ERAD and ERAD tuning: disposal of cargo and of ERAD regulators from the mammalian ER. (Q37809383)

23 August 2017

ERAD and ERAD tuning: disposal of cargo and of ERAD regulators from the mammalian ER. (English)

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23 August 2017

2

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23 August 2017

Riccardo Bernasconi

1

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PubMed ID

21075612

23 August 2017

language of work or name

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1 April 2011

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Current Opinion in Cell Biology

23 August 2017

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23 August 2017

23

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23 August 2017

176-183

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23 August 2017

2

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Human endoplasmic reticulum mannosidase I is subject to regulated proteolysis

23 August 2017

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12 December 2020

Defining the glycan destruction signal for endoplasmic reticulum-associated degradation

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12 December 2020

Oxidoreductase activity of oligosaccharyltransferase subunits Ost3p and Ost6p defines site-specific glycosylation efficiency

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12 December 2020

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

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12 December 2020

Accumulation of mutant alpha1-antitrypsin Z in the endoplasmic reticulum activates caspases-4 and -12, NFkappaB, and BAP31 but not the unfolded protein response.

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12 December 2020

A striking quality control subcompartment in Saccharomyces cerevisiae: the endoplasmic reticulum-associated compartment

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12 December 2020

Protein sorting receptors in the early secretory pathway

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12 December 2020

Use of modular substrates demonstrates mechanistic diversity and reveals differences in chaperone requirement of ERAD.

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12 December 2020

Stringent requirement for HRD1, SEL1L, and OS-9/XTP3-B for disposal of ERAD-LS substrates

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12 December 2020

Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins

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12 December 2020

Role of Herp in the endoplasmic reticulum stress response

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12 December 2020

Cell Biology. The proteome in balance

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12 December 2020

The role of UDP-Glc:glycoprotein glucosyltransferase 1 in the maturation of an obligate substrate prosaposin.

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12 December 2020

Cyclosporine A-sensitive, cyclophilin B-dependent endoplasmic reticulum-associated degradation

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12 December 2020

Intrinsic conformational determinants signal protein misfolding to the Hrd1/Htm1 endoplasmic reticulum-associated degradation system

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12 December 2020

Consequences of individual N-glycan deletions and of proteasomal inhibition on secretion of active BACE.

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12 December 2020

Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell

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12 December 2020

SEL1L, the homologue of yeast Hrd3p, is involved in protein dislocation from the mammalian ER.

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12 December 2020

Mechanisms for rescue of correctable folding defects in CFTRDelta F508.

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12 December 2020

Glycoprotein folding and the role of EDEM1, EDEM2 and EDEM3 in degradation of folding-defective glycoproteins

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12 December 2020

Accumulation of the insoluble PiZ variant of human alpha 1-antitrypsin within the hepatic endoplasmic reticulum does not elevate the steady-state level of grp78/BiP.

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12 December 2020

Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP

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12 December 2020

ERADicate ER stress or die trying

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12 December 2020

Protein synthesis upon acute nutrient restriction relies on proteasome function

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12 December 2020

The mammalian UPR boosts glycoprotein ERAD by suppressing the proteolytic downregulation of ER mannosidase I.

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12 December 2020

Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator

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12 December 2020

A luminal surveillance complex that selects misfolded glycoproteins for ER-associated degradation

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12 December 2020

EDEM1 reveals a quality control vesicular transport pathway out of the endoplasmic reticulum not involving the COPII exit sites

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12 December 2020

Most F508del-CFTR is targeted to degradation at an early folding checkpoint and independently of calnexin

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12 December 2020

EDEM1 regulates ER-associated degradation by accelerating de-mannosylation of folding-defective polypeptides and by inhibiting their covalent aggregation.

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12 December 2020

Htm1 protein generates the N-glycan signal for glycoprotein degradation in the endoplasmic reticulum

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12 December 2020

The sugar-binding ability of human OS-9 and its involvement in ER-associated degradation

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12 December 2020

Elucidation of the molecular logic by which misfolded alpha 1-antitrypsin is preferentially selected for degradation.

