Mechanistic insights into Notch receptor signaling from structural and biochemical studies (Q37785192)

23 August 2017

Mechanistic insights into Notch receptor signaling from structural and biochemical studies (English)

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23 August 2017

Rhett A Kovall

1

1 reference

PubMed ID

20816392

23 August 2017

Stephen C Blacklow

series ordinal

2

1 reference

23 August 2017

1 January 2010

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Current Topics in Developmental Biology

23 August 2017

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23 August 2017

92

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23 August 2017

31-71

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Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling.

23 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

The adhesion force of Notch with Delta and the rate of Notch signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

A conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Notch signaling in leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

The folding and structural integrity of the first LIN-12 module of human Notch1 are calcium-dependent.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Essential roles for ankyrin repeat and transactivation domains in induction of T-cell leukemia by notch1.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Suppressor of hairless directly activates transcription of enhancer of split complex genes in response to Notch receptor activity.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Default repression and Notch signaling: Hairless acts as an adaptor to recruit the corepressors Groucho and dCtBP to Suppressor of Hairless

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

The Notch transcription activation complex makes its move

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

A role of receptor Notch in ligand cis-inhibition in Drosophila.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

PTF1 is an organ-specific and Notch-independent basic helix-loop-helix complex containing the mammalian Suppressor of Hairless (RBP-J) or its paralogue, RBP-L.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

The effects of conformational heterogeneity on the binding of the Notch intracellular domain to effector proteins: a case of biologically tuned disorder

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

The Notch signaling pathway: transcriptional regulation at Notch target genes

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Inhibition of the DNA-binding activity of Drosophila suppressor of hairless and of its human homolog, KBF2/RBP-J kappa, by direct protein-protein interaction with Drosophila hairless

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Glycosyltransferase activity of Fringe modulates Notch-Delta interactions.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Kaposi's Sarcoma-associated herpesvirus lytic switch protein stimulates DNA binding of RBP-Jk/CSL to activate the Notch pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Site-directed mutagenesis study on DNA binding regions of the mouse homologue of Suppressor of Hairless, RBP-J kappa

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Localization of the delta-like-1-binding site in human Notch-1 and its modulation by calcium affinity

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Mutational and energetic studies of Notch 1 transcription complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Dose-dependent effects of the Notch ligand Delta1 on ex vivo differentiation and in vivo marrow repopulating ability of cord blood cells

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

The recombination signal sequence-binding protein RBP-2N functions as a transcriptional repressor

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

SEL-8, a nuclear protein required for LIN-12 and GLP-1 signaling in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

High-resolution crystal structure of the human Notch 1 ankyrin domain

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Myeloid translocation gene 16 (MTG16) interacts with Notch transcription complex components to integrate Notch signaling in hematopoietic cell fate specification

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Notch directly regulates Gata3 expression during T helper 2 cell differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

The suppressor of hairless protein participates in notch receptor signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

RAM-induced Allostery Facilitates Assembly of a Notch Pathway Active Transcription Complex

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

A notch1 ectodomain construct inhibits endothelial notch signaling, tumor growth, and angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

A model Notch response element detects Suppressor of Hairless-dependent molecular switch.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

In vivo consequences of deleting EGF repeats 8-12 including the ligand binding domain of mouse Notch1.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

The O-fucose glycan in the ligand-binding domain of Notch1 regulates embryogenesis and T cell development

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

The CSL transcription factor LAG-1 directly represses hlh-6 expression in C. elegans

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Role of conserved intracellular motifs in Serrate signalling, cis-inhibition and endocytosis

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Gene-specific targeting of the histone chaperone asf1 to mediate silencing

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

The molecular logic of Notch signaling--a structural and biochemical perspective.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Structural basis for autoinhibition of Notch

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Effects of S1 Cleavage on the Structure, Surface Export, and Signaling Activity of Human Notch1 and Notch2

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Analysis of gain-of-function mutations of the lin-12 gene of Caenorhabditis elegans.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Structural and functional properties of the human notch-1 ligand binding region.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

O-linked fucose and other post-translational modifications unique to EGF modules

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Masking of the CBF1/RBPJ kappa transcriptional repression domain by Epstein-Barr virus EBNA2.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Signalling downstream of activated mammalian Notch

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Neoplastic transformation by Notch requires nuclear localization

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Thermodynamic analysis of the CSL x Notch interaction: distribution of binding energy of the Notch RAM region to the CSL beta-trefoil domain and the mode of competition with the viral transactivator EBNA2.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

A histone deacetylase corepressor complex regulates the Notch signal transduction pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Conformational variability of the intracellular domain of Drosophila Notch and its interaction with Suppressor of Hairless

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Asparagine beta-hydroxylation stabilizes the ankyrin repeat domain fold

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

An intrinsic dominant negative activity of serrate that is modulated during wing development in Drosophila.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

OSM-11 facilitates LIN-12 Notch signaling during Caenorhabditis elegans vulval development

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

The canonical Notch signaling pathway: unfolding the activation mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Structures of CSL, Notch and Mastermind proteins: piecing together an active transcription complex

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

More complicated than it looks: assembly of Notch pathway transcription complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Crystal structure of the nuclear effector of Notch signaling, CSL, bound to DNA

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Notch activation stimulates transient and selective binding of Su(H)/CSL to target enhancers

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

The divergent DSL ligand Dll3 does not activate Notch signaling but cell autonomously attenuates signaling induced by other DSL ligands

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

In vivo analysis of the Notch receptor S1 cleavage

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Modulation of Notch signaling by antibodies specific for the extracellular negative regulatory region of NOTCH3

