Effect of sodium caprate on the intestinal absorption of two modified antisense oligonucleotides in pigs (Q44189262)

30 November 2017

Effect of sodium caprate on the intestinal absorption of two modified antisense oligonucleotides in pigs (English)

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30 November 2017

Araz A Raoof

1

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30 November 2017

Zeibun Ramtoola

2

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30 November 2017

Brain McKenna

3

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30 November 2017

Rosie Z Yu

4

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30 November 2017

Greg Hardee

5

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30 November 2017

Richard S Geary

6

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30 November 2017

language of work or name

English

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publication date

1 November 2002

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European Journal of Pharmaceutical Sciences

30 November 2017

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30 November 2017

17

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30 November 2017

3

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30 November 2017

131-138

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Sodium caprate elicits dilatations in human intestinal tight junctions and enhances drug absorption by the paracellular route

30 November 2017

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Intestinal permeation enhancers

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Antisense oligonucleotide therapeutics

1 reference

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Specific inhibition of PTEN expression reverses hyperglycemia in diabetic mice

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In vitro and in vivo evaluation of effects of sodium caprate on enteral peptide absorption and on mucosal morphology

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A Phase I trial of H-ras antisense oligonucleotide ISIS 2503 administered as a continuous intravenous infusion in patients with advanced carcinoma

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Development and Validation of a Pig Model for Colon-specific Drug Delivery

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Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals

1 reference

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Absorption of antisense oligonucleotides in rat intestine: effect of chemistry and length

1 reference

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7 January 2021

Mechanism of absorption enhancement in humans after rectal administration of ampicillin in suppositories containing sodium caprate

1 reference

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The influence of caprate on rectal absorption of phenoxymethylpenicillin: experience from an in-vivo perfusion in humans

1 reference

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Effects of absorption enhancers on the transport of model compounds in Caco-2 cell monolayers: assessment by confocal laser scanning microscopy

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Phase I trial of ISIS 104838, a 2'-methoxyethyl modified antisense oligonucleotide targeting tumor necrosis factor-alpha

1 reference

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7 January 2021

Reversible increase in tight junction permeability to macromolecules in rat ileal mucosa in vitro by sodium caprate, a constituent of milk fat.

1 reference

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Decanoic acid induced enhancement of rectal absorption of hydrophilic compounds in rats

1 reference

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Pharmacokinetics and tissue disposition in monkeys of an antisense oligonucleotide inhibitor of Ha-ras encapsulated in stealth liposomes

1 reference

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Comparison of pharmacokinetics and tissue disposition of an antisense phosphorothioate oligonucleotide targeting human Ha-ras mRNA in mouse and monkey.

1 reference

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7 January 2021

10.1016/S0928-0987(02)00162-8

Identifiers

DOI

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30 November 2017

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