Thymic epithelial cells: antigen presenting cells that regulate T cell repertoire and tolerance development (Q37997732)

26 August 2017

Thymic epithelial cells: antigen presenting cells that regulate T cell repertoire and tolerance development (English)

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26 August 2017

Konstantina Alexandropoulos

series ordinal

1

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PubMed ID

22454100

26 August 2017

Nichole M Danzl

series ordinal

2

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PubMed ID

22454100

26 August 2017

language of work or name

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1 December 2012

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26 August 2017

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26 August 2017

54

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26 August 2017

1-3

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26 August 2017

177-190

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https://scigraph.springernature.com/pub.10.1007/s12026-012-8301-y

26 August 2017

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Thymic medullary epithelial cell differentiation, thymocyte emigration, and the control of autoimmunity require lympho-epithelial cross talk via LTbetaR.

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Lymphostromal interactions in thymic development and function

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Mapping precursor movement through the postnatal thymus reveals specific microenvironments supporting defined stages of early lymphoid development

21 January 2018

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RAG-1-deficient mice have no mature B and T lymphocytes

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New member of the winged-helix protein family disrupted in mouse and rat nude mutations

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Early T lineage progenitors: new insights, but old questions remain

21 January 2018

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The stream of precursors that colonizes the thymus proceeds selectively through the early T lineage precursor stage of T cell development

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Analysis and expression of a cloned pre-T cell receptor gene

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Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes.

21 January 2018

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Positive selection of CD4+ T cells by TCR ligation without aggregation even in the absence of MHC.

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Peptides in positive and negative selection: a delicate balance

21 January 2018

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Self-representation in the thymus: an extended view

21 January 2018

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Promiscuous gene expression and central T-cell tolerance: more than meets the eye.

21 January 2018

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A central role for central tolerance

21 January 2018

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Antigen presentation in the thymus for positive selection and central tolerance induction

21 January 2018

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Role of thymic cortex-specific self-peptides in positive selection of T cells

21 January 2018

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Mechanics of T cell receptor gene rearrangement

21 January 2018

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Branching out to gain control: how the pre-TCR is linked to multiple functions

21 January 2018

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21 January 2018

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Positive and negative selection of T cells

21 January 2018

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Decision checkpoints in the thymus

21 January 2018

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Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells

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The repertoire of T cells shaped by a single MHC/peptide ligand.

21 January 2018

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A single peptide-MHC complex positively selects a diverse and specific CD8 T cell repertoire

21 January 2018

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Organ-specific autoimmunity in mice whose T cell repertoire is shaped by a single antigenic peptide

21 January 2018

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Thymoproteasome: probable role in generating positively selecting peptides

21 January 2018

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Regulation of CD8+ T cell development by thymus-specific proteasomes

21 January 2018

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The proteasome and MHC class I antigen processing

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Lysosomal cysteine proteases regulate antigen presentation

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Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus

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Cathepsin L regulates CD4+ T cell selection independently of its effect on invariant chain: a role in the generation of positively selecting peptide ligands

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Cloning of a novel MHC-encoded serine peptidase highly expressed by cortical epithelial cells of the thymus

21 January 2018

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21 January 2018

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Reproducible association with type 1 diabetes in the extended class I region of the major histocompatibility complex

21 January 2018

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Thymus-specific serine protease contributes to the diversification of the functional endogenous CD4 T cell receptor repertoire

21 January 2018

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Thymus-specific serine protease controls autoreactive CD4 T cell development and autoimmune diabetes in mice

21 January 2018

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Thymus-specific serine protease regulates positive selection of a subset of CD4+ thymocytes

21 January 2018

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Macroautophagy, endogenous MHC II loading and T cell selection: the benefits of breaking the rules

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Enhancing immunity through autophagy

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21 January 2018

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Autophagy and T cell education in the thymus: eat yourself to know yourself.

21 January 2018

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Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance

21 January 2018

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How thymic antigen presenting cells sample the body's self-antigens

21 January 2018

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The thymus medulla slowly yields its secrets.

