Advanced morpholino oligomers: a novel approach to antiviral therapy (Q37986972)

26 August 2017

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23 October 2022

Advanced morpholino oligomers: a novel approach to antiviral therapy (English)

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26 August 2017

3

Sina Bavari

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26 August 2017

Travis K Warren

1

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PubMed ID

22353544

26 August 2017

Amy C Shurtleff

series ordinal

2

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26 August 2017

14 February 2012

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PubMed ID

22353544

26 August 2017

1 April 2012

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23 October 2022

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26 August 2017

23 October 2022

94

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26 August 2017

80-88

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26 August 2017

1

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VP24 of Marburg virus influences formation of infectious particles

26 August 2017

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12 December 2020

Development of peptide-conjugated morpholino oligomers as pan-arenavirus inhibitors

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12 December 2020

A specificity comparison of four antisense types: morpholino, 2'-O-methyl RNA, DNA, and phosphorothioate DNA

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12 December 2020

Antiviral effects of antisense morpholino oligomers in murine coronavirus infection models

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12 December 2020

Virus-specific antiviral treatment for controlling severe and fatal outbreaks of feline calicivirus infection.

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12 December 2020

Inhibition of RNA virus infections with peptide-conjugated morpholino oligomers

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12 December 2020

Global suppression of the host antiviral response by Ebola- and Marburgviruses: increased antagonism of the type I interferon response is associated with enhanced virulence

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12 December 2020

Pharmacokinetics, biodistribution, stability and toxicity of a cell-penetrating peptide-morpholino oligomer conjugate.

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12 December 2020

Chemical modifications of antisense morpholino oligomers enhance their efficacy against Ebola virus infection

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12 December 2020

Inhibition of multiple subtypes of influenza A virus in cell cultures with morpholino oligomers

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12 December 2020

Genetic variation in the 3' non-coding region of dengue viruses.

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12 December 2020

Morpholino oligomers targeting the PB1 and NP genes enhance the survival of mice infected with highly pathogenic influenza A H7N7 virus

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12 December 2020

Nonhuman primates as models for the discovery and development of ebolavirus therapeutics

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12 December 2020

mRNA as gene therapeutic: how to control protein expression.

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12 December 2020

Phosphorothioate analogs of oligodeoxynucleotides: inhibitors of replication and cytopathic effects of human immunodeficiency virus

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12 December 2020

Antisense properties of peptide nucleic acid

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12 December 2020

Inhibition of Japanese encephalitis virus replication in cultured cells and mice by a peptide-conjugated morpholino oligomer.

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12 December 2020

Suppression of porcine reproductive and respiratory syndrome virus replication by morpholino antisense oligomers.

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12 December 2020

Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide

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12 December 2020

Inhibition of dengue virus serotypes 1 to 4 in vero cell cultures with morpholino oligomers

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12 December 2020

Oligodeoxynucleoside phosphorothioate stability in subcellular extracts, culture media, sera and cerebrospinal fluid

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12 December 2020

Oligonucleotide antiviral therapeutics: antisense and RNA interference for highly pathogenic RNA viruses

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12 December 2020

Nucleic acids-based therapeutics in the battle against pathogenic viruses

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12 December 2020

Managing potential laboratory exposure to ebola virus by using a patient biocontainment care unit

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12 December 2020

Design of antisense oligonucleotides stabilized by locked nucleic acids

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12 December 2020

Antisense morpholino-oligomers directed against the 5' end of the genome inhibit coronavirus proliferation and growth

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12 December 2020

Inhibition of foot-and-mouth disease virus infections in cell cultures with antisense morpholino oligomers.

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12 December 2020

Antisense treatments for biothreat agents.

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12 December 2020

Enhanced inhibition of porcine reproductive and respiratory syndrome virus replication by combination of morpholino oligomers

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12 December 2020

Activation of the alternative pathway of complement by a phosphorothioate oligonucleotide: potential mechanism of action.

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12 December 2020

Microneedles: a valuable physical enhancer to increase transdermal drug delivery

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12 December 2020

Efficacy of antisense morpholino oligomer targeted to c-myc in prostate cancer xenograft murine model and a Phase I safety study in humans

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12 December 2020

Inhibition of Rous sarcoma viral RNA translation by a specific oligodeoxyribonucleotide

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12 December 2020

Antiviral activity of morpholino oligomers designed to block various aspects of Equine arteritis virus amplification in cell culture.

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12 December 2020

Morpholino, siRNA, and S-DNA compared: impact of structure and mechanism of action on off-target effects and sequence specificity

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12 December 2020

Delivery of steric block morpholino oligomers by (R-X-R)4 peptides: structure-activity studies.

