Parkinson's disease and cancer: two wars, one front (Q37948585)

25 August 2017

Parkinson's disease and cancer: two wars, one front (English)

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25 August 2017

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Michael J Devine

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25 August 2017

Hélène Plun-Favreau

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2

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25 August 2017

Nicholas W Wood

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3

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25 August 2017

language of work or name

English

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publication date

24 October 2011

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25 August 2017

Nature Reviews Cancer

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25 August 2017

11

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25 August 2017

11

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25 August 2017

812-823

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https://scigraph.springernature.com/pub.10.1038/nrc3150

25 August 2017

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cites work

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

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Alpha-synuclein in Lewy bodies

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Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

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Genome-wide association study reveals genetic risk underlying Parkinson's disease

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Genetic analysis of pathways to Parkinson disease

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Hallmarks of Cancer: The Next Generation

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Patterns of somatic mutation in human cancer genomes

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The roles of intracellular protein-degradation pathways in neurodegeneration

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Neuronal pathology in Parkinson's disease

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Altered proteasomal function in sporadic Parkinson's disease

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Shaping genetic alterations in human cancer: the p53 mutation paradigm

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p53 regulation by ubiquitin

31 March 2020

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p53, a transformation-related cellular-encoded protein, can be used as a biochemical marker for the detection of primary mouse tumor cells

31 March 2020

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Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion

31 March 2020

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Gain of function of mutant p53 by coaggregation with multiple tumor suppressors

31 March 2020

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Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

31 March 2020

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Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

31 March 2020

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Ubiquitin, proteasome and parkin

31 March 2020

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S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function

31 March 2020

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Dopamine covalently modifies and functionally inactivates parkin

31 March 2020

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Inactivation of parkin by oxidative stress and C-terminal truncations: a protective role of molecular chaperones

31 March 2020

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Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin

31 March 2020

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Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy

31 March 2020

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Mutations in PINK1 and Parkin impair ubiquitination of Mitofusins in human fibroblasts

31 March 2020

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Allelic imbalance of chromosome 6q in ovarian tumours

31 March 2020

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M6P/IGF2R is mutated in squamous cell carcinoma of the lung

31 March 2020

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Parkin, a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25-q27

31 March 2020

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Somatic mutations of the Parkinson's disease-associated gene PARK2 in glioblastoma and other human malignancies

31 March 2020

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Deciphering the role of heterozygous mutations in genes associated with parkinsonism

31 March 2020

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Parkin enhances the expression of cyclin-dependent kinase 6 and negatively regulates the proliferation of breast cancer cells

31 March 2020

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Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease.

31 March 2020

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Role of the aggresome pathway in cancer: targeting histone deacetylase 6-dependent protein degradation

31 March 2020

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Parkin-mediated K63-linked polyubiquitination: a signal for targeting misfolded proteins to the aggresome-autophagy pathway.

31 March 2020

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The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress

31 March 2020

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Interactions of Wnt/beta-catenin signaling and sonic hedgehog regulate the neurogenesis of ventral midbrain dopamine neurons

31 March 2020

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Cyclin-dependent kinase 5 is essential for neuronal cell cycle arrest and differentiation

31 March 2020

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Cycling at the interface between neurodevelopment and neurodegeneration

31 March 2020

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Somatic mitochondrial DNA mutations in cortex and substantia nigra in aging and Parkinson's disease

31 March 2020

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High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease

31 March 2020

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Mitochondrial DNA damage and repair in neurodegenerative disorders

31 March 2020

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Expression of cyclin E in postmitotic neurons during development and in the adult mouse brain

31 March 2020

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Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity

31 March 2020

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Cdk5: multitasking between physiological and pathological conditions

31 March 2020

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The pRb/E2F cell-cycle pathway mediates cell death in Parkinson's disease

31 March 2020

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Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death.

31 March 2020

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FBXO7 mutations cause autosomal recessive, early-onset parkinsonian-pyramidal syndrome

31 March 2020

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The SCF ubiquitin ligase: an extended look

31 March 2020

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Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6.

31 March 2020

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The F-box protein Fbxo7 interacts with human inhibitor of apoptosis protein cIAP1 and promotes cIAP1 ubiquitination

31 March 2020

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Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

31 March 2020

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DJ-1 decreases Bax expression through repressing p53 transcriptional activity

31 March 2020

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Loss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6.

