Acquired radioresistance of cancer and the AKT/GSK3β/cyclin D1 overexpression cycle (Q37924479)

25 August 2017

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title

Acquired radioresistance of cancer and the AKT/GSK3β/cyclin D1 overexpression cycle (English)

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25 August 2017

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Tsutomu Shimura

1

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25 August 2017

1 September 2011

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Journal of Radiation Research

25 August 2017

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25 August 2017

52

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25 August 2017

5

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25 August 2017

539-544

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On the reaction kinetics of the radioadaptive response in cultured mouse cells.

25 August 2017

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The DNA damage response: putting checkpoints in perspective

21 January 2018

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Regulation of the cellular DNA double-strand break response

21 January 2018

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The DNA damage response: ten years after

21 January 2018

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Checkpoints: controls that ensure the order of cell cycle events

21 January 2018

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Inhibitors of mammalian G1 cyclin-dependent kinases

21 January 2018

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Mammalian G1- and S-phase checkpoints in response to DNA damage

21 January 2018

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Regulation of p53 in response to DNA damage

21 January 2018

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G1 cell-cycle control and cancer

21 January 2018

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Distinct Initiation and Maintenance Mechanisms Cooperate to Induce G1 Cell Cycle Arrest in Response to DNA Damage

21 January 2018

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Genotoxic stress-induced cyclin D1 phosphorylation and proteolysis are required for genomic stability

21 January 2018

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Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

21 January 2018

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Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway

21 January 2018

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AKT/PKB signaling: navigating downstream

21 January 2018

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ATM is required for rapid degradation of cyclin D1 in response to gamma-irradiation

21 January 2018

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F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage

21 January 2018

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Cyclin D1 production in cycling cells depends on ras in a cell-cycle-specific manner

21 January 2018

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Nuclear accumulation of cyclin D1 during S phase inhibits Cul4-dependent Cdt1 proteolysis and triggers p53-dependent DNA rereplication

21 January 2018

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Cyclin D1-mediated inhibition of repair and replicative DNA synthesis in human fibroblasts.

21 January 2018

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Cyclin D1 inhibits cell proliferation through binding to PCNA and cdk2.

21 January 2018

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Characteristics of gamma-H2AX foci at DNA double-strand breaks sites

21 January 2018

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DNA-PK is involved in repairing a transient surge of DNA breaks induced by deceleration of DNA replication

21 January 2018

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Bloom's syndrome helicase and Mus81 are required to induce transient double-strand DNA breaks in response to DNA replication stress

21 January 2018

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PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival

21 January 2018

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Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase

21 January 2018

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Cyclin D1 and D3 associate with the SCF complex and are coordinately elevated in breast cancer

21 January 2018

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The protein kinase B/Akt signalling pathway in human malignancy

21 January 2018

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Activation of the PI3-K/AKT pathway and implications for radioresistance mechanisms in head and neck cancer

21 January 2018

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The life of a cell: apoptosis regulation by the PI3K/PKB pathway

21 January 2018

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The activation of Akt/PKB signaling pathway and cell survival.

21 January 2018

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Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt.

21 January 2018

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Apoptosis-modulating agents in combination with radiotherapy-current status and outlook

21 January 2018

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Novel therapeutics in combination with radiotherapy to improve cancer treatment: rationale, mechanisms of action and clinical perspective

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1269/JRR.11098

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25 August 2017

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PubMed ID

21881296