Wnt/Myc interactions in intestinal cancer: partners in crime (Q37919623)

25 August 2017

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title

Wnt/Myc interactions in intestinal cancer: partners in crime (English)

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25 August 2017

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2

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25 August 2017

Kevin Myant

1

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PubMed ID

21851818

25 August 2017

language of work or name

English

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publication date

7 August 2011

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Experimental Cell Research

25 August 2017

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25 August 2017

317

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25 August 2017

19

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25 August 2017

2725-2731

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Whole population cell kinetics of mouse duodenal, jejunal, ileal, and colonic epithelia as determined by radioautography and flow cytometry

25 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

Wnt/beta-catenin is essential for intestinal homeostasis and maintenance of intestinal stem cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

Dysregulated expression of beta-catenin marks early neoplastic change in Apc mutant mice, but not all lesions arising in Msh2 deficient mice.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

Canonical Wnt signals are essential for homeostasis of the intestinal epithelium

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

Crypt-restricted proliferation and commitment to the Paneth cell lineage following Apc loss in the mouse intestine.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

The Intestinal Wnt/TCF Signature.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

Non-transcriptional control of DNA replication by c-Myc

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

c-MYC: more than just a matter of life and death

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

The c-Myc target gene network

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

Global mapping of c-Myc binding sites and target gene networks in human B cells

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

Deregulation of c-myc gene expression in human colon carcinoma is not accompanied by amplification or rearrangement of the gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

Identification of c-MYC as a target of the APC pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

A beta-catenin/TCF-coordinated chromatin loop at MYC integrates 5' and 3' Wnt responsive enhancers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

Upregulation of c-MYC in cis through a large chromatin loop linked to a cancer risk-associated single-nucleotide polymorphism in colorectal cancer cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

c-Myc is required for the formation of intestinal crypts but dispensable for homeostasis of the adult intestinal epithelium

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

Modelling Myc inhibition as a cancer therapy

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

Myc deletion rescues Apc deficiency in the small intestine

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

Myc heterozygosity attenuates the phenotypes of APC deficiency in the small intestine.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

Intestinal adenoma formation and MYC activation are regulated by cooperation between MYB and Wnt signaling.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

Distinct thresholds govern Myc's biological output in vivo

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

Acute overexpression of Myc in intestinal epithelium recapitulates some but not all the changes elicited by Wnt/beta-catenin pathway activation

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

Endogenous Myc maintains the tumor microenvironment

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in ApcDelta716 mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

ERK activation drives intestinal tumorigenesis in Apc(min/+) mice

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

B-catenin deficiency, but not Myc deletion, suppresses the immediate phenotypes of APC loss in the liver

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

CIP2A inhibits PP2A in human malignancies

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

MYC-dependent regulation and prognostic role of CIP2A in gastric cancer.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

CIP2A is associated with human breast cancer aggressivity

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

F-box and WD repeat domain-containing 7 regulates intestinal cell lineage commitment and is a haploinsufficient tumor suppressor.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

The ubiquitin-specific protease USP28 is required for MYC stability

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

Development of a lung cancer therapeutic based on the tumor suppressor microRNA-34

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

Inhibition of intestinal polyposis with reduced angiogenesis in ApcMin/+ mice due to decreases in c-Myc expression.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2011.08.001

10.1016/J.YEXCR.2011.08.001

7 January 2021

Identifiers

DOI

1 reference

25 August 2017

1 reference

PubMed ID

21851818