Nonhuman primates as models for the discovery and development of ebolavirus therapeutics (Q40332893)

19 September 2017

Nonhuman primates as models for the discovery and development of ebolavirus therapeutics (English)

1 reference

19 September 2017

3

Sina Bavari

1 reference

19 September 2017

Amy C Shurtleff

1

1 reference

PubMed ID

22647202

19 September 2017

Travis K Warren

series ordinal

2

1 reference

PubMed ID

22647202

19 September 2017

language of work or name

English

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publication date

1 March 2011

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Expert Opinion on Drug Discovery

19 September 2017

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19 September 2017

6

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19 September 2017

3

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19 September 2017

233-250

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Proposal for a revised taxonomy of the family Filoviridae: classification, names of taxa and viruses, and virus abbreviations

19 September 2017

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Preliminary report: isolation of Ebola virus from monkeys imported to USA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Isolation and partial characterisation of a new strain of Ebola virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Proportion of deaths and clinical features in Bundibugyo Ebola virus infection, Uganda

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Assessment of the risk of Ebola virus transmission from bodily fluids and fomites

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Marburg and Ebola viruses as aerosol threats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

The pathology of experimental Ebola virus infection in monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Ebola haemorrhagic fever: experimental infection of monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Haematological and biochemical monitoring of Ebola infection in rhesus monkeys: implications for patient management

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Pathogenesis of Ebola hemorrhagic fever in cynomolgus macaques: evidence that dendritic cells are early and sustained targets of infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

A mouse model for evaluation of prophylaxis and therapy of Ebola hemorrhagic fever

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Pathogenesis of experimental Ebola virus infection in guinea pigs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Establishing efficacy of human products using animals: the US food and drug administration's "animal rule".

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Progress towards the treatment of Ebola haemorrhagic fever

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Disease modeling for Ebola and Marburg viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Cytokine and chemokine expression in humans infected with Sudan Ebola virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Human asymptomatic Ebola infection and strong inflammatory response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Defective humoral responses and extensive intravascular apoptosis are associated with fatal outcome in Ebola virus-infected patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Early immune responses accompanying human asymptomatic Ebola infections

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Sequence analysis of the GP, NP, VP40 and VP24 genes of Ebola virus isolated from deceased, surviving and asymptomatically infected individuals during the 1996 outbreak in Gabon: comparative studies and phylogenetic characterization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Analysis of human peripheral blood samples from fatal and nonfatal cases of Ebola (Sudan) hemorrhagic fever: cellular responses, virus load, and nitric oxide levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Sequence-based human leukocyte antigen-B typing of patients infected with Ebola virus in Uganda in 2000: identification of alleles associated with fatal and nonfatal disease outcomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Ebola hemorrhagic fever in Kikwit, Democratic Republic of the Congo: clinical observations in 103 patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Ebola fever: the African emergency

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Human infection due to Ebola virus, subtype Côte d'Ivoire: clinical and biologic presentation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Clinical, virologic, and immunologic follow-up of convalescent Ebola hemorrhagic fever patients and their household contacts, Kikwit, Democratic Republic of the Congo. Commission de Lutte contre les Epidémies à Kikwit

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

An analysis of features of pathogenesis in two animal models of Ebola virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Depletion of peripheral blood T lymphocytes and NK cells during the course of ebola hemorrhagic Fever in cynomolgus macaques

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Pathogenesis of Ebola hemorrhagic fever in primate models: evidence that hemorrhage is not a direct effect of virus-induced cytolysis of endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Monocyte-derived human macrophages and peripheral blood mononuclear cells infected with ebola virus secrete MIP-1alpha and TNF-alpha and inhibit poly-IC-induced IFN-alpha in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Ebola virus: the role of macrophages and dendritic cells in the pathogenesis of Ebola hemorrhagic fever

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

NKp30-dependent cytolysis of filovirus-infected human dendritic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Ebola and Marburg viruses replicate in monocyte-derived dendritic cells without inducing the production of cytokines and full maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

A novel immunohistochemical assay for the detection of Ebola virus in skin: implications for diagnosis, spread, and surveillance of Ebola hemorrhagic fever. Commission de Lutte contre les Epidémies à Kikwit

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Ultrastructural pathology of experimental Ebola haemorrhagic fever virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Ebola (subtype Reston) virus among quarantined nonhuman primates recently imported from the Philippines to the United States

