Hypoxia-inducible factor inhibitors: a survey of recent patented compounds (2004 - 2010). (Q37826426)

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19 January 2020

review article

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title

Hypoxia-inducible factor inhibitors: a survey of recent patented compounds (2004 - 2010) (English)

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19 January 2020

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3

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19 January 2020

Hyun Seung Ban

series ordinal

1

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19 January 2020

author name string

Yoshikazu Uto

series ordinal

2

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19 January 2020

language of work or name

English

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publication date

6 January 2011

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Expert Opinion on Therapeutic Patents

19 January 2020

published in

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19 January 2020

volume

21

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19 January 2020

issue

2

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19 January 2020

page(s)

131-146

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A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

19 January 2020

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Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

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Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

21 January 2018

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Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

21 January 2018

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HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

21 January 2018

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Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

21 January 2018

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HIF-1-dependent transcriptional activity is required for oxygen-mediated HIF-1alpha degradation

21 January 2018

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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

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Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression

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Angiogenesis: an organizing principle for drug discovery?

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Hypoxia signalling in cancer and approaches to enforce tumour regression

21 January 2018

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The impact of O2 availability on human cancer

21 January 2018

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Targeting HIF-1 for cancer therapy

21 January 2018

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Mechanisms of inhibition of the thioredoxin growth factor system by antitumor 2-imidazolyl disulfides.

21 January 2018

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A Phase I pharmacokinetic and pharmacodynamic study of PX-12, a novel inhibitor of thioredoxin-1, in patients with advanced solid tumors.

21 January 2018

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Neratinib, an irreversible pan-ErbB receptor tyrosine kinase inhibitor: results of a phase II trial in patients with advanced non-small-cell lung cancer

21 January 2018

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Effects of the soluble guanylyl cyclase activator, YC-1, on vascular tone, cyclic GMP levels and phosphodiesterase activity

21 January 2018

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Inhibitory effect of YC-1 on the hypoxic induction of erythropoietin and vascular endothelial growth factor in Hep3B cells.

21 January 2018

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Potential antitumor agents. 64. Synthesis and antitumor evaluation of dibenzo[1,4]dioxin-1-carboxamides: a new class of weakly binding DNA-intercalating agents

21 January 2018

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Cell type-specific, topoisomerase II-dependent inhibition of hypoxia-inducible factor-1alpha protein accumulation by NSC 644221.

21 January 2018

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Development of novel inhibitors targeting HIF-1α towards anticancer drug discovery

21 January 2018

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Angiogenesis inhibitors derived from thalidomide

21 January 2018

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LW6, a novel HIF-1 inhibitor, promotes proteasomal degradation of HIF-1alpha via upregulation of VHL in a colon cancer cell line

21 January 2018

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(Aryloxyacetylamino)benzoic acid analogues: A new class of hypoxia-inducible factor-1 inhibitors.

21 January 2018

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A novel benzimidazole analogue inhibits the hypoxia-inducible factor (HIF)-1 pathway

21 January 2018

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FM19G11, a new hypoxia-inducible factor (HIF) modulator, affects stem cell differentiation status.

21 January 2018

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A novel steroidal inhibitor of estrogen-related receptor alpha (ERR alpha).

21 January 2018

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Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

21 January 2018

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Antiangiogenic properties of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin: an orally bioavailable heat shock protein 90 modulator

21 January 2018

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Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway

21 January 2018

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RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha

21 January 2018

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A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

21 January 2018

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A phase II trial of 17-(Allylamino)-17-demethoxygeldanamycin in patients with papillary and clear cell renal cell carcinoma.

21 January 2018

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Safety, efficacy, pharmacokinetics, and pharmacodynamics of the combination of sorafenib and tanespimycin

21 January 2018

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Chaetocin: a promising new antimyeloma agent with in vitro and in vivo activity mediated via imposition of oxidative stress

21 January 2018

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Preliminary evaluation of manassantin A, a potential neuroleptic agent from Saururus cernuus.

21 January 2018

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21 January 2018

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Human ACAT-1 and -2 inhibitory activities of saucerneol B, manassantin A and B isolated from Saururus chinensis.

21 January 2018

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Inhibition of PI3K by PX-866 prevents transforming growth factor-alpha-induced pulmonary fibrosis

21 January 2018

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A RNA antagonist of hypoxia-inducible factor-1alpha, EZN-2968, inhibits tumor cell growth

21 January 2018

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21 January 2018

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Prolyl hydroxylase domain-containing protein inhibitors as stabilizers of hypoxia-inducible factor: small molecule-based therapeutics for anemia

21 January 2018

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Targeting hypoxia and angiogenesis through HIF-1alpha inhibition.

21 January 2018

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21 January 2018

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The selective hypoxia inducible factor-1 inhibitor PX-478 provides in vivo radiosensitization through tumor stromal effects

21 January 2018

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Boron-containing phenoxyacetanilide derivatives as hypoxia-inducible factor (HIF)-1α inhibitors

21 January 2018

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Identification of HSP60 as a Primary Target ofo-Carboranylphenoxyacetanilide, an HIF-1α Inhibitor

21 January 2018

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Suppression of RelA/p65 transactivation activity by a lignoid manassantin isolated from Saururus chinensis

21 January 2018

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10.1517/13543776.2011.547477

21 January 2018

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21210751%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

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