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12 December 2020

Modulating proteostasis: peptidomimetic inhibitors and activators of protein folding

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12 December 2020

Autophagy-independent LC3 function in vesicular traffic.

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12 December 2020

Substrate-specific requirements for UGT1-dependent release from calnexin

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12 December 2020

Proteasome inhibitor (MG-132) treatment of mdx mice rescues the expression and membrane localization of dystrophin and dystrophin-associated proteins

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12 December 2020

One step at a time: endoplasmic reticulum-associated degradation

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12 December 2020

Regulation of basal cellular physiology by the homeostatic unfolded protein response

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12 December 2020

Coronaviruses Hijack the LC3-I-positive EDEMosomes, ER-derived vesicles exporting short-lived ERAD regulators, for replication

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12 December 2020

The human protein disulphide isomerase family: substrate interactions and functional properties

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12 December 2020

Sec61p is required for ERAD-L: genetic dissection of the translocation and ERAD-L functions of Sec61P using novel derivatives of CPY.

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12 December 2020

A complex of Yos9p and the HRD ligase integrates endoplasmic reticulum quality control into the degradation machinery.

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12 December 2020

Substrate-specific mediators of ER associated degradation (ERAD).

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12 December 2020

Deletion of Herp facilitates degradation of cytosolic proteins

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12 December 2020

N-glycan structures: recognition and processing in the ER.

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12 December 2020

The recognition motif of the glycoprotein-folding sensor enzyme UDP-Glc:glycoprotein glucosyltransferase

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12 December 2020

Segregation and rapid turnover of EDEM1 by an autophagy-like mechanism modulates standard ERAD and folding activities

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12 December 2020

Selective inhibition of endoplasmic reticulum-associated degradation rescues DeltaF508-cystic fibrosis transmembrane regulator and suppresses interleukin-8 levels: therapeutic implications.

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12 December 2020

N-glycan structure of a short-lived variant of ribophorin I expressed in the MadIA214 glycosylation-defective cell line reveals the role of a mannosidase that is not ER mannosidase I in the process of glycoprotein degradation

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12 December 2020

Glycoprotein folding, quality control and ER-associated degradation

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12 December 2020

Rapid degradation of a large fraction of newly synthesized proteins by proteasomes.

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12 December 2020

OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD

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12 December 2020

Roles of N-linked glycans in the endoplasmic reticulum

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12 December 2020

The role of autophagy in alpha-1-antitrypsin deficiency: a specific cellular response in genetic diseases associated with aggregation-prone proteins

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12 December 2020

Glucosidase and mannosidase inhibitors mediate increased secretion of mutant alpha1 antitrypsin Z.

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12 December 2020

Modularity of the Hrd1 ERAD complex underlies its diverse client range

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12 December 2020

Enhanced Catalysis of Ribonuclease B Folding by the Interaction of Calnexin or Calreticulin with ERp57

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12 December 2020

EDEM1 recognition and delivery of misfolded proteins to the SEL1L-containing ERAD complex

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12 December 2020

Ribophorin I acts as a substrate-specific facilitator of N-glycosylation

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12 December 2020

Interaction of the thiol-dependent reductase ERp57 with nascent glycoproteins

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12 December 2020

The UDP-Glc:Glycoprotein glucosyltransferase is essential for Schizosaccharomyces pombe viability under conditions of extreme endoplasmic reticulum stress

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12 December 2020

Basal autophagy is involved in the degradation of the ERAD component EDEM1.

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12 December 2020

Getting in and out from calnexin/calreticulin cycles

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12 December 2020

Misfolded proteins are sorted by a sequential checkpoint mechanism of ER quality control

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12 December 2020

Consequences of ERp57 deletion on oxidative folding of obligate and facultative clients of the calnexin cycle

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12 December 2020

10.1016/J.CEB.2010.10.002

Identifiers

DOI

1 reference

23 August 2017

1 reference

PubMed ID

21075612