Small molecule inhibitors of the hedgehog signaling pathway for the treatment of cancer (Q38039960)

27 August 2017

Small molecule inhibitors of the hedgehog signaling pathway for the treatment of cancer (English)

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27 August 2017

Jeong In Yun

1

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27 August 2017

Hyoung Rae Kim

2

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27 August 2017

Haeil Park

3

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27 August 2017

Sang Kyum Kim

4

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27 August 2017

Jongkook Lee

5

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27 August 2017

language of work or name

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1 August 2012

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Archives of Pharmacal Research

27 August 2017

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27 August 2017

35

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27 August 2017

8

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27 August 2017

1317-1333

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https://scigraph.springernature.com/pub.10.1007/s12272-012-0801-8

27 August 2017

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cites work

Hedgehog/GLI-mediated transcriptional inhibitors from Zizyphus cambodiana.

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

New hedgehog/GLI-signaling inhibitors from Adenium obesum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Learning from Jekyll to control Hyde: Hedgehog signaling in development and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Repression of smoothened by patched-dependent (pro-)vitamin D3 secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Assessing the efficacy of the hedgehog pathway inhibitor vitamin D3 in a murine xenograft model for pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Potent inhibitors of the hedgehog signaling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Second generation 2-pyridyl biphenyl amide inhibitors of the hedgehog pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Small molecule modulation of Smoothened activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

The cancer stem cell: premises, promises and challenges

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

The hedgehog signaling network

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Teratogen-mediated inhibition of target tissue response to Shh signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

The imidazopyridine derivative JK184 reveals dual roles for microtubules in Hedgehog signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Drugging the cancer stem cell compartment: lessons learned from the hedgehog and Wnt signal transduction pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

The cancer stem cell paradigm: a new understanding of tumor development and treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Arsenic trioxide - An old drug rediscovered

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

The therapeutic promise of the cancer stem cell concept

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Synthesis of cyclopamine using a biomimetic and diastereoselective approach.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Synthesis and biological evaluation of desmethylveramiline, a micromolar Hedgehog inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Study of a cyclopamine glucuronide prodrug for the selective chemotherapy of glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Protecting the hedgerow: p53 and hedgehog pathway interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Naturally occurring small-molecule inhibitors of hedgehog/GLI-mediated transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Activation of the hedgehog pathway in human hepatocellular carcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Hedgehog signaling in animal development: paradigms and principles

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Hedgehog signaling in development and cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Identification of MK-5710 ((8aS)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclo- propyl]-N-(1-phenyl-1H-pyrazol-5-yl)hexahydro-imidazo[1,5-a]pyrazine-7(1H)-carboxamide), a potent smoothened antagonist for use in Hedgehog pathway dependent malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Targeted inhibition of hedgehog signaling by cyclopamine prodrugs for advanced prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

A small-molecule antagonist of the hedgehog signaling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Identification and characterization of several dietary alkaloids as weak inhibitors of hedgehog signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Dose- and route-dependent teratogenicity, toxicity, and pharmacokinetic profiles of the hedgehog signaling antagonist cyclopamine in the mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Identification of Hedgehog signaling inhibitors with relevant human exposure by small molecule screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Phase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Structure-activity relationships and cancer-cell selective toxicity of novel inhibitors of glioma-associated oncogene homologue 1 (Gli1) mediated transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Novel lipid modifications of secreted protein signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Targeting Hedgehog--a cancer stem cell pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

1-amino-4-benzylphthalazines as orally bioavailable smoothened antagonists with antitumor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

cAMP, an activator of protein kinase A, suppresses the expression of sonic hedgehog

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Mutations affecting segment number and polarity in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Syntheses of aminoalcohol-derived macrocycles leading to a small-molecule binder to and inhibitor of Sonic Hedgehog

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Identification of a palmitic acid-modified form of human Sonic hedgehog

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Small-molecule inhibitors of the hedgehog signaling pathway as cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Cholesterol modification of hedgehog signaling proteins in animal development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Sonic hedgehog mediates the polarizing activity of the ZPA

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Terpenoids and a flavonoid glycoside from Acacia pennata leaves as hedgehog/GLI-mediated transcriptional inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Acoschimperoside P, 2'-acetate: a Hedgehog signaling inhibitory constituent from Vallaris glabra

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

New Hedgehog/GLI signaling inhibitors from Excoecaria agallocha.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

GDC-0449-a potent inhibitor of the hedgehog pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

A Bisindole Alkaloid with Hedgehog Signal Inhibitory Activity from the Myxomycete Perichaena chrysosperma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Topical treatment of Basal cell carcinomas in nevoid Basal cell carcinoma syndrome with a smoothened inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Common botanical compounds inhibit the hedgehog signaling pathway in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

A small molecule that binds Hedgehog and blocks its signaling in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

A novel synthetic smoothened antagonist transiently inhibits pancreatic adenocarcinoma xenografts in a mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Vitamin D3 inhibits hedgehog signaling and proliferation in murine Basal cell carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Targeting superficial or nodular Basal cell carcinoma with topically formulated small molecule inhibitor of smoothened

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Inhibition of the hedgehog pathway in advanced basal-cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Hedgehog antagonist cyclopamine isomerizes to less potent forms when acidified

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Activation of the hedgehog-signaling pathway in human cancer and the clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12272-012-0801-8

10.1007/S12272-012-0801-8

21 January 2018

Identifiers

DOI

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Dimensions Publication ID

27 August 2017

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