Two carbohydrate binding sites in the H(CC)-domain of tetanus neurotoxin are required for toxicity (Q44312023)

1 December 2017

Two carbohydrate binding sites in the H(CC)-domain of tetanus neurotoxin are required for toxicity (English)

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1 December 2017

1

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1 December 2017

Steffen Bade

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1 December 2017

Jürgen Alves

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3

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1 December 2017

Hans Bigalke

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4

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1 December 2017

Thomas Binz

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5

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1 December 2017

language of work or name

English

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publication date

1 February 2003

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Journal of Molecular Biology

1 December 2017

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1 December 2017

326

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1 December 2017

835-847

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1 December 2017

3

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Clostridial neurotoxins: new tools for dissecting exocytosis

1 December 2017

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Neurotoxins affecting neuroexocytosis

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The fixation of tetanus toxin by ganglioside.

7 January 2021

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The binding of botulinum toxin to membrane lipids: sphingolipids, steroids and fatty acids

7 January 2021

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Neuronal sensitivity to tetanus toxin requires gangliosides.

7 January 2021

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Gangliosides are the binding substances in neural cells for tetanus and botulinum toxins in mice

7 January 2021

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Neurospecific binding, internalization, and retrograde axonal transport.

7 January 2021

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Affinity-purified tetanus neurotoxin interaction with synaptic membranes: properties of a protease-sensitive receptor component.

7 January 2021

1 reference

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Characterization of tetanus toxin binding to rat brain membranes. Evidence for a high-affinity proteinase-sensitive receptor

7 January 2021

1 reference

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How do tetanus and botulinum toxins bind to neuronal membranes?

7 January 2021

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The high-affinity binding of Clostridium botulinum type B neurotoxin to synaptotagmin II associated with gangliosides GT1b/GD1a.

7 January 2021

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Binding of botulinum type B neurotoxin to Chinese hamster ovary cells transfected with rat synaptotagmin II cDNA

7 January 2021

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Ganglioside GT1b as a complementary receptor component for Clostridium botulinum neurotoxins

7 January 2021

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Tetanus toxin fragment C binds to a protein present in neuronal cell lines and motoneurons.

7 January 2021

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Lipid rafts act as specialized domains for tetanus toxin binding and internalization into neurons

7 January 2021

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High sensitivity of mouse neuronal cells to tetanus toxin requires a GPI-anchored protein

7 January 2021

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Structure of the receptor binding fragment HC of tetanus neurotoxin

7 January 2021

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C-terminal half of tetanus toxin fragment C is sufficient for neuronal binding and interaction with a putative protein receptor.

7 January 2021

1 reference

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Identification of a ganglioside recognition domain of tetanus toxin using a novel ganglioside photoaffinity ligand.

7 January 2021

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Identification of novel small molecule ligands that bind to tetanus toxin

7 January 2021

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The structures of the H(C) fragment of tetanus toxin with carbohydrate subunit complexes provide insight into ganglioside binding

7 January 2021

1 reference

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Polystyrene-adsorbed gangliosides for investigation of the structure of the tetanus-toxin receptor

7 January 2021

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Delineation and comparison of ganglioside-binding epitopes for the toxins of Vibrio cholerae, Escherichia coli, and Clostridium tetani: evidence for overlapping epitopes

7 January 2021

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The crystal structure of tetanus toxin Hc fragment complexed with a synthetic GT1b analogue suggests cross-linking between ganglioside receptors and the toxin

7 January 2021

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Crystal structure of the multifunctional paramyxovirus hemagglutinin-neuraminidase

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Influenza B virus neuraminidase can synthesize its own inhibitor

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Interaction between botulinum neurotoxin type A and ganglioside: ganglioside inactivates the neurotoxin and quenches its tryptophan fluorescence

7 January 2021

1 reference

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Sequence homology and structural analysis of the clostridial neurotoxins

7 January 2021

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Analysis of mutants of tetanus toxin HC fragment: ganglioside binding, cell binding and retrograde axonal transport properties

7 January 2021

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Crystal structure of cholera toxin B-pentamer bound to receptor GM1 pentasaccharide

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Galactose-binding site in Escherichia coli heat-labile enterotoxin (LT) and cholera toxin (CT)

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Crystallographic refinement of ricin to 2.5 A

7 January 2021

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2.8-A crystal structure of a nontoxic type-II ribosome-inactivating protein, ebulin l

7 January 2021

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Estimation of protein secondary structure from circular dichroism spectra: comparison of CONTIN, SELCON, and CDSSTR methods with an expanded reference set

7 January 2021

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Tyrosine-1290 of tetanus neurotoxin plays a key role in its binding to gangliosides and functional binding to neurones

7 January 2021

1 reference

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Structure-based sequence alignment for the beta-trefoil subdomain of the clostridial neurotoxin family provides residue level information about the putative ganglioside binding site

7 January 2021

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Crystal structure of botulinum neurotoxin type A and implications for toxicity

7 January 2021

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Structural analysis of the catalytic and binding sites of Clostridium botulinum neurotoxin B

7 January 2021

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Regulated internalization of caveolae

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Survival of FimH-expressing enterobacteria in macrophages relies on glycolipid traffic

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Tetanus toxin blocks the neuromuscular transmission in vitro like botulinum a toxin

7 January 2021

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Isolation of synaptic plasma membrane from brain by combined flotation-sedimentation density gradient centrifugation.

7 January 2021

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10.1016/S0022-2836(02)01403-1

7 January 2021

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DOI

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1 December 2017

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