Therapeutic application of histone deacetylase inhibitors for central nervous system disorders (Q37283454)

19 August 2017

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title

Therapeutic application of histone deacetylase inhibitors for central nervous system disorders (English)

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19 August 2017

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Aleksey G Kazantsev

1

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PubMed ID

18827828

19 August 2017

Leslie M Thompson

series ordinal

2

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19 August 2017

1 October 2008

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Nature Reviews Drug Discovery

19 August 2017

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19 August 2017

7

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19 August 2017

854-868

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19 August 2017

10

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https://scigraph.springernature.com/pub.10.1038/nrd2681

19 August 2017

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cites work

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Control of histone modifications

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Remodeling chromatin and stress resistance in the central nervous system: histone deacetylase inhibitors as novel and broadly effective neuroprotective agents.

31 March 2020

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Covalent modifications of histones during development and disease pathogenesis

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HDAC6 is a microtubule-associated deacetylase

31 March 2020

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In vivo destabilization of dynamic microtubules by HDAC6-mediated deacetylation

31 March 2020

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Sirtuins in mammals: insights into their biological function

31 March 2020

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Substrate and functional diversity of lysine acetylation revealed by a proteomics survey

31 March 2020

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Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2

31 March 2020

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Chromatin modifications and their function

31 March 2020

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Measurement of histone acetyltransferase and histone deacetylase activities and kinetics of histone acetylation

31 March 2020

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HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo

31 March 2020

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Anticancer activities of histone deacetylase inhibitors

31 March 2020

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Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis.

31 March 2020

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Histone deacetylase inhibitors: molecular mechanisms of action

31 March 2020

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A work in progress: the clinical development of histone deacetylase inhibitors

31 March 2020

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Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders.

31 March 2020

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Histone deacetylases: focus on the nervous system

31 March 2020

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Histone deacetylase inhibitors: possible implications for neurodegenerative disorders

31 March 2020

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Histone deacetylase inhibitors as therapeutics for polyglutamine disorders

31 March 2020

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Histone Deacetylases: Unique Players in Shaping the Epigenetic Histone Code

31 March 2020

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Functional domains of histone deacetylase-3

31 March 2020

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Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression

31 March 2020

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Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation

31 March 2020

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The histone deacetylase-3 complex contains nuclear receptor corepressors

31 March 2020

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Class IIa histone deacetylases: regulating the regulators

31 March 2020

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Class IIA HDACs in the regulation of neurodegeneration

31 March 2020

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Association of class II histone deacetylases with heterochromatin protein 1: potential role for histone methylation in control of muscle differentiation

31 March 2020

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Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo

31 March 2020

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Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases

31 March 2020

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Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases.

31 March 2020

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Histone deacetylase 4 possesses intrinsic nuclear import and export signals

31 March 2020

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The transcriptional corepressor MITR is a signal-responsive inhibitor of myogenesis

31 March 2020

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The histone deacetylase 9 gene encodes multiple protein isoforms

31 March 2020

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Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization

31 March 2020

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Mechanism for nucleocytoplasmic shuttling of histone deacetylase 7

31 March 2020

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CaM kinase IIdeltaC phosphorylation of 14-3-3beta in vascular smooth muscle cells: activation of class II HDAC repression

31 March 2020

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Identification of HDAC10, a novel class II human histone deacetylase containing a leucine-rich domain

31 March 2020

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Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family

31 March 2020

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Developmental expression of histone deacetylase 11 in the murine brain

31 March 2020

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Paths of convergence: sirtuins in aging and neurodegeneration

31 March 2020

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The biochemistry of sirtuins.

31 March 2020

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Preparation of enzymatically active recombinant class III protein deacetylases.

31 March 2020

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The Sir 2 family of protein deacetylases

31 March 2020

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Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin

31 March 2020

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BCL11A-dependent recruitment of SIRT1 to a promoter template in mammalian cells results in histone deacetylation and transcriptional repression

31 March 2020

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Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1

31 March 2020

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The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase

31 March 2020

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Microtubule deacetylases, SirT2 and HDAC6, in the nervous system

31 March 2020

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SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis

31 March 2020

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The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase

31 March 2020

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Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2

31 March 2020

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Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases

31 March 2020

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Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins

31 March 2020

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SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

31 March 2020

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Distribution of histone deacetylases 1-11 in the rat brain

31 March 2020

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Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases

31 March 2020

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Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor

31 March 2020

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Neuronal activity-dependent cell survival mediated by transcription factor MEF2

31 March 2020

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Identification of a transcriptional repressor related to the noncatalytic domain of histone deacetylases 4 and 5

31 March 2020

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Neuronal activity-dependent nucleocytoplasmic shuttling of HDAC4 and HDAC5.

