Milestones in huntington disease (Q37882602)

24 August 2017

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title

Milestones in huntington disease (English)

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24 August 2017

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1

Ira Shoulson

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24 August 2017

Anne B Young

2

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PubMed ID

21626556

24 August 2017

language of work or name

English

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publication date

1 May 2011

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24 August 2017

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24 August 2017

26

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6

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24 August 2017

1127-1133

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Localization of the Huntington's disease gene to a small segment of chromosome 4 flanked by D4S10 and the telomere

24 August 2017

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

21 January 2018

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Huntington's disease out of the closet?

21 January 2018

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Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset

21 January 2018

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Repeat instability in the 27-39 CAG range of the HD gene in the Venezuelan kindreds: Counseling implications.

21 January 2018

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Gametic but not somatic instability of CAG repeat length in Huntington's disease.

21 January 2018

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The relationship between CAG repeat length and clinical progression in Huntington's disease

21 January 2018

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CAG repeat number governs the development rate of pathology in Huntington's disease

21 January 2018

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A new model for prediction of the age of onset and penetrance for Huntington's disease based on CAG length.

21 January 2018

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At risk for Huntington disease: The PHAROS (Prospective Huntington At Risk Observational Study) cohort enrolled

21 January 2018

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Preparing for preventive clinical trials: the Predict-HD study

21 January 2018

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Detection of Huntington's disease decades before diagnosis: the Predict-HD study

21 January 2018

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Motor abnormalities in premanifest persons with Huntington's disease: the PREDICT-HD study

21 January 2018

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Onset and rate of striatal atrophy in preclinical Huntington disease

21 January 2018

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Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data

21 January 2018

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Regional cortical thinning in preclinical Huntington disease and its relationship to cognition

21 January 2018

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Dietary intake in adults at risk for Huntington disease: analysis of PHAROS research participants

21 January 2018

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Selective cholinergic denervation, independent from oxidative stress, in a mouse model of Alzheimer's disease

21 January 2018

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Creatine in Huntington disease is safe, tolerable, bioavailable in brain and reduces serum 8OH2'dG.

21 January 2018

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Cerebral cortex and the clinical expression of Huntington's disease: complexity and heterogeneity

21 January 2018

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Striatal inhomogeneities and basal ganglia function

21 January 2018

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The functional anatomy of basal ganglia disorders

21 January 2018

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Preproenkephalin messenger RNA?containing neurons in striatum of patients with symptomatic and presymptomatic huntington's disease: An in situ hybridization study

21 January 2018

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Preferential loss of striato-external pallidal projection neurons in presymptomatic Huntington's disease

21 January 2018

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Striatal and nigral neuron subpopulations in rigid Huntington's disease: implications for the functional anatomy of chorea and rigidity-akinesia

21 January 2018

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Differential loss of striatal projection neurons in Huntington disease

21 January 2018

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Selective sparing of a class of striatal neurons in Huntington's disease

21 January 2018

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Sparing of acetylcholinesterase-containing striatal neurons in Huntington's disease

21 January 2018

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Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

21 January 2018

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Striosomes and mood dysfunction in Huntington's disease.

21 January 2018

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Cell loss in the motor and cingulate cortex correlates with symptomatology in Huntington's disease

21 January 2018

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Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion

21 January 2018

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Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice

21 January 2018

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Therapeutic approaches to polyglutamine diseases: combating protein misfolding and aggregation.

21 January 2018

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Mutant huntingtin fragments form oligomers in a polyglutamine length-dependent manner in vitro and in vivo

21 January 2018

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Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration

21 January 2018

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Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human huntington disease gene

21 January 2018

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Regional and cellular gene expression changes in human Huntington's disease brain

21 January 2018

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Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage

21 January 2018

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Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease

21 January 2018

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Huntingtin modulates transcription, occupies gene promoters in vivo, and binds directly to DNA in a polyglutamine-dependent manner

21 January 2018

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Therapeutic application of histone deacetylase inhibitors for central nervous system disorders

21 January 2018

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Acetylation targets mutant huntingtin to autophagosomes for degradation

21 January 2018

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Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice

21 January 2018

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IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome.

21 January 2018

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Presymptomatic DNA testing for Huntington disease: identifying the need for psychological intervention

21 January 2018

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Huntington's disease: prenatal screening for late onset disease

21 January 2018

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Prenatal testing for Huntington's disease: a European collaborative study.

21 January 2018

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Predictive, pre-natal and diagnostic genetic testing for Huntington's disease: the experience in Canada from 1987 to 2000.

21 January 2018

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Predictive and pre-natal testing for Huntington Disease in Australia: results and challenges encountered during a 10-year period (1994-2003).

21 January 2018

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Non-disclosure preimplantation genetic diagnosis for Huntington's disease: practical and ethical dilemmas

21 January 2018

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Preimplantation genetic diagnosis for Huntington's disease with exclusion testing.

21 January 2018

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Non-disclosing preimplantation genetic diagnosis for Huntington disease

21 January 2018

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What were you thinking?: individuals at risk for Huntington Disease talk about having children

21 January 2018

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Pharmacological management of Huntington's disease: an evidence-based review

21 January 2018

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Tetrabenazine as antichorea therapy in Huntington disease: a randomized controlled trial

21 January 2018

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Letter: Double-blind trial of lithium carbonate and haloperidol in Huntington's chorea

21 January 2018

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Clozapine treatment of psychiatric symptoms resistant to neuroleptic treatment in patients with Huntington's chorea

21 January 2018

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Safety and tolerability of high-dosage coenzyme Q10 in Huntington's disease and healthy subjects

21 January 2018

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Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline

21 January 2018

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Functional aspects of creatine kinase in brain.

21 January 2018

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Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/MDS.23685

1 reference

24 August 2017

1 reference

PubMed ID

21626556