The rationale for targeting the LOX family in cancer (Q38027412)

27 August 2017

The rationale for targeting the LOX family in cancer (English)

1 reference

27 August 2017

Thomas R Cox

2

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Janine T. Erler

object named as

Janine T Erler

series ordinal

3

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author name string

Holly E Barker

series ordinal

1

1 reference

PubMed ID

22810810

27 August 2017

language of work or name

English

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publication date

19 July 2012

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27 August 2017

Nature Reviews Cancer

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27 August 2017

12

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27 August 2017

540-552

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27 August 2017

8

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https://scigraph.springernature.com/pub.10.1038/nrc3319

27 August 2017

0 references

cites work

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Abnormal deposition of collagen around hepatocytes in Wilson's disease is associated with hepatocyte specific expression of lysyl oxidase and lysyl oxidase like protein-2.

31 March 2020

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The human lysyl oxidase-like 2 protein functions as an amine oxidase toward collagen and elastin.

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Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies

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Stromal effects on mammary gland development and breast cancer

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Putting tumours in context

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Three-dimensional context regulation of metastasis

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Aberrant type I and type III collagen gene expression in human breast cancer in vivo

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Tenascin is a stromal marker for epithelial malignancy in the mammary gland

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Immunohistochemical study of type I collagen and type I pN-collagen in benign and malignant ovarian neoplasms

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The tension mounts: mechanics meets morphogenesis and malignancy

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Tensional homeostasis and the malignant phenotype

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Tumor-stroma interactions

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Tumor stroma and regulation of cancer development

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Paradoxical roles for lysyl oxidases in cancer--a prospect

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Matrix metalloproteinases

31 March 2020

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Lysyl oxidase and rrg messenger RNA.

31 March 2020

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Expression of Gene rrg Is Associated with Reversion of NIH 3Tt3 Transformed by LTR-c-H- ras

31 March 2020

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Down-regulation of lysyl oxidase-induced tumorigenic transformation in NRK-49F cells characterized by constitutive activation of ras proto-oncogene

31 March 2020

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The propeptide domain of lysyl oxidase induces phenotypic reversion of ras-transformed cells.

31 March 2020

1 reference

The tumor suppressor activity of the lysyl oxidase propeptide reverses the invasive phenotype of Her-2/neu-driven breast cancer.

31 March 2020

1 reference

The lysyl oxidase propeptide interacts with the receptor-type protein tyrosine phosphatase kappa and inhibits β-catenin transcriptional activity in lung cancer cells

31 March 2020

1 reference

Repression of BCL2 by the tumor suppressor activity of the lysyl oxidase propeptide inhibits transformed phenotype of lung and pancreatic cancer cells

31 March 2020

1 reference

A loss-of-function polymorphism in the propeptide domain of the LOX gene and breast cancer

31 March 2020

1 reference

The NH2-terminal propeptide of type I procollagen acts intracellularly to modulate cell function

31 March 2020

1 reference

LOXL1 and LOXL4 are epigenetically silenced and can inhibit ras/extracellular signal-regulated kinase signaling pathway in human bladder cancer

31 March 2020

1 reference

Hypermethylated SFRP1, but none of other nine genes "informative" for western countries, is valuable for bladder cancer detection in Mainland China.

31 March 2020

1 reference

Down-regulation of lysyl oxidase-like 2 (LOXL2) is associated with disease progression in lung adenocarcinomas.

31 March 2020

1 reference

Lysyl oxidase-like 2 as a new poor prognosis marker of squamous cell carcinomas

31 March 2020

1 reference

RETRACTED: Lysyl oxidase is essential for hypoxia-induced metastasis

31 March 2020

1 reference

The role of lysyl oxidase in SRC-dependent proliferation and metastasis of colorectal cancer

31 March 2020

1 reference

Gene expression profiling identifies clinically relevant subtypes of prostate cancer

31 March 2020

1 reference

Systematic variation in gene expression patterns in human cancer cell lines

31 March 2020

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Identification of human renal cell carcinoma associated genes by suppression subtractive hybridization

31 March 2020

1 reference

Expression profiling of renal epithelial neoplasms: a method for tumor classification and discovery of diagnostic molecular markers

31 March 2020

1 reference

Gene expression profiling of clear cell renal cell carcinoma: gene identification and prognostic classification

31 March 2020

1 reference

Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment

31 March 2020

1 reference

LOXL2-mediated matrix remodeling in metastasis and mammary gland involution

31 March 2020

1 reference

Lysyl oxidase-like 2 expression is increased in colon and esophageal tumors and associated with less differentiated colon tumors

31 March 2020

1 reference

Lysyl oxidase-like 2 (LOXL2), a new regulator of cell polarity required for metastatic dissemination of basal-like breast carcinomas

31 March 2020

1 reference

TIMP-1 expression in human colorectal cancer is associated with TGF-B1, LOXL2, INHBA1, TNF-AIP6 and TIMP-2 transcript profiles.

