BRACking news on triple-negative/basal-like breast cancers: how BRCA1 deficiency may result in the development of a selective tumor subtype (Q37958686)

25 August 2017

BRACking news on triple-negative/basal-like breast cancers: how BRCA1 deficiency may result in the development of a selective tumor subtype (English)

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25 August 2017

1

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25 August 2017

Roberta Maestro

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publication date

1 June 2012

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Cancer and Metastasis Reviews

25 August 2017

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25 August 2017

31

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25 August 2017

1-2

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25 August 2017

131-142

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https://scigraph.springernature.com/pub.10.1007/s10555-011-9336-6

25 August 2017

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cites work

Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

BRCA1 transcriptionally regulates genes involved in breast tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

BRCA1 dysfunction in sporadic basal-like breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Cancer susceptibility and the functions of BRCA1 and BRCA2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

The relationship between the roles of BRCA genes in DNA repair and cancer predisposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Biallelic inactivation of BRCA2 in Fanconi anemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

The role of BRCA1 in the cellular response to chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Brca1-deficient murine mammary epithelial cells have increased sensitivity to CDDP and MMS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Premature senescence is a major response to DNA cross-linking agents in BRCA1-defective cells: implication for tailored treatments of BRCA1 mutation carriers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Genomic profiling of breast tumours in relation to BRCA abnormalities and phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

The pathology of familial breast cancer: predictive value of immunohistochemical markers estrogen receptor, progesterone receptor, HER-2, and p53 in patients with mutations in BRCA1 and BRCA2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Germline BRCA1 mutations and a basal epithelial phenotype in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Hallmarks of 'BRCAness' in sporadic cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Repeated observation of breast tumor subtypes in independent gene expression data sets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Prediction of BRCA1 status in patients with breast cancer using estrogen receptor and basal phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Phenotypic characterization of BRCA1 and BRCA2 tumors based in a tissue microarray study with 37 immunohistochemical markers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Vimentin and laminin expression is associated with basal-like phenotype in both sporadic and BRCA1-associated breast carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Multifactorial analysis of differences between sporadic breast cancers and cancers involving BRCA1 and BRCA2 mutations

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

A mouse model of basal-like breast carcinoma with metaplastic elements

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

The basal-like mammary carcinomas induced by Brca1 or Bard1 inactivation implicate the BRCA1/BARD1 heterodimer in tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Triple-negative breast cancer: distinguishing between basal and nonbasal subtypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Basal-like breast cancer defined by five biomarkers has superior prognostic value than triple-negative phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

BRCA1 interacts with components of the histone deacetylase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

CBP/p300 interact with and function as transcriptional coactivators of BRCA1

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

An hGCN5/TRRAP histone acetyltransferase complex co-activates BRCA1 transactivation function through histone modification

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

BRD7, a subunit of SWI/SNF complexes, binds directly to BRCA1 and regulates BRCA1-dependent transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

The role of BRCA1 in transcriptional regulation and cell cycle control

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

BRCA1 and its toolbox for the maintenance of genome integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

BRCA1 induces DNA damage recognition factors and enhances nucleotide excision repair.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Transcriptional autoregulation by BRCA1.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Evidence for a transcriptional activation function of BRCA1 C-terminal region

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

BRCA1 is a component of the RNA polymerase II holoenzyme

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

BRCA1 Associates with Processive RNA Polymerase II

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

BRCA1: a locus-specific "liaison" in gene expression and genetic integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

BRCA1/BARD1 inhibition of mRNA 3' processing involves targeted degradation of RNA polymerase II.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

BRCA1/BARD1 ubiquitinate phosphorylated RNA polymerase II.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

BRCA1 modulates the expression of hnRNPA2B1 and KHSRP.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

The RNA-binding protein KSRP promotes decay of beta-catenin mRNA and is inactivated by PI3K-AKT signaling

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Messenger-RNA-binding proteins and the messages they carry

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Estrogen receptors: how do they signal and what are their targets

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Is estradiol a genotoxic mutagenic carcinogen?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Estrogen-induced reactive oxygen species-mediated signalings contribute to breast cancer

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Tamoxifen and risk of contralateral breast cancer in BRCA1 and BRCA2 mutation carriers: a case-control study. Hereditary Breast Cancer Clinical Study Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

BRCA1 in hormonal carcinogenesis: basic and clinical research

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

BRCA1 mediates ligand-independent transcriptional repression of the estrogen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Regulation of the estrogen-inducible gene expression profile by the breast cancer susceptibility gene BRCA1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

The complex relationship between BRCA1 and ERalpha in hereditary breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Molecular basis for estrogen receptor alpha deficiency in BRCA1-linked breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Re: Molecular basis for estrogen receptor alpha deficiency in BRCA1-linked breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Activation of mitogen-activated protein kinase in estrogen receptor alpha-positive breast cancer cells in vitro induces an in vivo molecular phenotype of estrogen receptor alpha-negative human breast tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Reversal of the estrogen receptor negative phenotype in breast cancer and restoration of antiestrogen response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

