The main anticancer bullets of the Chinese medicinal herb, thunder god vine. (Q37893952)

24 August 2017

3 references

26 July 2022

27 July 2022

The main anticancer bullets of the Chinese medicinal herb, thunder god vine (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6264543&resulttype=core&format=json

13 May 2020

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21 June 2021

Tripterygium wilfordii

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inferred from abstract

Tripterygium

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3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6264543&resulttype=core&format=json

13 May 2020

Guangbiao Zhou

series ordinal

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6264543&resulttype=core&format=json

13 May 2020

author name string

Zi Liu

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6264543&resulttype=core&format=json

13 May 2020

Liang Ma

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6264543&resulttype=core&format=json

13 May 2020

language of work or name

English

0 references

publication date

23 June 2011

4 references

24 August 2017

21 June 2021

26 July 2022

27 July 2022

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6264543&resulttype=core&format=json

13 May 2020

21 June 2021

16

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6264543&resulttype=core&format=json

13 May 2020

issue

6

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6264543&resulttype=core&format=json

13 May 2020

page(s)

5283-5297

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Creative Commons Attribution

13 May 2020

copyright license

3 references

21 June 2021

26 July 2022

27 July 2022

0 references

Anti-inflammatory and immunosuppressive compounds from Tripterygium wilfordii.

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12 December 2020

Studies on the total synthesis of triptolide. I

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12 December 2020

Inhibitory effect of triptolide on colony formation of breast and stomach cancer cell lines

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12 December 2020

Molecular Mechanism of Inhibition of the Human Protein Complex Hsp90-Cdc37, a Kinome Chaperone-Cochaperone, by Triterpene Celastrol

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12 December 2020

HSP90 inhibitor, celastrol, arrests human monocytic leukemia cell U937 at G0/G1 in thiol-containing agents reversible way

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12 December 2020

Effect of triptolide on urinary monocyte chemottractant protein-1 in patients with diabetic nephropathy

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12 December 2020

Inhibition of tumor cellular proteasome activity by triptolide extracted from the Chinese medicinal plant 'thunder god vine'.

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12 December 2020

Observation on serum anti-double stranded DNA antibodies of tripterine in systemic lupus erythematosus of (NZBxW)F1 mice

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12 December 2020

Celastrol blocks neuronal cell death and extends life in transgenic mouse model of amyotrophic lateral sclerosis

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12 December 2020

Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators

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12 December 2020

Male antifertility compounds from Tripterygium wilfordii Hook f

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12 December 2020

Merging traditional Chinese medicine with modern drug discovery technologies to find novel drugs and functional foods

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12 December 2020

Natural proteasome inhibitor celastrol suppresses androgen-independent prostate cancer progression by modulating apoptotic proteins and NF-kappaB

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12 December 2020

Clinical trial of Tripterygium Wilfordii Hook F. in human kidney transplantation in China

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12 December 2020

Triptolide abrogates oncogene FIP1L1-PDGFRalpha addiction and induces apoptosis in hypereosinophilic syndrome

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12 December 2020

Antiproliferative and proapoptotic activities of triptolide (PG490), a natural product entering clinical trials, on primary cultures of human prostatic epithelial cells

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12 December 2020

Molecular understanding and modern application of traditional medicines: triumphs and trials.

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12 December 2020

Tripterygium wilfordii, a Chinese herb effective in male fertility regulation

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12 December 2020

The Chinese anti-inflammatory and immunosuppressive herbal remedy Tripterygium wilfordii Hook F.

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12 December 2020

Triptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5.

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12 December 2020

Natural product Celastrol destabilizes tubulin heterodimer and facilitates mitotic cell death triggered by microtubule-targeting anti-cancer drugs

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12 December 2020

Triptolide functions as a potent angiogenesis inhibitor.

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12 December 2020

Celastrus-derived celastrol suppresses autoimmune arthritis by modulating antigen-induced cellular and humoral effector responses

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12 December 2020

Triptolide inhibits the growth and metastasis of solid tumors.

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12 December 2020

Triptolide therapy for neuroblastoma decreases cell viability in vitro and inhibits tumor growth in vivo

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12 December 2020

Triptolide induces caspase-dependent cell death mediated via the mitochondrial pathway in leukemic cells

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12 December 2020

The tumor proteasome is a primary target for the natural anticancer compound Withaferin A isolated from "Indian winter cherry".