31 March 2020

1 reference

Secreted LOXL2 is a novel therapeutic target that promotes gastric cancer metastasis via the Src/FAK pathway

31 March 2020

1 reference

Functional analysis of LOXL2 in pancreatic carcinoma

31 March 2020

1 reference

Gene expression profiles of microdissected pancreatic ductal adenocarcinoma.

31 March 2020

1 reference

Gene expression profiles identify epithelial-to-mesenchymal transition and activation of nuclear factor-kappaB signaling as characteristics of a high-risk head and neck squamous cell carcinoma.

31 March 2020

1 reference

LOXL4 is a selectively expressed candidate diagnostic antigen in head and neck cancer

31 March 2020

1 reference

Molecular Mechanisms of Tumor Invasion and Metastasis: An Integrated View

31 March 2020

1 reference

Lysyl oxidase-like 4 is alternatively spliced in an anatomic site-specific manner in tumors involving the serosal cavities

31 March 2020

1 reference

A tense situation: forcing tumour progression

31 March 2020

1 reference

Tissue cells feel and respond to the stiffness of their substrate

31 March 2020

1 reference

Matrix crosslinking forces tumor progression by enhancing integrin signaling

31 March 2020

1 reference

Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion

31 March 2020

1 reference

Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche

31 March 2020

1 reference

Cellular fibronectin binds to lysyl oxidase with high affinity and is critical for its proteolytic activation

31 March 2020

1 reference

Intratumoral hypoxia resulting in the presence of a fibrotic focus is an independent predictor of early distant relapse in lymph node-negative breast cancer patients

31 March 2020

1 reference

The presence of a fibrotic focus is an independent predictor of early metastasis in lymph node-negative breast cancer patients

31 March 2020

1 reference

The fibrotic focus in advanced colorectal carcinoma: a hitherto unrecognized histological predictor for liver metastasis

31 March 2020

1 reference

Prognostic value of extracapsular invasion and fibrotic focus in single lymph node metastasis of gastric cancer

31 March 2020

1 reference

Advanced Pancreatic Ductal Cancer: Fibrotic Focus and β-Catenin Expression Correlate With Outcome

31 March 2020

1 reference

Localization and activity of lysyl oxidase within nuclei of fibrogenic cells

31 March 2020

1 reference

Fully processed lysyl oxidase catalyst translocates from the extracellular space into nuclei of aortic smooth-muscle cells

31 March 2020

1 reference

Lysyl oxidase: an oxidative enzyme and effector of cell function

31 March 2020

1 reference

Intracellular localization of the matrix enzyme lysyl oxidase in polarized epithelial cells

31 March 2020

1 reference

Histone H1 is a substrate for lysyl oxidase and contains endogenous sodium borotritide-reducible residues

31 March 2020

1 reference

Demonstration of in vitro interaction between tumor suppressor lysyl oxidase and histones H1 and H2: definition of the regions involved

31 March 2020

1 reference

Lysyl oxidase oxidizes basic fibroblast growth factor and inactivates its mitogenic potential

31 March 2020

1 reference

Modulation of ras transformation affecting chromatin supraorganization as assessed by image analysis

31 March 2020

1 reference

Lysyl oxidase inhibits ras-mediated transformation by preventing activation of NF-kappa B.

31 March 2020

1 reference

The HIF-1-inducible lysyl oxidase activates HIF-1 via the Akt pathway in a positive regulation loop and synergizes with HIF-1 in promoting tumor cell growth

31 March 2020

1 reference

Hydrogen peroxide activates focal adhesion kinase and c-Src by a phosphatidylinositol 3 kinase-dependent mechanism and promotes cell migration in Caco-2 cell monolayers

31 March 2020

1 reference

Lysyl oxidase regulates breast cancer cell migration and adhesion through a hydrogen peroxide-mediated mechanism

31 March 2020

1 reference

Lysyl oxidases: a novel multifunctional amine oxidase family

31 March 2020

1 reference

Structural and functional diversity of lysyl oxidase and the LOX-like proteins

31 March 2020

1 reference

A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression

31 March 2020

1 reference

Switching on-off Snail: LOXL2 versus GSK3beta

31 March 2020

1 reference

Epithelial--mesenchymal and mesenchymal--epithelial transitions in carcinoma progression.