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12 December 2020

Inhibition of IRF-3 activation by VP35 is critical for the high level of virulence of ebola virus

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12 December 2020

Antisense oligonucleotide-based therapeutics for cancer

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12 December 2020

Fomivirsen: clinical pharmacology and potential drug interactions

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12 December 2020

Inhibition of iridovirus protein synthesis and virus replication by antisense morpholino oligonucleotides targeted to the major capsid protein, the 18 kDa immediate-early protein, and a viral homolog of RNA polymerase II.

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12 December 2020

Gene-specific countermeasures against Ebola virus based on antisense phosphorodiamidate morpholino oligomers.

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12 December 2020

Advanced antisense therapies for postexposure protection against lethal filovirus infections.

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12 December 2020

Ebola virus VP24 binds karyopherin alpha1 and blocks STAT1 nuclear accumulation

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12 December 2020

Aerosol and nasal delivery of vaccines and antiviral drugs against seasonal and pandemic influenza

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12 December 2020

Oligodeoxynucleotide stability in subcellular extracts and culture media

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12 December 2020

Stability of cell-penetrating peptide-morpholino oligomer conjugates in human serum and in cells.

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12 December 2020

Phosphorothioate oligodeoxynucleotides: antisense or anti-protein?

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12 December 2020

Technology evaluation: GEM-92, Hybridon Inc

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12 December 2020

Establishing efficacy of human products using animals: the US food and drug administration's "animal rule".

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12 December 2020

In vitro resistance selection and in vivo efficacy of morpholino oligomers against West Nile virus

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12 December 2020

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12 December 2020

Inhibition, escape, and attenuated growth of severe acute respiratory syndrome coronavirus treated with antisense morpholino oligomers

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12 December 2020

Postexposure protection of non-human primates against a lethal Ebola virus challenge with RNA interference: a proof-of-concept study

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12 December 2020

A morpholino oligomer targeting highly conserved internal ribosome entry site sequence is able to inhibit multiple species of picornavirus.

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12 December 2020

Peptide-conjugated morpholino oligomers inhibit porcine reproductive and respiratory syndrome virus replication

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12 December 2020

Inhibition of alphavirus infection in cell culture and in mice with antisense morpholino oligomers

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12 December 2020

Inhibition of dengue virus translation and RNA synthesis by a morpholino oligomer targeted to the top of the terminal 3' stem-loop structure

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12 December 2020

Antisense treatment of caliciviridae: an emerging disease agent of animals and humans

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12 December 2020

Inhibition of HSV-1 ocular infection with morpholino oligomers targeting ICP0 and ICP27.

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12 December 2020

Inhibition of flavivirus infections by antisense oligomers specifically suppressing viral translation and RNA replication

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12 December 2020

Pharmacokinetics and tissue distribution of a peptide nucleic acid after intravenous administration

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12 December 2020

Pharmacokinetics and biodistribution of phosphorodiamidate morpholino antisense oligomers.

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12 December 2020

Nucleocapsid formation and RNA synthesis of Marburg virus is dependent on two coiled coil motifs in the nucleoprotein

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12 December 2020

VP35 knockdown inhibits Ebola virus amplification and protects against lethal infection in mice

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12 December 2020

Chimeric oligodeoxynucleotide analogues: enhanced cell uptake of structures which direct ribonuclease H with high specificity

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12 December 2020

Nucleic acid-based inhibition of flavivirus infections

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12 December 2020

Neutrally charged phosphorodiamidate morpholino antisense oligomers: uptake, efficacy and pharmacokinetics.

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12 December 2020

Postexposure treatment of Marburg virus infection

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12 December 2020

Inhibition of influenza A H3N8 virus infections in mice by morpholino oligomers

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12 December 2020

Locked nucleic acid as a novel class of therapeutic agents

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12 December 2020

Cell-penetrating peptides as transporters for morpholino oligomers: effects of amino acid composition on intracellular delivery and cytotoxicity

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12 December 2020

CpG motifs in bacterial DNA trigger direct B-cell activation

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12 December 2020

Treatment of AG129 mice with antisense morpholino oligomers increases survival time following challenge with dengue 2 virus.

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12 December 2020

The use of single-stranded DNA and RNase H to promote quantitative 'hybrid arrest of translation' of mRNA/DNA hybrids in reticulocyte lysate cell-free translations

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12 December 2020

Reduction of herpes simplex virus type-2 replication in cell cultures and in rodent models with peptide-conjugated morpholino oligomers

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12 December 2020

Targeting the HIV-1 RNA leader sequence with synthetic oligonucleotides and siRNA: chemistry and cell delivery

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12 December 2020

10.1016/J.ANTIVIRAL.2012.02.004

Identifiers

DOI

1 reference

26 August 2017

0 references

1 reference

PubMed ID

22353544