Establishing the stem cell state: insights from regulatory network analysis of blood stem cell development (Q37984025)

26 August 2017

Establishing the stem cell state: insights from regulatory network analysis of blood stem cell development (English)

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26 August 2017

3

Berthold Göttgens

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26 August 2017

Judith Schütte

1

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PubMed ID

22334489

26 August 2017

Victoria Moignard

series ordinal

2

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26 August 2017

14 February 2012

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Wiley interdisciplinary reviews. Systems biology and medicine

26 August 2017

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26 August 2017

4

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26 August 2017

3

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26 August 2017

285-295

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Sheep cloned by nuclear transfer from a cultured cell line

26 August 2017

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Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

21 January 2018

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Forcing cells to change lineages

21 January 2018

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Expression of a single transfected cDNA converts fibroblasts to myoblasts

21 January 2018

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Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts which differentiate into endothelial cells in the absence of Gata1.

21 January 2018

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Transcription factor-mediated lineage switching reveals plasticity in primary committed progenitor cells

21 January 2018

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Stem cell states, fates, and the rules of attraction

21 January 2018

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Transcriptional regulatory networks in haematopoiesis

21 January 2018

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Emerging properties of animal gene regulatory networks

21 January 2018

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Network design principles from the sea urchin embryo

21 January 2018

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Reconstructing regulatory network transitions

21 January 2018

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Gene regulatory networks governing haematopoietic stem cell development and identity

21 January 2018

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Network motifs: theory and experimental approaches

21 January 2018

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Hematopoiesis: an evolving paradigm for stem cell biology

21 January 2018

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The Immunological Genome Project: networks of gene expression in immune cells.

21 January 2018

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Hematopoietic stem cells: the paradigmatic tissue-specific stem cell

21 January 2018

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From genes to cells to tissues--modelling the haematopoietic system.

21 January 2018

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Ontogeny of haematopoiesis: recent advances and open questions

21 January 2018

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Purification of primitive human hematopoietic cells capable of repopulating immune-deficient mice.

21 January 2018

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Isolation of single human hematopoietic stem cells capable of long-term multilineage engraftment.

21 January 2018

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Embryonic stem cell-derived hematopoietic stem cells

21 January 2018

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Control of self-renewal and differentiation of hematopoietic stem cells: HOXB4 on the threshold.

21 January 2018

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Autologous blood cell therapies from pluripotent stem cells

21 January 2018

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Purification and characterization of mouse hematopoietic stem cells

21 January 2018

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Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation

21 January 2018

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All hematopoietic cells develop from hematopoietic stem cells through Flk2/Flt3-positive progenitor cells

21 January 2018

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FLT3 expression initiates in fully multipotent mouse hematopoietic progenitor cells.

21 January 2018

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Chromosomal translocation in a human leukemic stem-cell line disrupts the T-cell antigen receptor delta-chain diversity region and results in a previously unreported fusion transcript

21 January 2018

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t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1

21 January 2018

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Progression of interleukin-2 (IL-2)-dependent rat T cell lymphoma lines to IL-2-independent growth following activation of a gene (Gfi-1) encoding a novel zinc finger protein

21 January 2018

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The Gfi-1B proto-oncoprotein represses p21WAF1 and inhibits myeloid cell differentiation

21 January 2018

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Gfi1 and Gfi1b: key regulators of hematopoiesis

21 January 2018

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Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene

21 January 2018

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Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL

21 January 2018

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Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

21 January 2018

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Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells

21 January 2018

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Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cells

21 January 2018

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The zinc-finger proto-oncogene Gfi-1b is essential for development of the erythroid and megakaryocytic lineages

21 January 2018

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Transcriptional regulation of haematopoietic transcription factors.

21 January 2018

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cis-Regulatory remodeling of the SCL locus during vertebrate evolution.

21 January 2018

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Expression of the leukemia oncogene Lmo2 is controlled by an array of tissue-specific elements dispersed over 100 kb and bound by Tal1/Lmo2, Ets, and Gata factors

21 January 2018

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Fli1, Elf1, and Ets1 regulate the proximal promoter of the LMO2 gene in endothelial cells.

