Current perspectives on the modulation of thermo-TRP channels: new advances and therapeutic implications (Q37960107)

25 August 2017

Current perspectives on the modulation of thermo-TRP channels: new advances and therapeutic implications (English)

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25 August 2017

Laura Vay

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25 August 2017

Chunjing Gu

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2

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25 August 2017

Peter A McNaughton

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3

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25 August 2017

language of work or name

English

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publication date

1 September 2010

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Expert Review of Clinical Pharmacology

25 August 2017

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25 August 2017

3

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25 August 2017

687-704

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25 August 2017

5

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Neuronal plasticity: increasing the gain in pain

25 August 2017

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Heat activation of TRPM5 underlies thermal sensitivity of sweet taste

21 January 2018

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A novel heat-activated current in nociceptive neurons and its sensitization by bradykinin

21 January 2018

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The capsaicin receptor: a heat-activated ion channel in the pain pathway

21 January 2018

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The cloned capsaicin receptor integrates multiple pain-producing stimuli

21 January 2018

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Understanding the role of voltage gating of polymodal TRP channels

21 January 2018

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The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels

21 January 2018

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Signalling pathways involved in the sensitisation of mouse nociceptive neurones by nerve growth factor

21 January 2018

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Potentiation of capsaicin receptor activity by metabotropic ATP receptors as a possible mechanism for ATP-evoked pain and hyperalgesia

21 January 2018

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Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide

21 January 2018

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The vanilloid receptor: a molecular gateway to the pain pathway

21 January 2018

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Low pH potentiates both capsaicin binding and channel gating of VR1 receptors

21 January 2018

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Ethanol elicits and potentiates nociceptor responses via the vanilloid receptor-1.

21 January 2018

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Anandamide and vanilloid TRPV1 receptors

21 January 2018

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Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances

21 January 2018

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Impaired nociception and pain sensation in mice lacking the capsaicin receptor

21 January 2018

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Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia

21 January 2018

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Sensitization of TRPV1 by EP1 and IP reveals peripheral nociceptive mechanism of prostaglandins

21 January 2018

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Vanilloid receptors take a TRP beyond the sensory afferent☆

21 January 2018

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Sense and specificity: a molecular identity for nociceptors

21 January 2018

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The temperature-sensitive ion channel TRPV2 is endogenously expressed and functional in the primary sensory cell line F-11.

21 January 2018

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A capsaicin-receptor homologue with a high threshold for noxious heat

21 January 2018

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TRPV2 Is a Component of Osmotically Sensitive Cation Channels in Murine Aortic Myocytes

21 January 2018

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2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3

21 January 2018

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TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons

21 January 2018

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Peripheral inflammation induces up-regulation of TRPV2 expression in rat DRG.

21 January 2018

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Increased TRPA1, TRPM8, and TRPV2 expression in dorsal root ganglia by nerve injury

21 January 2018

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A heat-sensitive TRP channel expressed in keratinocytes

21 January 2018

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TRPV3 is a temperature-sensitive vanilloid receptor-like protein.

21 January 2018

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TRPV3 is a calcium-permeable temperature-sensitive cation channel.

21 January 2018

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Heat-evoked activation of TRPV4 channels in a HEK293 cell expression system and in native mouse aorta endothelial cells

21 January 2018

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TRPV channels as thermosensory receptors in epithelial cells

21 January 2018

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Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin.

21 January 2018

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Warm temperature-sensitive transient receptor potential vanilloid 4 (TRPV4) plays an essential role in thermal hyperalgesia.

21 January 2018

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The TRPV1/2/3 activator 2-aminoethoxydiphenyl borate sensitizes native nociceptive neurons to heat in wildtype but not TRPV1 deficient mice

21 January 2018

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Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives

21 January 2018

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Activation of the TRPV4 ion channel is enhanced by phosphorylation.

21 January 2018

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Bisandrographolide from Andrographis paniculata activates TRPV4 channels.

21 January 2018

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TRPV3 in keratinocytes transmits temperature information to sensory neurons via ATP.

21 January 2018

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Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding

21 January 2018

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TRPV4 mediates pain-related behavior induced by mild hypertonic stimuli in the presence of inflammatory mediator

21 January 2018

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TRP channels: a TR(I)P through a world of multifunctional cation channels

21 January 2018

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A TRP channel that senses cold stimuli and menthol

21 January 2018

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Identification of a cold receptor reveals a general role for TRP channels in thermosensation

21 January 2018

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The contribution of TRPM8 channels to cold sensing in mammalian neurones

21 January 2018

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The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channel

21 January 2018

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A cold- and menthol-activated current in rat dorsal root ganglion neurones: properties and role in cold transduction.