31 March 2020

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Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

31 March 2020

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The functions of animal microRNAs

31 March 2020

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Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression

31 March 2020

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Targeting microRNAs in cancer: rationale, strategies and challenges

31 March 2020

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Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

31 March 2020

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Mitochondrial complex I deficiency in Parkinson's disease

31 March 2020

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Chronic systemic pesticide exposure reproduces features of Parkinson's disease

31 March 2020

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On the Origin of Cancer Cells

31 March 2020

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Therapy mediated by mitophagy abrogates tumor progression

31 March 2020

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Involvement of mitophagy in oncogenic K-Ras-induced transformation: overcoming a cellular energy deficit from glucose deficiency

31 March 2020

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Hereditary early-onset Parkinson's disease caused by mutations in PINK1

31 March 2020

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PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1

31 March 2020

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Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

31 March 2020

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Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

31 March 2020

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Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin

31 March 2020

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Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

31 March 2020

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Parallel high-throughput RNA interference screens identify PINK1 as a potential therapeutic target for the treatment of DNA mismatch repair-deficient cancers

31 March 2020

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Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.

31 March 2020

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DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation

31 March 2020

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DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2

31 March 2020

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RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways

31 March 2020

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Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics

31 March 2020

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Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1.

31 March 2020

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Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation

31 March 2020

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Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin

31 March 2020

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DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras

31 March 2020

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Upstream and downstream of mTOR

31 March 2020

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Targeting the phosphoinositide 3-kinase pathway in cancer

31 March 2020

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LRRK2 gene variation and its contribution to Parkinson disease

31 March 2020

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The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease

31 March 2020

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Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila

31 March 2020

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eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans

31 March 2020

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The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation

31 March 2020

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LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: impairment of the kinase activity by Parkinson's disease-associated mutations

31 March 2020

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Chromosomal amplification of leucine-rich repeat kinase-2 (LRRK2) is required for oncogenic MET signaling in papillary renal and thyroid carcinomas

31 March 2020

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AKT activity determines sensitivity to mammalian target of rapamycin (mTOR) inhibitors by regulating cyclin D1 and c-myc expression

31 March 2020

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Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss.

31 March 2020

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A new cytosolic pathway from a Parkinson disease-associated kinase, BRPK/PINK1: activation of AKT via mTORC2

31 March 2020

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Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway.

31 March 2020

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Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

31 March 2020

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DJ-1, a novel regulator of the tumor suppressor PTEN.

31 March 2020

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Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling

31 March 2020

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DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway.

31 March 2020

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Macrophage diversity enhances tumor progression and metastasis

31 March 2020

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Immunity, Inflammation, and Cancer

31 March 2020

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Gaucher disease: new molecular approaches to diagnosis and treatment

31 March 2020

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Increased risk of cancer in patients with Gaucher disease

31 March 2020

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Increased incidence of cancer in adult Gaucher disease in Western Europe

31 March 2020

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Pro-inflammatory cytokines and the pathogenesis of Gaucher's disease: increased release of interleukin-6 and interleukin-10.

31 March 2020

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The role of glucocerebrosidase mutations in Parkinson disease and Lewy body disorders

31 March 2020

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Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease

31 March 2020

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ER retention and degradation as the molecular basis underlying Gaucher disease heterogeneity

31 March 2020

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Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

31 March 2020

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Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies

31 March 2020

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Alpha-synuclein-glucocerebrosidase interactions in pharmacological Gaucher models: a biological link between Gaucher disease and parkinsonism.

31 March 2020

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Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

31 March 2020

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Microglial activation with atypical proinflammatory cytokine expression in a rat model of Parkinson's disease

31 March 2020

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Caspase signalling controls microglia activation and neurotoxicity.

31 March 2020

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Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs.