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12 December 2020

Celastrol and an EGCG pro-drug exhibit potent chemosensitizing activity in human leukemia cells

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12 December 2020

Effects of Celastrol on growth inhibition of U937 leukemia cells through the regulation of the Notch1/NF-kappaB signaling pathway in vitro.

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12 December 2020

Celastrol isolated from Tripterygium regelii induces apoptosis through both caspase-dependent and -independent pathways in human breast cancer cells.

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12 December 2020

Formal total synthesis of triptolide

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12 December 2020

Triptolide inactivates Akt and induces caspase-dependent death in cervical cancer cells via the mitochondrial pathway

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12 December 2020

Back to the future of oridonin: again, compound from medicinal herb shows potent antileukemia efficacies in vitro and in vivo

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12 December 2020

Triptolide exerts anti-tumor effect on oral cancer and KB cells in vitro and in vivo

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12 December 2020

Triptolide is a traditional Chinese medicine-derived inhibitor of polycystic kidney disease

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12 December 2020

Effect of celastrol on Akt signaling pathway and apoptosis of leukemic K562 cell line

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12 December 2020

Celastrol suppresses allergen-induced airway inflammation in a mouse allergic asthma model

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12 December 2020

Anti-inflammatory effects of triptolide in human bronchial epithelial cells

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12 December 2020

A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells

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12 December 2020

Triptolide alters histone H3K9 and H3K27 methylation state and induces G0/G1 arrest and caspase-dependent apoptosis in multiple myeloma in vitro

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12 December 2020

Celastrol, a triterpene, enhances TRAIL-induced apoptosis through the down-regulation of cell survival proteins and up-regulation of death receptors

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12 December 2020

A potential new treatment for rheumatoid arthritis: thunder god vine

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12 December 2020

Biologic activity of triptolide in t(8;21) acute myeloid leukemia cells

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12 December 2020

Celastrol: Molecular targets of Thunder God Vine

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12 December 2020

[In vitro study on cellular and molecular mechanism of tripterine treating leukemic mast cells]

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12 December 2020

Celastrol synergistically enhances temozolomide cytotoxicity in melanoma cells

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12 December 2020

The experimental study on the inhibitory effect of tripterine on airway inflammation in asthmatic mice

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12 December 2020

Herbal treatment for renal diseases.

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12 December 2020

Activity of triptolide against human mast cells harboring the kinase domain mutant KIT.

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12 December 2020

Role of Hsp-70 in triptolide-mediated cell death of neuroblastoma

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12 December 2020

Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice

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12 December 2020

Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-kappaB-regulated gene products and TAK1-mediated NF-kappaB activation

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12 December 2020

Celastrol can inhibit proteasome activity and upregulate the expression of heat shock protein genes, hsp30 and hsp70, in Xenopus laevis A6 cells

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12 December 2020

Antitumor activity of triptolide against cholangiocarcinoma growth in vitro and in hamsters

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12 December 2020

Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors

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12 December 2020

Triptolide downregulates Rac1 and the JAK/STAT3 pathway and inhibits colitis-related colon cancer progression

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12 December 2020

Apoptosis Induction in HL-60 Cells and Inhibition of Topoisomerase II by Triterpene Celastrol

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12 December 2020

Celastrol inhibits the growth of estrogen positive human breast cancer cells through modulation of estrogen receptor α.

1 reference

12 December 2020

AML1-ETO and C-KIT mutation/overexpression in t(8;21) leukemia: implication in stepwise leukemogenesis and response to Gleevec.

1 reference

12 December 2020

Triptolide binds covalently to a 90 kDa nuclear protein. Role of epoxides in binding and activity

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12 December 2020

[The effect of tripterine in prevention of glomerulosclerosis in lupus nephritis mice]

1 reference

12 December 2020

Celastrol causes apoptosis and cell cycle arrest in rat glioma cells

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12 December 2020

Reduction of beta-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease

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12 December 2020

Chronic inhibition of cardiac Kir2.1 and HERG potassium channels by celastrol with dual effects on both ion conductivity and protein trafficking.

1 reference

12 December 2020

Triptolide inhibits Bcr-Abl transcription and induces apoptosis in STI571-resistant chronic myelogenous leukemia cells harboring T315I mutation

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12 December 2020

Celastrol inhibits Hsp90 chaperoning of steroid receptors by inducing fibrillization of the Co-chaperone p23

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12 December 2020

Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alzheimer's disease

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12 December 2020

Retrospect and prospect of studies on Tripterygium Wilfordii Hook f.