21 January 2018

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Noxious heat receptors present in cold-sensory cells in rats

21 January 2018

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Two populations of cold-sensitive neurons in rat dorsal root ganglia and their modulation by nerve growth factor

21 January 2018

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TRPM8 is required for cold sensation in mice

21 January 2018

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Attenuated cold sensitivity in TRPM8 null mice

21 January 2018

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The menthol receptor TRPM8 is the principal detector of environmental cold

21 January 2018

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ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures

21 January 2018

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TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction

21 January 2018

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TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents

21 January 2018

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TRPA1 acts as a cold sensor in vitro and in vivo

21 January 2018

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TRPA1 channels mediate cold temperature sensing in mammalian vagal sensory neurons: pharmacological and genetic evidence.

21 January 2018

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Converting cold into pain.

21 January 2018

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Direct activation of the ion channel TRPA1 by Ca2+.

21 January 2018

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Transient receptor potential channel A1 is directly gated by calcium ions

21 January 2018

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ThermoTRP channels and cold sensing: what are they really up to?

21 January 2018

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TRPA1 mediates formalin-induced pain

21 January 2018

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TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury

21 January 2018

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Activation of Src-family kinases in spinal microglia contributes to mechanical hypersensitivity after nerve injury.

21 January 2018

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Differential expression of capsaicin-, menthol-, and mustard oil-sensitive receptors in naive rat geniculate ganglion neurons.

21 January 2018

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Molecular basis of infrared detection by snakes

21 January 2018

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Pungent products from garlic activate the sensory ion channel TRPA1

21 January 2018

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Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin

21 January 2018

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TRP channel activation by reversible covalent modification

21 January 2018

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Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines

21 January 2018

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Activation of TRPA1 channels by fenamate nonsteroidal anti-inflammatory drugs

21 January 2018

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Bimodal action of menthol on the transient receptor potential channel TRPA1.

21 January 2018

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Trp ion channels and temperature sensation

21 January 2018

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TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells

21 January 2018

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Modulation of temperature-sensitive TRP channels.

21 January 2018

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Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1).

21 January 2018

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Increased sensitivity of desensitized TRPV1 by PMA occurs through PKCepsilon-mediated phosphorylation at S800.

21 January 2018

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Direct phosphorylation of capsaicin receptor VR1 by protein kinase Cepsilon and identification of two target serine residues

21 January 2018

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cAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation

21 January 2018

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Proinflammatory mediators modulate the heat-activated ion channel TRPV1 via the scaffolding protein AKAP79/150

21 January 2018

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A-kinase anchoring protein 150 controls protein kinase C-mediated phosphorylation and sensitization of TRPV1

21 January 2018

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Induction of vanilloid receptor channel activity by protein kinase C

21 January 2018

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Protein kinase C-mediated Ca2+ entry in HEK 293 cells transiently expressing human TRPV4.

21 January 2018

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Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress

21 January 2018

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Tyrosine phosphorylation modulates the activity of TRPV4 in response to defined stimuli.

21 January 2018

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A TRPV2-PKA signaling module for transduction of physical stimuli in mast cells

21 January 2018

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PI3-kinase promotes TRPV2 activity independently of channel translocation to the plasma membrane.

21 January 2018

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Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels

21 January 2018

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Downregulation of transient receptor potential melastatin 8 by protein kinase C-mediated dephosphorylation.

21 January 2018

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Desensitization of cold- and menthol-sensitive rat dorsal root ganglion neurones by inflammatory mediators.

21 January 2018

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The transient receptor potential channel TRPM8 is inhibited via the alpha 2A adrenoreceptor signaling pathway

21 January 2018

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The nociceptor ion channel TRPA1 is potentiated and inactivated by permeating calcium ions.

21 January 2018

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Nociceptive signals induce trafficking of TRPA1 to the plasma membrane

21 January 2018

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Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain

21 January 2018

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Inhibition of transient receptor potential A1 channel by phosphatidylinositol-4,5-bisphosphate

21 January 2018

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Modulation of the transient receptor potential channel TRPA1 by phosphatidylinositol 4,5-biphosphate manipulators

21 January 2018

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Physiology of the neurotrophins

21 January 2018

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Reversal of neurochemical changes and pain-related behavior in a model of neuropathic pain using modified lentiviral vectors expressing GDNF.

