determination of tumor intravascular oxyhemoglobin saturations: dependence on vascular geometry and tumor growth

1 reference

12 December 2020

Fluorescence imaging of multiple myeloma cells in a clinically relevant SCID/NOD in vivo model: biologic and clinical implications

1 reference

12 December 2020

The SCID-rab model: a novel in vivo system for primary human myeloma demonstrating growth of CD138-expressing malignant cells

1 reference

12 December 2020

Upregulation of matrix metalloproteinase-9 in murine 5T33 multiple myeloma cells by interaction with bone marrow endothelial cells

1 reference

12 December 2020

Oxygenation of human tumors: evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements

1 reference

12 December 2020

Antepartum assessment of fetal cystic lymphangioma by magnetic resonance imaging

1 reference

12 December 2020

Measurement of Tumor Oxygenation: A Comparison between Polarographic Needle Electrodes and a Time-Resolved Luminescence-Based Optical Sensor

1 reference

12 December 2020

The OxyLite: a fibre-optic oxygen sensor

1 reference

12 December 2020

Localization of tumors and evaluation of their state of oxygenation by phosphorescence imaging

1 reference

12 December 2020

Oncogenomics to target myeloma in the bone marrow microenvironment

1 reference

12 December 2020

Oxygen saturation in the bone marrow of healthy volunteers

1 reference

12 December 2020

Prognostic potential of the pre-therapeutic tumor oxygenation status

1 reference

12 December 2020

Identifiers

DOI

10.1242/DMM.008961

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23115205%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23115205%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23115205%20AND%20SRC:MED&resulttype=core&format=json