Use of physiologically based pharmacokinetic modeling for assessment of drug-drug interactions. (Q37998136)

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27 January 2020

title

Use of physiologically based pharmacokinetic modeling for assessment of drug-drug interactions (English)

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1

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27 January 2020

author name string

Yumi Fukushima

series ordinal

2

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27 January 2020

Neil Parrott

series ordinal

3

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publication date

1 April 2012

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Future Medicinal Chemistry

27 January 2020

published in

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volume

4

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issue

5

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page(s)

681-693

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Towards a mechanism-based analysis of pharmacodynamic drug-drug interactions in vivo

27 January 2020

cites work

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Drug interactions at the blood-brain barrier: fact or fantasy?

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21 January 2018

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21 January 2018

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Effect of variations in the amounts of P-glycoprotein (ABCB1), BCRP (ABCG2) and CYP3A4 along the human small intestine on PBPK models for predicting intestinal first pass.

21 January 2018

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Confidence assessment of the Simcyp time-based approach and a static mathematical model in predicting clinical drug-drug interactions for mechanism-based CYP3A inhibitors

21 January 2018

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Physiologically based mechanistic modelling to predict complex drug-drug interactions involving simultaneous competitive and time-dependent enzyme inhibition by parent compound and its metabolite in both liver and gut - the effect of diltiazem on th

21 January 2018

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21 January 2018

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Dynamically simulating the interaction of midazolam and the CYP3A4 inhibitor itraconazole using individual coupled whole-body physiologically-based pharmacokinetic (WB-PBPK) models

21 January 2018

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21 January 2018

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Stochastic prediction of CYP3A-mediated inhibition of midazolam clearance by ketoconazole

21 January 2018

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21 January 2018

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Application of PBPK modelling in drug discovery and development at Pfizer

21 January 2018

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Model-based drug development

21 January 2018

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Applications of physiologically based pharmacokinetic (PBPK) modeling and simulation during regulatory review

21 January 2018

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Mechanistic modeling of hepatic transport from cells to whole body: application to napsagatran and fexofenadine

21 January 2018

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21 January 2018

Identifiers

DOI

10.4155/FMC.12.13

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27 January 2020

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