21 January 2018

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Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with adelta/c-fibers and colocalization with trk receptors

21 January 2018

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p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia

21 January 2018

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NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels.

21 January 2018

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Phosphoinositide 3-kinase binds to TRPV1 and mediates NGF-stimulated TRPV1 trafficking to the plasma membrane.

21 January 2018

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Phosphoinositide-3-kinase and mitogen activated protein kinase signaling pathways mediate acute NGF sensitization of TRPV1.

21 January 2018

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Sensitization and translocation of TRPV1 by insulin and IGF-I.

21 January 2018

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Translocation of a calcium-permeable cation channel induced by insulin-like growth factor-I

21 January 2018

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Regulation of calcium-permeable TRPV2 channel by insulin in pancreatic beta-cells

21 January 2018

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GDNF family neurotrophic factor signaling: four masters, one servant?

21 January 2018

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Glial cell-line-derived neurotrophic factor expression in skin alters the mechanical sensitivity of cutaneous nociceptors.

21 January 2018

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Glial cell line-derived neurotrophic factor family members sensitize nociceptors in vitro and produce thermal hyperalgesia in vivo.

21 January 2018

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Clinical development of TRPV1 antagonists: targeting a pivotal point in the pain pathway

21 January 2018

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The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept

21 January 2018

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Therapeutic potential of vanilloid receptor TRPV1 agonists and antagonists as analgesics: Recent advances and setbacks

21 January 2018

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Analgesic potential of TRPV1 antagonists

21 January 2018

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TRPV1 receptors in the CNS play a key role in broad-spectrum analgesia of TRPV1 antagonists

21 January 2018

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TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons

21 January 2018

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Reduced anxiety, conditioned fear, and hippocampal long-term potentiation in transient receptor potential vanilloid type 1 receptor-deficient mice.

21 January 2018

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Overexpressed transient receptor potential vanilloid 3 ion channels in skin keratinocytes modulate pain sensitivity via prostaglandin E2.

21 January 2018

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Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans

21 January 2018

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The vanilloid receptor TRPV1 is tonically activated in vivo and involved in body temperature regulation

21 January 2018

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Nonthermal activation of transient receptor potential vanilloid-1 channels in abdominal viscera tonically inhibits autonomic cold-defense effectors

21 January 2018

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Antihyperalgesic effects of (R,E)-N-(2-hydroxy-2,3-dihydro-1H-inden-4-yl)-3-(2-(piperidin-1-yl)-4-(trifluoromethyl)phenyl)-acrylamide (AMG8562), a novel transient receptor potential vanilloid type 1 modulator that does not cause hyperthermia in rats

21 January 2018

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Defining neuropathic pain

21 January 2018

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Identification and biological characterization of 6-aryl-7-isopropylquinazolinones as novel TRPV1 antagonists that are effective in models of chronic pain

21 January 2018

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Selective blockade of the capsaicin receptor TRPV1 attenuates bone cancer pain.

21 January 2018

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A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel transient receptor potential type V1 receptor antagonist, relieves pathophysiological pain associated with inflammation and tissue injury in rats

21 January 2018

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Pharmacological characterization of the TRPV1 receptor antagonist JYL1421 (SC0030) in vitro and in vivo in the rat.

21 January 2018

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N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. in vivo characterization in rat models of inflammatory and neu

21 January 2018

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The VR1 antagonist capsazepine reverses mechanical hyperalgesia in models of inflammatory and neuropathic pain.

21 January 2018

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[3H]A-778317 [1-((R)-5-tert-butyl-indan-1-yl)-3-isoquinolin-5-yl-urea]: a novel, stereoselective, high-affinity antagonist is a useful radioligand for the human transient receptor potential vanilloid-1 (TRPV1) receptor.

21 January 2018

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Binding of [(3)H]A-778317 to native transient receptor potential vanilloid-1 (TRPV1) channels in rat dorsal root ganglia and spinal cord

21 January 2018

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Identification of (R)-1-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)urea (ABT-102) as a potent TRPV1 antagonist for pain management

21 January 2018

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Novel vanilloid receptor-1 antagonists: 2. Structure-activity relationships of 4-oxopyrimidines leading to the selection of a clinical candidate

21 January 2018

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Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermia

21 January 2018

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Novel vanilloid receptor-1 antagonists: 3. The identification of a second-generation clinical candidate with improved physicochemical and pharmacokinetic properties.

