Diverse approaches for the enhancement of oral drug bioavailability (Q37863645)

24 August 2017

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title

Diverse approaches for the enhancement of oral drug bioavailability (English)

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24 August 2017

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Pius Fasinu

1

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Viness Pillay

Viness Pillay

2

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Yahya E Choonara

Yahya E Choonara

5

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Lisa C du Toit

4

Lisa C du Toit

1 reference

PubMed ID

21480294

24 August 2017

Valence M. K. Ndesendo

3

Valence M K Ndesendo

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24 August 2017

7 April 2011

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Biopharmaceutics and Drug Disposition

24 August 2017

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24 August 2017

32

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24 August 2017

4

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24 August 2017

185-209

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Drug treatment effects on disease progression.

24 August 2017

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Oral delivery of peptide drugs: barriers and developments.

21 January 2018

1 reference

Promoting absorption of drugs in humans using medium-chain fatty acid-based solid dosage forms: GIPET.

21 January 2018

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Chemical modification and formulation approaches to elevated drug transport across cell membranes

21 January 2018

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Intestinal permeation enhancers

21 January 2018

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Modeling of intestinal drug absorption: roles of transporters and metabolic enzymes (for the Gillette Review Series).

21 January 2018

1 reference

Is the oral route possible for peptide and protein drug delivery?

21 January 2018

1 reference

Administration routes and delivery systems of bisphosphonates for the treatment of bone resorption.

21 January 2018

1 reference

Absorption of the oral bisphosphonate alendronate in osteoporotic patients with Crohn's disease

21 January 2018

1 reference

Transdermal administration of bromocriptine

21 January 2018

1 reference

Making a case for domperidone in the treatment of gastrointestinal motility disorders

21 January 2018

1 reference

Human variability in CYP3A4 metabolism and CYP3A4-related uncertainty factors for risk assessment

21 January 2018

1 reference

Using anti-muscarinic drugs in the management of death rattle: evidence-based guidelines for palliative care

21 January 2018

1 reference

Metabolism of ketamine stereoisomers by human liver microsomes

21 January 2018

1 reference

Evaluation of the pharmacokinetic profile and analgesic efficacy of oral morphine after total hip arthroplasty.

21 January 2018

1 reference

Bioavailability and metabolism of prochlorperazine administered via the buccal and oral delivery route

21 January 2018

1 reference

Mixed effect modeling of sumatriptan pharmacokinetics during drug development: II. From healthy subjects to phase 2 dose ranging in patients.

21 January 2018

1 reference

Clinical pharmacokinetics and pharmacodynamics of cholinesterase inhibitors

21 January 2018

1 reference

Effect of fluvoxamine and erythromycin on the pharmacokinetics of oral lidocaine.

21 January 2018

1 reference

Biopharmaceutics and pharmacokinetics in drug research

21 January 2018

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Novel formulation strategies for improving oral bioavailability of drugs with poor membrane permeation or presystemic metabolism

21 January 2018

1 reference

Absorption enhancers in pulmonary protein delivery

21 January 2018

1 reference

Enhancement of intestinal absorption of poorly absorbed hydrophilic compounds by simultaneous use of mucolytic agent and non-ionic surfactant

21 January 2018

1 reference

Bisphosphonates: an overview with special reference to alendronate

21 January 2018

1 reference

The evaluation of some pharmaceutically acceptable excipients as permeation enhancers for amoxicillin

21 January 2018

1 reference

Effect of sodium caprate on the intestinal absorption of two modified antisense oligonucleotides in pigs

21 January 2018

1 reference

Papain: an effective permeation enhancer for orally administered low molecular weight heparin

21 January 2018

1 reference

Effects of plasma irradiation on the wettability and dissolution of compacts of griseofulvin.