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Notch3 signaling promotes the development of pulmonary arterial hypertension

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Histone demethylase KDM5A is an integral part of the core Notch-RBP-J repressor complex

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

SUMO modification regulates the transcriptional activity of MAML1.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

The Notch1 receptor is cleaved constitutively by a furin-like convertase

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Quantitative dissection of the Notch:CSL interaction: insights into the Notch-mediated transcriptional switch.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

The crystal structure of a partial mouse Notch-1 ankyrin domain: repeats 4 through 7 preserve an ankyrin fold.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Role of unusual O-glycans in intercellular signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Autoproteolysis coupled to protein folding in the SEA domain of the membrane-bound MUC1 mucin

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Solution structure of the SEA domain from the murine homologue of ovarian cancer antigen CA125 (MUC16)

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Hairless: the ignored antagonist of the Notch signalling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

In vivo structure-function analysis of Drosophila Hairless.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Crystal structure of the catalytic domain of human tumor necrosis factor-alpha-converting enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

A protein binding to the J kappa recombination sequence of immunoglobulin genes contains a sequence related to the integrase motif

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

RBP-L, a transcription factor related to RBP-Jkappa

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Direct inhibition of the NOTCH transcription factor complex

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Fringe is a glycosyltransferase that modifies Notch

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Histone chaperones ASF1 and NAP1 differentially modulate removal of active histone marks by LID-RPD3 complexes during NOTCH silencing.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Mechanisms that regulate mechanosensory hair cell differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

1 reference

7 January 2021

Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Notch-GATA synergy promotes endoderm-specific expression of ref-1 in C. elegans.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

The RRM domain of MINT, a novel Msx2 binding protein, recognizes and regulates the rat osteocalcin promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

DSL ligand endocytosis physically dissociates Notch1 heterodimers before activating proteolysis can occur

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Regulation of notch signaling by o-linked fucose.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Target selectivity of vertebrate notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probability

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

SHARP is a novel component of the Notch/RBP-Jkappa signalling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch target genes

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Fringe modulates Notch-ligand interactions.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Notch3 gene amplification in ovarian cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

LAG-3 is a putative transcriptional activator in the C. elegans Notch pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

CADASIL-associated Notch3 mutations have differential effects both on ligand binding and ligand-induced Notch3 receptor signaling through RBP-Jk

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

The interplay between DSL proteins and ubiquitin ligases in Notch signaling.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Fungal CSL transcription factors.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Calcium depletion dissociates and activates heterodimeric notch receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Specific EGF repeats of Notch mediate interactions with Delta and serrate: Implications for notch as a multifunctional receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

PEST sequences and regulation by proteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

GSK3beta is a negative regulator of the transcriptional coactivator MAML1.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

A proline repeat domain in the Notch co-activator MAML1 is important for the p300-mediated acetylation of MAML1.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

ETO, but not leukemogenic fusion protein AML1/ETO, augments RBP-Jkappa/SHARP-mediated repression of notch target genes

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Notch subunit heterodimerization and prevention of ligand-independent proteolytic activation depend, respectively, on a novel domain and the LNR repeats

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Requirement for dynamin during Notch signaling in Drosophila neurogenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Fringe modifies O-fucose on mouse Notch1 at epidermal growth factor-like repeats within the ligand-binding site and the Abruptex region

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Protein O -fucosyltransferase 1 is an essential component of Notch signaling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Sharp, an inducible cofactor that integrates nuclear receptor repression and activation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Presenilin is required for activity and nuclear access of Notch in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

The contribution of Notch1 to nephron segmentation in the developing kidney is revealed in a sensitized Notch2 background and can be augmented by reducing Mint dosage.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H)

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

LIM protein KyoT2 negatively regulates transcription by association with the RBP-J DNA-binding protein

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Mechanochemistry of receptor-ligand bonds.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Biophysics of catch bonds

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Recognition sequence of a highly conserved DNA binding protein RBP-J kappa

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Nuclear magnetic resonance structure of a prototype Lin12-Notch repeat module from human Notch1

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Ectodomain shedding and intramembrane cleavage of mammalian Notch proteins is not regulated through oligomerization.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

RBP-J kappa repression activity is mediated by a co-repressor and antagonized by the Epstein-Barr virus transcription factor EBNA2.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Identification of a GDP-L-fucose:polypeptide fucosyltransferase and enzymatic addition of O-linked fucose to EGF domains

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Modification of epidermal growth factor-like repeats with O-fucose. Molecular cloning and expression of a novel GDP-fucose protein O-fucosyltransferase

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Purification and characterization of a GDP-fucose:polypeptide fucosyltransferase from Chinese hamster ovary cells

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Alterations of the Notch pathway in lung cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Therapeutic antibody targeting of individual Notch receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

In vitro reconstitution of the modulation of Drosophila Notch-ligand binding by Fringe

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Chronic DLL4 blockade induces vascular neoplasms

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

A role for SKIP in EBNA2 activation of CBF1-repressed promoters

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Studies of the ankyrin repeats of the Drosophila melanogaster Notch receptor. 1. Solution conformational and hydrodynamic properties

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Structure and stability of the ankyrin domain of the Drosophila Notch receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

Contribution of conserved amino acids in mediating the interaction between EBNA2 and CBF1/RBPJk

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

beta-Trefoil fold. Patterns of structure and sequence in the Kunitz inhibitors interleukins-1 beta and 1 alpha and fibroblast growth factors

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2810%2992002-4

7 January 2021

10.1016/S0070-2153(10)92002-4

Identifiers

DOI

1 reference

23 August 2017

1 reference

PubMed ID

20816392