Molecular structures and functional relationships in clostridial neurotoxins (Q37876965)

24 August 2017

1 reference

title

Molecular structures and functional relationships in clostridial neurotoxins (English)

1 reference

24 August 2017

Subramanyam Swaminathan

series ordinal

1

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PubMed ID

21592305

24 August 2017

language of work or name

English

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publication date

13 June 2011

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24 August 2017

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24 August 2017

278

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24 August 2017

23

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24 August 2017

4467-4485

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Mechanism of action of tetanus and botulinum neurotoxins

24 August 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Tetanus and botulinum neurotoxins are zinc proteases specific for components of the neuroexocytosis apparatus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Structure and function of tetanus and botulinum neurotoxins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Structure and function of Clostridium botulinum toxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Identification of a Unique Ganglioside Binding Loop within Botulinum Neurotoxins C and D-SA,

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Bacterial protein toxins penetrate cells via a four-step mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Domain organization in Clostridium botulinum neurotoxin type E is unique: its implication in faster translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Crystal structure of botulinum neurotoxin type A and implications for toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Structural analysis of the catalytic and binding sites of Clostridium botulinum neurotoxin B

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Sequence homology and structural analysis of the clostridial neurotoxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Structure of the receptor binding fragment HC of tetanus neurotoxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Botulinum toxin and tetanus toxin recognize similar membrane determinants

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Gangliosides mediate inhibitory effects of tetanus and botulinum A neurotoxins on exocytosis in chromaffin cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Cell entry strategy of clostridial neurotoxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

How do tetanus and botulinum toxins bind to neuronal membranes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Identification of a ganglioside recognition domain of tetanus toxin using a novel ganglioside photoaffinity ligand.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

The structures of the H(C) fragment of tetanus toxin with carbohydrate subunit complexes provide insight into ganglioside binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

The crystal structure of tetanus toxin Hc fragment complexed with a synthetic GT1b analogue suggests cross-linking between ganglioside receptors and the toxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Two carbohydrate binding sites in the H(CC)-domain of tetanus neurotoxin are required for toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

The HCC-domain of botulinum neurotoxins A and B exhibits a singular ganglioside binding site displaying serotype specific carbohydrate interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Common binding site for disialyllactose and tri-peptide in C-fragment of tetanus neurotoxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Crystal Structure of Botulinum Neurotoxin Type A in Complex with the Cell Surface Co-Receptor GT1b—Insight into the Toxin–Neuron Interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Glycosylated SV2 and Gangliosides as Dual Receptors for Botulinum Neurotoxin Serotype F

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Crystal Structure of the Botulinum Neurotoxin Type G Binding Domain: Insight into Cell Surface Binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Botulinum neurotoxin serotype D attacks neurons via two carbohydrate-binding sites in a ganglioside-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Identification of the receptor-binding sites in the carboxyl-terminal half of the heavy chain of botulinum neurotoxin types C and D.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Characterization of tetanus toxin binding to rat brain membranes. Evidence for a high-affinity proteinase-sensitive receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Botulinum neurotoxin type B. Its purification, radioiodination and interaction with rat-brain synaptosomal membranes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

SV2 is the protein receptor for botulinum neurotoxin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Synaptotagmins I and II mediate entry of botulinum neurotoxin B into cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Identification of the protein receptor binding site of botulinum neurotoxins B and G proves the double-receptor concept.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Mechanism of botulinum neurotoxin B and G entry into hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Glycosylated SV2A and SV2B mediate the entry of botulinum neurotoxin E into neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

SV2 mediates entry of tetanus neurotoxin into central neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Structural basis of cell surface receptor recognition by botulinum neurotoxin B

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Role of metals in the biological activity of Clostridium botulinum neurotoxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Translocation of botulinum neurotoxin light chain protease through the heavy chain channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Crucial role of the disulfide bridge between botulinum neurotoxin light and heavy chains in protease translocation across membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Botulinum neurotoxin devoid of receptor binding domain translocates active protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Crystal structure of a catalytically active, non-toxic endopeptidase derivative of Clostridium botulinum toxin A

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Translocation of botulinum neurotoxin light chain protease by the heavy chain protein-conducting channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Membrane Interaction of botulinum neurotoxin A translocation (T) domain. The belt region is a regulatory loop for membrane interaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Mode of VAMP substrate recognition and inhibition of Clostridium botulinum neurotoxin F

