Mitophagy or how to control the Jekyll and Hyde embedded in mitochondrial metabolism: implications for melanoma progression and drug resistance (Q38043052)

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English	Mitophagy or how to control the Jekyll and Hyde embedded in mitochondrial metabolism: implications for melanoma progression and drug resistance	scientific article

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scholarly article

1 reference

Europe PubMed Central

27 August 2017

Mitophagy or how to control the Jekyll and Hyde embedded in mitochondrial metabolism: implications for melanoma progression and drug resistance (English)

1 reference

Europe PubMed Central

27 August 2017

author name string

María S Soengas

1

1 reference

Europe PubMed Central

27 August 2017

publication date

1 November 2012

1 reference

Europe PubMed Central

27 August 2017

Pigment Cell & Melanoma Research

1 reference

Europe PubMed Central

27 August 2017

25

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Europe PubMed Central

27 August 2017

6

1 reference

Europe PubMed Central

27 August 2017

721-731

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Europe PubMed Central

27 August 2017

Signaling by reactive oxygen and nitrogen species in skin diseases

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12021

21 January 2018

Self-killing of melanoma cells by cytosolic delivery of dsRNA: wiring innate immunity for a coordinated mobilization of endosomes, autophagosomes and the apoptotic machinery in tumor cells.

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12021

21 January 2018

Mitochondria sentencing about cellular life and death: a matter of oxidative stress

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12021

21 January 2018

The involvement of IL-1 in tumorigenesis, tumor invasiveness, metastasis and tumor-host interactions

1 reference

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21 January 2018

The pathways of mitophagy for quality control and clearance of mitochondria

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12021

21 January 2018

Melanoma revives an embryonic migration program to promote plasticity and invasion

1 reference

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21 January 2018

The antitumor agent imexon activates antioxidant gene expression: evidence for an oxidative stress response

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21 January 2018

Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer

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21 January 2018

Superoxide dismutase mimics: chemistry, pharmacology, and therapeutic potential

1 reference

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21 January 2018

The hypoxic microenvironment of the skin contributes to Akt-mediated melanocyte transformation.

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12021

21 January 2018

Notch1 is an effector of Akt and hypoxia in melanoma development

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12021

21 January 2018

Orchestrating the interferon antiviral response through the mitochondrial antiviral signaling (MAVS) adapter

1 reference

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21 January 2018

Parkin uses the UPS to ship off dysfunctional mitochondria

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12021

21 January 2018

Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12021

21 January 2018

The gluttonous side of malignant melanoma: basic and clinical implications of macroautophagy.

1 reference

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21 January 2018

Oxidative stress and thioredoxin-interacting protein promote intravasation of melanoma cells

1 reference

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21 January 2018

Malignant melanoma: modern black plague and genetic black box.

1 reference

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21 January 2018

Mitochondria: commanders of innate immunity and disease?

1 reference

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21 January 2018

Defects in mitochondrial DNA replication and human disease

1 reference

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21 January 2018

Links between metabolism and cancer

1 reference

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21 January 2018

Autophagy: an emerging immunological paradigm

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12021

21 January 2018

ROS-mediated mechanisms of autophagy stimulation and their relevance in cancer therapy

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12021

21 January 2018

Selective autophagy in cancer development and therapy

1 reference

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21 January 2018

Nix is critical to two distinct phases of mitophagy, reactive oxygen species-mediated autophagy induction and Parkin-ubiquitin-p62-mediated mitochondrial priming

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12021

21 January 2018

Approaches for targeting mitochondria in cancer therapy

1 reference

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21 January 2018

Resistance patterns with tyrosine kinase inhibitors in melanoma: new insights

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12021

21 January 2018

Reviewing the somatic genetics of melanoma: from current to future analytical approaches

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12021

21 January 2018

Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12021

21 January 2018

Arsenic trioxide - An old drug rediscovered

1 reference

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21 January 2018

Melanin as a target for melanoma chemotherapy: pro-oxidant effect of oxygen and metals on melanoma viability

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12021

21 January 2018

Reverse TCA cycle flux through isocitrate dehydrogenases 1 and 2 is required for lipogenesis in hypoxic melanoma cells

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12021

21 January 2018

From genes to drugs: targeted strategies for melanoma

1 reference

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21 January 2018

The reactive oxygen-driven tumor: relevance to melanoma

1 reference

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21 January 2018

Reactive oxygen species: an Achilles' heel of melanoma?

