Structural biology of dengue virus enzymes: towards rational design of therapeutics (Q38045106)

27 August 2017

Structural biology of dengue virus enzymes: towards rational design of therapeutics (English)

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27 August 2017

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2

Pei-Yong Shi

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27 August 2017

Christian G Noble

1

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27 August 2017

17 September 2012

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27 August 2017

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27 August 2017

96

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27 August 2017

115-126

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27 August 2017

2

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Alkylated flavanones from the bark of Cryptocarya chartacea as dengue virus NS5 polymerase inhibitors

27 August 2017

2 references

30 November 2021

https://opencitations.net/index/coci/api/v1/citations/10.1021/NP200715V

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Identification of a novel antiviral inhibitor of the flavivirus guanylyltransferase enzyme

16 October 2022

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https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

A structural and primary sequence comparison of the viral RNA-dependent RNA polymerases

16 October 2022

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https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Cleavage preference distinguishes the two-component NS2B–NS3 serine proteinases of Dengue and West Nile viruses

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Switching the Substrate Specificity of the Two-Component NS2B-NS3 Flavivirus Proteinase by Structure-Based Mutagenesis

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Crystal structure of the RNA polymerase domain of the West Nile virus non-structural protein 5

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Structure and functionality in flavivirus NS-proteins: perspectives for drug design

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Structural and Functional Analyses of a Conserved Hydrophobic Pocket of Flavivirus Methyltransferase

16 October 2022

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https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

16 October 2022

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https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Inhibition of dengue virus by targeting viral NS4B protein

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: new prospects for an old drug

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

West Nile Virus 5'-Cap Structure Is Formed by Sequential Guanine N-7 and Ribose 2'-O Methylations by Nonstructural Protein 5

16 October 2022

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https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Analysis of Flavivirus NS5 Methyltransferase Cap Binding

16 October 2022

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https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

A high-throughput screening assay for the identification of flavivirus NS5 capping enzyme GTP-binding inhibitors: implications for antiviral drug development

16 October 2022

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https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

A mechanism for initiating RNA-dependent RNA polymerization

16 October 2022

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https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Structure of West Nile virus NS3 protease: ligand stabilization of the catalytic conformation

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Inhibition of dengue virus polymerase by blocking of the RNA tunnel

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Biflavonoids of Dacrydium balansae with potent inhibitory activity on dengue 2 NS5 polymerase

16 October 2022

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https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Crystal structures of the RNA-dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors

16 October 2022

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https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Functional analysis of two cavities in flavivirus NS5 polymerase

16 October 2022

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https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Structure-based discovery of dengue virus protease inhibitors

16 October 2022

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https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

The flavivirus NS5 protein is a true RNA guanylyltransferase that catalyzes a two-step reaction to form the RNA cap structure

16 October 2022

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https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

An adenosine nucleoside inhibitor of dengue virus

16 October 2022

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https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Recognition of RNA cap in the Wesselsbron virus NS5 methyltransferase domain: implications for RNA-capping mechanisms in Flavivirus

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Structure of the methyltransferase domain from the Modoc virus, a flavivirus with no known vector

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

The structure of the RNA-dependent RNA polymerase from bovine viral diarrhea virus establishes the role of GTP in de novo initiation

16 October 2022

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https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Discovery of boceprevir, a direct-acting NS3/4A protease inhibitor for treatment of chronic hepatitis C infections

16 October 2022

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https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Peptide inhibitors of Dengue virus NS3 protease. Part 1: Warhead

16 October 2022

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https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Cell-free transcription/translation from PCR-amplified DNA for high-throughput NMR studies.

16 October 2022

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https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Potent cationic inhibitors of West Nile virus NS2B/NS3 protease with serum stability, cell permeability and antiviral activity

16 October 2022

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https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Mechanistic study of HCV polymerase inhibitors at individual steps of the polymerization reaction.

16 October 2022

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https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

De Novo Synthesis of Negative-Strand RNA by Dengue Virus RNA-Dependent RNA Polymerase In Vitro: Nucleotide, Primer, and Template Parameters

16 October 2022

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https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Distinct RNA Elements Confer Specificity to Flavivirus RNA Cap Methylation Events

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Small Molecule Inhibitors That Selectively Block Dengue Virus Methyltransferase

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

2'-O methylation of internal adenosine by flavivirus NS5 methyltransferase

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Towards the design of antiviral inhibitors against flaviviruses: the case for the multifunctional NS3 protein from Dengue virus as a target

16 October 2022

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https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

New NS5B polymerase inhibitors for hepatitis C.

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Binding of low molecular weight inhibitors promotes large conformational changes in the dengue virus NS2B-NS3 protease: fold analysis by pseudocontact shifts

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Tripeptide inhibitors of dengue and West Nile virus NS2B-NS3 protease

16 October 2022

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https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Flaviviral methyltransferase/RNA interaction: structural basis for enzyme inhibition

16 October 2022

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https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Functional profiling of recombinant NS3 proteases from all four serotypes of dengue virus using tetrapeptide and octapeptide substrate libraries.

16 October 2022

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https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Strategies for development of Dengue virus inhibitors

16 October 2022

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https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Molecular Mechanism of a Thumb Domain Hepatitis C Virus Nonnucleoside RNA-Dependent RNA Polymerase Inhibitor

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

A fluorescence quenching assay to discriminate between specific and nonspecific inhibitors of dengue virus protease.

16 October 2022

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https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Structure-guided fragment-based in silico drug design of dengue protease inhibitors.

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Comparative mechanistic studies of de novo RNA synthesis by flavivirus RNA-dependent RNA polymerases.