31 March 2020

1 reference

Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits

31 March 2020

1 reference

Carcinoma invasion and metastasis: a role for epithelial-mesenchymal transition?

31 March 2020

1 reference

The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1

31 March 2020

1 reference

Hypoxia/reoxygenation: a dynamic regulator of lysyl oxidase-facilitated breast cancer migration

31 March 2020

1 reference

A novel asymmetric 3D in-vitro assay for the study of tumor cell invasion

31 March 2020

1 reference

Transforming growth factor-beta induces extracellular matrix protein cross-linking lysyl oxidase (LOX) genes in human trabecular meshwork cells

31 March 2020

1 reference

TNF-α increases cardiac fibroblast lysyl oxidase expression through TGF-β and PI3Kinase signaling pathways.

31 March 2020

1 reference

Induction of cardiac fibroblast lysyl oxidase by TGF-β1 requires PI3K/Akt, Smad3, and MAPK signaling.

31 March 2020

1 reference

Lysyl oxidase binds transforming growth factor-beta and regulates its signaling via amine oxidase activity.

31 March 2020

1 reference

Lysyl oxidase like 4, a novel target gene of TGF-beta1 signaling, can negatively regulate TGF-beta1-induced cell motility in PLC/PRF/5 hepatoma cells

31 March 2020

1 reference

Transcriptional and post-transcriptional control of lysyl oxidase expression in vascular smooth muscle cells: effects of TGF-beta 1 and serum deprivation

31 March 2020

1 reference

Transforming growth factor-beta 1 increases lysyl oxidase enzyme activity and mRNA in rat aortic smooth muscle cells

31 March 2020

1 reference

Pre- and post-translational regulation of lysyl oxidase by transforming growth factor-beta 1 in osteoblastic MC3T3-E1 cells

31 March 2020

1 reference

Role of transforming growth factor beta in human disease

31 March 2020

1 reference

Lysyl oxidase contributes to mechanotransduction-mediated regulation of transforming growth factor-β signaling in breast cancer cells

31 March 2020

1 reference

Lysyl oxidase propeptide inhibits prostate cancer cell growth by mechanisms that target FGF-2-cell binding and signaling.

31 March 2020

1 reference

Recombinant lysyl oxidase propeptide protein inhibits growth and promotes apoptosis of pre-existing murine breast cancer xenografts

31 March 2020

1 reference

Metastasis suppressor proteins: discovery, molecular mechanisms, and clinical application

31 March 2020

1 reference

Tumor metastasis: mechanistic insights and clinical challenges

31 March 2020

1 reference

Metastasis: from dissemination to organ-specific colonization

31 March 2020

1 reference

Cancer metastasis: building a framework

31 March 2020

1 reference

Expression and Purification of Enzymatically Active Forms of the Human Lysyl Oxidase-like Protein 4

31 March 2020

1 reference

Purkinje cell toxicity ofβ-aminopropionitrile in the rat

31 March 2020

1 reference

Allylamine and beta-aminopropionitrile-induced vascular injury: an in vivo and in vitro study

31 March 2020

1 reference

Dithiocarbamates are teratogenic to developing zebrafish through inhibition of lysyl oxidase activity

31 March 2020

1 reference

Essential role of lysyl oxidases in notochord development

31 March 2020

1 reference

The toxicity pattern of D-penicillamine therapy. A guide to its use in rheumatoid arthritis

31 March 2020

1 reference

The LOXL2 gene encodes a new lysyl oxidase-like protein and is expressed at high levels in reproductive tissues

31 March 2020

1 reference

The potential for LOXL2 as a target for future cancer treatment.

31 March 2020

1 reference

Control of copper status for cancer therapy

31 March 2020

1 reference

Lysyl oxidase: properties, regulation and multiple functions in biology

31 March 2020

1 reference

Targeting hypoxic tumour cells to overcome metastasis.