1 reference

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21 January 2018

Mitochondria as therapeutic targets for the treatment of malignant disease

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12021

21 January 2018

Targeting mitochondria for cancer therapy

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12021

21 January 2018

Mitochondrial gateways to cancer

1 reference

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21 January 2018

The NAD(P)H:Quinone Oxidoreductase 1 induces cell cycle progression and proliferation of melanoma cells

1 reference

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21 January 2018

Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy

1 reference

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21 January 2018

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

1 reference

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21 January 2018

Mitochondrial morphology in mitophagy and macroautophagy

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12021

21 January 2018

Autophagy in health and disease. 5. Mitophagy as a way of life

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12021

21 January 2018

Overexpression of Akt converts radial growth melanoma to vertical growth melanoma.

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12021

21 January 2018

The pathophysiology of mitochondrial cell death

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12021

21 January 2018

Mitochondria and the autophagy-inflammation-cell death axis in organismal aging

1 reference

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21 January 2018

Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment

1 reference

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21 January 2018

Hallmarks of Cancer: The Next Generation

1 reference

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21 January 2018

A landscape of driver mutations in melanoma

1 reference

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21 January 2018

Cancer stem cells versus phenotype-switching in melanoma

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12021

21 January 2018

Autophagy as a target for anticancer therapy

1 reference

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21 January 2018

LKB1 and AMPK family signaling: the intimate link between cell polarity and energy metabolism

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12021

21 January 2018

PINK1- and Parkin-mediated mitophagy at a glance

1 reference

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21 January 2018

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

1 reference

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21 January 2018

Cutaneous photobiology. The melanocyte vs. the sun: who will win the final round?

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21 January 2018

mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties

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21 January 2018

Cell death assays for drug discovery

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21 January 2018

Parkin in the regulation of fat uptake and mitochondrial biology: emerging links in the pathophysiology of Parkinson's disease

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21 January 2018

Fine-tuning of Drp1/Fis1 availability by AKAP121/Siah2 regulates mitochondrial adaptation to hypoxia

1 reference

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21 January 2018

Otto Warburg's contributions to current concepts of cancer metabolism

1 reference

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21 January 2018

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

1 reference

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21 January 2018

Metabolism of ketonic acids in animal tissues

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12021

21 January 2018

Autophagy and the integrated stress response

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12021

21 January 2018

ATF2 - at the crossroad of nuclear and cytosolic functions

1 reference

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21 January 2018

PKCε promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12021

21 January 2018

Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin

1 reference

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21 January 2018

Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12021

21 January 2018

Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging

1 reference

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21 January 2018

The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes

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21 January 2018

Understanding the "lethal" drivers of tumor-stroma co-evolution: emerging role(s) for hypoxia, oxidative stress and autophagy/mitophagy in the tumor micro-environment

1 reference

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21 January 2018

Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

1 reference

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21 January 2018

LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanoma

1 reference

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21 January 2018

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

1 reference

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21 January 2018

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12021

21 January 2018

Delivery to mitochondria: a narrower approach for broader therapeutics

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12021

21 January 2018

Autophagy in tumorigenesis and energy metabolism: friend by day, foe by night

1 reference

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21 January 2018

Redox regulation in human melanocytes and melanoma

1 reference

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21 January 2018

A hyperfused mitochondrial state achieved at G1-S regulates cyclin E buildup and entry into S phase

1 reference

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21 January 2018

Mitochondrial clearance by autophagy in developing erythrocytes: clearly important, but just how much so?

