Canalicular ABC transporters and liver disease (Q37943784)

25 August 2017

Canalicular ABC transporters and liver disease (English)

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25 August 2017

5

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25 August 2017

Michael Nicolaou

1

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25 August 2017

Edward J Andress

2

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25 August 2017

Joseph K Zolnerciks

3

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25 August 2017

Peter H Dixon

4

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25 August 2017

Kenneth J Linton

6

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25 August 2017

1 January 2012

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25 August 2017

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25 August 2017

226

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25 August 2017

300-315

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25 August 2017

2

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Bile acids: chemistry, pathochemistry, biology, pathobiology, and therapeutics

25 August 2017

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The enzymes, regulation, and genetics of bile acid synthesis

21 January 2018

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The human bile salt export pump: characterization of substrate specificity and identification of inhibitors

21 January 2018

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21 January 2018

Bile acid biosynthesis

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The enterohepatic circulation of bile acids in mammals: form and functions

21 January 2018

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Enterohepatic bile salt transporters in normal physiology and liver disease

21 January 2018

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21 January 2018

Bile salt transporters

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Bile salt transporters: molecular characterization, function, and regulation

21 January 2018

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The sodium bile salt cotransport family SLC10

21 January 2018

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Radiation-inactivation analysis of the Na+/bile acid co-transport system from rabbit ileum

21 January 2018

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Molecular cloning, tissue distribution, and expression of a 14-kDa bile acid-binding protein from rat ileal cytosol

21 January 2018

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The heteromeric organic solute transporter alpha-beta, Ostalpha-Ostbeta, is an ileal basolateral bile acid transporter

21 January 2018

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Functional Complementation between a Novel Mammalian Polygenic Transport Complex and an Evolutionarily Ancient Organic Solute Transporter, OSTα-OSTβ

21 January 2018

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Organic solute transporter, OSTalpha-OSTbeta: its role in bile acid transport and cholestasis

21 January 2018

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21 January 2018

Bile acid transporters

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Hepatic transport of bile salts

21 January 2018

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Molecular cloning, chromosomal localization, and functional characterization of a human liver Na+/bile acid cotransporter

21 January 2018

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Substrate specificities of rat oatp1 and ntcp: implications for hepatic organic anion uptake

21 January 2018

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Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties

21 January 2018

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Bile acid transporters: structure, function, regulation and pathophysiological implications

21 January 2018

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The superfamily of organic anion transporting polypeptides

21 January 2018

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Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver

21 January 2018

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Identification of glutathione as a driving force and leukotriene C4 as a substrate for oatp1, the hepatic sinusoidal organic solute transporter.

21 January 2018

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Organic anion transporting polypeptide mediates organic anion/HCO3- exchange

21 January 2018

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Further characterization of the electrogenicity and pH sensitivity of the human organic anion-transporting polypeptides OATP1B1 and OATP1B3.

21 January 2018

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Intracellular transport of bile acids

21 January 2018

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21 January 2018

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Trafficking and transporter disorders in pediatric cholestasis

21 January 2018

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Rat liver canalicular membrane vesicles contain an ATP-dependent bile acid transport system

21 January 2018

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ATP-dependent bile-salt transport in canalicular rat liver plasma-membrane vesicles

21 January 2018

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The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver

21 January 2018

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A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis

21 January 2018

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Functional expression of the canalicular bile salt export pump of human liver

21 January 2018

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Targeted inactivation of sister of P-glycoprotein gene (spgp) in mice results in nonprogressive but persistent intrahepatic cholestasis

21 January 2018

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Bile acid transport in sister of P-glycoprotein (ABCB11) knockout mice

21 January 2018

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Expression and localization of hepatobiliary transport proteins in progressive familial intrahepatic cholestasis

21 January 2018

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Bile Salt Export Pump Gene Mutations in Two Japanese Patients With Progressive Familial Intrahepatic Cholestasis

21 January 2018

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Hepatocanalicular bile salt export pump deficiency in patients with progressive familial intrahepatic cholestasis

21 January 2018

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Benign recurrent intrahepatic cholestasis type 2 is caused by mutations in ABCB11

21 January 2018

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Missense mutations and single nucleotide polymorphisms in ABCB11 impair bile salt export pump processing and function or disrupt pre-messenger RNA splicing

21 January 2018

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Progressive familial intrahepatic cholestasis

21 January 2018

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Progressive familial intrahepatic cholestasis (PFIC) type 1, 2, and 3: a review of the liver pathology findings

21 January 2018

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A patient with novel ABCB11 gene mutations with phenotypic transition between BRIC2 and PFIC2.

