Targeting fibroblast-growth-factor-receptor-dependent signaling for cancer therapy. (Q37849781)

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24 January 2020

review article

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title

Targeting fibroblast-growth-factor-receptor-dependent signaling for cancer therapy (English)

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24 January 2020

author

Hedwig Sutterlüty-Fall

2

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24 January 2020

Michael Grusch

3

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24 January 2020

Walter Berger

5

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24 January 2020

author name string

Christine Heinzle

1

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24 January 2020

Bettina Grasl-Kraupp

4

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24 January 2020

Brigitte Marian

6

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24 January 2020

language of work or name

English

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publication date

7 March 2011

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Expert Opinion on Therapeutic Targets

24 January 2020

published in

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24 January 2020

volume

15

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24 January 2020

issue

7

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24 January 2020

page(s)

829-846

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Fibroblast growth factors

24 January 2020

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Expression of sprouty2 inhibits B-cell proliferation and is epigenetically silenced in mouse and human B-cell lymphomas

21 January 2018

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21 January 2018

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FGF-2 protects small cell lung cancer cells from apoptosis through a complex involving PKCepsilon, B-Raf and S6K2

21 January 2018

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Fibroblast growth factor-2 induces translational regulation of Bcl-XL and Bcl-2 via a MEK-dependent pathway: correlation with resistance to etoposide-induced apoptosis

21 January 2018

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An FGF1:FGF2 chimeric growth factor exhibits universal FGF receptor specificity, enhanced stability and augmented activity useful for epithelial proliferation and radioprotection.

21 January 2018

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Fibroblast growth factor 2-mediated translational control of IAPs blocks mitochondrial release of Smac/DIABLO and apoptosis in small cell lung cancer cells

21 January 2018

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The fibroblast growth factor receptor signaling pathway as a mediator of intrinsic resistance to EGFR-specific tyrosine kinase inhibitors in non-small cell lung cancer

21 January 2018

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Fibroblast growth factor and insulin-like growth factor differentially modulate the apoptosis and G1 arrest induced by anti-epidermal growth factor receptor monoclonal antibody.

21 January 2018

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The fibroblast growth factor receptor inhibitor PD173074 blocks small cell lung cancer growth in vitro and in vivo.

21 January 2018

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Pleiotropic effects of FGFR1 on cell proliferation, survival, and migration in a 3D mammary epithelial cell model

21 January 2018

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Androgen-induced programs for prostate epithelial growth and invasion arise in embryogenesis and are reactivated in cancer.

21 January 2018

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Cell adhesion and signalling by cadherins and Ig-CAMs in cancer

21 January 2018

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Altered fibroblast growth factor receptor 4 stability promotes prostate cancer progression

21 January 2018

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The transmembrane mutation G380R in fibroblast growth factor receptor 3 uncouples ligand-mediated receptor activation from down-regulation

21 January 2018

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Transmembrane helix-helix interactions involved in ErbB receptor signaling.

21 January 2018

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Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis

21 January 2018

1 reference

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Release of basic fibroblast growth factor, an angiogenic factor devoid of secretory signal sequence: A trivial phenomenon or a novel secretion mechanism?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.566217

Expression of fibroblast growth factors and their receptors in acquired immunodeficiency syndrome-associated Kaposi sarcoma tissue and derived cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.566217

De-regulated FGF receptors as therapeutic targets in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.566217

Fibroblast growth factors, their receptors and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.566217

A mouse model of hepatocellular carcinoma: ectopic expression of fibroblast growth factor 19 in skeletal muscle of transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.566217

Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.566217

Preclinical studies of fibroblast growth factor receptor 3 as a therapeutic target in multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.566217

CHIR-258 is efficacious in a newly developed fibroblast growth factor receptor 3-expressing orthotopic multiple myeloma model in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.566217

Resident hepatocyte fibroblast growth factor receptor 4 limits hepatocarcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.566217

A phase I pharmacokinetic and pharmacodynamic study of TKI258, an oral, multitargeted receptor tyrosine kinase inhibitor in patients with advanced solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.566217

Monoclonal antibody antagonists of hypothalamic FGFR1 cause potent but reversible hypophagia and weight loss in rodents and monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.566217

A soluble dominant negative fibroblast growth factor receptor 4 isoform in human MCF-7 breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.566217

BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.566217

Factors predicting response to EGFR tyrosine kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.566217

The inhibitory anti-FGFR3 antibody, PRO-001, is cytotoxic to t(4;14) multiple myeloma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.566217

Inhibition of fibroblast growth factor receptor 3 induces differentiation and apoptosis in t(4;14) myeloma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.566217

CHIR-258, a novel, multitargeted tyrosine kinase inhibitor for the potential treatment of t(4;14) multiple myeloma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.566217

Sprouty2 protein enhances the response to gefitinib through epidermal growth factor receptor in colon cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.566217

Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.566217

FGFR3-targeted mAb therapy for bladder cancer and multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.566217

Somatic mutations affect key pathways in lung adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.566217

Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.566217

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.566217

Loss-of-function fibroblast growth factor receptor-2 mutations in melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.566217

Drug-sensitive FGFR2 mutations in endometrial carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.566217

FGFR2 mutations are rare across histologic subtypes of ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.566217

Frequent activating FGFR2 mutations in endometrial carcinomas parallel germline mutations associated with craniosynostosis and skeletal dysplasia syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.566217

Prospective study of FGFR3 mutations as a prognostic factor in nonmuscle invasive urothelial bladder carcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.566217

FGFR3 protein expression and its relationship to mutation status and prognostic variables in bladder cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.566217

Role of activating fibroblast growth factor receptor 3 mutations in the development of bladder tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.566217

Analysis of FGFR3 gene mutations in multiple myeloma patients with t(4;14)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.566217

Mutation, SNP, and isoform analysis of fibroblast growth factor receptor 3 (FGFR3) in 150 newly diagnosed multiple myeloma patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.566217

Novel therapeutic targets in bladder cancer: mutation and expression of FGF receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.566217

Activating mutations in FGFR3 and HRAS reveal a shared genetic origin for congenital disorders and testicular tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.566217

An integrated genomic analysis of human glioblastoma multiforme

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.566217

Urothelial carcinoma following augmentation cystoplasty: an aggressive variant with distinct clinicopathological characteristics and molecular genetic alterations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.566217

Constitutive activating mutation of the FGFR3b in oral squamous cell carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.566217

Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.566217

CHIR-258: a potent inhibitor of FLT3 kinase in experimental tumor xenograft models of human acute myelogenous leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.566217

In vivo target modulation and biological activity of CHIR-258, a multitargeted growth factor receptor kinase inhibitor, in colon cancer models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.566217

Discovery and preclinical studies of (R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5- methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan- 2-ol (BMS-540215), an in vivo active potent VEGFR-2 inhibitor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.566217

Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.566217

RO4383596, an orally active KDR, FGFR, and PDGFR inhibitor: synthesis and biological evaluation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.566217

Functional FGFR4 Gly388Arg Polymorphism Predicts Prognosis in Lung Adenocarcinoma Patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.566217

Upregulation of basic fibroblast growth factor in breast carcinoma and its relationship to vascular density, oestrogen receptor, epidermal growth factor receptor and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.566217

10.1517/14728222.2011.566217

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21375471%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

1 reference