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Botulinum neurotoxin heavy chain belt as an intramolecular chaperone for the light chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Structural analysis of botulinum neurotoxin type E catalytic domain and its mutant Glu212-->Gln reveals the pivotal role of the Glu212 carboxylate in the catalytic pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Analysis of active site residues of botulinum neurotoxin E by mutational, functional, and structural studies: Glu335Gln is an apoenzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Crystal structure of botulinum neurotoxin type G light chain: serotype divergence in substrate recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Structural and biochemical studies of botulinum neurotoxin serotype C1 light chain protease: implications for dual substrate specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Structure- and substrate-based inhibitor design for Clostridium botulinum neurotoxin serotype A

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Crystal structure of Clostridium botulinum neurotoxin protease in a product-bound state: Evidence for noncanonical zinc protease activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Structures of Clostridium botulinum Neurotoxin Serotype A Light Chain complexed with small-molecule inhibitors highlight active-site flexibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Structural analysis of the catalytic domain of tetanus neurotoxin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

2.3 A crystal structure of tetanus neurotoxin light chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Arg(362) and Tyr(365) of the botulinum neurotoxin type a light chain are involved in transition state stabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

A single mutation in the recombinant light chain of tetanus toxin abolishes its proteolytic activity and removes the toxicity seen after reconstitution with native heavy chain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Active-site zinc ligands and activated H2O of zinc enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Zinc coordination, function, and structure of zinc enzymes and other proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Catalytic features of the botulinum neurotoxin A light chain revealed by high resolution structure of an inhibitory peptide complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

The role of zinc binding in the biological activity of botulinum toxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

SNAP-25 Substrate Peptide (Residues 180-183) Binds to but Bypasses Cleavage by Catalytically Active Clostridium botulinum Neurotoxin E

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Substrate recognition strategy for botulinum neurotoxin serotype A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Substrate Binding Mode and Its Implication on Drug Design for Botulinum Neurotoxin A

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Structure and enzymatic activity of botulinum neurotoxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Substrate recognition mechanism of VAMP/synaptobrevin-cleaving clostridial neurotoxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Botulinum neurotoxin serotype F: identification of substrate recognition requirements and development of inhibitors with low nanomolar affinity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Deciphering antibody properties that lead to potent botulinum neurotoxin neutralization

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Identification of novel small molecule ligands that bind to tetanus toxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Bimodal modulation of the botulinum neurotoxin protein-conducting channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

The evolving field of biodefence: therapeutic developments and diagnostics

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Inhibition of metalloprotease botulinum serotype A from a pseudo-peptide binding mode to a small molecule that is active in primary neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Conformational sampling of the botulinum neurotoxin serotype A light chain: implications for inhibitor binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Novel small molecule inhibitors of botulinum neurotoxin A metalloprotease activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Potent new small-molecule inhibitor of botulinum neurotoxin serotype A endopeptidase developed by synthesis-based computer-aided molecular design

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Computer-aided lead optimization: improved small-molecule inhibitor of the zinc endopeptidase of botulinum neurotoxin serotype A

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Quinolinol and peptide inhibitors of zinc protease in botulinum neurotoxin A: effects of zinc ion and peptides on inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Identification and biochemical characterization of small-molecule inhibitors of Clostridium botulinum neurotoxin serotype A

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Investigations into small molecule non-peptidic inhibitors of the botulinum neurotoxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Iterative Structure-Based Peptide-Like Inhibitor Design against the Botulinum Neurotoxin Serotype A

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

A Potent Peptidomimetic Inhibitor of Botulinum Neurotoxin Serotype A Has a Very Different Conformation than SNAP-25 Substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Basic tetrapeptides as potent intracellular inhibitors of type A botulinum neurotoxin protease activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

A high-affinity competitive inhibitor of type A botulinum neurotoxin protease activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Engineered toxins: new therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Engineering botulinum neurotoxin to extend therapeutic intervention.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Molecular architecture of botulinum neurotoxin E revealed by single particle electron microscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Novel chimeras of botulinum neurotoxins A and E unveil contributions from the binding, translocation, and protease domains to their functional characteristics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Gangliosides are the binding substances in neural cells for tetanus and botulinum toxins in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

Direct visualization of botulinum neurotoxin-induced channels in phospholipid vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08183.X

10.1111/J.1742-4658.2011.08183.X

21 January 2018

Identifiers

DOI

1 reference

24 August 2017

1 reference

PubMed ID

21592305