Elimination of intracellularly residing Mycobacterium tuberculosis through targeting of host and bacterial signaling mechanisms (Q38056148)

27 August 2017

Elimination of intracellularly residing Mycobacterium tuberculosis through targeting of host and bacterial signaling mechanisms (English)

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Mycobacterium tuberculosis

27 August 2017

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author name string

Rajesh Jayachandran

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1

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PubMed ID

23106276

27 August 2017

Nicole Scherr

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2

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PubMed ID

23106276

27 August 2017

Jean Pieters

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3

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27 August 2017

1 September 2012

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Expert Review of Anti-infective Therapy

27 August 2017

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27 August 2017

10

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27 August 2017

9

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27 August 2017

1007-1022

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The influence of reduced oxygen availability on pathogenicity and gene expression in Mycobacterium tuberculosis

27 August 2017

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Bacterial growth and cell division: a mycobacterial perspective

21 January 2018

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Regulation of the Mycobacterium tuberculosis hypoxic response gene encoding α-crystallin

21 January 2018

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Neutrophils and intracellular pathogens: beyond phagocytosis and killing

21 January 2018

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Cell-mediated immune responses in tuberculosis

21 January 2018

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The secret lives of the pathogenic mycobacteria

21 January 2018

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Mycobacterium tuberculosis: success through dormancy

21 January 2018

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Mycobacterium tuberculosis and the macrophage: maintaining a balance.

21 January 2018

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Neutrophils from Mycobacterium avium-infected mice produce TNF-alpha, IL-12, and IL-1 beta and have a putative role in early host response

21 January 2018

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Induction of apoptosis in human neutrophils by Mycobacterium tuberculosis is dependent on mature bacterial lipoproteins.

21 January 2018

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Neutrophils rapidly migrate via lymphatics after Mycobacterium bovis BCG intradermal vaccination and shuttle live bacilli to the draining lymph nodes.

21 January 2018

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Rapid neutrophil response controls fast-replicating intracellular bacteria but not slow-replicating Mycobacterium tuberculosis

21 January 2018

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Neutrophil-mediated innate immune resistance to mycobacteria

21 January 2018

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Lack of fusion of azurophil granules with phagosomes during phagocytosis of Mycobacterium smegmatis by human neutrophils is not actively controlled by the bacterium

21 January 2018

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Mechanisms of phagocytosis in macrophages

21 January 2018

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Mycobacteria use their surface-exposed glycolipids to infect human macrophages through a receptor-dependent process

21 January 2018

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A fatal attraction: Mycobacterium tuberculosis and HIV-1 target DC-SIGN to escape immune surveillance

21 January 2018

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Complement levels and activity in the normal and LPS-injured lung

21 January 2018

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Nonopsonic phagocytosis of zymosan and Mycobacterium kansasii by CR3 (CD11b/CD18) involves distinct molecular determinants and is or is not coupled with NADPH oxidase activation

21 January 2018

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Essential role for cholesterol in entry of mycobacteria into macrophages

21 January 2018

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Cloning of an M. tuberculosis DNA fragment associated with entry and survival inside cells.

21 January 2018

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Mycobacterium tuberculosis strains disrupted in mce3 and mce4 operons are attenuated in mice

21 January 2018

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Mce2 operon mutant strain of Mycobacterium tuberculosis is attenuated in C57BL/6 mice

21 January 2018

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Hypervirulent mutant of Mycobacterium tuberculosis resulting from disruption of the mce1 operon

21 January 2018

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The eukaryotic-like Ser/Thr protein kinases of Mycobacterium tuberculosis

21 January 2018

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Mycobacterium tuberculosis PtkA is a novel protein tyrosine kinase whose substrate is PtpA

21 January 2018

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Phosphoprotein phosphatase of Mycobacterium tuberculosis dephosphorylates serine–threonine kinases PknA and PknB

21 January 2018

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Cloning and characterization of secretory tyrosine phosphatases of Mycobacterium tuberculosis

21 January 2018

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Mycobacterium tuberculosis virulence is mediated by PtpA dephosphorylation of human vacuolar protein sorting 33B

21 January 2018

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Mycobacterium tuberculosis protein tyrosine phosphatase (PtpA) excludes host vacuolar-H+-ATPase to inhibit phagosome acidification

21 January 2018

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MptpB, a virulence factor from Mycobacterium tuberculosis, exhibits triple-specificity phosphatase activity

21 January 2018

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Protein tyrosine phosphatase PtpA is not required for Mycobacterium tuberculosis growth in mice

21 January 2018

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Protein structure similarity clustering and natural product structure as guiding principles in drug discovery.