31 March 2020

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Differential effects of Ca2+ and cAMP on transcription mediated by MEF2D and cAMP-response element-binding protein in hippocampal neurons.

31 March 2020

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Intracellular trafficking of histone deacetylase 4 regulates neuronal cell death.

31 March 2020

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SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes

31 March 2020

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Neuroprotection by histone deacetylase-related protein

31 March 2020

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The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress

31 March 2020

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HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin

31 March 2020

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HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS

31 March 2020

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HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor

31 March 2020

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Regulation of the dynamics of hsp90 action on the glucocorticoid receptor by acetylation/deacetylation of the chaperone

31 March 2020

1 reference

Sirtuin 2, a mammalian homolog of yeast silent information regulator-2 longevity regulator, is an oligodendroglial protein that decelerates cell differentiation through deacetylating alpha-tubulin

31 March 2020

1 reference

SIR2: a potential target for calorie restriction mimetics

31 March 2020

1 reference

Genetic links between diet and lifespan: shared mechanisms from yeast to humans

31 March 2020

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Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase

31 March 2020

1 reference

Predominant expression of Sir2alpha, an NAD-dependent histone deacetylase, in the embryonic mouse heart and brain.

31 March 2020

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The Sirtuin family: therapeutic targets to treat diseases of aging

31 March 2020

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Therapeutic role of sirtuins in neurodegenerative disease.

31 March 2020

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Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP

31 March 2020

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Truncated CBP protein leads to classical Rubinstein-Taybi syndrome phenotypes in mice: implications for a dominant-negative mechanism

31 March 2020

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Chromatin acetylation, memory, and LTP are impaired in CBP+/- mice: a model for the cognitive deficit in Rubinstein-Taybi syndrome and its amelioration.

31 March 2020

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The Rubinstein-Taybi syndrome: modeling mental impairment in the mouse

31 March 2020

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Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB:CBP-dependent transcriptional activation

31 March 2020

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Epigenetic regulation in psychiatric disorders

31 March 2020

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Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action

31 March 2020

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Antidepressant-like effects of the histone deacetylase inhibitor, sodium butyrate, in the mouse.

31 March 2020

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Recovery of learning and memory is associated with chromatin remodelling

31 March 2020

1 reference

Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

31 March 2020

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The story of Rett syndrome: from clinic to neurobiology

31 March 2020

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The odyssey of MeCP2 and parental imprinting

31 March 2020

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Friedreich's ataxia: clinical aspects and pathogenesis

31 March 2020

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Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia.

31 March 2020

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HDAC inhibitors correct frataxin deficiency in a Friedreich ataxia mouse model

31 March 2020

1 reference

A decade of molecular studies of fragile X syndrome

31 March 2020

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Transcription, translation and fragile X syndrome

31 March 2020

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Fragile X (CGG)n repeats induce a transcriptional repression in cis upon a linked promoter: evidence for a chromatin mediated effect

31 March 2020

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Synergistic effect of histone hyperacetylation and DNA demethylation in the reactivation of the FMR1 gene.

31 March 2020

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Quantitative analysis of DNA demethylation and transcriptional reactivation of the FMR1 gene in fragile X cells treated with 5-azadeoxycytidine

31 March 2020

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Differential epigenetic modifications in the FMR1 gene of the fragile X syndrome after reactivating pharmacological treatments.

31 March 2020

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SIRT1 inhibition alleviates gene silencing in Fragile X mental retardation syndrome

31 March 2020

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SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation

31 March 2020

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Trichostatin A increases SMN expression and survival in a mouse model of spinal muscular atrophy

31 March 2020

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The benzamide M344, a novel histone deacetylase inhibitor, significantly increases SMN2 RNA/protein levels in spinal muscular atrophy cells

31 March 2020

1 reference

Challenges and opportunities in clinical trials for spinal muscular atrophy

31 March 2020

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The role of histone acetylation in SMN gene expression.

