An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability (Q37728775)

22 August 2017

An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability (English)

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22 August 2017

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Christopher A. Cottrell

Christopher A Cottrell

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Jesper Pallesen

Jesper Pallesen

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Marit J. van Gils

Marit J van Gils

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Max Crispin

Max Crispin

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Ian Andrew Wilson

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Ian A Wilson

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22 August 2017

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Garnett Kelsoe

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Elise Landais

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Dennis R Burton

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Andrew B Ward

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Rogier W Sanders

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John P Moore

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22 August 2017

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Gabriel Ozorowski

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Per Johan Klasse

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Hanneke Schuitemaker

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Devin Sok

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Matthias Pauthner

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Karen L Saye-Francisco

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Karen Saye-Francisco

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Steven W de Taeye

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Anila Yasmeen

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Tom L G M van den Kerkhof

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Tom L G M van den Kerkhof

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Natalia de Val

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Anna Schorcht

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Stephanie Gumbs

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Inez Johanna

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Chi-Hui Liang

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Xiaoyan Nie

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Laura K Pritchard

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14 November 2016

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16199

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https://scigraph.springernature.com/pub.10.1038/nmicrobiol.2016.199

22 August 2017

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cites work

Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody

1 reference

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Composition and Antigenic Effects of Individual Glycan Sites of a Trimeric HIV-1 Envelope Glycoprotein

23 August 2017

1 reference

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Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes

23 August 2017

1 reference

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Dose-response curve slope helps predict therapeutic potency and breadth of HIV broadly neutralizing antibodies

23 August 2017

1 reference

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Design and structure of two HIV-1 clade C SOSIP.664 trimers that increase the arsenal of native-like Env immunogens

23 August 2017

1 reference

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Incomplete Neutralization and Deviation from Sigmoidal Neutralization Curves for HIV Broadly Neutralizing Monoclonal Antibodies

23 August 2017

1 reference

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HIV-1 VACCINES. HIV-1 neutralizing antibodies induced by native-like envelope trimers

23 August 2017

1 reference

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Structural Constraints Determine the Glycosylation of HIV-1 Envelope Trimers

23 August 2017

1 reference

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Antibody responses to envelope glycoproteins in HIV-1 infection

23 August 2017

1 reference

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Comprehensive antigenic map of a cleaved soluble HIV-1 envelope trimer

23 August 2017

1 reference

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HIV broadly neutralizing antibody targets

23 August 2017

1 reference

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Atomic-accuracy models from 4.5-Å cryo-electron microscopy data with density-guided iterative local refinement

23 August 2017

1 reference

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A native-like SOSIP.664 trimer based on an HIV-1 subtype B env gene

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5372380

Virological features associated with the development of broadly neutralizing antibodies to HIV-1

23 August 2017

1 reference

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Well-ordered trimeric HIV-1 subtype B and C soluble spike mimetics generated by negative selection display native-like properties

23 August 2017

1 reference

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Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5372380

Polyreactivity and autoreactivity among HIV-1 antibodies

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5372380

Comparative Protein Structure Modeling Using MODELLER

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5372380

Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-gp120 interface

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5372380

Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5372380

Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5372380

Cryo-EM Structure of a Fully Glycosylated Soluble Cleaved HIV-1 Envelope Trimer

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5372380

Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5372380

A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5372380

Addressing polyspecificity of antibodies selected from an in vitro yeast presentation system: a FACS-based, high-throughput selection and analytical tool

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5372380

Structural characterization of cleaved, soluble HIV-1 envelope glycoprotein trimers

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5372380

HIV-1 neutralizing antibodies: understanding nature's pathways

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5372380

Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5372380

RELION: implementation of a Bayesian approach to cryo-EM structure determination

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5372380

Prevention of overfitting in cryo-EM structure determination

23 August 2017

1 reference

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Cross-reactive broadly neutralizing antibodies: timing is everything

23 August 2017

1 reference

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Broad neutralization coverage of HIV by multiple highly potent antibodies

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5372380

Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding

23 August 2017

1 reference

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Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1

23 August 2017

1 reference

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Topological layers in the HIV-1 gp120 inner domain regulate gp41 interaction and CD4-triggered conformational transitions

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5372380

Analysis of memory B cell responses and isolation of novel monoclonal antibodies with neutralizing breadth from HIV-1-infected individuals

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5372380

MolProbity: all-atom structure validation for macromolecular crystallography

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5372380

Tiered categorization of a diverse panel of HIV-1 Env pseudoviruses for assessment of neutralizing antibodies

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5372380

Human immunodeficiency virus type 1 elite neutralizers: individuals with broad and potent neutralizing activity identified by using a high-throughput neutralization assay together with an analytical selection algorithm

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5372380

Factors associated with the development of cross-reactive neutralizing antibodies during human immunodeficiency virus type 1 infection

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5372380

IMGT, the international ImMunoGeneTics information system.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5372380

Frequency and phenotype of human immunodeficiency virus envelope-specific B cells from patients with broadly cross-neutralizing antibodies

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5372380

Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5372380

UCSF Chimera--a visualization system for exploratory research and analysis

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5372380

Polyreactivity of human IgG Fc-binding phage antibodies constructed from synovial fluid CD38+ B cells of patients with rheumatoid arthritis

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5372380

Structure, function and properties of antibody binding sites

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5372380

Differential binding of neutralizing and non-neutralizing antibodies to native-like soluble HIV-1 Env trimers, uncleaved Env proteins, and monomeric subunits

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5372380

Broadly neutralizing HIV antibodies define a glycan-dependent epitope on the prefusion conformation of gp41 on cleaved envelope trimers

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5372380

Cryo-EM structure of a native, fully glycosylated, cleaved HIV-1 envelope trimer

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5372380

Identification of Common Features in Prototype Broadly Neutralizing Antibodies to HIV Envelope V2 Apex to Facilitate Vaccine Design

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5372380

Affinity Maturation of a Potent Family of HIV Antibodies Is Primarily Focused on Accommodating or Avoiding Glycans.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5372380

Cleavage-independent HIV-1 Env trimers engineered as soluble native spike mimetics for vaccine design

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5372380

Model Building and Refinement of a Natively Glycosylated HIV-1 Env Protein by High-Resolution Cryoelectron Microscopy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5372380

In vivo protection by broadly neutralizing HIV antibodies

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5372380

Early development of broadly reactive HIV-1 neutralizing activity in elite neutralizers.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5372380

Isolation and propagation of HIV-1 on peripheral blood mononuclear cells

1 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27841852

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NMICROBIOL.2016.199

1 reference

22 August 2017

1 reference

22 August 2017

1 reference