Heterodimerisation of G protein-coupled receptors: implications for drug design and ligand screening (Q38028547)

27 August 2017

Heterodimerisation of G protein-coupled receptors: implications for drug design and ligand screening (English)

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G protein-coupled receptor

27 August 2017

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protein design

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author

Laura Saenz del Burgo

object named as

Laura Saenz del Burgo

series ordinal

1

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author name string

Graeme Milligan

series ordinal

2

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PubMed ID

22823130

27 August 2017

language of work or name

English

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publication date

19 April 2010

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Expert Opinion on Drug Discovery

27 August 2017

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27 August 2017

5

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27 August 2017

5

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27 August 2017

461-474

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Defects in G protein-coupled signal transduction in human disease

27 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F17460441003720467

Molecular tinkering of G protein-coupled receptors: an evolutionary success

21 January 2018

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Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation.

21 January 2018

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Constitutive and agonist-dependent homo-oligomerization of the thyrotropin-releasing hormone receptor. Detection in living cells using bioluminescence resonance energy transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003720467

International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the recognition and nomenclature of G protein-coupled receptor heteromultimers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003720467

Building a new conceptual framework for receptor heteromers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003720467

G-protein-coupled receptor oligomerization and its potential for drug discovery

21 January 2018

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Cardiac muscarinic receptors. Cooperativity as the basis for multiple states of affinity.

21 January 2018

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The alpha1b-adrenoceptor exists as a higher-order oligomer: effective oligomerization is required for receptor maturation, surface delivery, and function

21 January 2018

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Multiple interactions between transmembrane helices generate the oligomeric alpha1b-adrenoceptor.

21 January 2018

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Organization of the G protein-coupled receptors rhodopsin and opsin in native membranes

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441003720467

Oligomerization, Biogenesis, and Signaling Is Promoted by a Glycophorin A-like Dimerization Motif in Transmembrane Domain 1 of a Yeast G Protein-coupled Receptor

21 January 2018

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Crosstalk in G protein-coupled receptors: changes at the transmembrane homodimer interface determine activation

21 January 2018

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Oligomerization of the fifth transmembrane domain from the adenosine A2A receptor

21 January 2018

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Heterodimerization is required for the formation of a functional GABA(B) receptor

21 January 2018

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Involvement of the amino terminus of the B(2) receptor in agonist-induced receptor dimerization.

21 January 2018

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Dimerization of the delta opioid receptor: implication for a role in receptor internalization

21 January 2018

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Increased AT(1) receptor heterodimers in preeclampsia mediate enhanced angiotensin II responsiveness

21 January 2018

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Naturally occurring deletional mutation in the C-terminal cytoplasmic tail of CCR5 affects surface trafficking of CCR5.

21 January 2018

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The CXCR1 and CXCR2 receptors form constitutive homo- and heterodimers selectively and with equal apparent affinities

21 January 2018

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Cell surface delivery and structural re-organization by pharmacological chaperones of an oligomerization-defective alpha(1b)-adrenoceptor mutant demonstrates membrane targeting of GPCR oligomers

21 January 2018

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Sorting proteins to their target membranes

21 January 2018

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Hetero-oligomerization between beta2- and beta3-adrenergic receptors generates a beta-adrenergic signaling unit with distinct functional properties

21 January 2018

1 reference

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Heterodimerization of alpha 2A- and beta 1-adrenergic receptors

21 January 2018

1 reference

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Oligomerization of the alpha 1a- and alpha 1b-adrenergic receptor subtypes. Potential implications in receptor internalization

21 January 2018

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Oligomerization of mu- and delta-opioid receptors. Generation of novel functional properties

21 January 2018

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Dopamine D1 and D2 receptor Co-activation generates a novel phospholipase C-mediated calcium signal

21 January 2018

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Hypersensitization of the Orexin 1 receptor by the CB1 receptor: evidence for cross-talk blocked by the specific CB1 antagonist, SR141716

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003720467

G-protein-coupled receptor heterodimerization modulates receptor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003720467

A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003720467

Interactions between the Mas-related receptors MrgD and MrgE alter signalling and trafficking of MrgD.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441003720467

Identification of a novel human eicosanoid receptor coupled to G(i/o)

21 January 2018

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Identification of surrogate ligands for orphan G protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003720467

Properties of Arg389-β 1 -Adrenoceptor-G sα Fusion Proteins: Comparison with Gly389-β 1 -Adrenoceptor-G sα Fusion Proteins

21 January 2018

1 reference

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Insights into ligand pharmacology using receptor-G-protein fusion proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003720467

G protein-coupled receptor fusion proteins in drug discovery

21 January 2018

1 reference

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Novel pharmacological applications of G-protein-coupled receptor-G protein fusions

21 January 2018

1 reference

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Activation of an alpha2A-adrenoceptor-Galphao1 fusion protein dynamically regulates the palmitoylation status of the G protein but not of the receptor