31 March 2020

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In vitro and ex vivo evaluation of second-generation histone deacetylase inhibitors for the treatment of spinal muscular atrophy

31 March 2020

1 reference

Sodium phenylbutyrate prolongs survival and regulates expression of anti-apoptotic genes in transgenic amyotrophic lateral sclerosis mice

31 March 2020

1 reference

Sodium valproate exerts neuroprotective effects in vivo through CREB-binding protein-dependent mechanisms but does not improve survival in an amyotrophic lateral sclerosis mouse model

31 March 2020

1 reference

Sodium butyrate ameliorates phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy

31 March 2020

1 reference

Trinucleotide Repeat Disorders

31 March 2020

1 reference

The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

31 March 2020

1 reference

Polyglutamine and transcription: gene expression changes shared by DRPLA and Huntington's disease mouse models reveal context-independent effects

31 March 2020

1 reference

Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes

31 March 2020

1 reference

Gene profiling links SCA1 pathophysiology to glutamate signaling in Purkinje cells of transgenic mice

31 March 2020

1 reference

Ataxin 1, a SCA1 neurodegenerative disorder protein, is functionally linked to the silencing mediator of retinoid and thyroid hormone receptors

31 March 2020

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Transcriptional alterations and chromatin remodeling in polyglutamine diseases.

31 March 2020

1 reference

SCA17, a novel autosomal dominant cerebellar ataxia caused by an expanded polyglutamine in TATA-binding protein

31 March 2020

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Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy

31 March 2020

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Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexes

31 March 2020

1 reference

Ataxin-3 represses transcription via chromatin binding, interaction with histone deacetylase 3, and histone deacetylation

31 March 2020

1 reference

Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

31 March 2020

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Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease

31 March 2020

1 reference

Histone Deacetylase Inhibition by Sodium Butyrate Chemotherapy Ameliorates the Neurodegenerative Phenotype in Huntington's Disease Mice

31 March 2020

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Histone deacetylase inhibitors: a novel therapeutic approach to Huntington's disease (complex mechanism of neuronal death).

31 March 2020

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Differential contributions of Caenorhabditis elegans histone deacetylases to huntingtin polyglutamine toxicity.

31 March 2020

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Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington's disease.

31 March 2020

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Identification of genes that modify ataxin-1-induced neurodegeneration.

31 March 2020

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Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons.

31 March 2020

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Polyglutamine diseases: emerging concepts in pathogenesis and therapy

31 March 2020

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Huntington's disease: from pathology and genetics to potential therapies

31 March 2020

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Transcription meets metabolism in neurodegeneration

31 March 2020

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Drug targeting of dysregulated transcription in Huntington's disease

31 March 2020

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Mitochondrial-dependent Ca2+ handling in Huntington's disease striatal cells: effect of histone deacetylase inhibitors.

31 March 2020

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Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation

31 March 2020

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Protein aggregation and the ubiquitin proteasome pathway: gaining the UPPer hand on neurodegeneration

31 March 2020

1 reference

Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders

31 March 2020

1 reference

Autophagy and its possible roles in nervous system diseases, damage and repair

31 March 2020

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Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally

31 March 2020

1 reference

Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease

31 March 2020

1 reference

Multiple sclerosis: immune system molecule expression in the central nervous system

31 March 2020

1 reference

Multiple sclerosis: a complicated picture of autoimmunity.

31 March 2020

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Microglial activation and its implications in the brain diseases.

31 March 2020

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Transcriptional therapy with the histone deacetylase inhibitor trichostatin A ameliorates experimental autoimmune encephalomyelitis.

31 March 2020

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Rationale for the use of histone deacetylase inhibitors as a dual therapeutic modality in multiple sclerosis

31 March 2020

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Valproic acid reduces brain damage induced by transient focal cerebral ischemia in rats: potential roles of histone deacetylase inhibition and heat shock protein induction

31 March 2020

1 reference

Pharmacological inhibition of histone deacetylases by suberoylanilide hydroxamic acid specifically alters gene expression and reduces ischemic injury in the mouse brain.

31 March 2020

1 reference

Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action.

31 March 2020

1 reference

Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(waf1/cip1) in cell cycle-independent neuroprotection

31 March 2020

1 reference

The antiapoptotic actions of mood stabilizers: molecular mechanisms and therapeutic potentials

31 March 2020

1 reference

Histone deacetylase inhibition modulates kynurenine pathway activation in yeast, microglia, and mice expressing a mutant huntingtin fragment.

31 March 2020

1 reference

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

31 March 2020

1 reference

Niemann-Pick Type C disease and Alzheimer's disease: the APP-endosome connection fattens up.

31 March 2020

1 reference

Roles of proteolysis and lipid rafts in the processing of the amyloid precursor protein and prion protein

31 March 2020

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Type C Niemann-Pick disease: use of hydrophobic amines to study defective cholesterol transport

31 March 2020

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Lipid imbalance in the neurological disorder, Niemann-Pick C disease

31 March 2020

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The Niemann-Pick C proteins and trafficking of cholesterol through the late endosomal/lysosomal system

31 March 2020

1 reference

Lipid and cholesterol trafficking in NPC.