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Apoptosis induced in vitro and in vivo during infection by Ebola and Marburg viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Pathophysiology of shock and hemorrhage in a fulminating viral infection (Ebola).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Blood chemistry measurements and D-Dimer levels associated with fatal and nonfatal outcomes in humans infected with Sudan Ebola virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Mechanisms underlying coagulation abnormalities in ebola hemorrhagic fever: overexpression of tissue factor in primate monocytes/macrophages is a key event

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Markedly elevated levels of interferon (IFN)-gamma, IFN-alpha, interleukin (IL)-2, IL-10, and tumor necrosis factor-alpha associated with fatal Ebola virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Inflammatory responses in Ebola virus-infected patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Human fatal zaire ebola virus infection is associated with an aberrant innate immunity and with massive lymphocyte apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Functional CD8+ T cell responses in lethal Ebola virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Proinflammatory response during Ebola virus infection of primate models: possible involvement of the tumor necrosis factor receptor superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Inducible nitric oxide synthase-derived nitric oxide in gene regulation, cell death and cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

The temporal program of peripheral blood gene expression in the response of nonhuman primates to Ebola hemorrhagic fever

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

ELISA for the detection of antibodies to Ebola viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Laboratory diagnosis of Ebola hemorrhagic fever during an outbreak in Yambio, Sudan, 2004.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Rapid diagnosis of Ebola hemorrhagic fever by reverse transcription-PCR in an outbreak setting and assessment of patient viral load as a predictor of outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Effective post-exposure treatment of Ebola infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Evaluation of immune globulin and recombinant interferon-alpha2b for treatment of experimental Ebola virus infections

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

3-deazaneplanocin A induces massively increased interferon-alpha production in Ebola virus-infected mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Neutralizing antibody fails to impact the course of Ebola virus infection in monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Oligonucleotide antiviral therapeutics: antisense and RNA interference for highly pathogenic RNA viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Inhibition of RNA virus infections with peptide-conjugated morpholino oligomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Chemical modifications of antisense morpholino oligomers enhance their efficacy against Ebola virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Gene-specific countermeasures against Ebola virus based on antisense phosphorodiamidate morpholino oligomers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

VP35 knockdown inhibits Ebola virus amplification and protects against lethal infection in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Advanced antisense therapies for postexposure protection against lethal filovirus infections.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Progress towards in vivo use of siRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Interfering with disease: a progress report on siRNA-based therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

A status report on RNAi therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Postexposure protection of non-human primates against a lethal Ebola virus challenge with RNA interference: a proof-of-concept study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Misinterpreting the therapeutic effects of small interfering RNA caused by immune stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Accelerated vaccination for Ebola virus haemorrhagic fever in non-human primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Successful topical respiratory tract immunization of primates against Ebola virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Ebola virus-like particle-based vaccine protects nonhuman primates against lethal Ebola virus challenge

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Recombinant vesicular stomatitis virus vector mediates postexposure protection against Sudan Ebola hemorrhagic fever in nonhuman primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Interferon, Mx, and viral countermeasures

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Interferons (IFNs) are key cytokines in both innate and adaptive antiviral immune responses--and viruses counteract IFN action

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

The VP35 protein of Ebola virus inhibits the antiviral effect mediated by double-stranded RNA-dependent protein kinase PKR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Evasion of interferon responses by Ebola and Marburg viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Ebola virus VP24 proteins inhibit the interaction of NPI-1 subfamily karyopherin alpha proteins with activated STAT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Treatment of Ebola hemorrhagic fever with blood transfusions from convalescent patients. International Scientific and Technical Committee

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Ebola hemorrhagic fever: evaluation of passive immunotherapy in nonhuman primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Treatment of Ebola virus infection with a recombinant inhibitor of factor VIIa/tissue factor: a study in rhesus monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Recombinant human activated protein C for the postexposure treatment of Ebola hemorrhagic fever

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Managing potential laboratory exposure to ebola virus by using a patient biocontainment care unit

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Outbreaks of filovirus hemorrhagic fever: time to refocus on the patient

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Unexpected Ebola virus in a tertiary setting: clinical and epidemiologic aspects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

Clinical virology of Ebola hemorrhagic fever (EHF): virus, virus antigen, and IgG and IgM antibody findings among EHF patients in Kikwit, Democratic Republic of the Congo, 1995.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2011.554815

10.1517/17460441.2011.554815

21 January 2018

Identifiers

DOI

1 reference

19 September 2017

1 reference

PubMed ID

22647202