Expanding TRAF function: TRAF3 as a tri-faced immune regulator (Q37887494)

24 August 2017

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title

Expanding TRAF function: TRAF3 as a tri-faced immune regulator (English)

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24 August 2017

3

Michael Karin

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24 August 2017

Hans Häcker

1

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PubMed ID

21660053

24 August 2017

Ping-Hui Tseng

series ordinal

2

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24 August 2017

10 June 2011

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Nature Reviews Immunology

24 August 2017

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24 August 2017

11

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24 August 2017

457-468

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24 August 2017

7

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TRAF-mediated TNFR-family signaling

24 August 2017

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The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

31 March 2020

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Origin and physiological roles of inflammation

31 March 2020

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Pattern recognition receptors and inflammation

31 March 2020

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Modulation of experimental autoimmune encephalomyelitis through TRAF3-mediated suppression of interleukin 17 receptor signaling

31 March 2020

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TNF receptor-associated factor 3 is required for T cell-mediated immunity and TCR/CD28 signaling

31 March 2020

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A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor

31 March 2020

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Cooperation between TNF receptor-associated factors 1 and 2 in CD40 signaling.

31 March 2020

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Impaired neural tube closure, axial skeleton malformations, and tracheal ring disruption in TRAF4-deficient mice.

31 March 2020

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TRAF4 deficiency leads to tracheal malformation with resulting alterations in air flow to the lungs

31 March 2020

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Tumor necrosis factor-receptor-associated factor-4 is a positive regulator of transforming growth factor-beta signaling that affects neural crest formation

31 March 2020

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Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain

31 March 2020

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Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death

31 March 2020

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TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40

31 March 2020

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TRAF6 is a signal transducer for interleukin-1

31 March 2020

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TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-beta

31 March 2020

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Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6.

31 March 2020

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The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation

31 March 2020

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MyD88: an adapter that recruits IRAK to the IL-1 receptor complex

31 March 2020

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The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins

31 March 2020

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Crystal Structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 Complexes: Affinity, Specificity, and Regulation

31 March 2020

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Asymmetric recruitment of cIAPs by TRAF2

31 March 2020

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TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-{kappa}b and to prevent tnf-induced apoptosis.

31 March 2020

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Allosteric regulation of the ubiquitin:NIK and ubiquitin:TRAF3 E3 ligases by the lymphotoxin-beta receptor

31 March 2020

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Ubiquitylation in innate and adaptive immunity.

31 March 2020

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A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein

31 March 2020

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Inhibition of proteolysis and cell cycle progression in a multiubiquitination-deficient yeast mutant

31 March 2020

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Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain

31 March 2020

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TAK1 is a ubiquitin-dependent kinase of MKK and IKK

31 March 2020

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A ubiquitin replacement strategy in human cells reveals distinct mechanisms of IKK activation by TNFalpha and IL-1beta.

31 March 2020

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Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3

31 March 2020

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Two mechanistically and temporally distinct NF-kappaB activation pathways in IL-1 signaling

31 March 2020

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Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex

31 March 2020

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Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling

31 March 2020

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Structural Basis for the Lack of E2 Interaction in the RING Domain of TRAF2

31 March 2020

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The death domain kinase RIP mediates the TNF-induced NF-kappaB signal

31 March 2020

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Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

31 March 2020

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RIPK1 is not essential for TNFR1-induced activation of NF-kappaB.

31 March 2020

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Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction

31 March 2020

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A ubiquitin ligase complex assembles linear polyubiquitin chains

31 March 2020

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Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation

31 March 2020

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Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines

31 March 2020

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Mammalian MAP kinase signalling cascades

31 March 2020

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Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch

31 March 2020

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TNFR signaling: ubiquitin-conjugated TRAFfic signals control stop-and-go for MAPK signaling complexes

31 March 2020

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Mekk3 is essential for early embryonic cardiovascular development

31 March 2020

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Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6

31 March 2020

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Cutting edge: TNFR-associated factor (TRAF) 6 is essential for MyD88-dependent pathway but not toll/IL-1 receptor domain-containing adaptor-inducing IFN-beta (TRIF)-dependent pathway in TLR signaling

31 March 2020

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Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production

31 March 2020

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Essential function for the kinase TAK1 in innate and adaptive immune responses.

31 March 2020

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CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation

31 March 2020

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Toll-like receptor and RIG-I-like receptor signaling

31 March 2020

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Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6

31 March 2020

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Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

31 March 2020

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Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7

31 March 2020

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Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction

31 March 2020

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Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response

31 March 2020

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Regulation and function of NF-kappaB transcription factors in the immune system

31 March 2020

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The two NF-kappaB activation pathways and their role in innate and adaptive immunity

31 March 2020

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TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2/5-mediated activation of the noncanonical NF-kappaB pathway by TRAF-binding TNFRs

31 March 2020

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Involvement of CRAF1, a relative of TRAF, in CD40 signaling

31 March 2020

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Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activation

31 March 2020

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Regulation and function of IKK and IKK-related kinases

31 March 2020

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DUBA: a deubiquitinase that regulates type I interferon production

31 March 2020

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Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif

31 March 2020

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A functional C-terminal TRAF3-binding site in MAVS participates in positive and negative regulation of the IFN antiviral response

31 March 2020

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MAVS self-association mediates antiviral innate immune signaling

31 March 2020

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The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation

31 March 2020

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Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling

31 March 2020

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Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments

31 March 2020

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TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta

31 March 2020

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A cell biological view of Toll-like receptor function: regulation through compartmentalization.

31 March 2020

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Induction of p100 processing by NF-kappaB-inducing kinase involves docking IkappaB kinase alpha (IKKalpha) to p100 and IKKalpha-mediated phosphorylation

31 March 2020

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NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100

31 March 2020

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BAFF-induced NEMO-independent processing of NF-kappa B2 in maturing B cells.

31 March 2020

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Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway

31 March 2020

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TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor.

31 March 2020

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Tumor necrosis factor receptor-associated factor 3 is a critical regulator of B cell homeostasis in secondary lymphoid organs

31 March 2020

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Rescue of TRAF3-null mice by p100 NF-kappa B deficiency

31 March 2020

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Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation

31 March 2020

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Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma

31 March 2020

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Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma.

31 March 2020

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IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis

31 March 2020

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IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis

31 March 2020

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Control of canonical NF-kappaB activation through the NIK-IKK complex pathway

31 March 2020

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Mechanism of processing of the NF-kappa B2 p100 precursor: identification of the specific polyubiquitin chain-anchoring lysine residue and analysis of the role of NEDD8-modification on the SCF(beta-TrCP) ubiquitin ligase

31 March 2020

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Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis

31 March 2020

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TLR3 deficiency in patients with herpes simplex encephalitis

31 March 2020

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Specificity of TRAF3 in its negative regulation of the noncanonical NF-kappa B pathway

31 March 2020

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Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses

31 March 2020

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Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors.

31 March 2020

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Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

31 March 2020

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A novel RING finger protein interacts with the cytoplasmic domain of CD40

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21660053

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRI2998

1 reference

24 August 2017

1 reference

PubMed ID

21660053