In vivo production of novel vitamin D2 hydroxy-derivatives by human placentas, epidermal keratinocytes, Caco-2 colon cells and the adrenal gland. (Q37719172)

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scientific article published on 29 December 2013

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English	In vivo production of novel vitamin D2 hydroxy-derivatives by human placentas, epidermal keratinocytes, Caco-2 colon cells and the adrenal gland.	scientific article published on 29 December 2013

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In vivo production of novel vitamin D2 hydroxy-derivatives by human placentas, epidermal keratinocytes, Caco-2 colon cells and the adrenal gland (English)

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4 March 2020

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Andrzej Slominski

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Robert C Tuckey

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Wei Li

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Tae-Kang Kim

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Haleem Z Shehabi

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Edith K Y Tang

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Heather A E Benson

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Zongtao Lin

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Charles R Yates

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29 December 2013

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Molecular and Cellular Endocrinology

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383

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1-2

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181-192

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4 March 2020

Hydroxylation of CYP11A1-derived products of vitamin D3 metabolism by human and mouse CYP27B1.

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23 August 2017

Steroidogenesis in the skin: implications for local immune functions

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23 August 2017

20S-hydroxyvitamin D3, noncalcemic product of CYP11A1 action on vitamin D3, exhibits potent antifibrogenic activity in vivo

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23 August 2017

Cytochrome P450scc-dependent metabolism of 7-dehydrocholesterol in placenta and epidermal keratinocytes

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23 August 2017

In vivo evidence for a novel pathway of vitamin D₃ metabolism initiated by P450scc and modified by CYP27B1.

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23 August 2017

Production of 22-hydroxy metabolites of vitamin d3 by cytochrome p450scc (CYP11A1) and analysis of their biological activities on skin cells

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Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system

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Extra-adrenal glucocorticoids and mineralocorticoids: evidence for local synthesis, regulation, and function.

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The vitamin D receptor: a tumor suppressor in skin.

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Vitamin D: an ancient hormone

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23 August 2017

20-Hydroxyvitamin D2 is a noncalcemic analog of vitamin D with potent antiproliferative and prodifferentiation activities in normal and malignant cells

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The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders

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Purified mouse CYP27B1 can hydroxylate 20,23-dihydroxyvitamin D3, producing 1alpha,20,23-trihydroxyvitamin D3, which has altered biological activity

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23 August 2017

Products of vitamin D3 or 7-dehydrocholesterol metabolism by cytochrome P450scc show anti-leukemia effects, having low or absent calcemic activity.

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23 August 2017

20-Hydroxycholecalciferol, product of vitamin D3 hydroxylation by P450scc, decreases NF-kappaB activity by increasing IkappaB alpha levels in human keratinocytes

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23 August 2017

Pathways and products for the metabolism of vitamin D3 by cytochrome P450scc

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23 August 2017

20-Hydroxyvitamin D3, a product of vitamin D3 hydroxylation by cytochrome P450scc, stimulates keratinocyte differentiation

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23 August 2017

Vitamin D deficiency

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23 August 2017

Progesterone synthesis by the human placenta

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23 August 2017

A novel pathway for sequential transformation of 7-dehydrocholesterol and expression of the P450scc system in mammalian skin

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23 August 2017

A pathway for the metabolism of vitamin D3: unique hydroxylated metabolites formed during catalysis with cytochrome P450scc (CYP11A1).

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23 August 2017

Vitamin D: A millenium perspective

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23 August 2017

The ontogeny of 25-hydroxyvitamin D(3) 1alpha-hydroxylase expression in human placenta and decidua

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Evolutionary importance for the membrane enhancement of the production of vitamin D3 in the skin of poikilothermic animals

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The catalytic cycle of cytochrome P-450scc and intermediates in the conversion of cholesterol to pregnenolone

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23 August 2017

1,25-Dihydroxyvitamin D3 production by human keratinocytes. Kinetics and regulation

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23 August 2017

Synthesis of [6- 3 H]-1α-Hydroxyvitamin D 3 and Its Metabolism in Vivo to [ 3 H]-1α,25-Dihydroxyvitamin D 3

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23 August 2017

The role of CYP11A1 in the production of vitamin D metabolites and their role in the regulation of epidermal functions.

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6 September 2017

Novel vitamin D hydroxyderivatives inhibit melanoma growth and show differential effects on normal melanocytes

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Vitamin D 25-hydroxylase - Four decades of searching, are we there yet?

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High basal NF-κB activity in nonpigmented melanoma cells is associated with an enhanced sensitivity to vitamin D3 derivatives.

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Expression of catalytically active human cytochrome p450scc in Escherichia coli and mutagenesis of isoleucine-462.

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HaCaT cell line as a model system for vitamin D3 metabolism in human skin

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20,23-dihydroxyvitamin D3, novel P450scc product, stimulates differentiation and inhibits proliferation and NF-kappaB activity in human keratinocytes

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The cytochrome P450scc system opens an alternate pathway of vitamin D3 metabolism.

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Vitamin D receptor, UVR, and skin cancer: a potential protective mechanism

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Biopositive effects of low-dose UVB on epidermis: coordinate upregulation of antimicrobial peptides and permeability barrier reinforcement

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Kinetics of vitamin D3 metabolism by cytochrome P450scc (CYP11A1) in phospholipid vesicles and cyclodextrin.

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Demonstration of UVB-induced synthesis of 1 alpha,25-dihydroxyvitamin D3 (calcitriol) in human skin by microdialysis

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1 September 2018

UVB-induced conversion of 7-dehydrocholesterol to 1alpha,25-dihydroxyvitamin D3 in an in vitro human skin equivalent model

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Catalytic properties of cytochrome P-450scc purified from the human placenta: comparison to bovine cytochrome P-450scc

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12 December 2020

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10.1016/J.MCE.2013.12.012

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