5-HT2C receptor modulators: a patent survey (Q37789738)

23 August 2017

5-HT2C receptor modulators: a patent survey (English)

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23 August 2017

Junwon Lee

1

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23 August 2017

Myung Eun Jung

series ordinal

2

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23 August 2017

Jinhwa Lee

series ordinal

3

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23 August 2017

language of work or name

English

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publication date

17 September 2010

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Expert Opinion on Therapeutic Patents

23 August 2017

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23 August 2017

20

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23 August 2017

11

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23 August 2017

1429-1455

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A review of central 5-HT receptors and their function

23 August 2017

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https://api.crossref.org/works/10.1517%2F13543776.2010.518956

A review of serotonin toxicity data: implications for the mechanisms of antidepressant drug action

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Molecular biology of 5-HT receptors

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2010.518956

5-Hydroxytryptamine 2C (5-HT2C) receptor agonists as potential antiobesity agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Synthesis and structure-activity relationships of a series of substituted 2-(1H-furo[2,3-g]indazol-1-yl)ethylamine derivatives as 5-HT2C receptor agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Fine-tuning serotonin2c receptor function in the brain: molecular and functional implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Physiological and therapeutic relevance of constitutive activity of 5-HT 2A and 5-HT 2C receptors for the treatment of depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Serotonergic 5-HT2C receptors as a potential therapeutic target for the design antiepileptic drugs

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2010.518956

The binding of serotonergic ligands to the porcine choroid plexus: characterization of a new type of serotonin recognition site

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Regulation of serotonin-2C receptor G-protein coupling by RNA editing

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Messenger RNA editing of the human serotonin 5-HT2C receptor

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Serotonin 5-HT2C receptor RNA editing alters receptor basal activity: implications for serotonergic signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Regional distribution and cellular localization of 5-HT2C receptor mRNA in monkey brain: comparison with [3H]mesulergine binding sites and choline acetyltransferase mRNA.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Pharmacological characterisation of human 5-HT2 receptor subtypes

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Actual Causes of Death in the United States, 2000

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Serotonin 5-ht2c receptor agonists: potential for the treatment of obesity

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2010.518956

International trial of long-term dexfenfluramine in obesity.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Fenfluramine therapy in non-insulin-dependent diabetic patients: effects on body weight, glucose homeostasis, serum lipoproteins, and antipyrine metabolism

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Pharmacological targeting of the serotonergic system for the treatment of obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Leptin-independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2010.518956

SB-243213; a selective 5-HT2C receptor inverse agonist with improved anxiolytic profile: lack of tolerance and withdrawal anxiety

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.518956

A comparative study of the effects of selective and non-selective 5-HT2 receptor subtype antagonists in rat and mouse models of anxiety.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Effect of SB 200646A, a 5-HT2C/5-HT2B receptor antagonist, in two conflict models of anxiety.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.518956

SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Behavioral effects of systemically administered MK-212 are prevented by ritanserin microinfusion into the basolateral amygdala of rats exposed to the elevated plus-maze.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2010.518956

m-Chlorophenylpiperazine as a probe of serotonin function

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Serotonin 2C receptors within the basolateral amygdala induce acute fear-like responses in an open-field environment

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Insights into the structure and function of 5-HT(2) family serotonin receptors reveal novel strategies for therapeutic target development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Altered RNA editing of serotonin 2C receptor in a rat model of depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Altered RNA editing of serotonin 5-HT2C receptor induced by interferon: implications for depression associated with cytokine therapy

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Dual monoamine modulation for improved treatment of major depressive disorder

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Mechanisms of action of selective serotonin reuptake inhibitors in the treatment of psychiatric disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Physiological relevance of constitutive activity of 5-HT2A and 5-HT2C receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Augmentation of SSRI effects on serotonin by 5-HT2C antagonists: mechanistic studies.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Inactivation of 5-HT(2C) receptors potentiates consequences of serotonin reuptake blockade

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Serotonin (5-HT)2C receptors tonically inhibit dopamine (DA) and noradrenaline (NA), but not 5-HT, release in the frontal cortex in vivo.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Strategies for producing faster acting antidepressants.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2010.518956

RNA editing of the 5-HT(2C) receptor is reduced in schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Serotonin (5-HT)2A receptor activation enhances dialysate levels of dopamine and noradrenaline, but not 5-HT, in the frontal cortex of freely-moving rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Discriminative stimulus properties of mCPP and alprazolam are not mediated by anxiety.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Selective and nonselective serotonin antagonists block the aversive stimulus properties of MK212 and m-chlorophenylpiperazine (mCPP) in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Differential roles of 5-HT receptor subtypes in cue and cocaine reinstatement of cocaine-seeking behavior in rats

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Epilepsy and obesity in serotonin 5-HT2C receptor mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Effect of a 5-HT(2C) serotonin agonist, dexnorfenfluramine, on amyloid precursor protein metabolism in guinea pigs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Depression and incontinence

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Discovery of a novel azepine series of potent and selective 5-HT2C agonists as potential treatments for urinary incontinence

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Treatment of hot flushes with mirtazapine: four case reports

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.518956

The role of the 5-HT2 receptor in the regulation of sexual performance of male rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Discovery and structure-activity relationship of (1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin), a selective serotonin 5-HT2C receptor agonist for the treatment of obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Discovery and SAR of new benzazepines as potent and selective 5-HT(2C) receptor agonists for the treatment of obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.518956

The "selective" dopamine D1 receptor antagonist, SCH23390, is a potent and high efficacy agonist at cloned human serotonin2C receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.518956

WAY-163909 [(7bR, 10aR)-1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta-[b][1,4]diazepino[6,7,1hi]indole], a novel 5-hydroxytryptamine 2C receptor-selective agonist with anorectic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Cycloalkyl[b][1,4]benzodiazepinoindoles are agonists at the human 5-HT2C receptor

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Design and synthesis of piperazinylpyrimidinones as novel selective 5-HT(2C) agonists

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Design and synthesis of pyridazinone-based 5-HT(2C) agonists

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Metabolic diseases drug discovery world summit. July 28-29, 2003, San Diego, CA, USA.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Identification of 4-methyl-1,2,3,4,10,10a-hexahydropyrazino[1,2-a]indoles as 5-HT2C receptor agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Synthesis and biological evaluation of novel hexahydro-pyrido[3',2':4,5]pyrrolo[1,2-a]pyrazines as potent and selective 5-HT(2C) receptor agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Discovery of (R)-9-ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol- 6(2H)-one, a selective, orally active agonist of the 5-HT(2C) receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Pharmacological profile of YM348, a novel, potent and orally active 5-HT2C receptor agonist

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Antiobesity effect of YM348, a novel 5-HT2C receptor agonist, in Zucker rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Synthesis and structure-activity relationships of a series of benzazepine derivatives as 5-HT2C receptor agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Selective 5-hydroxytryptamine 2C receptor agonists derived from the lead compound tranylcypromine: identification of drugs with antidepressant-like action

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Biarylcarbamoylindolines are novel and selective 5-HT(2C) receptor inverse agonists: identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.518956

A series of bisaryl imidazolidin-2-ones has shown to be selective and orally active 5-HT2C receptor antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.518956

Synthesis and structure-activity relationship of 1H-indole-3-carboxylic acid pyridine-3-ylamides: a novel series of 5-HT2C receptor antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.518956

10.1517/13543776.2010.518956

21 January 2018

Identifiers

DOI

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23 August 2017

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