The micro-ribonucleic acid (miRNA) miR-206 targets the human estrogen receptor-alpha (ERalpha) and represses ERalpha messenger RNA and protein expression in breast cancer cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

miR-22 inhibits estrogen signaling by directly targeting the estrogen receptor alpha mRNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Insulin-like growth factor-I inhibits progesterone receptor expression in breast cancer cells via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway: progesterone receptor as a potential indicator of growth factor activity i

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Insulin-like growth factor (IGF)-system mRNA quantities in normal and tumor breast tissue of women with sporadic and familial breast cancer risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Basal cytokeratin and epidermal growth factor receptor expression are not predictive of BRCA1 mutation status in women with triple-negative breast cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Loss of BRCA1 leads to an increase in epidermal growth factor receptor expression in mammary epithelial cells, and epidermal growth factor receptor inhibition prevents estrogen receptor-negative cancers in BRCA1-mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

BRCA1 represses amphiregulin gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Autocrine and juxtacrine effects of amphiregulin on the proliferative, invasive, and migratory properties of normal and neoplastic human mammary epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Altered proliferation and differentiation properties of primary mammary epithelial cells from BRCA1 mutation carriers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Elevated insulin-like growth factor-I receptor (IGF-IR) levels in primary breast tumors associated with BRCA1 mutations

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Regulation of breast cancer metastasis by IGF signaling

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Insulin-like growth factor-I activates gene transcription programs strongly associated with poor breast cancer prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Insulin-like growth factor 1 (IGF-1)-induced twist expression is involved in the anti-apoptotic effects of the IGF-1 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Insulin-like growth factor-I-dependent up-regulation of ZEB1 drives epithelial-to-mesenchymal transition in human prostate cancer cells

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Epithelial-mesenchymal transition in breast cancer relates to the basal-like phenotype

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

P-cadherin expression as a prognostic biomarker in a 3992 case tissue microarray series of breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

BRCA1 transcriptionally regulates genes associated with the basal-like phenotype in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Placental cadherin and the basal epithelial phenotype of BRCA1-related breast cancer

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Prospective identification of tumorigenic breast cancer cells

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

CD44+/CD24- breast cancer cells exhibit enhanced invasive properties: an early step necessary for metastasis

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

The CD44+/CD24- phenotype is enriched in basal-like breast tumors

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Depletion of BRCA1 impairs differentiation but enhances proliferation of mammary epithelial cells

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

BRCA1 regulates human mammary stem/progenitor cell fate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Genetic predisposition directs breast cancer phenotype by dictating progenitor cell fate

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Slug is a direct Notch target required for initiation of cardiac cushion cellularization

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

A novel lung metastasis signature links Wnt signaling with cancer cell self-renewal and epithelial-mesenchymal transition in basal-like breast cancer

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

ERalpha signaling through slug regulates E-cadherin and EMT.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

The epithelial-mesenchymal transition generates cells with properties of stem cells

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

p63 and the epithelial stem cell: more than status quo?

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

p53/p63/p73 isoforms: an orchestra of isoforms to harmonise cell differentiation and response to stress.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

p63 induces key target genes required for epidermal morphogenesis

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

p63 Is essential for the proliferative potential of stem cells in stratified epithelia

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Loss of p63 expression is associated with tumor progression in bladder cancer

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Tumor-specific p73 up-regulation mediates p63 dependence in squamous cell carcinoma

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

p63 correlates with both BRCA1 and cytokeratin 5 in invasive breast carcinomas: further evidence for the pathogenesis of the basal phenotype of breast cancer.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

The p63/p73 network mediates chemosensitivity to cisplatin in a biologically defined subset of primary breast cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

The DeltaNp63 proteins are key allies of BRCA1 in the prevention of basal-like breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Breast cancer subtype approximated by estrogen receptor, progesterone receptor, and HER-2 is associated with local and distant recurrence after breast-conserving therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Triple-negative breast cancer: disease entity or title of convenience?

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Triple-Negative Breast Cancer

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Effect of BRCA1/2 mutation on short-term and long-term breast cancer survival: a systematic review and meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Clinical outcome of triple negative breast cancer in BRCA1 mutation carriers and noncarriers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Incidence and outcome of BRCA mutations in unselected patients with triple receptor-negative breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

BRCA1 mutations contribute to cell motility and invasion by affecting its main regulators.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

BRCA1 modulates malignant cell behavior, the expression of survivin and chemosensitivity in human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

High IGF-IR activity in triple-negative breast cancer cell lines and tumorgrafts correlates with sensitivity to anti-IGF-IR therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Nuclear Snail1 and nuclear ZEB1 protein expression in invasive and intraductal human breast carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

The basal-like breast carcinoma phenotype is regulated by SLUG gene expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Heterogeneity for stem cell-related markers according to tumor subtype and histologic stage in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

X chromosomal abnormalities in basal-like human breast cancer

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

BRCA1 supports XIST RNA concentration on the inactive X chromosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

Transcriptional activation by BRCA1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-011-9336-6

10.1007/S10555-011-9336-6

21 January 2018

Identifiers

DOI

1 reference

25 August 2017

1 reference

PubMed ID

22101651