Carbonic anhydrase inhibitors and activators for novel therapeutic applications (Q37909406)

25 August 2017

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title

Carbonic anhydrase inhibitors and activators for novel therapeutic applications (English)

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25 August 2017

1

Claudiu T Supuran

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25 August 2017

1 July 2011

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Future Medicinal Chemistry

25 August 2017

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25 August 2017

3

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25 August 2017

9

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25 August 2017

1165-1180

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Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

25 August 2017

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Carbonic anhydrase inhibitors

21 January 2018

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The alpha and beta classes carbonic anhydrases from Helicobacter pylori as novel drug targets

21 January 2018

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Carbonic anhydrase as a model for biophysical and physical-organic studies of proteins and protein-ligand binding

21 January 2018

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Structure and metal exchange in the cadmium carbonic anhydrase of marine diatoms

21 January 2018

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Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH.

21 January 2018

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Taking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies

21 January 2018

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Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX

21 January 2018

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Carbonic anhydrase in the scleractinian coral Stylophora pistillata: characterization, localization, and role in biomineralization

21 January 2018

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Carbonic anhydrases as targets for medicinal chemistry

21 January 2018

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Structural mechanics of the pH-dependent activity of beta-carbonic anhydrase from Mycobacterium tuberculosis

21 January 2018

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The gamma class of carbonic anhydrases

21 January 2018

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The archetype gamma-class carbonic anhydrase (Cam) contains iron when synthesized in vivo.

21 January 2018

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A role for iron in an ancient carbonic anhydrase

21 January 2018

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Sequestration of carbon dioxide by the hydrophobic pocket of the carbonic anhydrases

21 January 2018

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Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII, and XIV with L- and D-phenylalanine and crystallographic analysis of their adducts with isozyme II: stereospecific recognition within the active site of an enzyme and its cons

21 January 2018

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Carbonic anhydrase activators: kinetic and X-ray crystallographic study for the interaction of D- and L-tryptophan with the mammalian isoforms I-XIV

21 January 2018

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Cloning, characterization, and inhibition studies of a beta-carbonic anhydrase from Brucella suis.

21 January 2018

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Carbonic anhydrase inhibitors: inhibition of the beta-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with simple anions.

21 January 2018

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Carbonic anhydrase inhibitors. Inhibition of the beta-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with aliphatic and aromatic carboxylates

21 January 2018

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Carbonic anhydrases in fungi

21 January 2018

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Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides

21 January 2018

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Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct

21 January 2018

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Diuretics: from classical carbonic anhydrase inhibitors to novel applications of the sulfonamides

21 January 2018

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Carbonic anhydrase inhibitors. Sulfonamide diuretics revisited--old leads for new applications?

21 January 2018

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Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference

21 January 2018

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Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference

21 January 2018

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Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule

21 January 2018

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Efficacy of Low-dose Acetazolamide (125 mg BID) for the Prophylaxis of Acute Mountain Sickness: A Prospective, Double-blind, Randomized, Placebo-controlled Trial

21 January 2018

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Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition

21 January 2018

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Carbonic anhydrase inhibitors. Identification of selective inhibitors of the human mitochondrial isozymes VA and VB over the cytosolic isozymes I and II from a natural product-based phenolic library

21 January 2018

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Natural product-based phenols as novel probes for mycobacterial and fungal carbonic anhydrases

21 January 2018

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Carbonic anhydrase inhibitors: interactions of phenols with the 12 catalytically active mammalian isoforms (CA I-XIV).

21 January 2018

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Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid

21 January 2018

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In vitro inhibition of salicylic acid derivatives on human cytosolic carbonic anhydrase isozymes I and II.

21 January 2018

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Carbonic anhydrase inhibitors. Inhibition of human erythrocyte isozymes I and II with a series of antioxidant phenols.

21 January 2018

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Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids

21 January 2018

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Carbonic anhydrase inhibitors: glycosylsulfanilamides act as subnanomolar inhibitors of the human secreted isoform VI.

21 January 2018

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Crystal structure of the C183S/C217S mutant of human CA VII in complex with acetazolamide

21 January 2018

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Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides

21 January 2018

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Carbonic anhydrase inhibitors. Phenacetyl-, pyridylacetyl- and thienylacetyl-substituted aromatic sulfonamides act as potent and selective isoform VII inhibitors

21 January 2018

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Acetazolamide and midazolam act synergistically to inhibit neuropathic pain

21 January 2018

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Carbonic anhydrase inhibitors: stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II.

21 January 2018

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Carbonic anhydrase inhibitors: N-(p-sulfamoylphenyl)-alpha-D-glycopyranosylamines as topically acting antiglaucoma agents in hypertensive rabbits

21 January 2018

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Inhibition of carbonic anhydrases with glycosyltriazole benzene sulfonamides

21 January 2018

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Sulfonamide linked neoglycoconjugates--a new class of inhibitors for cancer-associated carbonic anhydrases

21 January 2018

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Therapeutic applications of glycosidic carbonic anhydrase inhibitors.

21 January 2018

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Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors

21 January 2018

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Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins

21 January 2018

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Coumarins incorporating hydroxy- and chloro-moieties selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II.

