Association Between Low-Density Lipoprotein Cholesterol-Lowering Genetic Variants and Risk of Type 2 Diabetes: A Meta-analysis (Q37744428)

22 August 2017

0 references

Association Between Low-Density Lipoprotein Cholesterol-Lowering Genetic Variants and Risk of Type 2 Diabetes: A Meta-analysis (English)

1 reference

22 August 2017

0 references

0 references

1 reference

1 reference

13

1 reference

22 August 2017

18

1 reference

22 August 2017

Yvonne T van der Schouw

33

1 reference

22 August 2017

35

Inês Barroso

0 references

Claudia Langenberg

39

Claudia Langenberg

0 references

Stephen Burgess

3

0 references

Carlotta Sacerdote

26

0 references

Heiner Boeing

11

Heiner Boeing

1 reference

22 August 2017

38

Naveed Sattar

1 reference

22 August 2017

Luca A Lotta

1

0 references

Sara Grioni

Sara Grioni

15

0 references

Paul W. Franks

Paul W Franks

14

0 references

Elio Riboli

Elio Riboli

24

0 references

Anne Tjønneland

Anne Tjonneland

30

0 references

David B Savage

David B Savage

37

0 references

Stephen O'Rahilly

Stephen O'Rahilly

36

0 references

Rudolf Kaaks

16

Rudolf Kaaks

1 reference

22 August 2017

31

Rosario Tumino

1 reference

22 August 2017

20

Kim Overvad

1 reference

22 August 2017

Mark I McCarthy

34

0 references

Salvatore Panico

22

Salvatore Panico

1 reference

22 August 2017

8

Eva Ardanaz

1 reference

22 August 2017

41

Nicholas J Wareham

1 reference

22 August 2017

12

Panos Deloukas

1 reference

22 August 2017

21

Domenico Palli

1 reference

22 August 2017

28

Nadia Slimani

1 reference

22 August 2017

2

Stephen J Sharp

1 reference

22 August 2017

40

Robert A Scott

1 reference

22 August 2017

25

Olov Rolandsson

1 reference

22 August 2017

Annemieke M W Spijkerman

29

Annemieke Mw Spijkerman

1 reference

22 August 2017

9

Larraitz Arriola

1 reference

22 August 2017

10

Beverley Balkau

1 reference

22 August 2017

6

Sara M Willems

1 reference

22 August 2017

John R B Perry

4

1 reference

22 August 2017

Isobel D Stewart

5

1 reference

22 August 2017

Jian'an Luan

7

1 reference

22 August 2017

Timothy J Key

17

1 reference

22 August 2017

Peter M Nilsson

19

1 reference

22 August 2017

Jose-Ramón Quirós

23

1 reference

22 August 2017

Elena C Salamanca

27

1 reference

22 August 2017

Daphne L van der A

32

1 reference

22 August 2017

language of work or name

English

0 references

publication date

1 October 2016

1 reference

The Journal of the American Medical Association

22 August 2017

1 reference

22 August 2017

316

1 reference

22 August 2017

13

1 reference

22 August 2017

1383-1391

1 reference

A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5386134

Combining information on multiple instrumental variables in Mendelian randomization: comparison of allele score and summarized data methods

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5386134

A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5386134

The support of human genetic evidence for approved drug indications

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5386134

Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5386134

Genetic studies of body mass index yield new insights for obesity biology

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5386134

New genetic loci link adipose and insulin biology to body fat distribution

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5386134

Efficacy and safety of LDL-lowering therapy among men and women: meta-analysis of individual data from 174,000 participants in 27 randomised trials

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5386134

Inactivating mutations in NPC1L1 and protection from coronary heart disease

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5386134

Genenames.org: the HGNC resources in 2015

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5386134

HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5386134

Discovery and refinement of loci associated with lipid levels

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5386134

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5386134

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5386134

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5386134

What makes UK Biobank special?

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5386134

Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5386134

Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5386134

Risk of incident diabetes with intensive-dose compared with moderate-dose statin therapy: a meta-analysis

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5386134

GCTA: a tool for genome-wide complex trait analysis

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5386134

METAL: fast and efficient meta-analysis of genomewide association scans

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5386134

Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5386134

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5386134

SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5386134

Reduced absorption of saturated fatty acids and resistance to diet-induced obesity and diabetes by ezetimibe-treated and Npc1l1-/- mice

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5386134

Beta-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5386134

NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5386134

Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5386134

‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease?*

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5386134

Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5386134

Treatment of blood cholesterol to reduce atherosclerotic cardiovascular disease risk in adults: synopsis of the 2013 American College of Cardiology/American Heart Association cholesterol guideline

22 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5386134

The effects of ezetimibe on non-alcoholic fatty liver disease and glucose metabolism: a randomised controlled trial

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5386134

Validating therapeutic targets through human genetics

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5386134

The loss-of-function PCSK9 p.R46L genetic variant does not alter glucose homeostasis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5386134

Using Genetic Variants to Assess the Relationship Between Circulating Lipids and Type 2 Diabetes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5386134

Association between familial hypercholesterolemia and prevalence of type 2 diabetes mellitus

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5386134

Hepatic NPC1L1 overexpression ameliorates glucose metabolism in diabetic mice via suppression of gluconeogenesis.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5386134

Niemann-Pick C1 Like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5386134

Proof That Lower Is Better--LDL Cholesterol and IMPROVE-IT

1 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27701660

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Effect of naturally random allocation to lower low-density lipoprotein cholesterol on the risk of coronary heart disease mediated by polymorphisms in NPC1L1, HMGCR, or both: a 2 × 2 factorial Mendelian randomization study

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27701660

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Developing medicines that mimic the natural successes of the human genome: lessons from NPC1L1, HMGCR, PCSK9, APOC3, and CETP

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27701660

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1001/JAMA.2016.14568

1 reference

22 August 2017

1 reference

22 August 2017

PubMed publication ID

27701660

1 reference