31 March 2020

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Constructing and deconstructing stem cell models of neurological disease

31 March 2020

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Somatic and germline mosaicism in sporadic early-onset Alzheimer's disease

31 March 2020

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Presenile dementia associated with mosaic trisomy 21 in a patient with a Down syndrome child

31 March 2020

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Prognostic factors for the progression of Parkinson's disease: a systematic review

31 March 2020

1 reference

Origin of life: The RNA world

31 March 2020

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Progress in the war on cancer

31 March 2020

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The evolving war on cancer

31 March 2020

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Low cancer rates among patients with Parkinson's disease

31 March 2020

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Occurrence of different cancers in patients with Parkinson's disease

31 March 2020

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Mortality and cancer incidence in patients with Parkinson's disease

31 March 2020

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A meta-analysis of coffee drinking, cigarette smoking, and the risk of Parkinson's disease

31 March 2020

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Atypical cancer pattern in patients with Parkinson's disease.

31 March 2020

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Parkinson's disease and cancer risk: a systematic review and meta-analysis

31 March 2020

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Meta-analysis of the relationship between Parkinson disease and melanoma

31 March 2020

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Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease

31 March 2020

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Targeting cancer with small molecule kinase inhibitors

31 March 2020

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Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease

31 March 2020

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Roscovitine confers tumor suppressive effect on therapy-resistant breast tumor cells

31 March 2020

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Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease

31 March 2020

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Targeting protein kinases in central nervous system disorders

31 March 2020

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Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease

31 March 2020

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Geldanamycin induces Hsp70 and prevents alpha-synuclein aggregation and toxicity in vitro

31 March 2020

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17-AAG induces cytoplasmic alpha-synuclein aggregate clearance by induction of autophagy

31 March 2020

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PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

31 March 2020

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Curcumin inhibits aggregation of alpha-synuclein

31 March 2020

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alpha-Synuclein is expressed in a variety of brain tumors showing neuronal differentiation.

31 March 2020

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Parkinson's disease-related protein, alpha-synuclein, in malignant melanoma

31 March 2020

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Synucleins are expressed in the majority of breast and ovarian carcinomas and in preneoplastic lesions of the ovary

31 March 2020

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The tumor suppressor UCHL1 forms a complex with p53/MDM2/ARF to promote p53 signaling and is frequently silenced in nasopharyngeal carcinoma.

31 March 2020

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Silencing of the UCHL1 gene in human colorectal and ovarian cancers.

31 March 2020

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CpG hypermethylation of the UCHL1 gene promoter is associated with pathogenesis and poor prognosis in renal cell carcinoma

31 March 2020

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Differential control of apoptosis by DJ-1 in prostate benign and cancer cells

31 March 2020

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An essay on the shaking palsy. 1817.

31 March 2020

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3,4-Dihydroxyphenylalanine and 5-hydroxytryptophan as reserpine antagonists

31 March 2020

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Distribution of noradrenaline and dopamine (3-hydroxytyramine) in the human brain and their behavior in diseases of the extrapyramidal system

31 March 2020

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Modification of Parkinsonism--chronic treatment with L-dopa

31 March 2020

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The ubiquitin pathway in Parkinson's disease.

31 March 2020

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Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

31 March 2020

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Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

31 March 2020

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Glucocerebrosidase mutations in subjects with parkinsonism

31 March 2020

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Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase

31 March 2020

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Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies

31 March 2020

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31 March 2020

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12 December 2020

Gaucher's disease: a disease with chronic stimulation of the immune system

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12 December 2020

The L-3,4-dioxyphenylalanine (DOPA)-effect in Parkinson-akinesia

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12 December 2020

Suppression of tumorigenicity of breast cancer cells by microcell-mediated chromosome transfer: studies on chromosomes 6 and 11

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12 December 2020

Limitations of cellular models in Parkinson's disease research

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12 December 2020

Synucleins are expressed in the majority of breast and ovarian carcinomas and in preneoplastic lesions of the ovary

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12 December 2020

Role of reactive oxygen species-dependent protein aggregation in metabolic stress-induced necrosis

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12 December 2020

Pathoanatomy of Parkinson's disease

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12 December 2020

Definition of a commonly deleted region in ovarian cancers to a 300-kb segment of chromosome 6q27.

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12 December 2020

p53-dependent neuronal cell death in a DJ-1-deficient zebrafish model of Parkinson's disease.

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12 December 2020

Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form

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12 December 2020

Proteomic profiling drug-induced apoptosis in non-small cell lung carcinoma: identification of RS/DJ-1 and RhoGDIalpha.

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12 December 2020

Aberrant protein folding as the molecular basis of cancer

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12 December 2020

Identifiers

DOI

10.1038/NRC3150

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25 August 2017

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