21 January 2018

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7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range

21 January 2018

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S-glycosyl primary sulfonamides--a new structural class for selective inhibition of cancer-associated carbonic anhydrases

21 January 2018

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Inhibition of carbonic anhydrase II by thioxolone: a mechanistic and structural study

21 January 2018

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Carbonic anhydrase inhibitors: thioxolone versus sulfonamides for obtaining isozyme-selective inhibitors?

21 January 2018

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Synchrotron Radiation Provides a Plausible Explanation for the Generation of a Free Radical Adduct of Thioxolone in Mutant Carbonic Anhydrase II

21 January 2018

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Ureido-substituted benzenesulfonamides potently inhibit carbonic anhydrase IX and show antimetastatic activity in a model of breast cancer metastasis.

21 January 2018

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Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors.

21 January 2018

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Characterization of CA XIII, a novel member of the carbonic anhydrase isozyme family

21 January 2018

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Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides

21 January 2018

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Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.

21 January 2018

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Carbonic anhydrase inhibitors. Inhibition of Plasmodium falciparum carbonic anhydrase with aromatic sulfonamides: towards antimalarials with a novel mechanism of action?

21 January 2018

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Malarial parasite carbonic anhydrase and its inhibitors

21 January 2018

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Structure and inhibition of the CO2-sensing carbonic anhydrase Can2 from the pathogenic fungus Cryptococcus neoformans

21 January 2018

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Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the pathogenic yeast Candida glabrata with anions.

21 January 2018

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Carbonic anhydrase inhibitors. The beta-carbonic anhydrases from the fungal pathogens Cryptococcus neoformans and Candida albicans are strongly inhibited by substituted-phenyl-1H-indole-5-sulfonamides.

21 January 2018

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Carbonic anhydrase inhibitors: inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates

21 January 2018

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Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with anions

21 January 2018

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Discovery of low nanomolar and subnanomolar inhibitors of the mycobacterial beta-carbonic anhydrases Rv1284 and Rv3273

21 January 2018

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Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis

21 January 2018

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Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate

21 January 2018

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Carbonic anhydrase inhibitors. Inhibition of the Rv1284 and Rv3273 beta-carbonic anhydrases from Mycobacterium tuberculosis with diazenylbenzenesulfonamides.

21 January 2018

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Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, Rv3588c.

21 January 2018

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External pH influences the transcriptional profile of the carbonic anhydrase, CAH-4b in Caenorhabditis elegans

21 January 2018

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Carbonic anhydrase inhibitors. The nematode alpha-carbonic anhydrase of Caenorhabditis elegans CAH-4b is highly inhibited by 2-(hydrazinocarbonyl)-3-substituted-phenyl-1H-indole-5-sulfonamides

21 January 2018

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A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases

21 January 2018

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Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII, and XIV with l- and d-histidine and crystallographic analysis of their adducts with isoform II: engineering proton-transfer processes within the active site of an enzyme.

21 January 2018

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Intramolecular proton shuttle supports not only catalytic but also noncatalytic function of carbonic anhydrase II.

21 January 2018

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Chemical rescue of proton transfer in catalysis by carbonic anhydrases in the beta- and gamma-class.

21 January 2018

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Carbonic anhydrase activators: X-ray crystallographic and spectroscopic investigations for the interaction of isozymes I and II with histamine

21 January 2018

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The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors

21 January 2018

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Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines.

21 January 2018

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Carbonic anhydrase activators: Activation of the beta-carbonic anhydrase from the pathogenic yeast Candida glabrata with amines and amino acids

21 January 2018

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Carbonic anhydrase inhibitors. Inhibition of isoforms I, II, IV, VA, VII, IX, and XIV with sulfonamides incorporating fructopyranose–thioureido tails

21 January 2018

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Carbonic Anhydrase Inhibitors: Hypoxia-Activatable Sulfonamides Incorporating Disulfide Bonds that Target the Tumor-Associated Isoform IX†

21 January 2018

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Carbonic anhydrase inhibitors. Inhibition of cytosolic isoforms I and II, and extracellular isoforms IV, IX, and XII with sulfamides incorporating sugar moieties

21 January 2018

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Carbonic Anhydrase Inhibitor Coated Gold Nanoparticles Selectively Inhibit the Tumor-Associated Isoform IX over the Cytosolic Isozymes I and II

21 January 2018

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Carbonic Anhydrase Inhibitors: Clash with Ala65 as a Means for Designing Inhibitors with Low Affinity for the Ubiquitous Isozyme II, Exemplified by the Crystal Structure of the Topiramate Sulfamide Analogue†

21 January 2018

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Carbonic anhydrase inhibitors: The β-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors

21 January 2018

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Carbonic anhydrase inhibitors. Inhibition of the fungal β-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids

21 January 2018

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Inhibition of the β-carbonic anhydrase from Streptococcus pneumoniae by inorganic anions and small molecules: Toward innovative drug design of antiinfectives?

21 January 2018

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Drug Design Studies of Carbonic Anhydrase Activators

21 January 2018

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Carbonic anhydrase activators: l-Adrenaline plugs the active site entrance of isozyme II, activating better isoforms I, IV, VA, VII, and XIV

21 January 2018

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21 January 2018

Identifiers

DOI

10.4155/FMC.11.69

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25 August 2017

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PubMed ID

21806379