31 March 2020

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Cholesterol accumulates in cell bodies, but is decreased in distal axons, of Niemann-Pick C1-deficient neurons

31 March 2020

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Trafficking of cholesterol from cell bodies to distal axons in Niemann Pick C1-deficient neurons

31 March 2020

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Defective cholesterol traffic and neuronal differentiation in neural stem cells of Niemann-Pick type C disease improved by valproic acid, a histone deacetylase inhibitor

31 March 2020

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SIRT1 deacetylates and positively regulates the nuclear receptor LXR

31 March 2020

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Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation.

31 March 2020

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Progressive dysfunction of the cholesterol biosynthesis pathway in the R6/2 mouse model of Huntington's disease.

31 March 2020

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Mutant huntingtin inhibits clathrin-independent endocytosis and causes accumulation of cholesterol in vitro and in vivo

31 March 2020

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Calorie restriction--the SIR2 connection

31 March 2020

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Calorie restriction, SIRT1 and metabolism: understanding longevity

31 March 2020

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Toward a unified theory of caloric restriction and longevity regulation

31 March 2020

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SIRT1 transgenic mice show phenotypes resembling calorie restriction

31 March 2020

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Sirtuins in aging and disease

31 March 2020

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Therapeutic potential of resveratrol: the in vivo evidence

31 March 2020

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SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis

31 March 2020

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SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling

31 March 2020

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Sirtuin inhibition protects from the polyalanine muscular dystrophy protein PABPN1.

31 March 2020

1 reference

SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons

31 March 2020

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Inhibitors of histone deacetylase as new anticancer agents

31 March 2020

1 reference

Histone acetylation and the cell-cycle in cancer

31 March 2020

1 reference

Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor

31 March 2020

1 reference

Synthesis and biological evaluation of 2-, 3-, and 4-acylaminocinnamyl-N-hydroxyamides as novel synthetic HDAC inhibitors

31 March 2020

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Histone deacetylase as a new target for cancer chemotherapy.

31 March 2020

1 reference

Zn2+-chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors

31 March 2020

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Design and synthesis of a potent histone deacetylase inhibitor

31 March 2020

1 reference

Histone Deacetylase Inhibitors: The Abbott Experience

31 March 2020

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Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors

31 March 2020

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Differential protein acetylation induced by novel histone deacetylase inhibitors

31 March 2020

1 reference

Exploring the connection unit in the HDAC inhibitor pharmacophore model: novel uracil-based hydroxamates

31 March 2020

1 reference

Bispyridinium dienes: histone deacetylase inhibitors with selective activities

31 March 2020

1 reference

R306465 is a novel potent inhibitor of class I histone deacetylases with broad-spectrum antitumoral activity against solid and haematological malignancies

31 March 2020

1 reference

Multidimensional chemical genetic analysis of diversity-oriented synthesis-derived deacetylase inhibitors using cell-based assays

31 March 2020

1 reference

Discovery of (Aryloxopropenyl)pyrrolyl Hydroxyamides as Selective Inhibitors of Class IIa Histone Deacetylase Homologue HD1-A

31 March 2020

1 reference

Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation

31 March 2020

1 reference

HDAC inhibitors: clinical update and mechanism-based potential.

31 March 2020

1 reference

Distinct pharmacological properties of second generation HDAC inhibitors with the benzamide or hydroxamate head group

31 March 2020

1 reference

MS-275, a potent orally available inhibitor of histone deacetylases--the development of an anticancer agent

31 March 2020

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Identification of novel isoform-selective inhibitors within class I histone deacetylases

31 March 2020

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The benzamide MS-275 is a potent, long-lasting brain region-selective inhibitor of histone deacetylases.

31 March 2020

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HDAC inhibitor increases histone H3 acetylation and reduces microglia inflammatory response following traumatic brain injury in rats

31 March 2020

1 reference

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

31 March 2020

1 reference

Fluorescence assay of SIRT protein deacetylases using an acetylated peptide substrate and a secondary trypsin reaction

31 March 2020

1 reference

Diverse effects of natural antioxidants on cyclosporin cytotoxicity in rat renal tubular cells

31 March 2020

1 reference

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

31 March 2020

1 reference

Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening

31 March 2020

1 reference

Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors.

31 March 2020

1 reference

Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1.

31 March 2020

1 reference

Structure-activity studies on suramin analogues as inhibitors of NAD+-dependent histone deacetylases (sirtuins)

31 March 2020

2 references

31 March 2020

inferred from DOI database lookup

7 January 2021

based on heuristic

Brain drug development and brain drug targeting.

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRD2681

1 reference

19 August 2017

1 reference

PubMed ID

18827828