21 January 2018

1 reference

Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs

21 January 2018

1 reference

Process-induced crystallinity changes in albuterol sulfate and its effect on powder physical stability

21 January 2018

1 reference

Preparation techniques and mechanisms of formation of biodegradable nanoparticles from preformed polymers

21 January 2018

1 reference

Solid dispersions as strategy to improve oral bioavailability of poor water soluble drugs

21 January 2018

1 reference

Effect of hydrogen bonding interactions on the release mechanism of felodipine from nanodispersions with polyvinylpyrrolidone

21 January 2018

1 reference

Use of compressed gas precipitation to enhance the dissolution behavior of a poorly water-soluble drug: generation of drug microparticles and drug-polymer solid dispersions

21 January 2018

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Formulation of poorly water-soluble drugs for oral administration: physicochemical and physiological issues and the lipid formulation classification system.

21 January 2018

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Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs

21 January 2018

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Predicting drug disposition via application of BCS: transport/absorption/ elimination interplay and development of a biopharmaceutics drug disposition classification system

21 January 2018

1 reference

Effect of liquid volume and food intake on the absolute bioavailability of danazol, a poorly soluble drug

21 January 2018

1 reference

Enhancing intestinal drug solubilisation using lipid-based delivery systems.

21 January 2018

1 reference

Patenting of nanopharmaceuticals in drug delivery: no small issue

21 January 2018

1 reference

DNA damage response to different surface chemistry of silver nanoparticles in mammalian cells

21 January 2018

1 reference

Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles

21 January 2018

1 reference

2,3-Dihydrowithaferin A-3beta-O-sulfate, a new potential prodrug of withaferin A from aeroponically grown Withania somnifera

21 January 2018

1 reference

Activation mechanisms of nucleoside phosphoramidate prodrugs

21 January 2018

1 reference

Prodrugs: design and clinical applications.

21 January 2018

1 reference

Restorative cell therapy for Parkinson's disease: a quest for the perfect cell

21 January 2018

1 reference

XP13512 [(+/-)-1-([(alpha-isobutanoyloxyethoxy)carbonyl] aminomethyl)-1-cyclohexane acetic acid], a novel gabapentin prodrug: I. Design, synthesis, enzymatic conversion to gabapentin, and transport by intestinal solute transporters

21 January 2018

1 reference

Formulation and development of gastroretentive drug delivery system for ofloxacin.

21 January 2018

1 reference

The disposition and metabolism of captopril

21 January 2018

1 reference

Drug delivery to the upper small intestine window using gastroretentive technologies.

21 January 2018

1 reference

Furosemide pharmacokinetics and pharmacodynamics following gastroretentive dosage form administration to healthy volunteers

21 January 2018

1 reference

Improvement in site-specific intestinal absorption of furosemide by Eudragit L100-55.

21 January 2018

1 reference

Acid-base properties and solubility of pindolol, diazepam and chlordiazepoxide in SDS micelles.

21 January 2018

1 reference

Floating drug delivery systems: an approach to oral controlled drug delivery via gastric retention

21 January 2018

1 reference

Gastroretentive drug delivery system of carbamazepine: formulation optimization using simplex lattice design: a technical note

21 January 2018

1 reference

Gastroretentive dosage forms: overview and special case of Helicobacter pylori

21 January 2018

1 reference

Gastroretentive drug delivery systems: current developments in novel system design and evaluation

21 January 2018

1 reference

Evaluation of a new controlled-drug delivery concept based on the use of thermoresponsive polymers

21 January 2018

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Biodegradable nanoparticles for oral delivery of peptides: is there a role for polymers to affect mucosal uptake?