31 March 2020

1 reference

Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation

31 March 2020

1 reference

Selective upregulation and amplification of the lysyl oxidase like-4 (LOXL4) gene in head and neck squamous cell carcinoma

31 March 2020

1 reference

Multiple bone morphogenetic protein 1-related mammalian metalloproteinases process pro-lysyl oxidase at the correct physiological site and control lysyl oxidase activation in mouse embryo fibroblast cultures

31 March 2020

1 reference

The Pro-regions of lysyl oxidase and lysyl oxidase-like 1 are required for deposition onto elastic fibers

31 March 2020

1 reference

A new gene with sequence and structural similarity to the gene encoding human lysyl oxidase

31 March 2020

1 reference

Differential expression of lysyl oxidases LOXL1 and LOX during growth and aging suggests specific roles in elastin and collagen fiber remodeling in rat aorta

31 March 2020

1 reference

Lysyl oxidase is required for vascular and diaphragmatic development in mice

31 March 2020

1 reference

Lysyl oxidase is essential for normal development and function of the respiratory system and for the integrity of elastic and collagen fibers in various tissues

31 March 2020

1 reference

Lysyl oxidase (lox) gene deficiency affects osteoblastic phenotype.

31 March 2020

1 reference

Lower urogenital tract anatomical and functional phenotype in lysyl oxidase like-1 knockout mice resembles female pelvic floor dysfunction in humans

31 March 2020

1 reference

Central nervous system, uterus, heart, and leukocyte expression of the LOXL3 gene, encoding a novel lysyl oxidase-like protein

31 March 2020

1 reference

A novel human lysyl oxidase-like gene (LOXL4) on chromosome 10q24 has an altered scavenger receptor cysteine rich domain

31 March 2020

1 reference

Cloning and characterization of a fifth human lysyl oxidase isoenzyme: the third member of the lysyl oxidase-related subfamily with four scavenger receptor cysteine-rich domains

31 March 2020

1 reference

A tissue-specific variant of the human lysyl oxidase-like protein 3 (LOXL3) functions as an amine oxidase with substrate specificity

31 March 2020

1 reference

Congenital cutis laxa and lysyl oxidase deficiency

31 March 2020

1 reference

31 March 2020

1 reference

Reduced lysyl oxidase activity in skin fibroblasts from patients with Menkes' syndrome

31 March 2020

1 reference

Lysyl oxidase deficiency: a new cause of human arterial dissection

31 March 2020

1 reference

Changes in aortic lysyl oxidase activity in diet-induced atherosclerosis in the rabbit

31 March 2020

1 reference

Increased expression of lysyl oxidase in skin with scleroderma

31 March 2020

1 reference

Lysyl oxidase: mechanism, regulation and relationship to liver fibrosis

31 March 2020

1 reference

Evidence for increased lysyl oxidase, the extracellular matrix-forming enzyme, in Alzheimer's disease brain

31 March 2020

1 reference

Regulation of lysyl oxidase-like 1 (LOXL1) and elastin-related genes by pathogenic factors associated with pseudoexfoliation syndrome

31 March 2020

1 reference

31 March 2020

1 reference

Association of LOXL1 common sequence variants in German and Italian patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma

31 March 2020

1 reference

Genetic association of LOXL1 gene variants and exfoliation glaucoma in a Utah cohort.

31 March 2020

1 reference

DNA sequence variants in the LOXL1 gene are associated with pseudoexfoliation glaucoma in a U.S. clinic-based population with broad ethnic diversity

31 March 2020

1 reference

Ancestral LOXL1 variants are associated with pseudoexfoliation in Caucasian Australians but with markedly lower penetrance than in Nordic people

31 March 2020

1 reference

Lysyl oxidase-like 1 polymorphisms and exfoliation syndrome in the Japanese population.

31 March 2020

1 reference

LOXL1 Mutations Are Associated with Exfoliation Syndrome in Patients from the Midwestern United States

31 March 2020

1 reference

Common sequence variants in the LOXL1 gene confer susceptibility to exfoliation glaucoma

31 March 2020

1 reference

LOX family enzymes expression in vaginal tissue of premenopausal women with severe pelvic organ prolapse.

31 March 2020

1 reference

Changes in expression of fibulin-5 and lysyl oxidase-like 1 associated with pelvic organ prolapse.

31 March 2020

1 reference

Deregulation of LOXL1 and HTRA1 gene expression in endometriosis

31 March 2020

1 reference

Single-nucleotide polymorphisms in the lysyl oxidase-like protein 4 and complement component 3 genes are associated with increased risk for endometriosis and endometriosis-associated infertility.