21 January 2018

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Inhibition of MptpB phosphatase from Mycobacterium tuberculosis impairs mycobacterial survival in macrophages

21 January 2018

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Discovery of protein phosphatase inhibitor classes by biology-oriented synthesis

21 January 2018

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Fragment-based substrate activity screening method for the identification of potent inhibitors of the Mycobacterium tuberculosis phosphatase PtpB.

21 January 2018

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Structural Basis for Selective Inhibition of Mycobacterium tuberculosis Protein Tyrosine Phosphatase PtpB

21 January 2018

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Fragment-based discovery of selective inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase PtpA.

21 January 2018

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Inhibition of Mycobacterium tuberculosis tyrosine phosphatase PtpA by synthetic chalcones: kinetics, molecular modeling, toxicity and effect on growth.

21 January 2018

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Synthesis, biological evaluation, and molecular modeling of chalcone derivatives as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatases (PtpA and PtpB).

21 January 2018

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Phosphorylation of Mycobacterium tuberculosis Ser/Thr phosphatase by PknA and PknB

21 January 2018

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PknB kinase activity is regulated by phosphorylation in two Thr residues and dephosphorylation by PstP, the cognate phospho-Ser/Thr phosphatase, in Mycobacterium tuberculosis

21 January 2018

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The condensing activities of the Mycobacterium tuberculosis type II fatty acid synthase are differentially regulated by phosphorylation

21 January 2018

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Secretion of an acid phosphatase (SapM) by Mycobacterium tuberculosis that is similar to eukaryotic acid phosphatases

21 January 2018

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Mechanism of phagolysosome biogenesis block by viable Mycobacterium tuberculosis

21 January 2018

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The fbpA/sapM double knock out strain of Mycobacterium tuberculosis is highly attenuated and immunogenic in macrophages

21 January 2018

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The Ser/Thr protein kinase PknB is essential for sustaining mycobacterial growth

21 January 2018

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Interdomain interaction reconstitutes the functionality of PknA, a eukaryotic type Ser/Thr kinase from Mycobacterium tuberculosis.

21 January 2018

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Ability of PknA, a mycobacterial eukaryotic-type serine/threonine kinase, to transphosphorylate MurD, a ligase involved in the process of peptidoglycan biosynthesis

21 January 2018

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The Mycobacterium tuberculosis serine/threonine kinases PknA and PknB: substrate identification and regulation of cell shape

21 January 2018

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Regulation of polar peptidoglycan biosynthesis by Wag31 phosphorylation in mycobacteria

21 January 2018

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Antigen 84, an effector of pleiomorphism in Mycobacterium smegmatis.

21 January 2018

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Phosphorylation of enoyl-acyl carrier protein reductase InhA impacts mycobacterial growth and survival

21 January 2018

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PknB-mediated phosphorylation of a novel substrate, N-acetylglucosamine-1-phosphate uridyltransferase, modulates its acetyltransferase activity

21 January 2018

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The Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III activity is inhibited by phosphorylation on a single threonine residue

21 January 2018

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Phosphorylation of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein reductase MabA regulates mycolic acid biosynthesis

21 January 2018

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Retracted: Novel Role of Phosphorylation-Dependent Interaction between FtsZ and FipA in Mycobacterial Cell Division

21 January 2018

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Forkhead-associated domain-containing protein Rv0019c and polyketide-associated protein PapA5, from substrates of serine/threonine protein kinase PknB to interacting proteins of Mycobacterium tuberculosis

21 January 2018

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The serine/threonine kinase PknB of Mycobacterium tuberculosis phosphorylates PBPA, a penicillin-binding protein required for cell division

21 January 2018

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A pseudokinase debut at the mycobacterial cell wall

21 January 2018

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A Phosphorylated Pseudokinase Complex Controls Cell Wall Synthesis in Mycobacteria

21 January 2018

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The extracytoplasmic domain of the Mycobacterium tuberculosis Ser/Thr kinase PknB binds specific muropeptides and is required for PknB localization

21 January 2018

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Effective inhibitors of the essential kinase PknB and their potential as anti-mycobacterial agents

21 January 2018

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Substituted aminopyrimidine protein kinase B (PknB) inhibitors show activity against Mycobacterium tuberculosis

21 January 2018

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Allosteric activation by dimerization of the PknD receptor Ser/Thr protein kinase from Mycobacterium tuberculosis

21 January 2018

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Effect of PstS sub-units or PknD deficiency on the survival of Mycobacterium tuberculosis

21 January 2018

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Role of Mycobacterium tuberculosis pknD in the pathogenesis of central nervous system tuberculosis

21 January 2018

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Role of protein kinase G in growth and glutamine metabolism of Mycobacterium bovis BCG.