21 January 2018

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Impaired expression and function of the bile salt export pump due to three novel ABCB11 mutations in intrahepatic cholestasis

21 January 2018

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Contribution of variant alleles of ABCB11 to susceptibility to intrahepatic cholestasis of pregnancy

21 January 2018

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Sequence analysis of bile salt export pump (ABCB11) and multidrug resistance p-glycoprotein 3 (ABCB4, MDR3) in patients with intrahepatic cholestasis of pregnancy

21 January 2018

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Genetic variability, haplotype structures, and ethnic diversity of hepatic transporters MDR3 (ABCB4) and bile salt export pump (ABCB11).

21 January 2018

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Enterohepatic transport of bile salts and genetics of cholestasis

21 January 2018

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Increased susceptibility for intrahepatic cholestasis of pregnancy and contraceptive-induced cholestasis in carriers of the 1331T>C polymorphism in the bile salt export pump

21 January 2018

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Potential role of trans-inhibition of the bile salt export pump by progesterone metabolites in the etiopathogenesis of intrahepatic cholestasis of pregnancy

21 January 2018

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Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver

21 January 2018

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Hepatocellular carcinoma in ten children under five years of age with bile salt export pump deficiency

21 January 2018

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Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

21 January 2018

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MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine

21 January 2018

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Hepatocyte-specific expression of the human MDR3 P-glycoprotein gene restores the biliary phosphatidylcholine excretion absent in Mdr2 (-/-) mice.

21 January 2018

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The wide spectrum of multidrug resistance 3 deficiency: from neonatal cholestasis to cirrhosis of adulthood

21 January 2018

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ABCB4 gene sequence variation in women with intrahepatic cholestasis of pregnancy.

21 January 2018

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Function and pathophysiological importance of ABCB4 (MDR3 P-glycoprotein).

21 January 2018

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MDR3 gene defect in adults with symptomatic intrahepatic and gallbladder cholesterol cholelithiasis

21 January 2018

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Heterozygous non-sense mutation of the MDR3 gene in familial intrahepatic cholestasis of pregnancy

21 January 2018

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Multidrug resistance 3 gene mutation 1712delT and estrogen receptor alpha gene polymorphisms in Finnish women with obstetric cholestasis

21 January 2018

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A second heterozygous MDR3 nonsense mutation associated with intrahepatic cholestasis of pregnancy

21 January 2018

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Heterozygous MDR3 missense mutation associated with intrahepatic cholestasis of pregnancy: evidence for a defect in protein trafficking

21 January 2018

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A missense mutation in ABCB4 gene involved in progressive familial intrahepatic cholestasis type 3 leads to a folding defect that can be rescued by low temperature.

21 January 2018

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Complementary functions of the flippase ATP8B1 and the floppase ABCB4 in maintaining canalicular membrane integrity.

21 January 2018

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A gene encoding a P-type ATPase mutated in two forms of hereditary cholestasis

21 January 2018

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ATP8B1 requires an accessory protein for endoplasmic reticulum exit and plasma membrane lipid flippase activity

21 January 2018

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Familial intrahepatic cholestasis 1: studies of localization and function

21 January 2018

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ATP8B1 mutations in British cases with intrahepatic cholestasis of pregnancy.

21 January 2018

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Sequence variation in the ATP8B1 gene and intrahepatic cholestasis of pregnancy

21 January 2018

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Characterization of mutations in ATP8B1 associated with hereditary cholestasis

21 January 2018

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ATP8B1 is essential for maintaining normal hearing

21 January 2018

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Recurrent familial intrahepatic cholestasis in the Faeroe Islands. Phenotypic heterogeneity but genetic homogeneity

21 January 2018

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EASL Clinical Practice Guidelines: management of cholestatic liver diseases.

21 January 2018

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Ursodeoxycholic acid 'mechanisms of action and clinical use in hepatobiliary disorders'.

21 January 2018

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Ursodeoxycholic acid treatment in children with Byler disease

21 January 2018

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Liver disease associated with canalicular transport defects: current and future therapies

21 January 2018

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Use of rifampin for severe pruritus in children with chronic cholestasis

21 January 2018

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Effect of cholestyramine on bile acid metabolism in normal man

21 January 2018

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Selective surgical management of progressive familial intrahepatic cholestasis (Byler's disease).

21 January 2018

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Nasobiliary drainage induces long-lasting remission in benign recurrent intrahepatic cholestasis

21 January 2018

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Allograft steatohepatitis in progressive familial intrahepatic cholestasis type 1 after living donor liver transplantation.

