Lipid rafts and clusters of apoptotic signaling molecule-enriched rafts in cancer therapy. (Q37750797)

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2 February 2020

review article

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title

Lipid rafts and clusters of apoptotic signaling molecule-enriched rafts in cancer therapy (English)

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2 February 2020

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2

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1

Faustino Mollinedo

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language of work or name

English

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publication date

1 May 2010

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2 February 2020

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volume

6

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issue

5

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page(s)

811-821

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Overcoming drug resistance by enhancing apoptosis of tumor cells.

2 February 2020

cites work

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Fas/CD95 death receptor and lipid rafts: new targets for apoptosis-directed cancer therapy.

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The Hallmarks of Cancer

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Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

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Bid: a Bax-like BH3 protein.

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Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax

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Caspase-10 triggers Bid cleavage and caspase cascade activation in FasL-induced apoptosis.

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The antitumor ether lipid ET-18-OCH(3) induces apoptosis through translocation and capping of Fas/CD95 into membrane rafts in human leukemic cells

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Lipid rafts and signal transduction

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Lipid rafts: elusive or illusive?

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Lipid rafts and membrane traffic

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Intracellular triggering of Fas, independently of FasL, as a new mechanism of antitumor ether lipid-induced apoptosis

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Intracellular triggering of Fas aggregation and recruitment of apoptotic molecules into Fas-enriched rafts in selective tumor cell apoptosis

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Edelfosine and perifosine induce selective apoptosis in multiple myeloma by recruitment of death receptors and downstream signaling molecules into lipid rafts.

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Edelfosine is incorporated into rafts and alters their organization

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Involvement of raft aggregates enriched in Fas/CD95 death-inducing signaling complex in the antileukemic action of edelfosine in Jurkat cells

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Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy

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Cisplatin-induced CD95 redistribution into membrane lipid rafts of HT29 human colon cancer cells.

21 January 2018

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Avicin D, a plant triterpenoid, induces cell apoptosis by recruitment of Fas and downstream signaling molecules into lipid rafts

21 January 2018

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Redistribution of CD95, DR4 and DR5 in rafts accounts for the synergistic toxicity of resveratrol and death receptor ligands in colon carcinoma cells

21 January 2018

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Involvement of mitochondria and recruitment of Fas/CD95 signaling in lipid rafts in resveratrol-mediated antimyeloma and antileukemia actions.

21 January 2018

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Fas receptor clustering and involvement of the death receptor pathway in rituximab-mediated apoptosis with concomitant sensitization of lymphoma B cells to fas-induced apoptosis

21 January 2018

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Lipid raft connection between extrinsic and intrinsic apoptotic pathways.

21 January 2018

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Involvement of mitochondria and caspase-3 in ET-18-OCH(3)-induced apoptosis of human leukemic cells.

21 January 2018

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Cholesterol and prostate cancer

21 January 2018

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Cholesteryl esters in malignancy

21 January 2018

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Elevated levels of cholesterol-rich lipid rafts in cancer cells are correlated with apoptosis sensitivity induced by cholesterol-depleting agents

21 January 2018

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TRAIL-receptor antibodies as a potential cancer treatment

21 January 2018

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The promise of cancer therapeutics targeting the TNF-related apoptosis-inducing ligand and TRAIL receptor pathway

21 January 2018

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TRAIL and cancer therapy.

21 January 2018

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Perifosine synergistically enhances TRAIL-induced myeloma cell apoptosis via up-regulation of death receptors

21 January 2018

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Cytoskeleton and apoptosis

21 January 2018

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Cortical actin organization: lessons from ERM (ezrin/radixin/moesin) proteins

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ERM proteins and merlin: integrators at the cell cortex

21 January 2018

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ERM proteins in epithelial cell organization and functions

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CD95 (APO-1/Fas) linkage to the actin cytoskeleton through ezrin in human T lymphocytes: a novel regulatory mechanism of the CD95 apoptotic pathway

21 January 2018

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GD3 glycosphingolipid contributes to Fas-mediated apoptosis via association with ezrin cytoskeletal protein

21 January 2018

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Molecular ordering of the initial signaling events of CD95.

21 January 2018

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Rho-ROCK-dependent ezrin-radixin-moesin phosphorylation regulates Fas-mediated apoptosis in Jurkat cells

21 January 2018

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Raft component GD3 associates with tubulin following CD95/Fas ligation.

21 January 2018

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Role of GD3-CLIPR-59 association in lymphoblastoid T cell apoptosis triggered by CD95/Fas

21 January 2018

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Quantitative proteomic analysis of B cell lipid rafts reveals that ezrin regulates antigen receptor-mediated lipid raft dynamics

21 January 2018

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Remodeling of cellular cytoskeleton by the acid sphingomyelinase/ceramide pathway

21 January 2018

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Changes in the lipid turnover, composition, and organization, as sphingolipid-enriched membrane domains, in rat cerebellar granule cells developing in vitro

21 January 2018

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Golgi fragmentation is associated with ceramide-induced cellular effects.

21 January 2018

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Segregation of gangliosides GM1 and GD3 on cell membranes, isolated membrane rafts, and defined supported lipid monolayers

21 January 2018

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Lipid raft heterogeneity: an enigma

21 January 2018

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Lipid rafts as functional heterogeneity in cell membranes

21 January 2018

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Resveratrol-induced apoptosis is associated with Fas redistribution in the rafts and the formation of a death-inducing signaling complex in colon cancer cells

21 January 2018

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Cytotoxicity of an Anti-cancer Lysophospholipid through Selective Modification of Lipid Raft Composition

21 January 2018

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Ceramide-mediated clustering is required for CD95-DISC formation

21 January 2018

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21 January 2018

Identifiers

DOI

10.2217/FON.10.34

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20465392%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

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