21 January 2018

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Protein kinase G from pathogenic mycobacteria promotes survival within macrophages

21 January 2018

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Differential expression of a virulence factor in pathogenic and non-pathogenic mycobacteria.

21 January 2018

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Structural basis for the specific inhibition of protein kinase G, a virulence factor of Mycobacterium tuberculosis

21 January 2018

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Key residues in Mycobacterium tuberculosis protein kinase G play a role in regulating kinase activity and survival in the host

21 January 2018

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Survival of pathogenic mycobacteria in macrophages is mediated through autophosphorylation of protein kinase G

21 January 2018

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A novel drug discovery concept for tuberculosis: inhibition of bacterial and host cell signalling.

21 January 2018

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Insights from the molecular docking of withanolide derivatives to the target protein PknG from Mycobacterium tuberculosis

21 January 2018

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Deletion of the Mycobacterium tuberculosis pknH gene confers a higher bacillary load during the chronic phase of infection in BALB/c mice

21 January 2018

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Convergence of Ser/Thr and two-component signaling to coordinate expression of the dormancy regulon in Mycobacterium tuberculosis

21 January 2018

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EmbR2, a structural homologue of EmbR, inhibits the Mycobacterium tuberculosis kinase/substrate pair PknH/EmbR

21 January 2018

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Mycobacterium tuberculosis protein kinase K confers survival advantage during early infection in mice and regulates growth in culture and during persistent infection: implications for immune modulation

21 January 2018

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The Mycobacterium tuberculosis protein kinase K modulates activation of transcription from the promoter of mycobacterial monooxygenase operon through phosphorylation of the transcriptional regulator VirS

21 January 2018

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Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

21 January 2018

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Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia

21 January 2018

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Imatinib-sensitive tyrosine kinases regulate mycobacterial pathogenesis and represent therapeutic targets against tuberculosis

21 January 2018

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Delivering proteins for export from the cytosol

21 January 2018

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Protein secretion systems in Mycobacteria.

21 January 2018

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SecA2 functions in the secretion of superoxide dismutase A and in the virulence of Mycobacterium tuberculosis

21 January 2018

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The SecA2 secretion factor of Mycobacterium tuberculosis promotes growth in macrophages and inhibits the host immune response

21 January 2018

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The Mycobacterium tuberculosis SecA2 system subverts phagosome maturation to promote growth in macrophages.

21 January 2018

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The ins and outs of Mycobacterium tuberculosis protein export

21 January 2018

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ESX/type VII secretion systems and their role in host-pathogen interaction

21 January 2018

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The primary mechanism of attenuation of bacillus Calmette-Guerin is a loss of secreted lytic function required for invasion of lung interstitial tissue

21 January 2018

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ESAT-6 proteins: protective antigens and virulence factors?

21 January 2018

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Tuberculous granuloma induction via interaction of a bacterial secreted protein with host epithelium

21 January 2018

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Protein export systems of Mycobacterium tuberculosis: novel targets for drug development?

21 January 2018

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Regulated proteolysis in Gram-negative bacteria--how and when?

21 January 2018

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The Mycobacterium tuberculosis proteasome: more than just a barrel-shaped protease

21 January 2018

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Inhibitors selective for mycobacterial versus human proteasomes

21 January 2018

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The proteasome of Mycobacterium tuberculosis is required for resistance to nitric oxide

21 January 2018

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Ubiquitin-like protein involved in the proteasome pathway of Mycobacterium tuberculosis

21 January 2018

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Mycobacterium tuberculosis MycP1 protease plays a dual role in regulation of ESX-1 secretion and virulence

21 January 2018

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Mycobacterium tuberculosis prevents inflammasome activation

21 January 2018

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cAMP synthesis and degradation by phagosomes regulate actin assembly and fusion events: consequences for mycobacteria.