21 January 2018

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Gfi1 expression is controlled by five distinct regulatory regions spread over 100 kilobases, with Scl/Tal1, Gata2, PU.1, Erg, Meis1, and Runx1 acting as upstream regulators in early hematopoietic cells.

21 January 2018

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Transcriptional regulation of the SCL locus: identification of an enhancer that targets the primitive erythroid lineage in vivo

21 January 2018

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The scl +18/19 stem cell enhancer is not required for hematopoiesis: identification of a 5' bifunctional hematopoietic-endothelial enhancer bound by Fli-1 and Elf-1

21 January 2018

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Transgenic analysis of the stem cell leukemia +19 stem cell enhancer in adult and embryonic hematopoietic and endothelial cells.

21 January 2018

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Transcriptional regulation of the stem cell leukemia gene by PU.1 and Elf-1.

21 January 2018

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In vivo fate-tracing studies using the Scl stem cell enhancer: embryonic hematopoietic stem cells significantly contribute to adult hematopoiesis.

21 January 2018

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The mouse Runx1 +23 hematopoietic stem cell enhancer confers hematopoietic specificity to both Runx1 promoters.

21 January 2018

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Runx1-mediated hematopoietic stem-cell emergence is controlled by a Gata/Ets/SCL-regulated enhancer

21 January 2018

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Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver

21 January 2018

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A compendium of genome-wide hematopoietic transcription factor maps supports the identification of gene regulatory control mechanisms

21 January 2018

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Genome-wide identification of cis-regulatory sequences controlling blood and endothelial development.

21 January 2018

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Gata2, Fli1, and Scl form a recursively wired gene-regulatory circuit during early hematopoietic development

21 January 2018

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The transcriptional program controlled by the stem cell leukemia gene Scl/Tal1 during early embryonic hematopoietic development.

21 January 2018

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Network motifs: simple building blocks of complex networks

21 January 2018

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Transcriptional regulation of haematopoiesis

21 January 2018

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PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors

21 January 2018

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Reciprocal activation of GATA-1 and PU.1 marks initial specification of hematopoietic stem cells into myeloerythroid and myelolymphoid lineages

21 January 2018

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Computational modeling of the hematopoietic erythroid-myeloid switch reveals insights into cooperativity, priming, and irreversibility

21 January 2018

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Establishing the transcriptional programme for blood: the SCL stem cell enhancer is regulated by a multiprotein complex containing Ets and GATA factors.

21 January 2018

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The gata1/pu.1 lineage fate paradigm varies between blood populations and is modulated by tif1γ.

21 January 2018

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GATA motifs regulate early hematopoietic lineage-specific expression of the Gata2 gene

21 January 2018

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Modeling reveals bistability and low-pass filtering in the network module determining blood stem cell fate

21 January 2018

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Regulation of B lymphocyte and macrophage development by graded expression of PU.1.

21 January 2018

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Constitutive expression of PU.1 in fetal hematopoietic progenitors blocks T cell development at the pro-T cell stage

21 January 2018

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Intrinsic requirement for zinc finger transcription factor Gfi-1 in neutrophil differentiation

21 January 2018

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The transcriptional repressor Gfi1 affects development of early, uncommitted c-Kit+ T cell progenitors and CD4/CD8 lineage decision in the thymus

21 January 2018

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A recurrent network involving the transcription factors PU.1 and Gfi1 orchestrates innate and adaptive immune cell fates

21 January 2018

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C/EBPalpha induces PU.1 and interacts with AP-1 and NF-kappaB to regulate myeloid development

21 January 2018

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Stepwise reprogramming of B cells into macrophages

21 January 2018

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Clonal selection and learning in the antibody system

21 January 2018

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An incoherent regulatory network architecture that orchestrates B cell diversification in response to antigen signaling.

21 January 2018

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Functional cis-regulatory genomics for systems biology

21 January 2018

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Early chromatin unfolding by RUNX1: a molecular explanation for differential requirements during specification versus maintenance of the hematopoietic gene expression program

21 January 2018

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The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage

21 January 2018

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Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators.

21 January 2018

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PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/WSBM.1163

1 reference

26 August 2017

1 reference

PubMed ID

22334489