TRPA1 modulators in preclinical development (Q37638751)

21 August 2017

1 reference

title

TRPA1 modulators in preclinical development (English)

1 reference

21 August 2017

Félix Viana

1

1 reference

PubMed ID

19939193

21 August 2017

Antonio Ferrer-Montiel

series ordinal

2

1 reference

PubMed ID

19939193

21 August 2017

language of work or name

English

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publication date

1 December 2009

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Expert Opinion on Therapeutic Patents

21 August 2017

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21 August 2017

19

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21 August 2017

12

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21 August 2017

1787-1799

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https://api.crossref.org/works/10.1517%2F13543770903393771

21 August 2017

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TRP channels: an overview

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

An introduction to TRP channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

TRP channels as cellular sensors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Trp ion channels and temperature sensation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Roles of transient receptor potential channels in pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Transient receptor potential channels: targeting pain at the source

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

An ankyrin-like protein with transmembrane domains is specifically lost after oncogenic transformation of human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

TRPA1 channels mediate cold temperature sensing in mammalian vagal sensory neurons: pharmacological and genetic evidence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Oral irritation by mustard oil: self-desensitization and cross-desensitization with capsaicin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Time course of self-desensitization of oral irritation by nicotine and capsaicin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

A painful trp can be a bonding experience

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

More than cool: promiscuous relationships of menthol and other sensory compounds.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

The pungency of garlic: activation of TRPA1 and TRPV1 in response to allicin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Pungent products from garlic activate the sensory ion channel TRPA1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

TRPA1 mediates formalin-induced pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

TRPA1 mediates the noxious effects of natural sesquiterpene deterrents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Transient receptor potential ankyrin 1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Transient receptor potential A1 is a sensory receptor for multiple products of oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

TRPA1 is a major oxidant sensor in murine airway sensory neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

painless, a Drosophila Gene Essential for Nociception

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Caenorhabditis elegans TRPA-1 functions in mechanosensation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Nociceptor and hair cell transducer properties of TRPA1, a channel for pain and hearing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

TRPA1 modulates mechanotransduction in cutaneous sensory neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Pharmacological blockade of TRPA1 inhibits mechanical firing in nociceptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Molecular and cellular limits to somatosensory specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

TRPA1 is differentially modulated by the amphipathic molecules trinitrophenol and chlorpromazine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Burning cold: involvement of TRPA1 in noxious cold sensation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Variable threshold of trigeminal cold-thermosensitive neurons is determined by a balance between TRPM8 and Kv1 potassium channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

TRPA1 acts as a cold sensor in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Cold sensitivity of recombinant TRPA1 channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

TRP channel activation by reversible covalent modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Transient receptor potential channels in sensory neurons are targets of the antimycotic agent clotrimazole

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

TRPA1 channels: novel targets of 1,4-dihydropyridines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Bimodal action of menthol on the transient receptor potential channel TRPA1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Identification of transmembrane domain 5 as a critical molecular determinant of menthol sensitivity in mammalian TRPA1 channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

The nociceptor ion channel TRPA1 is potentiated and inactivated by permeating calcium ions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Zinc activates damage-sensing TRPA1 ion channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Contribution of TRPM8 channels to cold transduction in primary sensory neurons and peripheral nerve terminals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Caffeine activates mouse TRPA1 channels but suppresses human TRPA1 channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

TRPA1: the species difference

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Species-specific pharmacology of Trichloro(sulfanyl)ethyl benzamides as transient receptor potential ankyrin 1 (TRPA1) antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Molecular determinants of species-specific activation or blockade of TRPA1 channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Transient receptor potential channel A1 is directly gated by calcium ions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Direct activation of the ion channel TRPA1 by Ca2+.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Activation of transient receptor potential A1 channels by mustard oil, tetrahydrocannabinol and Ca2+ reveals different functional channel states

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Essential role for the putative S6 inner pore region in the activation gating of the human TRPA1 channel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Clioquinol and pyrithione activate TRPA1 by increasing intracellular Zn2+.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Requirement of a soluble intracellular factor for activation of transient receptor potential A1 by pungent chemicals: role of inorganic polyphosphates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Phospholipase C and protein kinase A mediate bradykinin sensitization of TRPA1: a molecular mechanism of inflammatory pain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Modulation of the transient receptor potential channel TRPA1 by phosphatidylinositol 4,5-biphosphate manipulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Inhibition of transient receptor potential A1 channel by phosphatidylinositol-4,5-bisphosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Expression and function of the ion channel TRPA1 in vagal afferent nerves innervating mouse lungs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

TRPA1: a potential target for anti-tussive therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Relative contributions of TRPA1 and TRPV1 channels in the activation of vagal bronchopulmonary C-fibres by the endogenous autacoid 4-oxononenal

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Cutaneous nociception evoked by 15-delta PGJ2 via activation of ion channel TRPA1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Prostaglandin-induced activation of nociceptive neurons via direct interaction with transient receptor potential A1 (TRPA1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Nitrooleic acid, an endogenous product of nitrative stress, activates nociceptive sensory nerves via the direct activation of TRPA1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Functional TRP and ASIC-like channels in cultured urothelial cells from the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

On the origin of bladder sensing: Tr(i)ps in urology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Capsaicin-like activity of some natural pungent substances on peripheral endings of visceral primary afferents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Distribution and function of the hydrogen sulfide-sensitive TRPA1 ion channel in rat urinary bladder

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Differential expression profile of cold (TRPA1) and cool (TRPM8) receptors in human urogenital organs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Calcitonin gene-related peptide acts as a novel vasodilator neurotransmitter in mesenteric resistance vessels of the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

1,4-Dihydropyridines as calcium channel ligands and privileged structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Transient receptor potential melastatin 8 channel involvement in the regulation of vascular tone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Neuropathic pain: a clinical perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Pathobiology of neuropathic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

TRPA1 in bradykinin-induced mechanical hypersensitivity of vagal C fibers in guinea pig esophagus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Identification of a cold receptor reveals a general role for TRP channels in thermosensation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

A TRP channel that senses cold stimuli and menthol

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Attenuated cold sensitivity in TRPM8 null mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Involvement of increased expression of transient receptor potential melastatin 8 in oxaliplatin-induced cold allodynia in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Attenuation of mechanical hypersensitivity by an antagonist of the TRPA1 ion channel in diabetic animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Body-temperature maintenance as the predominant function of the vanilloid receptor TRPV1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

Pore dilation occurs in TRPA1 but not in TRPM8 channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903393771

10.1517/13543770903393771

21 January 2018

Identifiers

DOI

1 reference

21 August 2017

1 reference

PubMed ID

19939193