The selective hypoxia inducible factor-1 inhibitor PX-478 provides in vivo radiosensitization through tumor stromal effects (Q41847706)

13 October 2017

The selective hypoxia inducible factor-1 inhibitor PX-478 provides in vivo radiosensitization through tumor stromal effects (English)

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13 October 2017

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Garth Powis

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David L Schwartz

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Arun Thitai-Kumar

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Yi He

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Ryan Williams

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Robert Lemos

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Junghwan Oh

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Andrei Volgin

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Suren Soghomonyan

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Ryuichi Nishii

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Mian Alauddin

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Uday Mukhopadhay

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Zhenghong Peng

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William Bornmann

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Juri Gelovani

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1 April 2009

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Molecular Cancer Therapeutics

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947-958

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describes a project that uses

13 October 2017

ImageQuant

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2908257/fullTextXML

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cites work

Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1alpha

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Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy

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Early reoxygenation in tumors after irradiation: determining factors and consequences for radiotherapy regimens using daily multiple fractions

5 June 2018

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Hypoxia inducible factor-1: a novel target for cancer therapy

5 June 2018

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Dynamic contrast-enhanced and diffusion MRI show rapid and dramatic changes in tumor microenvironment in response to inhibition of HIF-1alpha using PX-478.

5 June 2018

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Differential gene up-regulation by hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha in HEK293T cells

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Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1alpha.

5 June 2018

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5 June 2018

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Regulation of angiogenesis by hypoxia: role of the HIF system

5 June 2018

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Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression

5 June 2018

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HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus

5 June 2018

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Hypoxia in human soft tissue sarcomas: adverse impact on survival and no association with p53 mutations

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HIF-1: mediator of physiological and pathophysiological responses to hypoxia

5 June 2018

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Modification of radiation sensitivity: The oxygen effect

5 June 2018

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Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity

5 June 2018

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18 August 2018

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Suppression of tumor growth through disruption of hypoxia-inducible transcription

18 August 2018

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Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix

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12 December 2020

Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma

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12 December 2020

A confirmatory prognostic study on oxygenation status and loco-regional control in advanced head and neck squamous cell carcinoma treated by radiation therapy

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12 December 2020

Application of a macromolecular contrast agent for detection of alterations of tumor vessel permeability induced by radiation

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12 December 2020

Therapeutic targeting of the tumor microenvironment

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12 December 2020

Tumor response to radiotherapy regulated by endothelial cell apoptosis

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12 December 2020

Scanning electron microscopy of irradiated recipient blood vessels in head and neck free flaps

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12 December 2020

10.1158/1535-7163.MCT-08-0981

Identifiers

DOI

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13 October 2017

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13 October 2017

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