21 January 2018

1 reference

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Uncovering the pharmacology of the G protein-coupled receptor GPR40: high apparent constitutive activity in guanosine 5'-O-(3-[35S]thio)triphosphate binding studies reflects binding of an endogenous agonist

21 January 2018

1 reference

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The G12 family of G proteins as a reporter of thromboxane A2 receptor activity

21 January 2018

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Cellular signaling by an agonist-activated receptor/Gs alpha fusion protein

21 January 2018

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21 January 2018

Bring your own G protein

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Multiple signaling states of G-protein-coupled receptors

21 January 2018

1 reference

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Inverse, protean, and ligand-selective agonism: matters of receptor conformation

21 January 2018

1 reference

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Functional Selectivity and Classical Concepts of Quantitative Pharmacology

21 January 2018

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Protean agonism at the dopamine D2 receptor: (S)-3-(3-hydroxyphenyl)-N-propylpiperidine is an agonist for activation of Go1 but an antagonist/inverse agonist for Gi1,Gi2, and Gi3.

21 January 2018

1 reference

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Dimers of class A G protein-coupled receptors function via agonist-mediated trans-activation of associated G proteins

21 January 2018

1 reference

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Nuclear targeting signal recognition: a key control point in nuclear transport?

21 January 2018

1 reference

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Angiotensin II-induced nuclear targeting of the angiotensin type 1 (AT1) receptor in brain neurons.

21 January 2018

1 reference

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Agonist-independent nuclear localization of the Apelin, angiotensin AT1, and bradykinin B2 receptors

21 January 2018

1 reference

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Dopamine receptor oligomerization visualized in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003720467

Using ligand-induced conformational change to screen for compounds targeting G-protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003720467

Mu-opioid receptor heterooligomer formation with the dopamine D1 receptor as directly visualized in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003720467

Targeting G protein-coupled receptor kinases to their receptor substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003720467

Diversity in arrestin function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003720467

The structural basis of arrestin-mediated regulation of G-protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003720467

Transduction of receptor signals by beta-arrestins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003720467

Arrestin development: emerging roles for beta-arrestins in developmental signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003720467

G protein coupled receptors as drug targets: the role of beta-arrestins

21 January 2018

1 reference

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Multifaceted roles of beta-arrestins in the regulation of seven-membrane-spanning receptor trafficking and signalling

21 January 2018

1 reference

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Differential affinities of visual arrestin, beta arrestin1, and beta arrestin2 for G protein-coupled receptors delineate two major classes of receptors

21 January 2018

1 reference

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Demonstration of improvements to the bioluminescence resonance energy transfer (BRET) technology for the monitoring of G protein-coupled receptors in live cells

21 January 2018

1 reference

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High-throughput screening of G protein-coupled receptor antagonists using a bioluminescence resonance energy transfer 1-based beta-arrestin2 recruitment assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003720467

Monitoring interactions between G-protein-coupled receptors and beta-arrestins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003720467

Illuminating insights into protein-protein interactions using bioluminescence resonance energy transfer (BRET).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003720467

Methods to monitor the quaternary structure of G protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003720467

Extended bioluminescence resonance energy transfer (eBRET) for monitoring prolonged protein-protein interactions in live cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003720467

Applications of bioluminescence- and fluorescence resonance energy transfer to drug discovery at G protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003720467

Beta-arrestins and cell signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003720467

Phosphorylation-independent desensitization of GABA(B) receptor by GRK4

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003720467

Homo- and hetero-oligomerization of thyrotropin-releasing hormone (TRH) receptor subtypes. Differential regulation of beta-arrestins 1 and 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003720467

Recent advances in bioluminescence resonance energy transfer technologies to study GPCR heteromerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003720467

21 January 2018

Protein Complementation

1 reference

https://api.crossref.org/works/10.1517%2F17460441003720467

High resolution refinement of β-galactosidase in a new crystal form reveals multiple metal-binding sites and provides a structural basis for α-complementation

21 January 2018

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Enzyme fragment complementation: a flexible high throughput screening assay technology

21 January 2018

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Beta galactosidase enzyme fragment complementation as a novel technology for high throughput screening

21 January 2018

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Evaluation of the InteraX system technology in a high-throughput screening environment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003720467

Domain swapping in the human histamine H1 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441003720467

Agonist-dependent dissociation of oligomeric complexes of G protein-coupled cholecystokinin receptors demonstrated in living cells using bioluminescence resonance energy transfer

21 January 2018

1 reference

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Lipid-facing correlated mutations and dimerization in G-protein coupled receptors

21 January 2018

1 reference

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10.1517/17460441003720467

21 January 2018

Identifiers

DOI

1 reference

27 August 2017

1 reference

PubMed ID

22823130