21 January 2018

1 reference

Polysaccharides for colon targeted drug delivery

21 January 2018

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Polysaccharides in colon-specific drug delivery

21 January 2018

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In vitro and in vivo evaluation of an oral system for time and/or site-specific drug delivery

21 January 2018

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Enteric coated HPMC capsules designed to achieve intestinal targeting

21 January 2018

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Colonic drug delivery: prodrug approach

21 January 2018

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Microbially triggered drug delivery to the colon

21 January 2018

1 reference

P-glycoprotein expression and regulation. Age-related changes and potential effects on drug therapy

21 January 2018

1 reference

Biochemical, cellular, and pharmacological aspects of the multidrug transporter

21 January 2018

1 reference

Effects of poly(ethylene glycol) on efflux transporter activity in Caco-2 cell monolayers

21 January 2018

1 reference

Analysis of Multidrug Transporter in Living Cells. Inhibition of P-glycoprotein-mediated Efflux of Anthracyclines by Ionophores

21 January 2018

1 reference

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

21 January 2018

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Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

21 January 2018

1 reference

P-glycoprotein inhibitors and their screening: a perspective from bioavailability enhancement

21 January 2018

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Functional role of P-glycoprotein in limiting peroral drug absorption: optimizing drug delivery

21 January 2018

1 reference

Advanced pharmacokinetic models based on organ clearance, circulatory, and fractal concepts

21 January 2018

1 reference

Distribution of cytochrome P450 2C, 2E1, 3A4, and 3A5 in human colon mucosa

21 January 2018

1 reference

Intestinal metabolism promotes regional differences in apical uptake of indinavir: coupled effect of P-glycoprotein and cytochrome P450 3A on indinavir membrane permeability in rat.

21 January 2018

1 reference

Rat olfactory bulb and epithelium UDP-glucuronosyltransferase 2A1 (UGT2A1) expression: in situ mRNA localization and quantitative analysis

21 January 2018

1 reference

Systemic distribution of steroid sulfatase and estrogen sulfotransferase in human adult and fetal tissues

21 January 2018

1 reference

Human proton/oligopeptide transporter (POT) genes: identification of putative human genes using bioinformatics

21 January 2018

1 reference

Microbial metabolites of ingested caffeic acid are absorbed by the monocarboxylic acid transporter (MCT) in intestinal Caco-2 cell monolayers

21 January 2018

1 reference

Prediction of P-glycoprotein substrates by a support vector machine approach.

21 January 2018

1 reference

The influence of MDR1 polymorphisms on P-glycoprotein expression and function in humans

21 January 2018

1 reference

Enhanced oral absorption of paclitaxel in a novel self-microemulsifying drug delivery system with or without concomitant use of P-glycoprotein inhibitors

21 January 2018

1 reference

Use of P-glycoprotein and BCRP inhibitors to improve oral bioavailability and CNS penetration of anticancer drugs

21 January 2018

1 reference

Enhanced oral bioavailability of paclitaxel by coadministration of the P-glycoprotein inhibitor KR30031.

21 January 2018

1 reference

Risperidone and paliperidone inhibit p-glycoprotein activity in vitro.

21 January 2018

1 reference

Role of P-glycoprotein-mediated secretion in absorptive drug permeability: An approach using passive membrane permeability and affinity to P-glycoprotein

21 January 2018

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Effect of quercetin on Hoechst 33342 transport by purified and reconstituted P-glycoprotein.

21 January 2018

1 reference

A comparison of commonly used polyethoxylated pharmaceutical excipients on their ability to inhibit P-glycoprotein activity in vitro

21 January 2018

1 reference

Influence of vitamin E TPGS poly(ethylene glycol) chain length on apical efflux transporters in Caco-2 cell monolayers

21 January 2018

1 reference

Cytochrome P450 enzymes and drug metabolism--basic concepts and methods of assessment

21 January 2018

1 reference

The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature

21 January 2018

1 reference

Flavonoids diosmetin and luteolin inhibit midazolam metabolism by human liver microsomes and recombinant CYP 3A4 and CYP3A5 enzymes.

21 January 2018

1 reference

Grapefruit juice-drug interactions

21 January 2018

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Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression

21 January 2018

1 reference

Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study

21 January 2018

1 reference

Directed evolution by in vitro compartmentalization

21 January 2018

1 reference

In vitro evaluation and modification of pectinate gel beads containing trimethyl chitosan, as a multi-particulate system for delivery of water-soluble macromolecules to colon

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/BDD.750

1 reference

24 August 2017

1 reference

PubMed ID

21480294