21 January 2018

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Cyclic AMP intoxication of macrophages by a Mycobacterium tuberculosis adenylate cyclase

21 January 2018

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Molecular cloning of a novel actin-binding protein, p57, with a WD repeat and a leucine zipper motif

21 January 2018

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A coat protein on phagosomes involved in the intracellular survival of mycobacteria

21 January 2018

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The ancient regulatory-protein family of WD-repeat proteins

21 January 2018

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The WD repeat: a common architecture for diverse functions

21 January 2018

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RNA interference in J774 macrophages reveals a role for coronin 1 in mycobacterial trafficking but not in actin-dependent processes

21 January 2018

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Coronin-1a inhibits autophagosome formation around Mycobacterium tuberculosis-containing phagosomes and assists mycobacterial survival in macrophages

21 January 2018

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Genome-wide analysis of the host intracellular network that regulates survival of Mycobacterium tuberculosis.

21 January 2018

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Regulation of T cell survival through coronin-1-mediated generation of inositol-1,4,5-trisphosphate and calcium mobilization after T cell receptor triggering.

21 January 2018

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Survival of mycobacteria in macrophages is mediated by coronin 1-dependent activation of calcineurin

21 January 2018

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Coronin 1 is essential for IgM-mediated Ca2+ mobilization in B cells but dispensable for the generation of immune responses in vivo

21 January 2018

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Inhibition of Ca(2+) signaling by Mycobacterium tuberculosis is associated with reduced phagosome-lysosome fusion and increased survival within human macrophages

21 January 2018

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Calcium signalling in lymphocytes.

21 January 2018

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Lipoamide dehydrogenase mediates retention of coronin-1 on BCG vacuoles, leading to arrest in phagosome maturation

21 January 2018

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The interferon-inducible GTPases.

21 January 2018

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Immune Control of Tuberculosis by IFN-γ-Inducible LRG-47

21 January 2018

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Human IRGM induces autophagy to eliminate intracellular mycobacteria

21 January 2018

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Lack of acidification in Mycobacterium phagosomes produced by exclusion of the vesicular proton-ATPase

21 January 2018

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A family of IFN-γ-inducible 65-kD GTPases protects against bacterial infection

21 January 2018

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Voltage gated calcium channels negatively regulate protective immunity to Mycobacterium tuberculosis

21 January 2018

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International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels

21 January 2018

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Overview of molecular relationships in the voltage-gated ion channel superfamily.

21 January 2018

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Regulation of podosome formation in macrophages by a splice variant of the sodium channel SCN8A.

21 January 2018

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Expression of the voltage-gated sodium channel NaV1.5 in the macrophage late endosome regulates endosomal acidification

21 January 2018

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Endosomal and non-endosomal functions of ESCRT proteins

21 January 2018

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ESCRT factors restrict mycobacterial growth

21 January 2018

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Identification of host-dependent survival factors for intracellular Mycobacterium tuberculosis through an siRNA screen

21 January 2018

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Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment

21 January 2018

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Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase

21 January 2018

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Mycobacterium tuberculosis isocitrate lyases 1 and 2 are jointly required for in vivo growth and virulence

21 January 2018

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TB drug discovery: addressing issues of persistence and resistance

21 January 2018

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Immunological control of tuberculosis: role of tumour necrosis factor and more

21 January 2018

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Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large

21 January 2018

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Innate immune recognition of Mycobacterium tuberculosis

21 January 2018

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A human IFNGR1 small deletion hotspot associated with dominant susceptibility to mycobacterial infection

21 January 2018

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Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients

21 January 2018

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Toll-like receptor pathways in the immune responses to mycobacteria

21 January 2018

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Cellular responses to interferon-gamma

21 January 2018

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IL-12 and IFN-gamma in host defense against mycobacteria and salmonella in mice and men.

21 January 2018

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Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

21 January 2018

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The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults

21 January 2018

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Regulation of phagosome maturation by signals from toll-like receptors.

21 January 2018

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Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response

21 January 2018

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The structure of PknB in complex with mitoxantrone, an ATP-competitive inhibitor, suggests a mode of protein kinase regulation in mycobacteria

21 January 2018

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Lipid lunch for persistent pathogen

21 January 2018

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21 January 2018

Identifiers

DOI

10.1586/ERI.12.95

1 reference

27 August 2017

1 reference

PubMed ID

23106276