31 March 2020

1 reference

Systematic screening of lysyl oxidase-like (LOXL) family genes demonstrates that LOXL2 is a susceptibility gene to intracranial aneurysms.

31 March 2020

1 reference

T-lymphocytes mediate left ventricular fibrillar collagen cross-linking and diastolic dysfunction in mice.

31 March 2020

1 reference

T lymphocyte regulation of lysyl oxidase in diet-induced cardiac fibrosis

31 March 2020

1 reference

Receptor activity modifying protein-3 mediates the protumorigenic activity of lysyl oxidase-like protein-2.

31 March 2020

1 reference

Metastatic susceptibility locus, an 8p hot-spot for tumour progression disrupted in colorectal liver metastases: 13 candidate genes examined at the DNA, mRNA and protein level

31 March 2020

1 reference

Lysyl oxidase-like 2 promotes migration in noninvasive breast cancer cells but not in normal breast epithelial cells

31 March 2020

1 reference

The lysyl oxidase LOX is absent in basal and squamous cell carcinomas and its knockdown induces an invading phenotype in a skin equivalent model

31 March 2020

1 reference

Lysyl oxidase-like protein localizes to sites of de novo fibrinogenesis in fibrosis and in the early stromal reaction of ductal breast carcinomas.

31 March 2020

1 reference

12 December 2020

Collagen cross-linking. Effect of D-penicillamine on cross-linking in vitro

1 reference

12 December 2020

Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition

1 reference

12 December 2020

Regulation of lysyl oxidase, collagen, and connective tissue growth factor by TGF-beta1 and detection in human gingiva

1 reference

12 December 2020

Immunohistochemical localization of lysyl oxidase with monoclonal antibodies.

1 reference

12 December 2020

Post-translational glycosylation and proteolytic processing of a lysyl oxidase precursor.

1 reference

12 December 2020

The use of D-penicillamine in cystinuria: efficacy and untoward reactions

1 reference

12 December 2020

Evaluation of LOXL1 polymorphisms in exfoliation syndrome in a Chinese population

1 reference

12 December 2020

Down-regulation of lysyl oxydase-like in aging and venous insufficiency.

1 reference

12 December 2020

Extracellular matrix and integrin signalling: the shape of things to come

1 reference

12 December 2020

Differential expression of the LOX family genes in human colorectal adenocarcinomas

1 reference

12 December 2020

Forkhead box A1 transcriptional pathway in KRT7-expressing esophageal squamous cell carcinomas with extensive lymph node metastasis.

1 reference

12 December 2020

Lysyl oxidase enzymatic function increases stiffness to drive colorectal cancer progression through FAK.

1 reference

12 December 2020

Regulation of lysyl oxidase and cyclooxygenase expression in human lung fibroblasts: interactions among TGF-beta, IL-1 beta, and prostaglandin E.

1 reference

12 December 2020

Functional analysis of the 5' flanking domain of the LOXL4 gene in head and neck squamous cell carcinoma cells.

1 reference

12 December 2020

Overexpression of a novel lysyl oxidase-like gene in human head and neck squamous cell carcinomas.

1 reference

12 December 2020

Association of non-synonymous single nucleotide polymorphisms in the LOXL1 gene with pseudoexfoliation syndrome in India

1 reference

12 December 2020

Vaccination strategy to target lysyl oxidase-like 4 in dendritic cell based immunotherapy for head and neck cancer.

1 reference

12 December 2020

Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells

1 reference

12 December 2020

Selected adverse reactions of D-penicillamine.

1 reference

12 December 2020

Lysyl oxidase gene expression in the stromal reaction to in situ and invasive ductal breast carcinoma

1 reference

12 December 2020

Major LOXL1 risk allele is reversed in exfoliation glaucoma in a black South African population.

1 reference

12 December 2020

LOXL1 genetic polymorphisms are associated with exfoliation glaucoma in the Japanese population

1 reference

12 December 2020

[Mapping of a deletion interval on 8p21-22 in prostate cancer by gene dosage PCR]

1 reference

12 December 2020

Accumulation of extracellular matrix in the liver induces high metastatic potential of hepatocellular carcinoma to the lung.

1 reference

12 December 2020

A molecular role for lysyl oxidase in breast cancer invasion

1 reference

12 December 2020

Copper deficiency induced by tetrathiomolybdate suppresses tumor growth and angiogenesis.

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRC3319

1 reference

PubMed ID

22810810

Dimensions Publication ID

27 August 2017

0 references

1 reference

PubMed ID

22810810