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12 December 2020

Preclinical studies of celastrol and acetyl isogambogic acid in melanoma.

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12 December 2020

Clinical observation on effect of triptolide tablet in treating patients with psoriasis vulgaris

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12 December 2020

Celastrol suppresses angiogenesis-mediated tumor growth through inhibition of AKT/mammalian target of rapamycin pathway

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12 December 2020

Triptolide and chemotherapy cooperate in tumor cell apoptosis. A role for the p53 pathway

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12 December 2020

Triptolide, an inhibitor of the human heat shock response that enhances stress-induced cell death

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12 December 2020

Triptolide inhibits Jak2 transcription and induces apoptosis in human myeloproliferative disorder cells bearing Jak2V617F through caspase-3-mediated cleavage of Mcl-1.

1 reference

12 December 2020

XPB, a subunit of TFIIH, is a target of the natural product triptolide.

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12 December 2020

Celastrol potentiates radiotherapy by impairment of DNA damage processing in human prostate cancer

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12 December 2020

Selective alkylation: a biomimetic reaction of the antileukemic triptolides?

1 reference

12 December 2020

Comparison of Tripterygium wilfordii Hook F versus sulfasalazine in the treatment of rheumatoid arthritis: a randomized trial

1 reference

12 December 2020

Anticancer activity of Celastrol in combination with ErbB2-targeted therapeutics for treatment of ErbB2-overexpressing breast cancers

1 reference

12 December 2020

Celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor.

1 reference

12 December 2020

Efficacy of T2 in active Crohn's disease: a prospective study report

1 reference

12 December 2020

Celastrol, a novel HSP90 inhibitor, depletes Bcr-Abl and induces apoptosis in imatinib-resistant chronic myelogenous leukemia cells harboring T315I mutation

1 reference

12 December 2020

Triptolide induces pancreatic cancer cell death via inhibition of heat shock protein 70.

1 reference

12 December 2020

TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

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12 December 2020

Triptolide induces cell death in pancreatic cancer cells by apoptotic and autophagic pathways

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12 December 2020

Celastrol inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression

1 reference

12 December 2020

Enhancement of radiation sensitivity in lung cancer cells by celastrol is mediated by inhibition of Hsp90.

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12 December 2020

Triptolide and its expanding multiple pharmacological functions

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12 December 2020

Tumor inhibitors. LXXIV. Triptolide and tripdiolide, novel antileukemic diterpenoid triepoxides from Tripterygium wilfordii

1 reference

12 December 2020

Inhibition of NF-κB activation through targeting IκB kinase by celastrol, a quinone methide triterpenoid

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12 December 2020

Celastrol acts as a potent antimetastatic agent targeting beta1 integrin and inhibiting cell-extracellular matrix adhesion, in part via the p38 mitogen-activated protein kinase pathway

1 reference

12 December 2020

RNA polymerase - an important molecular target of triptolide in cancer cells

1 reference

12 December 2020

Antiangiogenic effect of celastrol on the growth of human glioma: an in vitro and in vivo study.

1 reference

12 December 2020

Triptolide induced cytotoxic effects on human promyelocytic leukemia, T cell lymphoma and human hepatocellular carcinoma cell lines

1 reference

12 December 2020

Inhibition of anthrax lethal toxin-induced cytolysis of RAW264.7 cells by celastrol

1 reference

12 December 2020

[Several monomes from Tripterygium wilfordii inhibit proliferation of glioma cells in vitro]

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12 December 2020

Escaping cell death: survival proteins in cancer

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12 December 2020

Functional p53 is required for triptolide-induced apoptosis and AP-1 and nuclear factor-kappaB activation in gastric cancer cells

1 reference

12 December 2020

Effect of tripterine on collagen-induced arthritis in rats

1 reference

12 December 2020

PG490 (triptolide) cooperates with tumor necrosis factor-alpha to induce apoptosis in tumor cells

1 reference

12 December 2020

Triptolide inhibits transcription factor NF-kappaB and induces apoptosis of multiple myeloma cells

1 reference

12 December 2020

10.3390/MOLECULES16065283

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6264543&resulttype=core&format=json

13 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6264543&resulttype=core&format=json

13 May 2020

21701438

1 reference