Developing inhibitors of glycan processing enzymes as tools for enabling glycobiology. (Q38027408)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22810773%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

title

Developing inhibitors of glycan processing enzymes as tools for enabling glycobiology (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22810773%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

0 references

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22810773%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

author name string

Tracey M Gloster

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22810773%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

publication date

18 July 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22810773%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

published in

Nature Chemical Biology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22810773%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

volume

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22810773%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

page(s)

683-694

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22810773%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

issue

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22810773%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nchembio.1029

8 February 2020

exact match

0 references

cites work

Demonstration by monoclonal antibodies that carbohydrate structures of glycoproteins and glycolipids are onco-developmental antigens

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Regulation of cytokine receptors by Golgi N-glycan processing and endocytosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Asymmetric membrane ganglioside sialidase activity specifies axonal fate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Protein quality control in the ER: the recognition of misfolded proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Fringe is a glycosyltransferase that modifies Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

ELAM-1 Mediates Cell Adhesion by Recognition of a Carbohydrate Ligand, Sialyl-Le x

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Dietary and genetic control of glucose transporter 2 glycosylation promotes insulin secretion in suppressing diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

The art of the chemical probe

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Ligand efficiency indices for effective drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

The influence of drug-like concepts on decision-making in medicinal chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

The Carbohydrate-Active EnZymes database (CAZy): an expert resource for Glycogenomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Mechanistic insights into glycosidase chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Binding Energy and Catalysis: The Implications for Transition-State Analogs and Catalytic Antibodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Glycosidase inhibition: assessing mimicry of the transition state

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Glycosidase inhibition: an assessment of the binding of 18 putative transition-state mimics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

High-throughput screening for human lysosomal beta-N-Acetyl hexosaminidase inhibitors acting as pharmacological chaperones

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Identification and characterization of acidic mammalian chitinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Structures of human pancreatic α-amylase in complex with acarviostatins: Implications for drug design against type II diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

The search for novel human pancreatic alpha-amylase inhibitors: high-throughput screening of terrestrial and marine natural product extracts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Structural Basis for Substrate Selectivity in Human Maltase-Glucoamylase and Sucrase-Isomaltase N-terminal Domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Antidiabetic medicinal plants as a source of alpha glucosidase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Treating lysosomal storage diseases with pharmacological chaperones: from concept to clinics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Chemical chaperones increase the cellular activity of N370S beta -glucosidase: a therapeutic strategy for Gaucher disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

The iminosugar isofagomine increases the activity of N370S mutant acid beta-glucosidase in Gaucher fibroblasts by several mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

The pharmacological chaperone isofagomine increases the activity of the Gaucher disease L444P mutant form of beta-glucosidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

The pharmacological chaperone 1-deoxygalactonojirimycin reduces tissue globotriaosylceramide levels in a mouse model of Fabry disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

An open-label Phase I/II clinical trial of pyrimethamine for the treatment of patients affected with chronic GM2 gangliosidosis (Tay-Sachs or Sandhoff variants)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Isofagomine increases lysosomal delivery of exogenous glucocerebrosidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Cycling of O-linked beta-N-acetylglucosamine on nucleocytoplasmic proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Inhibition of O-GlcNAcase in perfused rat hearts by NAG-thiazolines at the time of reperfusion is cardioprotective in an O-GlcNAc-dependent manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Nutrient sensor O-GlcNAc transferase regulates breast cancer tumorigenesis through targeting of the oncogenic transcription factor FoxM1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Aberrant O-GlcNAcylation characterizes chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Evidence of a balance between phosphorylation and O-GlcNAc glycosylation of Tau proteins--a role in nuclear localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

O-GlcNAcase uses substrate-assisted catalysis: kinetic analysis and development of highly selective mechanism-inspired inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Analysis of PUGNAc and NAG-thiazoline as transition state analogues for human O-GlcNAcase: mechanistic and structural insights into inhibitor selectivity and transition state poise

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Elevation of Global O-GlcNAc in rodents using a selective O-GlcNAcase inhibitor does not cause insulin resistance or perturb glucohomeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Structure and mechanism of a bacterial beta-glucosaminidase having O-GlcNAcase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

GlcNAcstatins are nanomolar inhibitors of human O -GlcNAcase inducing cellular hyper- O -GlcNAcylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

GlcNAcstatin: a picomolar, selective O-GlcNAcase inhibitor that modulates intracellular O-glcNAcylation levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Cell-Penetrant, Nanomolar O-GlcNAcase Inhibitors Selective against Lysosomal Hexosaminidases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Screening-based discovery of drug-likeO-GlcNAcase inhibitor scaffolds

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Chitinases and chitinase-like proteins: potential therapeutic targets for the treatment of T-helper type 2 allergies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Structure-Based Dissection of the Natural Product Cyclopentapeptide Chitinase Inhibitor Argifin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Glycosyltransferases: structures, functions, and mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Trapping and characterization of covalent intermediates of mutant retaining glycosyltransferases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Mechanistic evidence for a front-side, SNi-type reaction in a retaining glycosyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

A potent and highly selective inhibitor of human alpha-1,3-fucosyltransferase via click chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