21 January 2018

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De novo bile salt transporter antibodies as a possible cause of recurrent graft failure after liver transplantation: a novel mechanism of cholestasis

21 January 2018

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Membrane phosphatidylserine distribution as a non-apoptotic signalling mechanism in lymphocytes

21 January 2018

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Membrane lipids: where they are and how they behave

21 January 2018

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A flippase-independent function of ATP8B1, the protein affected in familial intrahepatic cholestasis type 1, is required for apical protein expression and microvillus formation in polarized epithelial cells

21 January 2018

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Hepatic secretion of phospholipid vesicles in the mouse critically depends on mdr2 or MDR3 P-glycoprotein expression. Visualization by electron microscopy

21 January 2018

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"Don't know much bile-ology"

21 January 2018

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Nuclear orphan receptors control cholesterol catabolism.

21 January 2018

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Identification of a nuclear receptor for bile acids

21 January 2018

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A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

21 January 2018

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Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors

21 January 2018

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Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor.

21 January 2018

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Farnesoid X Receptor Activates Transcription of the Phospholipid Pump MDR3

21 January 2018

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Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface

21 January 2018

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NPC1L1 and cholesterol transport

21 January 2018

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Comparison of intestinal absorption of cholesterol with different plant sterols in man.

21 January 2018

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Metabolism of beta-sitosterol in man.

21 January 2018

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Mapping a gene involved in regulating dietary cholesterol absorption. The sitosterolemia locus is found at chromosome 2p21

21 January 2018

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Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption

21 January 2018

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Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters

21 January 2018

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Phytosterolaemia, xanthomatosis and premature atherosclerotic arterial disease: a case with high plant sterol absorption, impaired sterol elimination and low cholesterol synthesis

21 January 2018

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Rapid quantification of free and esterified phytosterols in human serum using APPI-LC-MS/MS.

21 January 2018

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Specificity of the commonly used enzymatic assay for plasma cholesterol determination

21 January 2018

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Sitosterolemia--a rare disease. Are elevated plant sterols an additional risk factor?

21 January 2018

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β-Sitosterolemia and Xanthomatosis

21 January 2018

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Stomatocytic haemolysis and macrothrombocytopenia (Mediterranean stomatocytosis/macrothrombocytopenia) is the haematological presentation of phytosterolaemia

21 January 2018

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Intestinal cholesterol absorption inhibitor ezetimibe added to cholestyramine for sitosterolemia and xanthomatosis.

21 January 2018

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No association between plasma levels of plant sterols and atherosclerosis in mice and men.

21 January 2018

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Sitosterol-containing lipoproteins trigger free sterol-induced caspase-independent death in ACAT-competent macrophages

21 January 2018

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Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes

21 January 2018

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Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene

21 January 2018

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A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome

21 January 2018

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Single nucleotide polymorphisms in multidrug resistance associated protein 2 (MRP2/ABCC2): its impact on drug disposition

21 January 2018

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Chronic idiopathic jaundice with unidentified pigment in liver cells; a new clinicopathologic entity with a report of 12 cases

21 January 2018

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Characterization of mice lacking the multidrug resistance protein MRP2 (ABCC2).

21 January 2018

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Effect of ABCC2 (MRP2) transport function on erythromycin metabolism

21 January 2018

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Functionally overlapping roles of Abcg2 (Bcrp1) and Abcc2 (Mrp2) in the elimination of methotrexate and its main toxic metabolite 7-hydroxymethotrexate in vivo

21 January 2018

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Effects of cytochrome P450 3A (CYP3A) and the drug transporters P-glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) on the pharmacokinetics of lopinavir

21 January 2018

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Individual and combined roles of CYP3A, P-glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) in the pharmacokinetics of docetaxel

21 January 2018

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P-glycoprotein (P-gp/Abcb1), Abcc2, and Abcc3 determine the pharmacokinetics of etoposide

21 January 2018

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A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

21 January 2018

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A multidrug resistance transporter from human MCF-7 breast cancer cells

21 January 2018

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Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2)

21 January 2018

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Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

21 January 2018

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Localization of the ABCG2 mitoxantrone resistance-associated protein in normal tissues.

21 January 2018

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The breast cancer resistance protein transporter ABCG2 is expressed in the human kidney proximal tubule apical membrane.

21 January 2018

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Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites

21 January 2018

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Localisation of breast cancer resistance protein in microvessel endothelium of human brain

21 January 2018

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The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype

21 January 2018

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Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells

21 January 2018

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Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

21 January 2018

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The physiological function of drug-transporting P-glycoproteins

21 January 2018

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The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria.

21 January 2018

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Physiological and pharmacological roles of ABCG2 (BCRP): recent findings in Abcg2 knockout mice

21 January 2018

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Involvement of breast cancer resistance protein (ABCG2) in the biliary excretion mechanism of fluoroquinolones.

21 January 2018

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The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues

21 January 2018

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A "silent" polymorphism in the MDR1 gene changes substrate specificity

21 January 2018

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FIC1 and BSEP defects in Taiwanese patients with chronic intrahepatic cholestasis with low γ-glutamyltranspeptidase levels

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/PATH.3019

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25 August 2017

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