From mitochondrial dysfunction to amyloid beta formation: novel insights into the pathogenesis of Alzheimer's disease. (Q38029575)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22833458%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

title

From mitochondrial dysfunction to amyloid beta formation: novel insights into the pathogenesis of Alzheimer's disease (English)

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9 February 2020

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3

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9 February 2020

author name string

Kristina Leuner

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22833458%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Walter E Müller

series ordinal

2

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9 February 2020

language of work or name

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26 July 2012

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9 February 2020

published in

Molecular Neurobiology

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9 February 2020

volume

46

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9 February 2020

issue

1

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9 February 2020

page(s)

186-193

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https://scigraph.springernature.com/pub.10.1007/s12035-012-8307-4

9 February 2020

exact match

0 references

1 reference

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Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

21 January 2018

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Mitochondrial dysfunction: the first domino in brain aging and Alzheimer's disease?

21 January 2018

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Aging and amyloid beta-induced oxidative DNA damage and mitochondrial dysfunction in Alzheimer's disease: implications for early intervention and therapeutics

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The role of mitochondria in reactive oxygen species metabolism and signaling

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The mechanism of mitochondrial superoxide production by the cytochrome bc1 complex

21 January 2018

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Ageing and neuronal vulnerability

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Regulation of autophagy by ROS: physiology and pathology

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Enhanced ROS-generation in lymphocytes from Alzheimer's patients

21 January 2018

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ROS generation, lipid peroxidation and antioxidant enzyme activities in the aging brain

21 January 2018

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Regional difference of ROS generation, lipid peroxidation, and antioxidant enzyme activity in rat brain and their dietary modulation.

21 January 2018

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Elevated oxidative stress in models of normal brain aging and Alzheimer's disease

21 January 2018

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21 January 2018

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Time-course of mitochondrial gene expressions in mice brains: implications for mitochondrial dysfunction, oxidative damage, and cytochrome c in aging

21 January 2018

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Inhibition of mitochondrial respiratory complex I by nitric oxide, peroxynitrite and S-nitrosothiols

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Gene regulation and DNA damage in the ageing human brain

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Proteome alterations in rat mitochondria caused by aging

21 January 2018

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Ageing alters the supramolecular architecture of OxPhos complexes in rat brain cortex.

21 January 2018

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Tissue-specific changes of mitochondrial functions in aged rats: effect of a long-term dietary treatment with N-acetylcysteine

21 January 2018

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Brain aging, Alzheimer's disease, and mitochondria

21 January 2018

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A synergistic dysfunction of mitochondrial fission/fusion dynamics and mitophagy in Alzheimer's disease

21 January 2018

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The molecular link between beta- and gamma-secretase activity on the amyloid beta precursor protein

21 January 2018

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Beta-site APP cleaving enzyme up-regulation induced by 4-hydroxynonenal is mediated by stress-activated protein kinases pathways.

21 January 2018

1 reference

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Oxidative lipid modification of nicastrin enhances amyloidogenic γ-secretase activity in Alzheimer's disease.

21 January 2018

1 reference

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Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation

21 January 2018

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Mice with mitochondrial complex I deficiency develop a fatal encephalomyopathy

21 January 2018

1 reference

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Antisense directed at the Abeta region of APP decreases brain oxidative markers in aged senescence accelerated mice

21 January 2018

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Interaction between α-synuclein and other proteins in neurodegenerative disorders.

21 January 2018

1 reference

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Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders

21 January 2018

1 reference

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alpha-Synuclein enhances secretion and toxicity of amyloid beta peptides in PC12 cells.

21 January 2018

1 reference

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Risk factors for dementia in people with down syndrome: issues in assessment and diagnosis

21 January 2018

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Oxidative stress: a bridge between Down's syndrome and Alzheimer's disease

21 January 2018

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Mitochondrial dysfunction in mouse trisomy 16 brain

21 January 2018

1 reference

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Deficit of complex I activity in human skin fibroblasts with chromosome 21 trisomy and overproduction of reactive oxygen species by mitochondria: involvement of the cAMP/PKA signalling pathway.

21 January 2018

1 reference

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The up-regulation of BACE1 mediated by hypoxia and ischemic injury: role of oxidative stress and HIF1alpha

21 January 2018

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Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression

21 January 2018

1 reference

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Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation

21 January 2018

1 reference

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The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production

21 January 2018

1 reference

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Cerebral infarctions and the likelihood of dementia from Alzheimer disease pathology.

21 January 2018

1 reference

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The neuropathology of probable Alzheimer disease and mild cognitive impairment

21 January 2018

1 reference

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Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease

21 January 2018

1 reference

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NFkappaB-dependent control of BACE1 promoter transactivation by Abeta42.

21 January 2018

1 reference

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Mitochondrial dysfunction: an early event in Alzheimer pathology accumulates with age in AD transgenic mice

21 January 2018

1 reference

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Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice

21 January 2018

1 reference

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Oligomeric and fibrillar species of beta-amyloid (A beta 42) both impair mitochondrial function in P301L tau transgenic mice.

21 January 2018

1 reference

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Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

21 January 2018

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Proteomic and functional alterations in brain mitochondria from Tg2576 mice occur before amyloid plaque deposition.

21 January 2018

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The amyloid beta-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae

21 January 2018

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ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease.

21 January 2018

1 reference

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Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria

21 January 2018

1 reference

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Degradation of the amyloid beta-protein by the novel mitochondrial peptidasome, PreP

21 January 2018

1 reference

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Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L tau transgenic mice.

21 January 2018

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Cytochrome c oxidase deficiency in neurons decreases both oxidative stress and amyloid formation in a mouse model of Alzheimer's disease

21 January 2018

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The role of cytochrome c oxidase deficiency in ROS and amyloid plaque formation

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Mitochondrial dementia: a sporadic case of progressive cognitive and behavioral decline with hearing loss due to the rare m.3291T>C MELAS mutation.

21 January 2018

1 reference

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Alzheimer-type pathology in a patient with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS).

21 January 2018

1 reference

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Soluble Beta-Amyloid Leads to Mitochondrial Defects in Amyloid Precursor Protein and Tau Transgenic Mice

21 January 2018

1 reference

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Decreased proteolytic activity of the mitochondrial amyloid-β degrading enzyme, PreP peptidasome, in Alzheimer's disease brain mitochondria

21 January 2018

1 reference

12 December 2020

Cognitive impairment and increased Aβ levels induced by paraquat exposure are attenuated by enhanced removal of mitochondrial H(2)O(2).

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Mitochondria-ros crosstalk in the control of cell death and aging

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Quantitative proteomic analysis of mitochondria in aging PS-1 transgenic mice

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Epidemiology of Alzheimer's disease: occurrence, determinants, and strategies toward intervention

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Oxidative Stress and its Implications for Future Treatments and Management of Alzheimer Disease

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Complex I-mediated reactive oxygen species generation: modulation by cytochrome c and NAD(P)+ oxidation-reduction state.

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Amyloid-Beta interaction with mitochondria

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Nuclear but not mitochondrial DNA involvement in respiratory complex I defects found in senescence-accelerated mouse strain, SAMP8

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Control of OXPHOS efficiency by complex I in brain mitochondria

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Gene Microarrays in Hippocampal Aging: Statistical Profiling Identifies Novel Processes Correlated with Cognitive Impairment

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Oxidative Stress and Down Syndrome: A Route toward Alzheimer-Like Dementia

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Mitochondrial metabolism of reactive oxygen species.

1 reference

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Amyloid-β₄₂ activates the expression of BACE1 through the JNK pathway

1 reference

12 December 2020