An efficient approach to the discovery of potent inhibitors against glycosyltransferases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

High-throughput screening for inhibitors of sialyl- and fucosyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

The sweet and sour of cancer: glycans as novel therapeutic targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

A genetic approach to Mammalian glycan function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Grand challenge commentary: Chemical transdifferentiation and regenerative medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

A phase 2 study of eliglustat tartrate (Genz-112638), an oral substrate reduction therapy for Gaucher disease type 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Long-term miglustat therapy in children with Niemann-Pick disease type C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Inhibition of glucosylceramide accumulation results in effective blockade of polycystic kidney disease in mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

A disaccharide-based inhibitor of glycosylation attenuates metastatic tumor cell dissemination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Intracellular inhibition of blood group A glycosyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Deoxygenated Disaccharide Analogs as Specific Inhibitors of 1-4-Galactosyltransferase 1 and Selectin-mediated Tumor Metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Prevention of leukocyte migration to inflamed skin with a novel fluorosugar modifier of cutaneous lymphocyte-associated antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Peracetylated 4-fluoro-glucosamine reduces the content and repertoire of N- and O-glycans without direct incorporation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Hijacking a biosynthetic pathway yields a glycosyltransferase inhibitor within cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Global metabolic inhibitors of sialyl- and fucosyltransferases remodel the glycome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

O-linked N-acetylglucosaminyltransferase inhibition prevents G2/M transition in Xenopus laevis oocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Structure of human O-GlcNAc transferase and its complex with a peptide substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

The Hexapeptide inhibitor of Galbeta 1,3GalNAc-specific alpha 2,3-sialyltransferase as a generic inhibitor of sialyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

A novel sialyltransferase inhibitor suppresses FAK/paxillin signaling and cancer angiogenesis and metastasis pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

A vital role for glycosphingolipid synthesis during development and differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Prevention of lysosomal storage in Tay-Sachs mice treated with N-butyldeoxynojirimycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Novel oral treatment of Gaucher's disease with N-butyldeoxynojirimycin (OGT 918) to decrease substrate biosynthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Nonleadlikeness and leadlikeness in biochemical screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Golgi -mannosidase II cleaves two sugars sequentially in the same catalytic site

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Recent developments of transition-state analogue glycosidase inhibitors of non-natural product origin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

The war against influenza: discovery and development of sialidase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Development of GlcNAc-inspired iminocyclitiols as potent and selective N-acetyl-beta-hexosaminidase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Structural rationale for low-nanomolar binding of transition state mimics to a family GH3 beta-D-glucan glucohydrolase from barley

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Rationally designed squaryldiamides – a novel class of sugar-nucleotide mimics?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

Crystal structures of human pancreatic alpha-amylase in complex with carbohydrate and proteinaceous inhibitors

21 January 2018

1 reference

12 December 2020

A search for pyrophosphate mimics for the development of substrates and inhibitors of glycosyltransferases

1 reference

12 December 2020

Inhibition of mucin glycosylation by aryl-N-acetyl-alpha-galactosaminides in human colon cancer cells.

1 reference

12 December 2020

The mechanism of inhibition of glycosylphosphatidylinositol anchor biosynthesis in Trypanosoma brucei by mannosamine

1 reference

12 December 2020

N-butyldeoxynojirimycin is a novel inhibitor of glycolipid biosynthesis.

1 reference

12 December 2020

A novel sialyltransferase inhibitor AL10 suppresses invasion and metastasis of lung cancer cells by inhibiting integrin-mediated signaling.

1 reference

12 December 2020

Structural and mechanistic basis for a new mode of glycosyltransferase inhibition

1 reference

12 December 2020

Triad of polar residues implicated in pH specificity of acidic mammalian chitinase

1 reference

12 December 2020

Trafficking of lysosomal enzymes.

1 reference

12 December 2020

Substrate reduction therapy with miglustat in chronic GM2 gangliosidosis type Sandhoff: results of a 3-year follow-up

1 reference

12 December 2020

Comparison of the effects of acarbose and voglibose in healthy subjects

1 reference

12 December 2020

Recycling cell surface glycoproteins undergo limited oligosaccharide reprocessing in LEC1 mutant Chinese hamster ovary cells

1 reference

12 December 2020

A strategy to discover inhibitors of O-linked glycosylation

1 reference

12 December 2020

Biological activities of the two major components of tunicamycin

1 reference

12 December 2020

Inhibiting glycosphingolipid synthesis improves glycemic control and insulin sensitivity in animal models of type 2 diabetes

1 reference

12 December 2020

Analogs of ceramide that inhibit glucocerebroside synthetase in mouse brain

1 reference

12 December 2020

Acidic mammalian chitinase is not a critical target for allergic airway disease

1 reference

12 December 2020

The effect of acarbose and miglitol (BAY-M-1099) on postprandial glucose levels following ingestion of various sources of starch by nondiabetic and streptozotocin-induced diabetic rats

1 reference

12 December 2020

Efficient Sialyltransferase Inhibitors Based on Transition-State Analogues of the Sialyl Donor

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1029

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NCHEMBIO.1029

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22810773%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

1 reference