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12021

21 January 2018

The ubiquitin ligase Siah2 and the hypoxia response

1 reference

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21 January 2018

AMP kinase-related kinase NUAK2 affects tumor growth, migration, and clinical outcome of human melanoma

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21 January 2018

p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both

1 reference

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21 January 2018

Mitochondria: in sickness and in health

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21 January 2018

Constitutively active inflammasome in human melanoma cells mediating autoinflammation via caspase-1 processing and secretion of interleukin-1beta

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21 January 2018

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

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21 January 2018

The many faces of Notch signaling in skin-derived cells

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21 January 2018

A comprehensive catalogue of somatic mutations from a human cancer genome

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21 January 2018

The mitochondrial fusion-promoting factor mitofusin is a substrate of the PINK1/parkin pathway

1 reference

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21 January 2018

Mutant BRAF melanomas--dependence and resistance

1 reference

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21 January 2018

The ubiquitin ligase Siah2 regulates tumorigenesis and metastasis by HIF-dependent and -independent pathways

1 reference

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21 January 2018

Regulation of inflammasome signaling

1 reference

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21 January 2018

The good and the bad of chemokines/chemokine receptors in melanoma

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21 January 2018

A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth

1 reference

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21 January 2018

Regulation of autophagy by ROS: physiology and pathology

1 reference

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21 January 2018

Comparative metabolic flux profiling of melanoma cell lines: beyond the Warburg effect

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21 January 2018

HIF-1: upstream and downstream of cancer metabolism

1 reference

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21 January 2018

Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

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21 January 2018

Inflammasomes in health and disease

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21 January 2018

Targeted activation of innate immunity for therapeutic induction of autophagy and apoptosis in melanoma cells

1 reference

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21 January 2018

Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate.

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21 January 2018

Melanoma: from mutations to medicine

1 reference

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21 January 2018

NF-kappaB activation in melanoma

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21 January 2018

Mitochondrial dysfunction in ataxia-telangiectasia

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21 January 2018

Ambra1: a Parkin-binding protein involved in mitophagy

1 reference

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21 January 2018

A novel BH3 mimetic reveals a mitogen-activated protein kinase-dependent mechanism of melanoma cell death controlled by p53 and reactive oxygen species.

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12021

21 January 2018

Inflammasome polymorphisms confer susceptibility to sporadic malignant melanoma.

1 reference

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21 January 2018

Melanoma and the tumor microenvironment

1 reference

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21 January 2018

Mitochondria removal by autophagy

1 reference

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21 January 2018

PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility

1 reference

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21 January 2018

Exome sequencing identifies GRIN2A as frequently mutated in melanoma

1 reference

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21 January 2018

Biogenesis and cargo selectivity of autophagosomes

1 reference

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21 January 2018

From serendipity to mitochondria-targeted nanocarriers

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21 January 2018

Mitochondrial fusion and fission in cell life and death

1 reference

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21 January 2018

Molecular profiling of a lethal tumor microenvironment, as defined by stromal caveolin-1 status in breast cancers

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21 January 2018

Reactive oxygen species in melanoma and its therapeutic implications

1 reference

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21 January 2018

Eaten alive: a history of macroautophagy

1 reference

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21 January 2018

Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial membrane

1 reference

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21 January 2018

Mechanisms of mitophagy

1 reference

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21 January 2018

Mitophagy and mitochondrial morphology in human melanoma-derived cells post exposure to simulated sunlight

1 reference

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21 January 2018

Role of BNIP3 and NIX in cell death, autophagy, and mitophagy

1 reference

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21 January 2018

Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation

1 reference

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21 January 2018

Mitochondrial ROS-induced ROS release: an update and review

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21 January 2018

Superoxide dismutase as a target for the selective killing of cancer cells

1 reference

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21 January 2018

Identifiers

10.1111/PCMR.12021

1 reference

Europe PubMed Central

27 August 2017

1 reference

Europe PubMed Central

27 August 2017

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