Dimers of class A G protein-coupled receptors function via agonist-mediated trans-activation of associated G proteins (Q44550521)

4 December 2017

Dimers of class A G protein-coupled receptors function via agonist-mediated trans-activation of associated G proteins (English)

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G protein-coupled receptor

4 December 2017

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author name string

Juan J Carrillo

series ordinal

1

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4 December 2017

John Pediani

series ordinal

2

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4 December 2017

Graeme Milligan

series ordinal

3

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4 December 2017

language of work or name

English

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publication date

14 August 2003

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Journal of Biological Chemistry

4 December 2017

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4 December 2017

278

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4 December 2017

42578-42587

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4 December 2017

43

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Oligomerization of G-protein-coupled transmitter receptors.

4 December 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306165200

Heterodimerization of G-protein-coupled receptors: pharmacology, signaling and trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306165200

G-protein-coupled receptor oligomerization and its potential for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306165200

Heterodimerization is required for the formation of a functional GABA(B) receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306165200

GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306165200

GABA(B)-receptor subtypes assemble into functional heteromeric complexes.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M306165200

A single subunit (GB2) is required for G-protein activation by the heterodimeric GABA(B) receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306165200

Function of GB1 and GB2 subunits in G protein coupling of GABA(B) receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306165200

Co-expression of defective luteinizing hormone receptor fragments partially reconstitutes ligand-induced signal generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306165200

Cis- and trans-activation of hormone receptors: the LH receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306165200

Two defective heterozygous luteinizing hormone receptors can rescue hormone action

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306165200

Insights into ligand pharmacology using receptor-G-protein fusion proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306165200

Isolation and mass spectrometry of transcription factor complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306165200

Specific involvement of G proteins in regulation of serum response factor-mediated gene transcription by different receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306165200

Differential involvement of Galpha12 and Galpha13 in receptor-mediated stress fiber formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306165200

Embryonic cardiomyocyte hypoplasia and craniofacial defects in G alpha q/G alpha 11-mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306165200

In vivo functions of heterotrimeric G-proteins: studies in Galpha-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306165200

Enhanced degradation of the phosphoinositidase C-linked guanine-nucleotide-binding protein Gq alpha/G11 alpha following activation of the human M1 muscarinic acetylcholine receptor expressed in CHO cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306165200

Measurement of agonist-dependent and -independent signal initiation of alpha(1b)-adrenoceptor mutants by direct analysis of guanine nucleotide exchange on the G protein galpha(11).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306165200

Mutational and computational analysis of the alpha(1b)-adrenergic receptor. Involvement of basic and hydrophobic residues in receptor activation and G protein coupling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306165200

Effective information transfer from the alpha 1b-adrenoceptor to Galpha 11 requires both beta/gamma interactions and an aromatic group four amino acids from the C terminus of the G protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306165200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306165200

Homo- and hetero-oligomeric interactions between G-protein-coupled receptors in living cells monitored by two variants of bioluminescence resonance energy transfer (BRET): hetero-oligomers between receptor subtypes form more efficiently than between

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306165200

Coordinated agonist regulation of receptor and G protein palmitoylation and functional rescue of palmitoylation-deficient mutants of the G protein G11alpha following fusion to the alpha1b-adrenoreceptor: palmitoylation of G11alpha is not required fo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306165200

Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306165200

A peptide derived from a beta2-adrenergic receptor transmembrane domain inhibits both receptor dimerization and activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306165200

Structure-based analysis of GPCR function: evidence for a novel pentameric assembly between the dimeric leukotriene B4 receptor BLT1 and the G-protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306165200

The fourth transmembrane segment forms the interface of the dopamine D2 receptor homodimer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306165200

Organization of the G protein-coupled receptors rhodopsin and opsin in native membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306165200

C5a receptor oligomerization. I. Disulfide trapping reveals oligomers and potential contact surfaces in a G protein-coupled receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306165200

Structural models for dimerization of G-protein coupled receptors: the opioid receptor homodimers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306165200

G-protein-coupled receptor heterodimerization modulates receptor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306165200

Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306165200

Homo- and heterodimerization of somatostatin receptor subtypes. Inactivation of sst(3) receptor function by heterodimerization with sst(2A).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306165200

AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306165200

Chemokine receptor homo- or heterodimerization activates distinct signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306165200

The chemokine monocyte chemoattractant protein-1 induces functional responses through dimerization of its receptor CCR2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306165200

The G protein-coupled receptor repertoires of human and mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306165200

The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306165200

Principles: extending the utility of [35S]GTP gamma S binding assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306165200

Agonist occupation of an alpha2A-adrenoreceptor-Gi1alpha fusion protein results in activation of both receptor-linked and endogenous Gi proteins. Comparisons of their contributions to GTPase activity and signal transduction and analysis of receptor-

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306165200

Promiscuous coupling at receptor-Galpha fusion proteins. The receptor of one covalent complex interacts with the alpha-subunit of another

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306165200

Quantitative assessment of beta 1- and beta 2-adrenergic receptor homo- and heterodimerization by bioluminescence resonance energy transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306165200

Restricting the mobility of Gs alpha: impact on receptor and effector coupling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306165200

Inhibition of Gonadotropin-Releasing Hormone Receptor Signaling by Expression of a Splice Variant of the Human Receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306165200

Lipid-facing correlated mutations and dimerization in G-protein coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306165200

Thioacylation is required for targeting G-protein subunit G(o1alpha) to detergent-insoluble caveolin-containing membrane domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306165200

Rhodopsin dimers in native disc membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306165200

A model for the functioning of family 3 GPCRs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306165200

Signal transduction and hormone-dependent internalization of the thyrotropin-releasing hormone receptor in cells lacking Gq and G11

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306165200

The extracellular N-terminal domain and transmembrane domains 1 and 2 mediate oligomerization of a yeast G protein-coupled receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306165200

Prediction of heterodimerization interfaces of G-protein coupled receptors with a new subtractive correlated mutation method

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306165200

21 January 2018

Identifiers

DOI

10.1074/JBC.M306165200

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4 December 2017

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