Novel N-methyl-D-aspartate receptor antagonists: a review of compounds patented since 2006. (Q37807432)

23 August 2017

Novel N-methyl-D-aspartate receptor antagonists: a review of compounds patented since 2006. (English)

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23 August 2017

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Manuel Koller

1

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PubMed ID

21054234

23 August 2017

Stephan Urwyler

series ordinal

2

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PubMed ID

21054234

23 August 2017

language of work or name

English

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publication date

8 November 2010

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Expert Opinion on Therapeutic Patents

23 August 2017

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23 August 2017

20

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23 August 2017

12

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23 August 2017

1683-1702

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NMDA receptor subunits: function and pharmacology.

23 August 2017

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Allosteric modulation of NMDA receptor via elevation of brain glycine and D-serine: the therapeutic potentials for schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.533656

Influence of the NR3A subunit on NMDA receptor functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.533656

The modulation of N-methyl-D-aspartate receptors by redox and alkylating reagents in rat cortical neurones in vitro.

21 January 2018

1 reference

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Molecular basis of NMDA receptor-coupled ion channel modulation by S-nitrosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.533656

The NMDA receptor as a therapeutic target in major depressive disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.533656

NR2B subunit selective NMDA antagonists inhibit neurotoxic effect of alcohol-withdrawal in primary cultures of rat cortical neurones

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.533656

Behavioural pharmacology: 40+ years of progress, with a focus on glutamate receptors and cognition

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2010.533656

Glutamate receptor dysfunction and schizophrenia

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2010.533656

Progress towards validating the NMDA receptor hypofunction hypothesis of schizophrenia

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2010.533656

Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.533656

Allosteric modulators of NR2B-containing NMDA receptors: molecular mechanisms and therapeutic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.533656

Memantine: a review of its use in moderate to severe Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.533656

Molecular determinants of the anticonvulsant felbamate binding site in the N-methyl-D-aspartate receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.533656

Dextromethorphan: a review of N-methyl-d-aspartate receptor antagonist in the management of pain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.533656

Memantine: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system--too little activation is bad, too much is even worse

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.533656

Developmental and regional expression in the rat brain and functional properties of four NMDA receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.533656

Developmental changes in NMDA neurotoxicity reflect developmental changes in subunit composition of NMDA receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.533656

NR2B selective NMDA antagonists: the evolution of the ifenprodil-type pharmacophore

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.533656

Indole-2-carboxamidines as novel NR2B selective NMDA receptor antagonists.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.533656

Phenylethanolamines inhibit NMDA receptors by enhancing proton inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.533656

Enantiomeric propanolamines as selective N-methyl-D-aspartate 2B receptor antagonists.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.533656

Synthesis, structural activity-relationships, and biological evaluation of novel amide-based allosteric binding site antagonists in NR1A/NR2B N-methyl-D-aspartate receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.533656

The glycine/NMDA receptor antagonist, R-(+)-HA-966, blocks activation of the mesolimbic dopaminergic system induced by phencyclidine and dizocilpine (MK-801) in rodents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.533656

A randomized, double-blind, placebo-controlled trial of a glycine antagonist in neuropathic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.533656

Potentiation of the NMDA receptor in the treatment of schizophrenia: focused on the glycine site

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.533656

GLYX-13: a monoclonal antibody-derived peptide that acts as an N-methyl-D-aspartate receptor modulator.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.533656

A NMDA receptor glycine site partial agonist, GLYX-13, simultaneously enhances LTP and reduces LTD at Schaffer collateral-CA1 synapses in hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.533656

Hippocampal long-term depression: master or minion in declarative memory processes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.533656

Differential modulation of glutamatergic transmission by 3,5-dibromo-L-phenylalanine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.533656

Efficacy of 3,5-dibromo-L-phenylalanine in rat models of stroke, seizures and sensorimotor gating deficit

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.533656

Stability studies of oxazolidine-based compounds using 1H NMR spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.533656

Effects of the N-methyl-D-aspartate receptor antagonist perzinfotel [EAA-090; [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)-ethyl]phosphonic acid] on chemically induced thermal hypersensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.533656

PET and SPECT imaging of the NMDA receptor system: an overview of radiotracer development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.533656

Synthesis and in vitro evaluation of (18)F-labelled S-fluoroalkyl diarylguanidines: Novel high-affinity NMDA receptor antagonists for imaging with PET.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.533656

Orally efficacious NR2B-selective NMDA receptor antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.533656

Dizocilpine-like discriminative stimulus effects of low-affinity uncompetitive NMDA antagonists.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.533656

Memantine preferentially blocks extrasynaptic over synaptic NMDA receptor currents in hippocampal autapses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.533656

A six-month, placebo-controlled trial of D-cycloserine co-administered with conventional antipsychotics in schizophrenia patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.533656

Comparative study of action mechanisms of dimebon and memantine on AMPA- and NMDA-subtypes glutamate receptors in rat cerebral neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.533656

Differential roles of NMDA receptor subtypes in ischemic neuronal cell death and ischemic tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.533656

Single-channel activations and concentration jumps: comparison of recombinant NR1a/NR2A and NR1a/NR2D NMDA receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.533656

Structure-activity analysis of a novel NR2C/NR2D-preferring NMDA receptor antagonist: 1-(phenanthrene-2-carbonyl) piperazine-2,3-dicarboxylic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.533656

Quinazolin-4-one derivatives: A novel class of noncompetitive NR2C/D subunit-selective N-methyl-D-aspartate receptor antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.533656

Characterization of a soluble ligand binding domain of the NMDA receptor regulatory subunit NR3A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.533656

Novel treatment of excitotoxicity: targeted disruption of intracellular signalling from glutamate receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.533656

Treatment of ischemic brain damage by perturbing NMDA receptor- PSD-95 protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.533656

PDZ Protein Interactions Underlying NMDA Receptor-Mediated Excitotoxicity and Neuroprotection by PSD-95 Inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.533656

Glycine potentiates the NMDA response in cultured mouse brain neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.533656

10.1517/13543776.2010.533656

21 January 2018

Identifiers

DOI

1 reference

23 August 2017

1 reference

PubMed ID

21054234