21 January 2018

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Species-specific pharmacology of Trichloro(sulfanyl)ethyl benzamides as transient receptor potential ankyrin 1 (TRPA1) antagonists

21 January 2018

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Design and synthesis of peripherally restricted transient receptor potential vanilloid 1 (TRPV1) antagonists

21 January 2018

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Characterization of SB-705498, a potent and selective vanilloid receptor-1 (VR1/TRPV1) antagonist that inhibits the capsaicin-, acid-, and heat-mediated activation of the receptor

21 January 2018

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Discovery of small molecule antagonists of TRPV1.

21 January 2018

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Discovery of SB-705498: a potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development

21 January 2018

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GRC-6211, a new oral specific TRPV1 antagonist, decreases bladder overactivity and noxious bladder input in cystitis animal models

21 January 2018

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A-kinase anchoring protein mediates TRPV1 thermal hyperalgesia through PKA phosphorylation of TRPV1

21 January 2018

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Protein kinase A anchoring via AKAP150 is essential for TRPV1 modulation by forskolin and prostaglandin E2 in mouse sensory neurons

21 January 2018

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Functional changes in the vanilloid receptor subtype 1 channel during and after acute desensitization.

21 January 2018

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Quantitative sensory testing in measurement of neuropathic pain phenomena and other sensory abnormalities.

21 January 2018

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Controlled trial of high-concentration capsaicin patch for treatment of painful HIV neuropathy

21 January 2018

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TRPV1 shows dynamic ionic selectivity during agonist stimulation.

21 January 2018

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Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers

21 January 2018

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Pharmacological characterization and molecular determinants of the activation of transient receptor potential V2 channel orthologs by 2-aminoethoxydiphenyl borate.

21 January 2018

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Activation properties of heterologously expressed mammalian TRPV2: evidence for species dependence

21 January 2018

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Chemotactic peptide fMetLeuPhe induces translocation of the TRPV2 channel in macrophages

21 January 2018

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A high-threshold heat-activated channel in cultured rat dorsal root ganglion neurons resembles TRPV2 and is blocked by gadolinium

21 January 2018

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Citral sensing by Transient [corrected] receptor potential channels in dorsal root ganglion neurons

21 January 2018

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A transient receptor potential vanilloid 4-dependent mechanism of hyperalgesia is engaged by concerted action of inflammatory mediators.

21 January 2018

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Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice

21 January 2018

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Marked attenuation of inflammatory mediator-induced C-fiber sensitization for mechanical and hypotonic stimuli in TRPV4-/- mice

21 January 2018

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A role for transient receptor potential vanilloid 4 in tonicity-induced neurogenic inflammation.

21 January 2018

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Transient receptor potential vanilloid 4 is essential in chemotherapy-induced neuropathic pain in the rat.

21 January 2018

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Identification and characterization of novel TRPV4 modulators

21 January 2018

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A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition.

21 January 2018

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HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity

21 January 2018

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Attenuation of mechanical hypersensitivity by an antagonist of the TRPA1 ion channel in diabetic animals

21 January 2018

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21 January 2018

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Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain

21 January 2018

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TRPM8 mechanism of cold allodynia after chronic nerve injury.

21 January 2018

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Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay

21 January 2018

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Diversity in the neural circuitry of cold sensing revealed by genetic axonal labeling of transient receptor potential melastatin 8 neurons

21 January 2018

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Specificity of cold thermotransduction is determined by differential ionic channel expression

21 January 2018

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Chemical and cold sensitivity of two distinct populations of TRPM8-expressing somatosensory neurons

21 January 2018

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Bidirectional shifts of TRPM8 channel gating by temperature and chemical agents modulate the cold sensitivity of mammalian thermoreceptors.

21 January 2018

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Differential role of the menthol-binding residue Y745 in the antagonism of thermally gated TRPM8 channels.

21 January 2018

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Transient receptor potential cation channels in disease

21 January 2018

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The effects of the TRPV1 antagonist SB-705498 on TRPV1 receptor-mediated activity and inflammatory hyperalgesia in humans

21 January 2018

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On the putative role of transient receptor potential cation channels in asthma

21 January 2018

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TRPA1 modulators in preclinical development

21 January 2018

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Peripheral and Central Mechanisms of NGF-induced Hyperalgesia

21 January 2018

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21 January 2018

Identifiers

DOI

10.1586/ECP.10.41

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25 August 2017

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