21 January 2018

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Medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters

21 January 2018

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Self-antigen presentation by thymic stromal cells: a subtle division of labor

21 January 2018

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Back to central tolerance

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12026-012-8301-Y

Thymic emigration revisited

21 January 2018

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"Promiscuous" expression of tissue antigens in the thymus: a key to T-cell tolerance and autoimmunity?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8301-Y

CD4 T cell tolerance to human C-reactive protein, an inducible serum protein, is mediated by medullary thymic epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8301-Y

Projection of an immunological self shadow within the thymus by the aire protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8301-Y

Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8301-Y

Promiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8301-Y

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8301-Y

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8301-Y

Aire, master of many trades

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8301-Y

Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8301-Y

The autoimmune regulator PHD finger binds to non-methylated histone H3K4 to activate gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8301-Y

Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8301-Y

Aire's partners in the molecular control of immunological tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8301-Y

Thymus-specific deletion of insulin induces autoimmune diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8301-Y

An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8301-Y

The cellular mechanism of Aire control of T cell tolerance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8301-Y

Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8301-Y

Positional cloning of the APECED gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8301-Y

Cloning of the APECED gene provides new insight into human autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8301-Y

Clonal analysis reveals a common progenitor for thymic cortical and medullary epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8301-Y

Formation of a functional thymus initiated by a postnatal epithelial progenitor cell.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8301-Y

Control of central self-tolerance induction by autoreactive CD4+ thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8301-Y

Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8301-Y

Contrasting models of promiscuous gene expression by thymic epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8301-Y

Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8301-Y

Promiscuous gene expression and the developmental dynamics of medullary thymic epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8301-Y

Interdependence of cortical thymic epithelial cell differentiation and T-lineage commitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8301-Y

The nu gene acts cell-autonomously and is required for differentiation of thymic epithelial progenitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8301-Y

Thymopoiesis in mice depends on a Foxn1-positive thymic epithelial cell lineage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8301-Y

Transcriptional regulation of thymus organogenesis and thymic epithelial cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8301-Y

Foxn1 is required to maintain the postnatal thymic microenvironment in a dosage-sensitive manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8301-Y

The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8301-Y

The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8301-Y

Dependence of self-tolerance on TRAF6-directed development of thymic stroma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8301-Y

Coordinate activation of c-Src by SH3- and SH2-binding sites on a novel p130Cas-related protein, Sin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8301-Y

Sin: good or bad? A T lymphocyte perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8301-Y

Regulation of medullary thymic epithelial cell differentiation and function by the signaling protein Sin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8301-Y

Constitutive class I-restricted exogenous presentation of self antigens in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8301-Y

Antibody-enhanced cross-presentation of self antigen breaks T cell tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8301-Y

Keratinocyte growth factor/fibroblast growth factor 7, a homeostatic factor with therapeutic potential for epithelial protection and repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8301-Y

Regulation of thymic epithelium by keratinocyte growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8301-Y

Keratinocyte growth factor: effects on keratinocytes and mechanisms of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8301-Y

Proline-rich sequences that bind to Src homology 3 domains with individual specificities

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8301-Y

Contribution of Src and Ras pathways in FGF-2 induced endothelial cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8301-Y

FGF signals for cell proliferation and migration through different pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8301-Y

Graft-versus-host disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8301-Y

Keratinocyte growth factor (KGF) is required for postnatal thymic regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8301-Y

Graft-versus-host-disease-associated thymic damage results in the appearance of T cell clones with anti-host reactivity

21 January 2018

1 reference

12 December 2020

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

1 reference

12 December 2020

Autonomous versus dendritic cell-dependent contributions of medullary thymic epithelial cells to central tolerance

1 reference

12 December 2020

Precursor thymocyte proliferation and differentiation are controlled by signals unrelated to the pre-TCR

1 reference

12 December 2020

Origin of regulatory T cells with known specificity for antigen

1 reference

12 December 2020

Molecular cloning of a cDNA encoding a phosphoprotein, Efs, which contains a Src homology 3 domain and associates with Fyn

1 reference

12 December 2020

Characterization of TCR gene rearrangements during adult murine T cell development.

1 reference

12 December 2020

A novel role for autophagy in T cell education

1 reference

12 December 2020

Positive and Negative CD4+ Thymocyte Selection by a Single MHC Class II/Peptide Ligand Affected by Its Expression Level in the Thymus

1 reference

12 December 2020

A domain of Foxn1 required for crosstalk-dependent thymic epithelial cell differentiation

1 reference

12 December 2020

Autoantigen-Specific Interactions with CD4+ Thymocytes Control Mature Medullary Thymic Epithelial Cell Cellularity

1 reference

12 December 2020

Peptide contributes to the specificity of positive selection of CD8+ T cells in the thymus

1 reference

12 December 2020

Lymphotoxin pathway and Aire influences on thymic medullary epithelial cells are unconnected

1 reference

12 December 2020

Recovery of immune reactivity after T-cell-depleted bone marrow transplantation depends on thymic activity

1 reference

12 December 2020

Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice

1 reference

12 December 2020

The autoimmune regulator PHD finger binds to non-methylated histone H3K4 to activate gene expression

1 reference

12 December 2020

10.1007/S12026-012-8301-Y

Identifiers

DOI

1 reference

26 August 2017

1 reference

PubMed ID

22454100