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

A novel in vitro replication system for Dengue virus. Initiation of RNA synthesis at the 3'-end of exogenous viral RNA templates requires 5'- and 3'-terminal complementary sequence motifs of the viral RNA.

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Flavivirus methyltransferase: a novel antiviral target

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

The flavivirus polymerase as a target for drug discovery.

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Characterization of the elongation complex of dengue virus RNA polymerase: assembly, kinetics of nucleotide incorporation, and fidelity

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Mutagenesis of the NS3 protease of dengue virus type 2.

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

NMR Analysis of the Dynamic Exchange of the NS2B Cofactor between Open and Closed Conformations of the West Nile Virus NS2B-NS3 Protease

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Crystal Structure of a Novel Conformational State of the Flavivirus NS3 Protein: Implications for Polyprotein Processing and Viral Replication

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Mechanism of Hepatitis C Virus RNA Polymerase Inhibition with Dihydroxypyrimidines

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Serotype-Specific Structural Differences in the Protease-Cofactor Complexes of the Dengue Virus Family

16 October 2022

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https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

A fluorescence-based alkaline phosphatase-coupled polymerase assay for identification of inhibitors of dengue virus RNA-dependent RNA polymerase

16 October 2022

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https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Arresting initiation of hepatitis C virus RNA synthesis using heterocyclic derivatives.

16 October 2022

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https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Mutational analysis of bovine viral diarrhea virus RNA-dependent RNA polymerase.

16 October 2022

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https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Structural Analysis of the Hepatitis C Virus RNA Polymerase in Complex with Ribonucleotides

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Structural evidence for regulation and specificity of flaviviral proteases and evolution of theFlaviviridaefold

16 October 2022

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https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Fragment-based discovery of hepatitis C virus NS5b RNA polymerase inhibitors

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

A comparison of viral RNA-dependent RNA polymerases

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Dengue virus RNA polymerase NS5: a potential therapeutic target?

16 October 2022

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https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

2'-O methylation of the viral mRNA cap evades host restriction by IFIT family members

16 October 2022

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https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Flacourtosides A-F, phenolic glycosides isolated from Flacourtia ramontchi

16 October 2022

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https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Nuclear localization of dengue virus nonstructural protein 5 through its importin alpha/beta-recognized nuclear localization sequences is integral to viral infection.

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

A structural basis for the inhibition of the NS5 dengue virus mRNA 2'-O-methyltransferase domain by ribavirin 5'-triphosphate.

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Enzymology of RNA cap synthesis

16 October 2022

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https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Replication strategy of Kunjin virus: evidence for recycling role of replicative form RNA as template in semiconservative and asymmetric replication

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

An RNA cap (nucleoside-2'-O-)-methyltransferase in the flavivirus RNA polymerase NS5: crystal structure and functional characterization

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Crystal Structure of the Dengue Virus RNA-Dependent RNA Polymerase Catalytic Domain at 1.85-Angstrom Resolution

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

West Nile Virus Methyltransferase Catalyzes Two Methylations of the Viral RNA Cap through a Substrate-Repositioning Mechanism

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Both nonstructural proteins NS2B and NS3 are required for the proteolytic processing of dengue virus nonstructural proteins

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Crystal structure of the Murray Valley encephalitis virus NS5 methyltransferase domain in complex with cap analogues

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Structural and functional analysis of methylation and 5'-RNA sequence requirements of short capped RNAs by the methyltransferase domain of dengue virus NS5

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Crystal Structure of the Dengue Virus Methyltransferase Bound to a 5′-Capped Octameric RNA

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Ligand-Bound Structures of the Dengue Virus Protease Reveal the Active Conformation

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

The phylogeny of RNA-dependent RNA polymerases of positive-strand RNA viruses

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Mechanisms of activity and inhibition of the hepatitis C virus RNA-dependent RNA polymerase

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Biochemical and genetic characterization of dengue virus methyltransferase

16 October 2022

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https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

N-sulfonylanthranilic acid derivatives as allosteric inhibitors of dengue viral RNA-dependent RNA polymerase

16 October 2022

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https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Retro peptide-hybrids as selective inhibitors of the Dengue virus NS2B-NS3 protease.

16 October 2022

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https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Characterization of the West Nile virus protease substrate specificity and inhibitors.

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

The interdomain region of dengue NS5 protein that binds to the viral helicase NS3 contains independently functional importin beta 1 and importin alpha/beta-recognized nuclear localization signals

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Sequence analysis of the membrane protein V3 of the flavivirus West Nile virus and of its gene

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Use of parallel validation high-throughput screens to reduce false positives and identify novel dengue NS2B-NS3 protease inhibitors

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Interdomain communication in hepatitis C virus polymerase abolished by small molecule inhibitors bound to a novel allosteric site

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

A novel mechanism to ensure terminal initiation by hepatitis C virus NS5B polymerase

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

A scintillation proximity assay for dengue virus NS5 2'-O-methyltransferase-kinetic and inhibition analyses.

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Peptide inhibitors of dengue virus NS3 protease. Part 2: SAR study of tetrapeptide aldehyde inhibitors.

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus.

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

De novo synthesis of RNA by the dengue virus RNA-dependent RNA polymerase exhibits temperature dependence at the initiation but not elongation phase

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

Insights to substrate binding and processing by West Nile Virus NS3 protease through combined modeling, protease mutagenesis, and kinetic studies

16 October 2022

1 reference

https://api.crossref.org/works/10.1016/J.ANTIVIRAL.2012.09.007

10.1016/J.ANTIVIRAL.2012.09.007

16 October 2022

Identifiers

DOI

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27 August 2017

1 reference

PubMed ID

22995600