Haploinsufficiency in mouse models of DNA repair deficiency: modifiers of penetrance (Q37939634)

25 August 2017

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title

Haploinsufficiency in mouse models of DNA repair deficiency: modifiers of penetrance (English)

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25 August 2017

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Diane C Cabelof

1

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25 August 2017

publication date

28 September 2011

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Cellular and Molecular Life Sciences

25 August 2017

published in

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25 August 2017

volume

69

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25 August 2017

issue

5

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25 August 2017

page(s)

727-740

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https://scigraph.springernature.com/pub.10.1007/s00018-011-0839-7

25 August 2017

exact match

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cites work

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Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage

21 January 2018

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Haploinsufficiency of poly(ADP-ribose) polymerase-1-mediated poly(ADP-ribosyl)ation for centrosome duplication.

21 January 2018

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Mutagenesis is elevated in male germ cells obtained from DNA polymerase-beta heterozygous mice

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DNA polymerase beta is critical for genomic stability of sperm cells

21 January 2018

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Imbalanced base excision repair in response to folate deficiency is accelerated by polymerase beta haploinsufficiency

21 January 2018

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Folate deficiency provides protection against colon carcinogenesis in DNA polymerase beta haploinsufficient mice

21 January 2018

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Haploinsufficiency in DNA polymerase beta increases cancer risk with age and alters mortality rate.

21 January 2018

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Ku80 deletion suppresses spontaneous tumors and induces a p53-mediated DNA damage response

21 January 2018

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Spontaneous mutagenesis is enhanced in Apex heterozygous mice

21 January 2018

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Folate deficiency regulates expression of DNA polymerase β in response to oxidative stress

21 January 2018

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Mouse models of XRCC1 DNA repair polymorphisms and cancer

21 January 2018

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Aag-initiated base excision repair drives alkylation-induced retinal degeneration in mice

21 January 2018

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Novel nuclear and mitochondrial glycosylases revealed by disruption of the mouse Nth1 gene encoding an endonuclease III homolog for repair of thymine glycols

21 January 2018

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Targeted deletion of mNth1 reveals a novel DNA repair enzyme activity.

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Requirement of mammalian DNA polymerase-beta in base-excision repair.

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Requirement for the Xrcc1 DNA base excision repair gene during early mouse development

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Rescue of Xrcc1 knockout mouse embryo lethality by transgene-complementation.

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Base excision repair deficient mice lacking the Aag alkyladenine DNA glycosylase.

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Characterization of defective nucleotide excision repair in XPC mutant mice

21 January 2018

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XPC is involved in genome maintenance through multiple pathways in different tissues.

21 January 2018

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Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA.

21 January 2018

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Mice with DNA repair gene (ERCC-1) deficiency have elevated levels of p53, liver nuclear abnormalities and die before weaning

21 January 2018

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Increased genomic instability is not a prerequisite for shortened lifespan in DNA repair deficient mice

21 January 2018

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DNA repair and tumorigenesis: lessons from hereditary cancer syndromes

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Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

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Meiotic pachytene arrest in MLH1-deficient mice

21 January 2018

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Roles of MGMT and MLH1 proteins in alkylation-induced apoptosis and mutagenesis

21 January 2018

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Mutation in the mismatch repair gene Msh6 causes cancer susceptibility

21 January 2018

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Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over

21 January 2018

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Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis

21 January 2018

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Collaboration and competition between DNA double‐strand break repair pathways

21 January 2018

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Rad21-cohesin haploinsufficiency impedes DNA repair and enhances gastrointestinal radiosensitivity in mice

21 January 2018

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Xrcc2 is required for genetic stability, embryonic neurogenesis and viability in mice

21 January 2018

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Xrcc2 modulates spontaneous and radiation-induced tumorigenesis in Apcmin/+ mice.

21 January 2018

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V(D)J and immunoglobulin class switch recombinations: a paradigm to study the regulation of DNA end-joining.

21 January 2018

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Growth retardation and leaky SCID phenotype of Ku70-deficient mice.

21 January 2018

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Ku70 is required for DNA repair but not for T cell antigen receptor gene recombination In vivo

21 January 2018

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Mice lacking Alkbh1 display sex-ratio distortion and unilateral eye defects

21 January 2018

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Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA

21 January 2018

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Brca1 controls homology-directed DNA repair

21 January 2018

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BRCA2 is required for homology-directed repair of chromosomal breaks

21 January 2018

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Heterogenic loss of the wild-type BRCA allele in human breast tumorigenesis

21 January 2018

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Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development.

21 January 2018

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Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities

21 January 2018

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Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

21 January 2018

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Brca2 is required for embryonic cellular proliferation in the mouse

21 January 2018

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Brca1 heterozygous mice have shortened life span and are prone to ovarian tumorigenesis with haploinsufficiency upon ionizing irradiation.

21 January 2018

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Involvement of Brca2 in DNA repair

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-011-0839-7

Increased rates of spontaneous sister chromatid exchange in lymphocytes of BRCA2+/- carriers of familial breast cancer clusters

21 January 2018

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Expanded roles of the Fanconi anemia pathway in preserving genomic stability

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-011-0839-7

Inactivation of Palb2 gene leads to mesoderm differentiation defect and early embryonic lethality in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0839-7

Epithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout mice

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-011-0839-7

Fancm-deficient mice reveal unique features of Fanconi anemia complementation group M.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-011-0839-7

Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-011-0839-7

Beyond ATM: the protein kinase landscape of the DNA damage response

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-011-0839-7

A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-011-0839-7

Stage-specific apoptosis, developmental delay, and embryonic lethality in mice homozygous for a targeted disruption in the murine Bloom's syndrome gene

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-011-0839-7

Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0839-7

ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0839-7

Hemizygosity for Atm and Brca1 influence the balance between cell transformation and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0839-7

Heterozygosity for the mouse Apex gene results in phenotypes associated with oxidative stress.

21 January 2018

1 reference

12 December 2020

Passing the baton in base excision repair

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12 December 2020

Mouse models for hereditary nonpolyposis colorectal cancer

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12 December 2020

Targeted disruption of the DNA repair methyltransferase gene renders mice hypersensitive to alkylating agent

1 reference

12 December 2020

Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity

1 reference

12 December 2020

Base excision repair deficiency caused by polymerase beta haploinsufficiency: accelerated DNA damage and increased mutational response to carcinogens

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12 December 2020

Genetic interaction between HAP1/REF-1 and p53

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12 December 2020

Tumorigenesis in Mlh1 and Mlh1/Apc1638N mutant mice

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12 December 2020

DNA repair methyltransferase (Mgmt) knockout mice are sensitive to the lethal effects of chemotherapeutic alkylating agents

1 reference

12 December 2020

Ultraviolet B radiation-induced skin cancer in mice defective in the Xpc, Trp53, and Apex (HAP1) genes: genotype-specific effects on cancer predisposition and pathology of tumors

1 reference

12 December 2020

Enhanced intestinal adenomatous polyp formation in Pms2-/-;Min mice

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12 December 2020

XRCC1 haploinsufficiency in mice has little effect on aging, but adversely modifies exposure-dependent susceptibility

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12 December 2020

ATR disruption leads to chromosomal fragmentation and early embryonic lethality

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12 December 2020

Mammalian nucleotide excision repair proteins and interstrand crosslink repair

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12 December 2020

A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination

1 reference

12 December 2020

10.1007/S00018-011-0839-7

Identifiers

DOI

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25 August 2017

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